Opioid abuse and its effects to the brain reward system

March 19, 2014

Opioid abuse and its effects to the brain reward system-How does the reward center in the brain work?

The brain is the life controller and must not be affected by opioid addiction or abuse

Life is the most precious and price less gift humanity has. This is only useful and meaning full with proper functioning brain. We all understand that the brain is certainly a busy little organ yet it is on duty tirelessly for life without taking any vacation, the moment it possess for whatever reason life ends or serenity is rearranged. Despite it busy roles in driving the body; it knows fun and pleasure when it sees it. When an external stimulus, such as a particular food or a potential mate, has been encountered and deemed a pleasurable sensation, the cerebral cortex signals the ventral tegmental area of the brain to release the chemical dopamine into the amygdala, the prefrontal cortex and the nucleus acumens. These latter regions of the brain make up the reward system. These areas work in conjunction to deliver a sense of pleasure and focus the attention of the individual so that he or she learns to repeat the behavior once more. Researchers theorize that this is how behaviors necessary for survival, such as reproduction and eating, are learned.

Interestingly, the reward center doesn’t kick into gear only when we eat something delicious or meet a potential new love interest. It turns out that generosity can be quite a kick too! MRI studies have revealed that when we perform an act of kindness, the brain’s reward center is aroused and we experience feelings of pleasure. The brain is flooded with happiness-inducing dopamine whenever we give a homeless person some money or help out someone in need. A study conducted in 2008 confirmed the belief that spending money on other people can result in elevated feelings of happiness for the giver.

It might not be all fun and games for the reward center, however, a recent study came to a startling conclusion that the brain’s reward center responds to bad experiences as well as good. Doing something scary or even merely thinking about it can trigger a release of dopamine. In essence, dopamine isn’t just triggered by fun and pleasurable events. Negative things can do the trick too.

Opioid abuse and its effects to the brain reward system-Reward pathway

The most important reward pathway in brain is the mesolimbic dopamine system. This circuit (VTA-NAc) is a key detector of a rewarding stimulus. Under normal conditions, the circuit controls an individual’s responses to natural rewards, such as food, sex, and social interactions, and is therefore an important determinant of motivation and incentive drive. In simplistic terms, activation of the pathway tells the individual to repeat what it just did to get that reward. It also tells the memory centers in the brain to pay particular attention to all features of that rewarding experience, so it can be repeated in the future. Not surprisingly, it is a very old pathway from an evolutionary point of view. The use of dopamine neurons to mediate behavioral responses to natural rewards is seen in worms and flies, which evolved 1-2 billion years ago.

The VTA-NAc pathway is part of a series of parallel, integrated circuits, which involve several other key brain regions.

The VTA is the site of dopaminergic neurons, which tell the organism whether an environmental stimulus (natural reward, drug of abuse, stress) is rewarding or aversive.

The NAc, also called ventral striatum, is a principle target of VTA dopamine neurons. This region mediates the rewarding effects of natural rewards and drugs of abuse.

The amygdala is particularly important for conditioned forms of learning. It helps an organism establish associations between environmental cues and whether or not that particular experience was rewarding or aversive, for example, remembering what accompanied finding food or fleeing a predator. It also interacts with the VTA-NAc pathway to determine the rewarding or aversive value of an environmental stimulus (natural reward, drug of abuse, stress).

The hippocampus is critical for declarative memory, the memory of persons, places, or things. Along with the amygdala, it establishes memories of drug experiences which are important mediators of relapse.

The hypothalamus is important for coordinating an individual’s interest in rewards with the body’s physiological state. This region integrates brain function with the physiological needs of the organism.

Probably the most important, but least understood, are frontal regions of cerebral cortex, such as medial prefrontal cortex, anterior cingulate cortex, and orbitofrontal cortex, which provide executive control over choices made in the environment (for example, whether to seek a reward).

The locus coeruleus is the primary site of noradrenergic neurons in the brain, which pervasively modulate brain function to regulate the state of activation and mood of the organism.

The dorsal raphe is the primary site of serotonergic neurons in the brain, which, like noradrenergic neurons, pervasively modulate brain function to regulate the state of activation and mood of the organism.

