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Stem Cell Treatment for Autism Spectrum Disorders

March 2, 2015

Stem Cell Treatment for Autism Spectrum Disorders

The medicinal properties of the stem cells have seen it being used for treatment of myriad ailments or as therapy for many diseases that are not even treatable. for the cases of these diseases that are not treatable the stem cell therapy helps to alleviate on the dangerous symptoms of the diseases and offer comfort as well as lengthen the lives of those who are victims of these diseases. needless the stem cell therapy has become a crucial component of regenerative medicine with many researchers still working around the subject to find out how its applicability can be useful in treating lifestyle diseases that have become a problem to this generation and many generations to come. The stem cell therapy has been proposed as an effective therapy in cases of autism. Autism spectrum disorders are complex neurodevelopmental disorders. This term refers to a heterogeneous group of varied conditions characterized by dysfunctions in social interactions, skills, and communication, restricted interests, and repetitive stereotypic verbal and non-verbal behaviors, influencing the ability to relate to others. Cognitive, emotional and neurobehavioral abnormalities characterize the core symptoms. The prevalence of these disorders has dramatically increased in the last years, with present rates of 1 in every 88 children aged 8 years in the United States, according to Centers for Disease Control.

Autism Spectrum Disorders

Autism Spectrum Disorders are presumed to be a lifelong disability with multiple impacts on child and adult health. Without a doubt, adult autistic individuals show limited independence because of their learning disability. Adult patients of autism spectrum disorders experience problems in communication. They are not able to read and write well. They’ve got poor comprehension of whatever they read. Apart from impaired communication, they also exhibit stereotyped behaviors and restricted interests. The children affected require special and intensive parental, school, and social support without which coping with the condition may become a nightmare. Autism Spectrum Disorders results in a substantial impact not only on the person’s quality of life but also that of their family. Autism Spectrum Disorders patients are not very easy to take care of, apart from their impaired social behavior, the cost of caring for them is so high. It is estimated that the cost of caring for a single person suffering from Autism Spectrum Disorders for a life time is $3.2 million, therefore this disease by all means is a global problem that should be prioritized and fought from all fronts.

Though the most salient symptoms of these diseases is seen in the cognitive, emotional and neurobehavioral abnormalities, Autism Spectrum Disorders are also characterized by a broad range of biochemical, toxicological and immune involvement, including oxidative stress, endoplasmic reticulum stress, decreased methylation capacity, limited production of glutathione, mitochondrial dysfunction, intestinal dysbiosis, increased toxic metal burden, and immune dysregulations including autoimmunity. Due to these complex problems there has never been any effective medication for autism spectrum disorders that has shown dependable level of efficacy. Today there are only few medications that are licensed by FDA for treating autism related disorders. Needless to emphasize these medications that are available in pharmacies such as anti-psychotics have failed to address the core symptoms of autism spectrum disorders. These medications are quite palliative and have potential adverse effects on the user. For this reason there are other alternative treatments of Autism Spectrum Disorders that have since surfaced. these may include; behavioral, nutritional, and biomedical approaches therefore this creates a vacuum that can be filled with effective therapies like the stem cell therapy but still there is need for more research that a better treatments for this disorder can be found. Despite medical technology advancements it is good to be blunt, Autism spectrum disorders are still untreatable pathologies. Mesenchymal stem cells possess the immunological properties which make them promising candidates as a novel therapeutic option but there is no single therapy that has been found that can treat autism spectrum disorders.

This is how stem cell therapy works for autism

Autism Spectrum DisordersAs mentioned earlier Stem cells are precursors of all cells and are capable of forming cells of other types hematopoietic, nervous and cardiovascular system, endocrine organs, bone, cartilage and muscle tissue. It is with this ability of stem cells to shift shape that it can be harnessed to help treat autism. Early animal studies have shown that stem cells isolated from umbilical cord blood can stimulate cells in the spinal cord to regrow their myelin layers, and in doing so help restore connections with surrounding cells. Autism is thought to result from impaired connectivity in the brain. Because of this, it is practical to apply this therapy on patients with autism spectrum disorders besides Mesenchymal stem cells can regulate the immune system. the mesenchymal stem cells can also help to reverse inflammatory conditions and perhaps this is why very many institutions in the US and across the globe have been doing trials on ability of the stem cells to treat even Cohn’s disease which is a condition resembling the gut inflammation in autistic children. Autism is a serious disease that should be prioritized by the public health stakeholders plus you also need information on how to leave with this disease, Visit us at AWAREmed Health and Wellness Resource Centre at Myrtle Beach, South Carolina. Dr. Dalal Akoury (MD) an expert in integrative and regenerative medicine will be able to help.

