Mitochondrial dysfunction and obesity

February 12, 2014

Mitochondrial dysfunction and obesity-In action

Mitochondrial diseases result from failures of the mitochondria, specialized compartments present in every cell of the body except red blood cells

Dysfunction means that something is not working or functioning in the correct way. Mitochondrial dysfunction refers to a situation in which the mitochondria are not working properly.

Mitochondrial diseases result from failures of the mitochondria, specialized compartments present in every cell of the body except red blood cells. Mitochondria are responsible for creating more than 90% of the energy needed by the body to sustain life and support growth.

When they fail, less and less energy is generated within the cell. Cell injury and even cell death follow. If this process is repeated throughout the body, whole systems begin to fail, and the life of the person in whom this is happening is severely compromised. The disease primarily affects children, but adult onset is becoming more and more common.

Depending on which cells are affected, symptoms may include loss of motor control, muscle weakness and pain, gastro-intestinal disorders and swallowing difficulties, poor growth, cardiac disease, liver disease, diabetes, respiratory complications, seizures, visual/hearing problems, lactic acidosis, developmental delays and susceptibility to infection

Mitochondrial dysfunction -Approaches to Resuscitate Aging Mitochondria

Understanding the proposed mechanisms by which mitochondrial dysfunction can contribute to aging and aging related diseases suggests several potential interventions. These include:

Maintenance of optimal Krebs cycle and respiratory chain efficiency.
Restoration of mitochondrial membrane fluidity.
Reduction in deleterious free radical activity.

CoQ10

Coenzyme Q10 is probably the most widely used cofactor for treating mitochondrial-related diseases. CoQ10 functions as the electron carrier in the inner mitochondrial membrane, transferring electrons from complexes I and II to complex III. In addition to increasing biosynthesis of ATP (the universal energy molecule), and acting as a potent free radical scavenger, CoQ10 also reduces lactic acid levels, improves muscle strength, and decreases muscle fatigability.¹

Mitochondrial dysfunction-restoration will cause weight loss

The role of your metabolism is to take the oxygen we breathe and the food we eat and process it to make energy, the fuel for life. (The fuel for your car is called gas. The fuel for your body is called ATP and it is produced from the combustion of food and oxygen.)

When they are not working properly, you suffer all the symptoms of low energy: fatigue, memory loss, pain, rapid aging, and more. Along the way, many things can go wrong that may impede your metabolism, make it run less efficiently, or practically shut it down.

Fatigue is the most common symptom of poorly functioning mitochondria. We need to keep them in top shape. The reason we poop out as we age is the constant insult and injury we give our mitochondria.

We have over 100,000 trillion of these powerhouses in our body, and each one contains 17,000 little assembly lines for making ATP, our major fuel. They use over ninety percent of the oxygen we breathe. They take up forty percent of the space inside the heart cells. The only problem is they are very sensitive to damage.

And the injury is from uncontrolled oxidative stress, which results from toxic insults, infections, allergens, stress, and just eating too much poor quality food.

Dr. Bruce Ames, the renowned scientist from the University of California at Berkeley, has spent the last decade discovering how we can give ourselves a metabolic tune up.

In one study he gave old rats who were tired, wouldn’t get on the treadmill anymore, and couldn’t find the cheese in the maze, or swim very far, two molecules that boost metabolism, that make the mitochondria run better. They are alpha lipoic acid and acetyl-L-carnitine.

Overnight these rats became young rats. They got up on the treadmill themselves, swam long distances without fatiguing and could easily find the cheese in the maze like young healthy rats. How could that happen?

Well, he simply gave the cells the raw materials they need for optimal function. As we age, our metabolism burns out from a lifetime of damage and insults. So again, the way to get healthy, the way to ultra-Wellness is very simple.

Depending on which cells are affected, symptoms may include loss of motor control, muscle weakness and pain, gastrointestinal disorders and swallowing difficulties…

Ultimately the goal of Ultra Wellness is to give everyone a metabolic tune up.