Of course, these various brain regions, and many more, do not function separately. Rather, they function in a highly inter-related manner and mediate an individual’s responses to a range of environmental stimuli.

Opioid abuse and its effects to the brain reward system-What are opioids?

Opioids are medications that relieve pain. They reduce the intensity of pain signals reaching the brain and affect those brain areas controlling emotion, which diminishes the effects of a painful stimulus. Medications that fall within this class include hydrocodone (e.g., Vicodin), oxycodone (e.g., OxyContin, Percocet), morphine (e.g., Kadian, Avinza), codeine, and related drugs. Hydrocodone products are the most commonly prescribed for a variety of painful conditions, including dental and injury-related pain. Morphine is often used before and after surgical procedures to alleviate severe pain. Codeine, on the other hand, is often prescribed for mild pain.

Symptoms of opioid abuse can be categorized by physical state.

Opioid abuse and its effects to the brain reward system-Intoxication state

Patients with opioid use disorders frequently relapse and present with intoxication. Symptoms vary according to level of intoxication. For mild to moderate intoxication, individuals may present with drowsiness, pupillary constriction, and slurred speech. For severe overdose, patients may experience respiratory depression, stupor, and coma. A severe overdose may be fatal.

Opioid abuse and its effects to the brain reward system-Withdrawal state

Symptoms of withdrawal include the following:

Autonomic symptoms – diarrhea, rhinorrhea, diaphoresis, lacrimation, shivering, nausea, emesis, piloerection
Central nervous system arousal – sleeplessness, restlessness, tremors
Pain – abdominal cramping, bone pains, and diffuse muscle aching
Craving – for the medication

Opioid abuse and its effects to the brain reward system-How does the reward center in the brain work?

Breast Cancer and Alcohol; Role of Alcohol

March 17, 2014

Breast cancer and Alcohol-Role of alcohol

Breast cancer and Alcohol-Definition

Alcohol has great effect on the causes of cancer, keep health by a voiding alcohol

Breast cancer is that which forms in tissues of the breast. The most common type of breast cancer is ductal carcinoma, which begins in the lining of the milk ducts (thin tubes that carry milk from the lobules of the breast to the nipple).

Another type of breast cancer is lobular carcinoma, which begins in the lobules (milk glands) of the breast. Invasive breast cancer is breast cancer that has spread from where it began in the breast ducts or lobules to surrounding normal tissue. Breast cancer occurs in both men and women, although male breast cancer is rare.

Breast cancer and Alcohol-Potential link between alcohol consumption and the cancer

Scientists looking at particular enzyme found a biological molecule that accelerates chemical reactions known as CYP2E1. Their findings offer a possible target to improve outcomes for patients in the later stages of the disease.

This enzyme, known as CYP2E1, has been implicated in various liver diseases linked to alcohol consumption, Alcoholic Liver Disease (ALD), as well as diabetes, obesity and cancer. That is Breast Cancer and Alcohol are closely linked.

They wanted to understand why an enzyme known to function mainly in the liver was found to be heavily present in some types of breast cancer tissues. They also wanted to explore what other activities this enzyme might have that control the development of breast cancer. Their findings revealed that the enzyme breaks down various molecules within cells, including alcohol. The by-products of this metabolism include reactive oxygen species (ROS), resulting in something called oxidative stress, in normal physiological conditions this aids cellular functions, whereas when concentrations of ROS are high or oxidative stress becomes chronic, cells can be seriously damaged. Breast Cancer and Alcohol are closely related.

Previous studies have shown that the enzyme is most strongly expressed in early stages of breast tumors rather than more developed tumors and scientists believe that it contributes to the progression of breast cancer.

The study, published in Breast Cancer Research, found that depending on the stage of the breast cancer, high levels of the enzyme can help cells survive during stress. It was also found that inhibiting the activity of the enzyme in cells with high migratory potential promoted cell migration a process linked to cancer spreading known as metastasis.