Stem Cell Treatment for Autism Spectrum Disorders

 

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Heroin Use on the Rise despite Its High Cost of Treatment

February 28, 2015

 Heroin on the Rise despite its High Cost of Treatment

Contrary to the common rule of demand and supply that the use of a product will be high when its price is at the lowest, heroin use has been on the rise in spite of the rise in its cost as well as the cost of treating those who are addicted to the drug.

To begin with, heroin is a highly addictive drug which is also illegal. Heroine is one of the drugs that are not very easy to stop using, thanks to its highly addictive nature and to its adverse withdrawal symptoms. Millions of those using heroine are too scared of its withdrawal effects to even attempt quitting it.  Heroin is made from the resin of poppy plants. Milky, sap-like opium is first removed from the pod of the poppy flower. This opium is refined to make morphine after further refined into different forms of heroin.

Being that the drug is mostly injected; those using this drug do not face its withdrawal side effects but also has high risks of acquiring other diseases that can be transmitted through sharing needles like HIV/AIDS.

How much do Heroin addicts spend on it heroin?

Heroine is one of the rare commodities whose increase in price do not interfere with its consumption. This drug is just as expensive as cocaine as or even slightly more than cocaine in other places but still people use it more in some places than even cocaine. Therefore, there must be some other reasons why people are turning to the use of heroine as opposed to other drugs. The factors that drive people to use of cocaine may not be new and we will explore them in this article. However, there is more than one way to look at the cost of heroine. Some people opine that the cost of heroine just like other goods and services depends on demand and supply and this may be true so it is better to stay away from using this drug even when it is being sold at a throw away price since you may not afford it later when you are now dependent on it. It is quite funny that when it comes to addictive drugs you will be able to access them for free from addicts who are ready to share them with you but when you have become dependent you shall have to find your own ways of getting your daily heroin.

Heroin

There are some hidden costs of using heroin that most people do not even think of. Most people will only be wary of the price of acquiring their daily heroin dosages for their recreational use but they give a blind eye to the real cost that arises when you need to be cured from the side effects of this drug.  A 2000 survey by the U.S. Government found that the cost of heroin addiction to our country may be anywhere from $15 billion to $20 billion dollars per year. Most of this tremendous figure is due to the price tag on treating medical conditions associated with IV heroin use – specifically, HIV/AIDS and hepatitis. The use of heroin has another hidden cost– the societal ills cost. This is the cost that you and I pay when these addicts turn to crime just in a bid to find   money to buy their much needed heroine doses daily.

The cost of getting your daily dosage of heroin to fulfill your craving cannot be compared to the cost of treating all the ills that come with using the drug. The sad truth however is, most people who are using heroin cannot afford to cater for the cost to treat the side effects that come with it. The cost of treating a heroin addict is too expensive to be compared to the mere cost of obtaining a daily dosage no matter how long you are top use the drug before you seek medical attention.

Some of the side effects of heroin

Heroine is often used mainly because of the euphoria that sets in immediately it is used but afterwards a feeling of drowsiness sets in. Just like other drugs of abuse, heroin has myriads of side effects. These may include;

  • Shortness of breath
  • Dry mouth
  • Constricted (small) pupils
  • Sudden changes in behavior or actions
  • Disorientation
  • Cycles of hyper alertness followed by suddenly nodding off
  • Droopy appearance, as if extremities are heavy

Another serious problem with heroine is because of the way it is taken. Mostly heroin is injected. Unfortunately these needles are often shared increasing the spread of such diseases as HIV/AIDS and hepatitis among other diseases. Dependence on heroin is also dangerous.

Heroin overdose is dangerous

heroinOne of the serious problems that will arise in case of heroin overdose is death. Does that sound scary? Even as scary as it sounds many people still indulge in using heroin for mere recreational purposes. However there are measures that are put in place to treat heroin overdose.  Methadone (Dolophine, Methadose) and buprenorphine among other drugs are today used for treatment of heroin overdose. These drugs block the opioid receptors in the brain hence stops the effects of the heroin. However the use of these drugs is highly regulated in different states and hence may not be very accessible to a street user of heroin.

Finally, you need more information to stay away from dependence on heroin and other drugs as these have crippled societies and that is why here at AWAREmed we are dedicated to finding the best solutions to addiction and dependence on substances. Dr. Dalal Akoury (MD) is always in the mood of helping any patient to be addiction free. Do not hesitate to call on her for help in managing any sort of chronic pain or any type of addiction as well as other diseases.