First, find the things that damage your metabolism and mitochondria.
Second, give your body the things that help the mitochondria function optimally.
Getting rid of toxins in the body will give you more energy. So here’s another reason to exercise: Exercise accelerates the detoxification process.
Exercise pushes the blood to circulate more efficiently through the body, allowing nutrients to move easily to reach all the organs and muscles.
Exercise helps lymph fluids circulate through the body, which removes toxins and other harmful materials. When you exercise, you naturally take in more oxygen; to make room for the added oxygen, your cells kick out toxins that are taking up space. When you exercise properly, your build up a sweat and toxins are released through the pores of the skin.
Playing at anaerobic levels is a great way to get in peak shape. It doesn’t do anything for longevity, or probably for overall health, but it’s great for vim, vigor and pure fitness.
Regular exercise is one of the most important things you can do for health. Participation in physical activity improves several body functions. These include: weight control, decreased risk of cardiovascular disease, decreased risk of diabetes, reduced risk of cancer, improved strength of bones and muscle, enhanced emotional status, decreases the natural degenerative changes that come with aging, and increases your chances to live longer.
That said, being consistently active can actually cause degeneration. Rest and recovery periods are essential as these periods allow the body to repair and rebuild itself.

Mitochondrial dysfunction –and exercise

It must be noted that consistent exercise can lead to overuse injury. Be sure to discern between consistently exercising and regular exercise.

Mitochondrial dysfunction and obesity-In action

Female hormones and weight loss

February 10, 2014

Female hormones and weight loss-what you need to know

Female hormones and their sites

A quick observation at a male versus a female body tells you right away something is different. While we can certainly recognize the obvious, we ignore these differences when we talk about diet and exercise for fat loss. The standard health and fitness advice of eat less and exercise more often does not work once people get out of their twenties and into their thirties, forties and beyond, and women are especially impacted.

So what are the difference between men and women, what determines where women store fat, and what can women do to address the fitness and fat loss issues that are unique to them?

The differences between men and women:

Women usually have smaller waists and more fat storage on the hips, thighs, and breasts. Estrogen and progesterone have much to do with this.

Estrogen is largely responsible for greater fat storage around the hips and thighs while both estrogen and progesterone impact larger breasts.

Because wom en experience monthly hormone fluctuations through the menstrual cycle, they know from experience that hormones impact how they feel, function, and look. They seem to intuitively get the fact that hormones play a role in determining whether they store fat or burn fat and where on the body it is lost or gained. To understand why women are so different, you have to understand their hormones.

Brief review of the menstrual cycle.

No discussion of female fat loss can take place without understanding the normal female menstrual cycle. The first day of bleeding for a woman represents day one of the menstrual cycle.

The menstrual cycle can then be divided into two phases, the follicular phase (named for the maturing of the ovarian follicle) and the luteal phase (named for the corpeus luteum which ovarian follicles become after ovulation). Ovulation, the release of an egg from the ovaries separates these two parts of the cycle.

The follicular phase is associated with higher estrogen levels compared to progesterone, while the luteal phase is the reverse. The relative ratios of these two hormones can have an impact on female related fat loss and health.

Estrogen and progesterone balance

A key fat loss measure in women is the estrogen and progesterone balance and how those hormones interact with other hormones like cortisol or insulin. Bigger hips and thighs on a women suggest greater estrogen levels relative to progesterone. The reverse of that, larger breasts and smaller hips and thighs, MAY indicate the opposite balance of these hormones.

The menstrual cycle is another key indicator of hormone balance. Since the time just before menses is usually a progesterone dominant time, PMS is a strong indication there is a progesterone deficiency relative to estrogen.

A woman can have higher than normal progesterone levels but still have a relative deficiency if estrogen levels are much higher in comparison. Many women with low progesterone relative to estrogen will report feeling like a completely different person before ovulation (the first two weeks of cycle) vs. after ovulation (last two weeks of cycle), where they feel much worse. This ill feeling usually manifests as depression, breast tenderness, moodiness, fatigue, lack of motivation, bloating, and other complaints.