Breast cancer and Alcohol-Causes and risk factors

We have not fully understood the causes of breast cancer, as a result of this may be difficult to say with certainty why one woman may develop breast cancer and another may not. However the risk factors are known, some of these can change the likelihood that someone may develop breast cancer. There are some factors you cannot do anything about, but there are some you can change.

Alcohol

Your risk of developing breast cancer can increase with the amount of alcohol you drink. Research shows that, for every 200 women who regularly have two alcoholic drinks a day, there are three more women with breast cancer compared with women who do not drink at all. That study confirms that Breast Cancer and Alcohol has a cause and effect relationship.

Age

The risk of developing breast cancer increases as you get older. Breast cancer is most common among women over 50 who have been through the menopause. 8 out of 10 breast cancer cases occur in women over 50.

All women between 50 and 70 years of age should be screened for breast cancer every three years as part of the NHS Breast Screening programme. Women over the age of 70 are still eligible to be screened and can arrange this through their GP or local screening unit. Currently, there are ongoing pilot studies looking at widening the screening age range to 47-73.

Family history

If you have close relatives who have had breast cancer or ovarian cancer, you may have a higher risk of developing breast cancer. However, as breast cancer is the most common cancer in women, it is possible for it to occur more than once in the same family by chance.

Most breast cancer cases are not hereditary. However, particular genes, known as BRCA1 and BRCA2, can increase your risk of developing both breast and ovarian cancer. It is possible for these genes to be passed on from a parent to their child. If you have, for example, two or more close relatives from the same side of your family who have had breast cancer under the age of 50, you may be eligible for surveillance for breast cancer or for genetic screening to look for the genes that make developing breast cancer more likely.

Previous diagnosis of breast cancer

If you have previously had breast cancer or early non-invasive cancer cell changes contained within breast ducts, you have a higher risk of developing it again, either in your other breast or in the same breast again.

Previous benign breast lump

A benign breast lump does not mean you have breast cancer, but certain types of lump may slightly increase your risk of developing it. Certain benign changes in your breast tissue, such as atypical ductal hyperplasia (cells growing abnormally in ducts) or lobular carcinoma in situ (abnormal cells inside your breast lobes), can make getting breast cancer more likely. If you drink alcohol specially more than 2 glasses per day it will increase your risk to develop breast cancer. Breast cancer and alcohol go hand in hand.

Breast density

Your breasts are made up of thousands of tiny glands (lobules), which produce milk. This glandular tissue contains a higher concentration of breast cells than other breast tissue, making it denser. Women with denser breast tissue may have a higher risk of developing breast cancer because there are more cells that can become cancerous. This is specially true if you drink alcohol regularly. Breast cancer and alcohol have been closely associated.

Dense breast tissue can also make a breast scan (mammogram) harder to read because it makes any lumps or areas of abnormal tissue harder to spot. Younger women tend to have denser breasts. As you get older, the amount of glandular tissue in your breasts decreases and is replaced by fat, so your breasts become less dense.

Being overweight or obese

Breast Cancer and Alcohol; The role of Alcohol is more pronounced if you have been through the menopause and are overweight or obese, you may be more at risk of developing breast cancer. This is thought to be linked to the amount of estrogen in your body, as being overweight or obese after the menopause causes more estrogen to be produced.

Being tall

If you are taller than average, you are more likely to develop breast cancer than someone who is shorter than average. This may be due to interactions between genes, nutrition and hormones, but the reason is not fully understood.

Hormone replacement therapy (HRT)

Hormone replacement therapy (HRT) is associated with a slightly increased risk of developing breast cancer. Both combined HRT and estrogen-only HRT can increase your risk of developing breast cancer, although the risk is slightly higher if you take combined HRT. When you are considering HRT pay attention to the fact that Breast Cancer and Alcohol may play a role in Breast cancer development with HRT.

It is estimated there will be an extra 19 cases of breast cancer for every 1,000 women taking combined HRT for 10 years. The risk continues to increase slightly the longer you take HRT, but returns to normal once you stop taking it.