 Heroin on the Rise despite its High Cost of Treatment

 

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Substance Use Disorder Treatment with Nervine Herbs

February 27, 2015

Substance Use Disorder Treatment with Nervine Herbs

The basic knowledge of drugs is that they are substances that interfere with the normal functioning of the body. This therefore means that after using some drugs and substances a person’s behavior will be altered by the substances he has used. However it should be known that there are far more damages that drug and substances use cause to an individual health wise. Substance use disorder, also known as drug use disorder, is a condition in which the use of one or more substances leads to a clinically significant impairment or distress. In this context contrary to common knowledge that substance can mean any physical matter, the term substance here is used to mean drugs. Substance Use Disorder refers to the overuse of, or dependence on, a drug leading to effects that are detrimental to the individual’s physical and mental health as well as the effect on other people’s welfare.

The diagnosis of substance abuse disorder has improved treatment of patients. Before his approach to treatment of addiction related cases, doctors used to treat addiction and other clinically significant abuse as separate issues but with substance use disorder diagnosis, doctors can simultaneously treat both addiction and non-addiction related dysfunctional substance abuse in patients. the rule of this approach of treatment is that the doctor will identify the specific cause of problems to an individual for example if a person is alcohol-related issues then he Is termed to suffer alcohol use disorder  while a person suffering from cocaine is termed to be suffering from stimulant use disorder.

Nervine Herbs

a person suffering from any substance use disorder will exhibit at least three and at most eleven specific symptoms related to the use of the substance with the most prominent examples of these symptoms being substance cravings, an inability to curb substance intake, the development of tolerance to a substance’s effects, serious life disruptions that stem from substance use, use of substances in clearly dangerous circumstances and devotion of significant time or resources to either using a substance or recovering from substance intake. However, people affected by the minimum number of symptoms have mild substance use disorder, while people affected with many or most of the required symptoms have major or severe substance use disorder but all of these people need substance use disorder treatment in order to be free from the effects of the drugs they are using.

Treatment of substance use disorder with nervine herbs

What are Nervine Herbs?

The Nervines are herbs that are very essential in supporting the nervous system. The nervines may work as tonics and to create a mild calming effect. The tonic nervines may include the Skullcap and the oat tops while Catnip and chamomile can be used for mild calming of the nervous system. Apart from these two categories there are also nervines that work as strong sedatives on the nervous system, they may include the Hops and the Valerian among others. Generally the nervine herbs are used to relieve nagging muscle tension and spasms, circular thoughts, insomnia, and the occasional worry that has become a part of day to day life. Some of these herbs provide multiple nervine actions, such as Skullcap which relaxes the muscles, helps calm worried thoughts, and nourishes the nervous system. Others such as Oat Tops, are not necessarily relaxing to the physical body, but help restore and support healthy nerve functioning when taken on a regular basis.

The nervous system is Composed of the all the nerve tissues in the body and plays very critical roles in the body. They are composed of the nerve tissues that receive stimuli and transmit stimuli to the nervous systems and to initiate responses. The central nervous system consists of the brain and the spinal cord and functions as the points of collection of all the nerve impulses. This is how the nervous system works; the sensory nervous system receives the stimuli, the central nervous system interprets them while the motor nervous system initiates responses.

The nervous system are very vital in the body and so they ought to be performing at optimum always, however due to some of the substances that a person may use such as drugs and alcohol the communication between these nerve tissues may be tampered with leading to rise of some complications in a person . Therefore there is need for the entire nervous system to replenished, relaxed and strengthened and nothing does that better than the nervines. The nervines are herbs that are specifically for the nervous system. They correct all the defects in the nervous system as well as strengthening the nervous system.

Nervine Herbs

Here are some of the useful Nervine Herbs

Catnip – this nervine is a very gentle sedative that is used in solving insomnia related problems. Some drugs may often leave the user with sleeplessness after along use. Catnip could be the answer. It’s also good for headaches.

California poppy – this herb has anti-anxiety, sedative, and analgesic properties. It’s used to promote relaxation in those seeking rest from nerve pain.

Passion flower – This stunning plant offers anti-spasmodic power and is helpful with tension headaches, occasional nerve pain, nervous restlessness, and restful sleep. Good for many symptoms of substance use disorder.

Lavender – Calming herb that is often used in aromatherapy applications for its mild calming action. This herb is uplifting hence good for low moods. It is good for mild anxiety and improves sleep quality.  For persistent depression use lavender with holy basil and damiana.

Finally, Here at AWAREmed Health and Wellness Resource Center we are committed to availing help to addicts by availing some of the most integrative approaches to healing an addict. We advocate for natural healing to all kinds of addiction. In case you are struggling with addiction just call on Dr. Dalal Akoury (MD) at Myrtle Beach, South Carolina for help.