Female fat distributions

Progesterone & estrogen both play a role in keeping the waist of women smaller. This is because estrogen works against the action of insulin (and testosterone a belly fat storing hormone in women) while both estrogen and progesterone oppose the action of cortisol. Insulin and cortisol, together with testosterone and low estrogen, are implicated in belly fat deposition in women.

Estrogen is the biggest factor in increasing fat storage at the hips and thighs providing the hour-glass shape. Progesterone with estrogen halts the storage of fat around the waist, but stress can have more of a negative impact on progesterone’s action. High stress has been shown to negatively impact progesterone, so women who see fat accumulating around the waist may want to work to reduce stress and raise progesterone.

Estrogen is a little different. Estrogen works to increase fat storage by up-regulating what is known as alpha-adrenergic receptors in female fat depots around the hips and thighs. Adrenergic receptors are like the gas and brake peddles on your car and work to accelerate or decrease fat usage. Beta-adrenergic receptors increase fat burning while alpha adrenergic receptors block it. The hips and thighs of a woman have higher amounts of alpha adrenergic receptors compared to men. This is also the major reason it is so difficult for some women to lose fat from the hips and thighs.

It is interesting to note here that one of the best ways to decrease the action of these alpha receptors is by using a low carb diet. This is why many women find fantastic results when they switch from the standard high carb diets and adopt more low carb eating patterns.

Many women have plenty of fat to spare in the hips and thighs but instead of burning it, they will become smaller in the torso and breast first and remain bigger on the bottom. This is a very frustrating scenario for many. Estrogen increases alpha-adrenergic receptor numbers while progesterone decreases it. Progesterone, like testosterone in men, MAY increase beta-adrenergic receptors. In this way, estrogen and progesterone work to influence the ability to burn fat and determine from which areas it will be taken from. This is an issue of hormone balance not calories.

Female hormone changes: age, lifestyle, and the environment

Female hormones have a great contribution to loosing weight

Women are often duped into believing the low calorie diet and aerobic exercise myth. This approach to weight loss rarely works and often creates damage to their body as a consequence. As a woman ages, as a consequence of stress, or because of environmental estrogen mimicking compounds several things begin to occur. The ovaries decrease their production of estrogen and progesterone. This exacerbates estrogen and progesterone balance, further pushing the body more towards estrogen dominance.

There are also many estrogen mimickers in our food and environment. At the same time, fat cells continue to produce estrogen through an enzyme called aromatase present in fat cells. This also leads the estrogen/progesterone balance to shift more towards estrogen. At the same time slimming and muscle building hormones, like human growth hormone (HGH) and DHEA, decline. Together this creates the perfect storm for female related fat gain and most of it occurs in the mid-section.

DHEA, HGH and progesterone are all hormones that act to keep a woman lean and block the storage of fat in the middle of her body. The tricky part is that a low calorie diet and a focus on aerobic exercise makes this worse because they do nothing to restore these powerful hormones and may actually worsen the estrogen progesterone imbalance in the long run.

Solutions to the problem:

Women should be focused on eating more of the right things and exercising smarter. This means eating higher amounts of vegetables and “estrogen free protein as well as engaging in weight training over cardio. There are only three ways to reliably restore HGH in the body: sleep, adequate protein, and intense exercise using weights.

Weight training is perhaps the most important aspect of this and is critical for female health especially to stop the belly fat that accumulates during aging. HGH is to women what testosterone is to men. It keeps them looking young, lean, and firm. Once progesterone levels fall due to stress, menopause, or other factors, HGH is all that is left to keep belly fat in check

Women falsely believe less intense exercise like walking and yoga will give them the desired “look” of their younger years. While these activities are exceedingly healthy, they will not be adequate to generate the hormonal effect needed to raise HGH. However, they will work synergistically with more intense exercise to lower the negative impact of cortisol.