Breast cancer and Alcohol-Role of alcohol

The source of death in Cocaine and Heroin

March 17, 2014

The source of death in Cocaine and Heroin-Drug Scourge

There is evidence of heroin and cocaine deaths in male than female according to studies conducted

The society and the world over are weeping in great anguish of endless death thanks to the renewed vigor in drug usage. You take a walk in the streets and parks of our beautiful nations and you are saddened with what you see, young and old together drinking and smoking publicly and secretly. Our governments have legalized the use of some of these drugs and are making millions and millions of money inform of taxes all in the name of revenue for development, security and wellbeing of its citizens.

When you take a keen observation on majority of illness keeping patients in hospitals for weeks, months and even years are 90 percent related to the drug consumption. It does not matter the intensity of the consumption, whether one is an addict or not the common denominator is that both are using drugs. Legal or illegal, cheap or expensive whatever the adjective you choose to describe the noun drug we have patients in hospitals, at homes and learning institutions suffering from different illnesses associated with drug use.

Researches are working round the clock trying to find remedies for drug related problems and the authorities/governments are spending a big percentage of the revenue they collect from firms associated with drugs in treatment research and creating awareness of what they themselves are promoting in some way. Anyway there are numerous types of drugs being abused today and it is all important that we talk about them openly and without any shame. I beseech all of us to face the society with the real truth about the abuse of drugs but for the purpose of this article I want to zero in to two killer drugs in our society (especially in Europe) today that is Cocaine and Heroin.

The source of death in Cocaine and Heroin-Drug induced deaths

Much as there are many unreported cases, the number of reported drug-induced deaths today can be influenced by the prevalence and patterns of drug use (injection, polydrug use), the age and the co-morbidities of drug users, and the availability of treatment and emergency services, as well as by the quality of data collection and reporting. Improvements in the reliability of European data have allowed better descriptions of trends, and most countries have now adopted a case definition endorsed by the EMCDDA. Nevertheless, caution must be exercised when comparing countries because there are still differences in reporting methodology and data sources. But the common denominator is that drug induced deaths are skyrocketing.

The source of death in Cocaine and Heroin-Opioids

Opioids, mainly heroin or its metabolites, are present in the majority of drug-induced deaths reported in Europe. In the 22 countries providing data for 2008 or 2009, opioids accounted for the large majority of all cases: over 90 % in five countries, and between 80 % and 90 % in a further 12. Substances often found in addition to heroin include alcohol, benzodiazepines, other opioids and, in some countries, cocaine.

This suggests that a substantial proportion of all drug-induced fatalities occur in a context of polydrug use, as illustrated by a review of toxicology of drug-related deaths in Scotland in 2000-07. It showed that the presence of heroin and alcohol were positively associated, particularly among older males. Among men whose deaths were related to heroin, alcohol was present in 53 % of those aged 35 and more, compared to 36 % in cases under 35.

Men account for most overdose deaths reported in Europe at 81 %. Overall, there are around four males for each female case (with the ratio ranging from 1.4:1 in Poland to 31:1 in Romania). In the Member States that joined the EU more recently, reported drug-induced deaths are more likely in males and in younger people compared to the pre-2004 Member States and Norway. Patterns differ across Europe, with higher proportions of males reported in southern countries. Denmark, the Netherlands, Sweden and Norway report higher proportions of older cases. In the majority of countries, the average age of those dying of heroin overdoses is in the mid-thirties, and in many countries it is increasing.

A number of factors are associated with fatal and non-fatal heroin overdoses. These include injection and simultaneous use of other substances, in particular alcohol, benzodiazepines and some antidepressants. Other factors linked with overdoses are binge drug use, co-morbidity, homelessness, poor mental health (e.g. depression and intentional poisoning), not being in drug treatment, previous experience of overdose, and being alone at the time of overdose. The time immediately after release from prison or discharge from drug treatment is a particularly risky period for overdoses, as illustrated by a number of longitudinal studies.

The source of death in Cocaine and Heroin-Trends in drug-induced deaths

Drug-induced deaths increased sharply in Europe during the 1980s and early 1990s, paralleling the increase in heroin use and drug injection, and thereafter remained at high levels. Between 2000 and 2003, most EU Member States reported a decrease, followed by a subsequent increase from 2003 until 2008. Preliminary data available for 2009 suggest an overall figure equal to or slightly below that for 2008. Where a comparison is possible, the numbers of deaths reported have decreased in some of the largest countries, including Germany, Italy and the United Kingdom.