Substance Use Disorder Treatment with Nervine Herbs

 

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Herbs That Increase Dopamine Level

February 25, 2015

Herbs That Increase Dopamine Level

Popularly known as the brain’s feel good hormone, dopamine is responsible for sending feelings of well-being and pleasure into the body.  Apart from this known function, other functions of dopamine include; control weight, energy levels, and supports brain and heart health. Without it, we would be more fat, unhappy, and tired. Dopamine is one of the most crucial neurotransmitters in the body. Dopamine has very many functions in the body but to many people it is famous for its good feeling effects that it is always identified with but this should not be the case as it has functions beyond the mesolimbic pathway. In the brain dopamine plays such roles as: It plays a big role in starting movement, and the destruction of dopamine neurons in an area of the brain called the substantia nigra is what produces the symptoms of Parkinson’s disease. Dopamine also plays an important role as a hormone acting to inhibit prolactin to stop the release of breast milk. Back in the mesolimbic pathway, dopamine can play a role in psychosis, and many antipsychotics for treatment of schizophrenia target dopamine. Dopamine is involved in the frontal cortex in executive functions like attention. In the rest of the body, dopamine is involved in nausea, in kidney function, and in heart function. Owing to its many functions that are all crucial, it is important that dopamine be in good levels for the optimal performance of the body.

Ginseng

Dopamine is crucial in our bodies but the use of drugs of abuse will lead to depletion of dopamine giving rise to some diseases like depression among others. Some drugs of leisure are loved for their euphoric feelings; they affect the normal production of brain chemicals. At the beginning they may induce a sudden surge in the production of feel good brain chemicals, however when you have used the drugs for some time they will lead to depletion in the levels of the brain chemicals such as serotonin and dopamine. In the brain the production of neurotransmitter happens naturally without intervention of any other drug. These basic neurotransmitters include; dopamine, serotonin, GABA, acetylcholine. The body also produces other chemicals known as endorphins which work as the body’s own opiates functioning to fight pain naturally.

These neurotransmitters have specific functions that they accomplish in the body. Each function is important and works in conjunction with the functions of the other neurotransmitters to make life what it ought to be. These functions are; Serotonin regulates sleep and appetite, Acetylcholine for processing information and memory, GABA acts as your calming neurotransmitter while dopamine is the feel good chemical, plays an important role in mood, energy, attitude, motivation.

When you use these drugs of pleasure thy hike the levels of dopamine in the brain beyond the accepted levels. This will force the brain to find a means by which to suppress the production of the neurotransmitter that has been hiked by drug use. naturally, the production of dopamine will be reduced by the brain after sensing that the hike in the levels of dopamine is caused by factors out of the body, therefore when a person who has been using drugs stops using them, the levels of dopamine and serotonin will be too low below the normal levels and this beckons such feelings of depression, anxiety, nervousness and lack of interest in everything. The level of dopamine in the body can however be restored naturally by use of herbs. Here are some of the herbs that are effective in restoring levels of dopamine even after drug use.

The Dopamine Boosters

St. John’s wort Ginseng– ginseng does not only increase the level of dopamine in the body but also works in rejuvenating, restorative, boosts energy and vitality and is tonic to the brain. Ginseng is often prescribed for patients fighting depression which is a common symptom of withdrawal from drug use. This herb is a better therapy for those who are under physical, emotional, mental or spiritual stress as it is a very strong antidepressant and adaptogenic. Ginseng promotes strong nerves, sound sleep, improves memory, clear thinking and enhances concentration.

Red clover -Red clover not only increases the dopamine levels in the brain but also nourishes the entire body, provides plenty of protein, B vitamins, and calcium, all essential brain nourishing nutrients.

St. John’s wort -St. John’s wort is effective against mild to moderate depression, alleviates anxiety, insomnia, and irritability and eases pain. It increases the level of dopamine in the brain as well.

Peppermint– contrary to what many people believe, peppermint is not psychoactive but is rather sedating, stimulating and pain relieving. Peppermint is one of the many herbs that can be used to restore the level of dopamine in the brain and restore the normal bodily functions.

Fenugreek -Fenugreek is a herb and a spice commonly eaten in many parts of the world, and has been used for centuries by practitioners of Ayurvedic Herb medicine and Traditional Chinese Medicine. It also increases the levels of dopamine and so can be used by patients whose dopamine level have floored as a result of drug use.

Today the patients have varied options when it comes to restoring the levels of testosterone in the body, however going the natural way is more beneficial as it is safe and inexpensive as well. It is good to note that by increasing the level of dopamine in your body, you are setting good grounds for addiction treatment and recovery. However, these problems need to be treated effectively through integrative medicine. Dr. Dalal Akoury (MD) is an expert at this.  Call her on (843) 213-1480 for help.