Female hormones and weight loss-what you need to know

Healthy Rapid Weight Loss Begins with Safe Detox

January 14, 2014

Effect of toxins and neurotoxicity in pathogenesis of obesity

Healthy Rapid Weight Loss Begins with Safe Detox; Obesity is a metabolic disorder that can be characterized by abnormal accumulation of fat with associated co-morbidities. According to World Health Organization (WHO, 2010), over 300 million adults and 12 million children are obese, globally. Obesity is a complex disorder that involved several causatives including genetic, environmental and other factors. Obesity results in impaired energy homeostasis that is regulated by the higher centers. Studies have confirmed the role of hypothalamus in obesity (Kennedy 1953). However, the complete role of hypothalamus on fat regulation is unknown. Environmental toxins could contribute to neuronal damage, neurotoxicity and obesity in humans (Chung and Yoon 2008; Edwards and Myers 2008). Obesity due to environmental toxins is often less studied by the research community.

Industrial heavy metals and biotoxins exposure could cause obesity in humans. A study conducted by Turunen et al (2008) has suggested that increased marine fish consumptions are linked with higher exposure to environmental toxins and obesity risk. Obesity could increase the susceptibility of metal-induced cardiovascular effects (Chen et al. 2007; Lant and Storey 2010). Neuronal control is the main component of fat regulation and energy homeostasis maintenance. Gross anomalies in the frontal lobe could contribute to obesity (Pannacciulli et al. 2006; Taki et al. 2008; Ward et al. 2005). Experimental studies have demonstrated the direct association between increased adiposity and exacerbated neurodegeneration (Chen and Lipton 2006; Moroz et al. 2008; Sriram et al. 2002). Diabetic experimental animals fed with high-fat diet have exhibited symptoms of obesity with reduced brain weight and brain substrates including tau proteins (Moroz et al. 2008).

In experimental animals, methamphetamine induce dopaminergic neurotoxicity with reduced levels of striatal dopamine, dopamine transporter and tyrosine hydroxylase (Deng and Cadet 1999; Kogan et al. 1976; Sonsalla et al. 1989) and marked degree of neurodegeneration. When compared to lean experimental animals, the neurotoxic insult effects of methamphetamine were exaggerated in obese animals. Administration of methamphetamine could result in up-regulation of mitochondrial uncoupling protein-2 in the obese animals. These effects reduce ATP yield and cause obesity. Increased adipocyte apoptosis was reported in obese individuals with progressive neurodegeneration (Bharathi et al. 2006; Hirata 2002; Koh 2001; Ong and Farooqui 2005). In experimental animal studies, neurotoxins induced polyQ aggregation that was mediated by daf-16 and insulin-signaling pathway that contributes to obesity (Voisine et al. 2007; Ayyadevara et al. 2008; Gami et al. 2006; Grad and Lemire 2004; Inoue et al. 2005; Tullet et al. 2008). These studies have confirmed that obesity aggravates or induce neurodegeneration with impaired release of neurotransmitters such as norepinephrine (Belsare et al. 2010).

Healthy Rapid Weight Loss Begins with Safe Detox. Addictive substances such as MPTP are highly lipophilic in nature that readily cross the blood-brain barrier and cell membranes. The neuroactive chemical is metabolized intra-cellularly into MPP+. Due to polarity, the xenobiotic is released and taken up by dopamine metabolizing cells via the DAT ((Russ et al. 1996; Javitch et al. 1985). MPP+ inactivates complex I of mitochondrial respiratory chain in the dopaminergic neurons (Mizuno et al, 1988) and reduce ATP levels with increased free radical generation. These molecular changes contribute to neurodegeneration of dopaminergic neurons and obesity.

Healthy Rapid Weight Loss Begins with Safe Detox; * Detoxification and weight loss

Proper detoxification is vital for prevention of obesity and to promote weight loss among obese individuals. Detoxification process significantly reduces white adipose tissue storage in the vital organs and prevents generation of excessive fatty acids which are toxic to biological membrane.