The reasons for the sustained or increasing numbers of reported drug-induced deaths in some countries are difficult to explain, especially given the indications of decreases in injecting drug use and increases in the numbers of opioid users in contact with treatment and harm-reduction services. Possible explanations include: increased levels of polydrug use or high-risk behavior; increases in the numbers of relapsing opioid users leaving prison or treatment; and an ageing cohort of more vulnerable drug users.

The source of death in Cocaine and Heroin-Overall mortality related to drug use

Overall mortality related to drug use comprises drug-induced deaths and those caused indirectly through the use of drugs, such as through the transmission of infectious diseases, cardiovascular problems and accidents. Deaths indirectly related to drug use are difficult to quantify, but their impact on public health can be considerable. Such deaths are mainly concentrated among problem drug users, although some (e.g. traffic accidents) occur among occasional users.

Estimates of overall drug-related mortality can be derived in various ways, for example by combining information from mortality cohort studies with estimates of drug use prevalence. Another approach is to use existing general mortality statistics and estimate the proportion related to drug use.

The source of death in Cocaine and Heroin-Drug Scourge

Buprenorphine for the treatment of addiction

March 15, 2014

Buprenorphine for the treatment of addiction-Is it the best

If you are suffering from addiction seek treatment but remember Buprenorphine may not be a better option.

Buprenorphine is used to help you keep off street drugs such as heroin. It can prevent or reduce the unpleasant withdrawal symptoms when you stop using such drugs. It is a medicine that is similar to heroin and works as a replacement treatment. Many people choose to stay on buprenorphine long-term, although some people gradually reduce their dose and come off it.

The effects of buprenorphine last longer than heroin so it is usually prescribed as a once-daily dose. To begin with, you will usually be asked to take it under the supervision of the pharmacist who dispenses the buprenorphine to you. This means there can be no doubt about how much buprenorphine you take at each dose. This supervision may be relaxed after a few months of your taking a regular maintenance dose.

Buprenorphine is also available combined with another medicine called naloxone (the tablet brand name is Suboxone). Naloxone blocks the action of buprenorphine and the effect of the combination is that, if you are tempted to crush the tablet and try to inject it, you will start to get withdrawal effects.

Buprenorphine for the treatment of addiction-Can buprenorphine cause problems?

As with all medications, Buprenorphine (Suboxone) drug treatment also has some disadvantages. It is still a medication and if you prefer to break free from any kind of addiction immediately, then Buprenorphine may not be the way to go. Also, you may not be completely Buprenorphine-free by the time you leave drug treatment, even if you opt for an inpatient drug rehab program.

Some may consider these disadvantages while others consider them well worth the advantage of avoiding opiate withdrawal symptoms. Also, some initial studies on long-term use of Buprenorphine suggest that there are anti-depressant effects of the drug as well. The dosing schedule is also relatively easy to maintain as most don’t even have to take it every day. Additionally, you can’t abuse Suboxone, get high off of it or overdose on it like you can with some other opiate addiction maintenance or detox drugs, like methadone. Much as this may offer treatment for addiction, it is in itself addiction and should not be encouraged. Its demerits far much out ways the merits just have a look at the conditions lined below before and during its usage.

Buprenorphine for the treatment of addiction-Before taking buprenorphine

Some medicines are not suitable for people with certain conditions, and sometimes a medicine may only be used if extra care is taken. For these reasons, before you start taking buprenorphine it is important that your doctor knows:

If you have liver or kidney problems.
If you have prostate problems or any difficulties passing urine.
If you have any breathing problems, such as asthma or chronic obstructive pulmonary disease (COPD).
If you have been told you have low blood pressure.
If you have any problems with your thyroid or adrenal glands.
If you have epilepsy.
If you have a problem with your bile duct.
If you are pregnant or breast-feeding.
If you have been constipated for more than a week or have an inflammatory bowel problem.
If you have a condition causing muscle weakness, called myasthenia gravis.
If you have recently had a severe head injury.
If you have ever had an allergic reaction to a medicine.
If you are taking any other street drugs or medicines. This includes any medicines you are taking which are available to buy without a prescription, such as herbal and complementary medicines.

