Understanding toxins and weight regulation
Understanding toxins and weight regulation is very important in the weight loss recovery process
Understanding toxins and weight regulation: Underlying mechanisms
The underlying mechanisms of toxins come in various ways as we will be discussion progressively. Toxins can alter the hormonal regulation of weight, a process that involves insulin, leptin, thyroid, cortisol, adiponectin, resistin, sex hormones, and gut hormones, including ghrelin, peptide (PYY), and cholecystokinin (CCK). And speaking to the experts at AWAREmed health and wellness resource center under the leadership of doctor Dalal Akoury MD, it is quite clear that understanding toxins and how they affect weight regulation are very important. And to start us off, the influence of toxins on metabolism occurs through 5 key ways including:
- Mechanisms
- Hormonal regulation,
- Neuro-regulatory mechanisms,
- Immune regulatory mechanisms,
- Mitochondrial function, and
- Oxidative stress.
Toxins alter thyroid hormone metabolism and receptor function leading to lowered metabolic rate. Important Neuro-regulatory mechanisms affected by toxins include hypothalamic satiety modulation through effects on peripheral and central inhibitors and stimulators of appetite, including leptin, cortisol, melanocyte stimulating hormone (MSH), and neuropeptide (NPY). Stress-induced autonomic dysfunction it also alters appetite and weight-control mechanisms. Toxins can influence weight through toxin-mediated increases in inflammatory cytokines (TNF-α, IL-6) on the peroxisome proliferator-activated receptor (PPAR) family of nuclear receptors promoting insulin resistance, and on melanocortin receptor (MCR) system altering central appetite regulation.
Counter-regulatory signals triggered by inflammation such as suppressors of cytokine signaling (SOCS) induce leptin resistance. Toxins alter mitochondrial energetics by damaging enzymes involved in fatty acid oxidation and thermogenesis. Oxidative stress influences weight via NFκ B-mediated mechanisms of gene transcription that control insulin resistance and inflammation. Other mechanisms may include direct effects of toxins on hepatic control of lipid and glucose metabolism, and on inflammatory cytokines
Understanding toxins and weight regulation: Where do toxins come from?
According to the AWAREmed health center, exposure to toxins originates from two main sources: the environment (external toxins) and the gut (breakdown products of our metabolism, or internal toxins). Both can overload endogenous detoxification mechanisms.
The dangers from without the external toxins include chemical toxins and heavy metals. The heavy metals that cause the illest health are lead, mercury, cadmium, arsenic, nickel, and aluminum. Chemical toxins include volatile organic compounds (VOCs), solvents (cleaning materials, formaldehyde, toluene, and benzene), medications, alcohol, pesticides, herbicides, and food additives.
Infections (hepatitis C virus) and mold toxins (sick building syndrome) are other common sources of toxins. Our modern refined diet can be considered toxic because it places an extra burden on detoxification systems through excessive consumption of sugar, high fructose corn syrup (the two most important causes of elevated liver function tests),trans fatty acids, alcohol, caffeine, aspartame, foods made with genetically modified organisms (GMOs), and the various plastics, pathogens, hormones, and antibiotics found in our food supply.
Danger from within internal toxins includes microbial compounds (from bacteria, yeast, or other organisms), and the breakdown products of normal protein metabolism. Bacteria and yeast in the gut produce waste products, metabolic by-products and cellular debris that can interfere with many body functions and lead to increased inflammation and oxidative stress. These include endotoxins, toxic amines, toxic derivatives of bile, and various carcinogenic substances such as putrescence and cadaverine. Lastly, by-products of normal protein metabolism, including urea and ammonia, require detoxification. We appreciate that your weight regulation is not that simple and that is why AWAREmed health is offering treatment solutions tailored at transforming each individual’s life through increasing awareness about health and wellness and by empowering individuals to find their own inner healing power. For all your weight related concerns, schedule an appointment with doctor Akoury today.
Understanding toxins and weight regulation: Underlying mechanisms
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