Exposure to fat soluble toxins such as mold, PCB’s, formaldehyde, alcohol, pesticides and acetaldehyde due to digestive toxicity or overgrowth of intestinal candida could increase the risk of neurotoxicity and obesity. In low levels of toxicity, these environmental toxins cause thyroid dysfunction, liver degeneration and cellular health (Koob GF & Volkow ND, 2010; Spooren W et al, 2010; Purzycki CB & Shain DH, 2010; Hiestand PC et al, 2008).

Excessive exposure to these toxins could cause rapid weight gain with impaired defense mechanisms. Toxic challenges could contribute to neurotoxicity and metabolic crash. The role of fat-soluble toxins on neurotoxicity is mediated by activation of immune system and brain cell damage. These changes contribute to obesity and addictive behaviours with risk of Parkinsonism and Alzheimer’s disease (Russell L et al, 1991; Barone R et al, 2007).

Healthy Rapid Weight Loss Begins with Safe Detox under the supervision of a trusted qualified physician who understands proper and safe detox. Dr. Dalal Akoury the Founder of AWAREmed can coach through Healthy detox. Call 843-213-1480

The aim of the detoxification is to reduce the accumulation of fat-soluble toxins in the vital organs and circulation that contributes to obesity. Detoxification process promotes weight loss in a natural way by preventing neurotoxicity associated with dopaminergic and leptin pathways. Generally, detoxification includes tailored diet such as Leptin diet with moderate exercise regimen to meet the individualized needs and to relive stress. Detoxification programmes could be organ-specific including liver, bowel or general. Healthy weight loss programme should include proper detoxification with healthy and balanced diet.

Healthy Rapid Weight Loss Begins with Safe Detox * Liver detox and its effect on weight loss

Modern lifestyle with stress is a major contributing factor for obesity and unhealthy lifestyle. In the recent days, detoxification as a potential weight loss method is gaining steam among the health conscious individuals. Detoxification programme includes healthy diet with balanced nutritional supplements to flush out the toxins. Liver detoxification process includes drinking of adequate levels of water with organic foods such as fresh fruits, raw and nutritious vegetables to aid liver health.

During active liver detox process, consumption of alcohol, caffeinated beverages, refined and/or processed food or tobacco are not allowed. These changes could improve the liver health; help the tissues to purge the toxin and to regenerate.

Liver detox diet mostly comprised of antioxidants, fiber rich diet with lifestyle changes and exercise. Physical activity including moderate exercising is recommended to aid toxin elimination via the sweat and stools. Liver cleansing diets generally promote intestinal health with proper elimination of the waste substances including urine and stools.

Liver detox aids weight loss by reducing the stress mechanisms and negative neural feedback mechanisms that are linked with obesity. Liver detoxification cleanses the liver toxins and aids proper functioning including normal synthesis of enzymes, optimization of food assimilation and cholesterol regulation.

Healthy Rapid Weight Loss Begins with Safe Detox * Proper elimination of stool, urine, skin to achieve weight loss

Proper detox programme should aid complete elimination of stool, urine and sweat to improve weight loss among obese individuals. In addition with body’s own natural detoxification process, detox diets comprised of high-fiber diet, complex carbohydrates, proteins, vitamins and minerals improve the excretory system to function properly.

Adequate water consumptions regulate the renal system and aids elimination of waste substances including urea, salts, creatinine and uric acid. Normal fluid elimination could optimize fluid retention/balance and prevents obesity. Proper elimination of urine and sweat prevents edema and improve weight loss among obese individuals. Daily defecation is vital for weight loss. Weight loss diet should promote colonic microbiome that detoxify food wastes and strengthen intestinal walls against the entry of pathogenic microorganisms.

Liver aids detoxification process and converts lipid-soluble chemicals into water-soluble compounds and promotes renal excretion. Lipid-soluble toxins are the main contributors of neurotoxicity and obesity. Some toxins are also eliminated via the lungs and skin during moderate physical activities including exercise.