Buprenorphine for the treatment of addiction-Getting the most from your treatment

Some people feel uncomfortable during the first 2 to 3 days of taking buprenorphine. Do not be tempted to take heroin on top, and do not take more than the dose your doctor has prescribed for you.
It is important that you keep your regular appointments with your doctor or clinic so your progress can be reviewed. You will be asked to give a urine sample from time to time.
Buprenorphine cannot be supplied to you without a prescription. You will not be able to ask for any changes to be made to your supply, as your pharmacist can only dispense the prescription exactly as your doctor has directed.
There are several different brands and strengths of buprenorphine tablets, so each time you collect a supply, check to make sure it contains what you are expecting.
You are more likely to succeed in staying off heroin if you have support and counseling in addition to taking buprenorphine. Local drug community teams, self-help groups and other agencies may be of help. It is much harder to ‘do it alone’, so go for counseling and help if it is available in your area.
You should not take any street drugs or drink too much alcohol while you are on buprenorphine. This is because other street drugs such as benzodiazepines (benzos) and alcohol can affect buprenorphine and increase the chance of unwanted effects.
You should tell the DVLA that you are taking buprenorphine if you are a driver. You are likely to be banned from driving at first, although you may be allowed to drive again later, subject to an annual medical review. Your doctor will tell you when you can resume driving.
Do not stop taking buprenorphine without discussing this with your doctor or drug-team worker first. It is important that buprenorphine should be taken regularly to reduce the risk of withdrawal symptoms occurring. When you are ready to consider becoming drug-free, your doctor or drug-team worker will be able to help you decide on the best way to do this in order to keep withdrawal effects to a minimum.
If you are planning any trip abroad, you should carry a letter with you from your doctor to explain that you have been prescribed buprenorphine. This is because buprenorphine is classed as a ‘controlled drug’ and is subject to certain restrictions.
If you buy any medicines, check with a pharmacist that they are suitable for you to take with buprenorphine. Many other medicines have similar side-effects to buprenorphine and taking them together will increase the risk of unwanted effects.
If you are having an operation or dental treatment, tell the person carrying out the treatment that you are taking buprenorphine.

So many side effects and so many conditions attached making buprenorphine not to be right for addiction treatment not now and certainly not ever.

Buprenorphine for the treatment of addiction-Is it the best

Heavy Metal Toxicity cause Obesity

March 15, 2014

Heavy Metal Toxicity cause Obesity-It can be a voided

Healthy living requires you to a void heavy metals like lead, their toxicity is hazardous to your health.

By merely mentioning toxicity we automatically see dangers of being overweight and other health complications. For the purpose of this article we will look at the effects of metal toxicity in our lives pointing out elements that may be associated with obesity and weight gain.

There are many individual metals causing varying degrees of illness based on acute and chronic exposures. Heavy metal is the term used for a group of elements that have particular weight characteristics. Some of these heavy metals includes: cobalt, copper, iron, manganese, molybdenum, vanadium, strontium, and zinc are essential to health in trace amounts.

Others are non-essential and can be harmful to health in excessive amounts. They include cadmium, antimony, chromium, mercury, lead, and arsenic the last three being the most common in cases of heavy metal toxicity.

A toxic body needs to be detoxifying to have the body cleansed and instances of overweight which comes as a result of toxicity.

Heavy Metal Toxicity cause Obesity-Chelation

Chelation is the process by which a metal or mineral (such as calcium, lead, cadmium, iron, arsenic, aluminum, etc.) is bound by another substance. Chelation therapy is the process of using synthetic amino acids for the purpose of removing heavy metals from the body or for improving circulation by removing harmful calcium. Certain synthetic amino acids have a high binding affinity to minerals and metals which allow them to pull heavy metals out of the tissues of the body.

Since they are synthetic, the body cannot use them and they are excreted from the body along with whatever metal they are bound to. Chelation is ideally done through intravenous administration. This is the most effective way to remove heavy metals from the tissues of the body and to avoid stomach upset and possible intoxication by heavy metals moving from the gastrointestinal system into circulation which can occur with oral chelation.