Herbs That Increase Dopamine Level

 

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Kynurenine Tryptophan Cycle in Addiction

February 16, 2015

Kynurenine Tryptophan Cycle in Addiction

The immune system is an important part of normal body functioning. It is constantly modulating a balance between tolerance to non-harmful antigens and responsiveness to some pathogens. The process that facilitates tolerance is not known. However, recent studies show that this tolerance is due to tryptophan catabolism via the kynurenine metabolic pathway. The breakdown of tryptophan requires several enzymes which. These enzymes are found in various cells which includes those of the immune system.

Some of these enzymes involved in the breakdown of tryptophan produced through activation of the immune system. This process involves among others limitation of enzymes that are present in the dendritic cells and macrophages, 3-dioxygenase and indoleamine 2. Recent studies have shown that inhibition of these enzymes can result in the body rejecting allogeneic fetuses. This means that breakdown of tryptophan is necessary in immune tolerance aspects.

Some theories have been invented to try and explain how catabolism of tryptophan facilitates tolerance to drugs like alcohol. One such theory holds it that breakdown of tryptophan ends up suppressing proliferation of T cells by greatly reducing the supply of this amino acid that is critical in body processes. The other theory states that the down streaming of the metabolites involved in catabolism of tryptophan act as suppressors of some immune cells mainly through mechanisms of pro-apoptotic processes.

Kynurenine Tryptophan Cycle

What is tryptophan?

It is an amino acid that is required by all processes of the body for the synthesis of proteins and other body metabolic functions. Tryptophan is synthesized mainly from molecules like phosphoenolpyruvate that are present in bacteria, plants and fungi. Such organisms activate the tryptophan throughout the food chain. Animals are incapable of synthesizing this amino acid and because of this it must be taken in the diet in form of proteins which are then broken down into the respective amino acids in the digestive tract. The tryptophan that results from diet is deposited in the liver via the hepatic portal system. The protein that is not broken down in the liver enters into any of the two metabolic processes.

Because animals are incapable of synthesizing tryptophan, they must take it in the form of proteins, which are then hydrolyzed into the constituent amino acids in the digestive system. Dietary tryptophan is delivered to the liver through the hepatic portal system, and that portion which is not used for protein synthesis in the liver can then follow one of two basic metabolic fates.

In the first place, the protein that does not undergo synthesis can enter into the blood stream to later be used for synthesis of proteins and other cell functions in the body. Secondly, it can undergo degradation in the liver via a number of steps of metabolism which is basically referred to as the kynurenine pathway. Besides being a building block for proteins in the body, tryptophan also acts as the only source of substrate used for the production of important molecules in the body. Tryptophan is used in the gut and nervous system for serotonin synthesis and on the other hand pineal gland is useful in melatonin synthesis.  In case the content of niacin in the body is not enough to carry out metabolic processes, tryptophan come in to facilitate cellular cofactor synthesis and nicotinamide adenine dinucleotide (NAD +) synthesis. NAD + synthesis as research shows take place mostly in the liver.

The kynurenine pathway

The kynurenine pathway results from proteins that are not synthesized in the liver. The enzymatic reactions take place proceeding from tryptophan. The main intermediates of the metabolic system include quinolinate, 3-hydroxyanthranilate and kynurenine. A catabolic reaction is completed in the liver and this result in the total oxidation of the amino acid tryptophan and in the process carbon dioxide and adenosine triphosphate are produced.

Tryptophan metabolism and addiction

Tryptophan metabolism and addiction

 

The three stages that take place in the kynurenine pathway include an intial stage that involves tryptophan being broken down into kynurenine. The second stage starts from the produced kynurenine all the way to production of quinolinate. The final stage of the process involves enzymes that translate into total oxidation. The other processes that occurs within the three major processes picolinate production, kynuretic acid synthesis and synthesis of NAD +.

Most cells in the body have some of the enzymes that are involved in the kynurenine pathway. However, only hepatocytes have been shown to contain each and every enzyme that is used in every stage of the kynurenine pathway.  Since the liver is the only tissue in the body that contains all thes enzymes of the pathway, the liver then acts as the major site in which NAD + is synthesized from tryptophan. Diet and intake of certain substances like alcohol can affect the flow of metabolisms in the kynurenine pathway. For more information about this topic visit www.awaremednetwork.com. At AwareMed you will also find other health and awareness tips that will benefit you.

Kynurenine Tryptophan Cycle in Addiction

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