Proper elimination of waste substances as urine, sweat and stools acts a natural detoxification process and reduce the effects of naturally-derived toxins in the body. To promote proper elimination of urine, sweat and stools it is important to consume required levels of water with balanced, fiber-rich diet. These steps can increase satiety and maintains optimal blood glucose with proper elimination of waste substances. Normal blood glucose homeostasis with balanced food could reduce the obesity risk in humans.

Healthy Rapid Weight Loss Begins with Safe Detox What is *The Proper detoxification and mechanisms that facilitate weight loss?

Proper detoxification is important for balance of body mechanisms to lose weight. Some processes including treatment of hormonal imbalances, neutralization or enzyme potentiated desensitization with exercise could facilitate weight loss.

Treatment of hormonal imbalances, particularly adrenal and thyroid functions could improve the metabolic rate. Hormonal imbalances could delay the metabolic rate and also the detoxification process

Neutralization or Enzyme Potentiated Desensitization could reduce the sensitization against harmful chemicals and to reduce toxic load in the body. Decreased free radicals generation could prevent the onset of metabolic syndrome, a key causative of obesity. Normalization of glucose and other metabolic pathways could facilitate weight loss among obese individuals. (McEwen LM, 1973; McEwen LM, 1975)

When combined with patient-specific exercises, the metabolic rate could be increased with reduced gut transit time. These mechanisms lower the food clearance rate from the gut and increase satiety. Improved glucose metabolism with food control could facilitate weight loss.

Healthy Rapid Weight Loss Begins with Safe Detox addresses the* Links between detoxification pathways and weight loss

Detoxification promotes healthy weight loss by intake of nutrients with less calories, sugar and salt which are addictive in nature that contributes to obesity. Detoxification reduces dopaminergic cellular neurotoxicity and obesity.

Detoxification processes directly affects the leptin, insulin and dopamine pathways that contributes to food addiction and cravings. Fiber-rich diets with nutrients increase plasma ghrelin levels that regulate insulin and leptin pathways. Controlled and healthy weight loss can be achieved by regulation of white adipose tissue formation which depends on insulin and leptin pathways. Ghrelin controls satiety and appetite and promotes weight loss among obese individuals.

Healthy Rapid Weight Loss Begins with Safe Detox

Stress Slow Killer is Serious Business

December 4, 2013

Dr. Dalal Akoury

Stress Slow Killer is Serious Business

Stress Slow Killer affects us physically and emotionally. The stress response is mediated through HPA axis and activation of the autonomic nervous system. The aim is to mobilize energy for the “fight or flight” response. This brings about changes in almost all organs and tissues as a whole. In an acute event, after the stressor disappears, the homeostasis or internal equilibrium is regained. In case where the stress continues it leads to chronic disorders involving many organs and this also depends on the nature of stress.

The effects of Stress Slow Killer on each organ

Stress Slow Killer and the Nervous System:

Stress leads to activation of HPA axis once the hypothalamus receives signals from cerebral cortex which are perceived as stress. Then hypothalamus releases corticotropin releasing hormone which stimulates the anterior pituitary to produce adrenocorticotropic hormone (ACTH). ACTH is secreted into the systemic circulation and stimulates the adrenal glands to produce stress hormone called cortisol.

There is stimulation of autonomic nervous system which is caused by direct stimulation of both sympathetic and parasympathetic systems. This is done by hypothalamus. The sympathetic activation leads to release of adrenaline and noradrenaline by the adrenal medulla. These hormones increase the heart rate, raise blood pressure, increase glucose levels in the blood and suppress digestive and reproductive functions. This stimulation is more obvious when the stressor is strong like acute pain. In people with chronic pain, this effect is weak and not clinically obvious unless there is aggravation of symptoms. After the stressor disappears, the parasympathetic nervous system helps in reverting back to normal and regain of internal equilibrium. The autonomic nervous system also interacts with the enteric nervous system and has anti-inflammatory properties.

Stress Slow Killer and the Musculoskeletal system

Due to the effect of stress, the muscle tone increases as the body is prepared for the “fight or flight” response. It results in tension headache and back pain.