Heavy Metal Toxicity cause Obesity-Signs and Symptoms

To demonstrate the magnitude of heavy metal’s toxicity, take for example lead, it can affect the nervous system, gastrointestinal system, cardiovascular system, blood production, kidneys, and reproductive system.
Symptoms of heavy metal toxicity include mental confusion, pain in muscles and joints, headaches, short-term memory loss, gastrointestinal upsets, food intolerances/allergies, vision problems, chronic fatigue, and others.

Heavy Metal Toxicity cause Obesity-Lead in Your Body is not safe

It’s important to remember that since lead was removed from gasoline and house paint several decades ago, the average person’s blood lead level has dropped dramatically. But our levels of lead are still a great deal higher than those of people who lived before the industrial age. That’s because we continue to be exposed to lead in our soil and water, as well as from our own bones, where it is stored once it’s introduced into our system.

Five decades ago the average blood levels of lead were about 40 micrograms/deciliter. The level considered “safe” by the government has continued to fall and is now considered less than 10 micrograms/deciliter. But this new study and others like it question the idea that ANY level of this toxic metal is safe.

Today researchers have found that a blood level of lead over 2 micrograms/deciliter caused dramatic increases in heart attacks, strokes, and death. In fact, after controlling for all other risk factors, including cholesterol, high blood pressure, smoking, and inflammation, the researchers found that the risk of death from all causes in people with a lead level that high increased by 25 percent, deaths from heart disease increased by 55 percent, risk of heart attacks increased by 151 percent, and risk of stroke increased by 89 percent.

What’s even more remarkable is that nearly 40 percent of all Americans are estimated to have blood levels of lead high enough to cause these problems. This is potentially a greater risk for heart disease than cholesterol!

A report in the Journal of the American Medical Association found that high blood pressure in postmenopausal women is strongly correlated to blood lead levels. This is because bones break down faster during menopause releasing stored lead and injuring blood vessels, which leads to high blood pressure

High lead may also be responsible for kidney failure as well. A study in The New England Journal of Medicine found that using chelation therapy with EDTA to reduce lead levels in patients with kidney failure could prevent further loss of kidney function, save billions in healthcare costs, and eliminate the need for dialysis in millions of people.

Heavy Metal Toxicity cause Obesity-Six Tips to Help You Get the Lead Out

Luckily there are steps you can take to help you heal from lead poisoning if you have been exposed. Try the following:

Find out if you are lead-toxic. The easiest test is a simple blood lead test. Anything higher than 2 micrograms/deciliter is toxic and should be treated. Unfortunately, the blood test only checks for current or ongoing exposures, so you must also take a heavy metal challenge test with DMSA, EDTA, or DMPS, which can be administered by a doctor trained in heavy metal detoxification to find a qualified doctor
Don’t get into the house with your shoes on. A great deal of lead can be tracked into your house in the dust on the soles of shoes. Leaving your shoes at the door helps reduce the amount of contamination in your home.
Test your water for heavy metals. There are a number of home test kits available online. If you prefer to have a professional test your water, call your city water provider or look for labs in your area that will perform this kind of test.
Buy a carbon or reverse osmosis water filter for your drinking water. These filters remove lead and other toxic substances like PCBs.
Take 1,000 milligrams of buffered ascorbic acid (vitamin C) a day. This helps remove lead from the body.
Take 2,000 to 4,000 IU of vitamin D3 a day to prevent your bones from releasing lead into your bloodstream.

Besides the tips efforts must be made further to detoxify the body for better health, this can be done more effectively at AWAREmed Health and Wellness Resource Center under Doctor Akoury’s who care for patients like you. At this facility we focus on Neuroendocrine Restoration (NER) to reinstate normality through realization of the oneness of Spirit, Mind, and Body, Unifying the threesome into ONE. If lead is causing you gain and leading you to being obese because of toxic substances, this is the place to be.

Heavy Metal Toxicity cause Obesity-It can be a voided

Category Archives: Healthy Aging