Stress Slow Killer and the Respiratory system

Stress increases respiratory rate to increase the availability of oxygen to all organs and muscles so as to prepare for the stress response. This occurs due to direct stimulation of the respiratory center. An excessive stimulation may bring panic attack in some individuals.

Stress Slow Killer and the Cardiovascular system

Acute stress causes activation of the cardiovascular system. This occurs mainly due to release of noradrenaline and adrenaline from the adrenal medulla. These hormones act on the heart to produce the effects which include rapid heart rate, stronger contractions of heart and palpitations. The blood flow to the skeletal muscles and heart increases due to dilatation of blood vessels. These changes occur with acute stress.

Chronic stress is associated with inflammation of arteries of heart (coronary arteries) and may lead to heart attack. There is also higher incidence of hypertension, stroke and atherosclerosis.

Stress Slow Killer and the Endocrine system

Stress related ACTH stimulation results in enlargement of adrenal glands which are required to produce increased amounts of stress hormones. The adrenal cortex produces cortisol and adrenal medulla secretes noradrenaline and adrenaline. These three adrenal hormones play a crucial role in the stress response.

Stress Slow Killer and the Gastrointestinal system

Stress promotes increased consumption of palatable food. Severe stress is associated with nausea and vomiting. It may result in reflux esophagitis. Under the effects of cortisol and adrenaline, liver produces more glucose which is used for energy production by various organs and skeletal muscles. Stress affects digestion adversely and may modulate gut motility to produce diarrhea or constipation.

Stress Slow Killer and the Reproductive system

The stress response leads to suppression of reproductive function. Chronic stress impairs testosterone secretion in the testes. The sperm production is reduced and infertility may occur. In women, the menstrual cycles become irregular and painful or may develop complete amenorrhea. The sexual desire is reduced significantly.

Stress Slow Killer and the Immune system

Stress leads to suppression of immunity so as to conserve energy. In case of chronic stress, this increases the risk of infections due to poor immunity.

Stress Slow Killer and the Cellular and molecular effects of stress

Stress increases intracellular calcium. This effect is seen in association with message induced stress which stimulates the mast cells to release histamine which causes local vasodilatation and improves perfusion.

On exposure to stress, the cells generate heat shock proteins which promote cell survival. Exposure of cells to temperature of 3 to 5 °C above normal, reactive oxygen species causes induction of heat shock proteins 27 and 70. These proteins inhibit apoptosis and promote survival.

Apoptosis or programmed cell death occurs if a cell is partially damages due to stress or fails to sustain stress. During this process, special enzymes called caspases are activated which bring about protein changes resulting in cell death.

Autophagy is characterised by self-destruction of cell organelles like mitochondria and cytoplasmic proteins. Autophagy is observed in cells exposed to stressors like starvation, ischemia reperfusion injury, increased intracellular calcium and endoplasmic reticulum stress.

So Stress Slow Killer affects each system in the body, each organ and each cell.

Stress Slow Killer is Serious Business

Botox Beauty without botox or fillers

December 2, 2013

Your Secret to Botox Beauty without Botox

There is no Fountain of Youth, unfortunately. As we age, we are constantly looking at our reflections, wondering how we can best improve upon our looks and maintain our youthful complexion and beauty. We have sought out moisturizers, creams, injections and the like in order to maintain the semblance of youth. It’s become an incredible, multi-billion dollar industry that has employed thousands worldwide, and yet, it’s not necessary to spend a fortune to maintain beauty.

There are a few simple steps everyone can follow in order to continue to be beautiful, and they are inexpensive and easy. By following these steps and incorporating them into a daily routine, virtually anyone can stay beautiful. Botox Beauty without botox or fillers is easy to attain ask Dr. Dalal Akoury?

1. Clean and moisturize daily: You should wash and moisturize your face at least twice daily. Ensure you use a cleanser designed for your skin type. If you have oily skin, you should use a cleanser specifically for oily skin. Tea tree oil-based cleansers, for instance, would be ideal for combination skin, as it’s good to dry out the oily skin, but not so harsh that it would abuse the dryer skin.

It’s also important to consider the sort of moisturizer you are looking at applying. Most moisturizers now come with a variety of SPF levels in order to help protect your skin while it’s hydrating your skin at the same time. There are also moisturizers designed specifically for certain skin types, so it’s important to realize that you need the right one for your skin.

2. Water – it does a body good: Botox Beauty without botox or fillers is possible when you remember the importance of drinking those 8- 8 ounce glasses of water daily can not be emphasized enough. Not only does it keep your system running smoothly, water is vital for the efficient running of your body and its systems. You have to remember, the human body is made up of 70 per cent water, and as such, drinking enough water is critical. The added benefit of drinking nearly two liters of water daily is that it keeps your skin clear and your body running efficiently. However, drinking that quantity of water can lead to going to the washroom a lot, so it’s important to remember to go to the bathroom regularly and not hold the need to go back.
3. Brush your teeth: It should come as no surprise that good teeth health helps keep your body healthy as well. In addition, there is something to be said for the power of a beautiful white smile to help people look younger. You should brush your teeth at least twice a day for at least two minutes each time. To brighten your smile, use a whitening toothpaste on a regular basis. That will help your smile continue looking its best. That is the easy way to experience Botox Beauty without botox or fillers.
4. Get green: The population of the western world has a tendency to not eat a lot of fruits and vegetables. The problem is, we need to eat at least five portions of fruits and vegetables per day. If we don’t, our bodies tend not to run as smoothly and we also don’t look as healthy physically. Eating a sufficient amount of fruits and vegetables ensures your skin will continue to look healthy and glow youthfully.
5. Exercise, exercise, exercise: It’s important to realize how very vital regular exercise is to the efficient functioning of the human body. Exercise not only keeps your blood flowing well, it also helps improve your digestion, as material moves through your digestive system more smoothly while you are exercising. That’s why so many people like the idea of going for a walk after dinner; they need to improve their body’s digestion of what may have been a heavy meal.
6. Relax and stay natural: Keep makeup to a minimum, for starters. Most cosmetics will block pores to an extent, which means you could run into issues in terms of keeping your skin clear. Avoiding a lot of makeup can mean you look more natural, which is generally a great deal more appealing than someone who has heavy makeup on. In fact, there is definitely some appeal to keeping your face makeup free, as you look natural. Avoid unesessary makeup to enjoy Botox Beauty without botox or fillers.
7. Smile! Another way of looking natural is simply by smiling. So many people like the look of someone who is honestly and genuinely smiling as it makes the person seem far more open and friendly than they usually do. In fact, smiling and friendly people seem far more appealing to people than people who are frowning.
8. Sleep: It’s really important to get enough sleep on a regular basis for the simple fact it keeps the body running at optimal efficiency. If we can’t get enough sleep, we know that we get shadows under our eyes and our skin may look puffy and generally worn. It’s really hard, at times, to get enough sleep, simply because we live in a very busy 21st century world. However, it’s always important to get enough sleep; not only will that have an impact on how we look overall, a lack of sleep can affect our judgment and reaction times when we’re engaged in activities requiring our full concentration, such as driving. If you get into an accident, you will definitely struggle with looking beautiful and feeling beautiful.

There are many different strategies we can all make use of when it comes to looking and feeling beautiful. Certainly, there’s a lot to keep in mind, particularly since today’s society is so busy. Many of us are eating highly processed food, which definitely means that we are running the risk of putting on unnecessary weight, which definitely can have a significant impact on how we view ourselves in the first place. It’s also important to drink plenty of water, smile at people, and generally try to get enough sleep. Without taking the time and ensuring all of this is being done – particularly the water drinking – you have a really hard time ensuring that you can maintain your own personal level of beauty as naturally as possible.

Your Secret to Botox Beauty without Botox

Category Archives: Healthy Aging