Tag Archives: Stem-cell therapy

stem cell therapy

Stem Cell Therapy medical applications

August 24, 2016

It is likely that you haven’t been able to figure out what stem cell therapy is due to several debates that have been going on. According to several research findings, stem cell therapy can treat a variety of illnesses, injuries, and many other health complications.

This has been proven by the fact that blood stem cells have the ability to treat several blood ailments, a therapy that has saved thousands of patients especially kids suffering from leukemia, bone injuries and more.

Despite all the apparent research findings, there are a few individuals who haven’t been able to understand it fully. Scientists are however doing some research to figure out other possibilities.

There are a lot of debates between scientists and ethics enthusiasts who don’t understand the strategy behind this amazing finding and other available limitations. This was one thing that made the former US president, George Bush to put some limitations such as, not funding research that involved an embryonic stem cells.

The good news is, the research is to continue since the restrictions that were initially placed by Bush were overturned by the now US President, Barack Obama.

 

stem cell therapy

How stem cell therapy work

Several embryonic stem cells are obtained approximately six days after they are fertilized from a human embryo. This procedure is always intended to treat infertility, a process called Vitro Fertilization.

One of the reasons use of the embryonic stem cells has led to several debates is the fact that they can renew themselves in a culture dish in a laboratory and can differentiate into different kinds of cells.

This makes them better substitutes for procedures such as organ transplants that need obtaining another person’s organ. They are also known to be quite beneficial in the development of several drugs.

Currently, the research on stem cell therapy is still on its way to maturity due to several unaddressed issues, and it may take up to 10 years to be fully employed. Despite several debates around this procedure such as safety issues and animal experimentations, stem cell therapy has proven to be beneficial to patients who weren’t able to benefit from the previously available therapies.

For example, the University of Pittsburgh used the cells from the embryo transplanted into the brains of up to 12 stroke patients, and the results came out as expected.

It is evident that stem cell therapy stands a chance to handle many serious illnesses. For example, the neurogenerative ailments such as multiple sclerosis, spinal cord injuries, diabetes, heart failure, Parkinson’s and much more.

Other studies have also shown that it can treat muscular as well as retinal degeneration that is known to result in blindness. Up to now, it is placed on the most effective therapeutic approaches that may fully restore and maintain the function of the retina hence stop the blindness. But all this is yet to be implemented provided everyone is more than willing to accept the use of embryonic stem cells.

 

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Stem Cells: The New Medicine Medical Research Has Provided

June 8, 2015

Stem Cells: The New Medicine

Stem cell research has been conducted for many years. With stem cells we can now have a better understanding of how organisms that are complex develop from something simple as a fertilized egg. In a laboratory setting, researchers are able to follow up the process of stem cells division into specialized cells that make up the brain, bone and skin as well as other types of cells.

The process involves identifying mechanisms and signals that determine whether or not a stem cell will differentiate into something complex. Understanding will help us understand which processes control the normal cell and organ development.

The stem cell research has been triggered for years by development of serious medical conditions such as birth defects and cancer which often are as a result of abnormal growth and development of cells. Wen cells do not mature, divide and differentiate as they should then conditions such as cancer are likely to develop. A better understanding of molecular and genetic controls of the process of cell division and differentiation will yield more information as to why these conditions come to be and in the process new approaches can be sort. This is an important goal in research on stem cells.

Stem Cell

What is a stem cell?

A stem cell is basically a cell that has not reached maturity and one that can potentially become specialized into different cells types in the boy for the formation of different body organs. Stem cells exist in two types: embryonic stem cells and adult stem cells. Embryonic stem cells come to be during division of a newly fertilized cell. When these stem cells divide, they are differentiated to become any type of cell in the body that is required for the formation of different body organs as the foetus develop in the womb.

Adult stem cells on the other hand are very different from embryonic stem cells. These types if stem cells are found I already developed tissues. They are therefore found in both children and infants. These stem cells are not developed or a fertilized egg but are found later when different tissues have already developed. These types of stem cells act like replacement cells. This means that they undergo division regularly in order to replace worn out, dead or lost cells. They are specialized to take the place of cells that have been lost or those that have died. Adult stem cells can be found in tissues of the body such as blood, brain, bone, skin and muscle. N as much as research on stem cells has been going on for long, the research has not been able to yield much result due to the inability to develop and differentiate these cells in a laboratory setting.

 

The medical breakthrough in stem cells research

As seen much earlier, stem cells are immature cells that have the tendency to develop and specialize into any type of cells. This being the case, researchers have tried to use stem cells in understanding and dealing with medical conditions such as birth defects and different types of cancers like leukemia. Because stem cells can be specialized into any type of cells they have the potential of treating disease and other disorders.

Today stem cells research procedures are used life-saving options for patients suffering from lymphoma, leukemia, some types of tumors and other disorders of the blood.

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Bone marrow transplant: For many years bone marrow transplant has been used tin treatment of diseases like leukemia. Bone marrow transplant involves removal of a donors bone marrow stem cells and replacing them with those of a sick patient. If the procedure proves successful, the bone marrow form a healthy donor migrates into the bone marrow of the patient. The healthy bone marrow will then begin producing healthy white blood cells which will end up replacing the abnormal cells in the patient. His s one of the major breakthroughs in stem cells transplant hat has seen many leukemia patients get a second chance.

Peripheral blood stem cells (PBSCs): naturally may of the blood stem cells are fund n he bone marrow, however a small number of these can be found n he blood stream. The process of obtaining stem cells from the bone marrow is usually a difficult process. Since stem cells are also resent in the blood, they can be obtained with ease form drawn blood making the process of obtaining stem cells easier. The only problem is that, stem cells in the blood stream exist sparsely in the blood stream which can prove difficulty while trying to extract enough of them for a transplant.

Umbilical cord stem cells transplant: the umbilical code s normally discarded as a waste product of the process of birth. However research shows that the blood found in the umbilical cord is rich in stem cells. These can be harvested and used to treat patients of cancer and other conditions of cell defects. These stems cells have been used to treating the same conditions as those treated by stem cells of the bone marrow and PBSCs.

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Stem cells transplant is proving to be a promising approach to health conditions such as lymphoma and leukemia. You can tap into these benefits. Dr. Dalal Okoury is an expert in integrative medicine. Don’t also forget to attend the Integrative Addiction Conference 2015. The conference will provide a once in a lifetime opportunity of approaches to identifying and treating patients of addiction. Visit http://www.integrativeaddiction2015.com for more information about the addiction conference.

Stem Cells: The New Medicine Medical Research Has Provided

 

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Mesenchymal Stem Cells for Treatment of Cardiovascular Diseases

June 3, 2015

Mesenchymal Stem Cells Role in Cardiovascular Diseases

Cardiovascular diseaseThe use of stem cells in treatment of various diseases has been given lots of consideration in the recent past. scientists have been busy doing researches trying to find out if the stem cell therapy which is termed by many as the medical miracle of the 21century can be a break in treatment of the diseases that have proved stubborn to conventional treatment methods. Stem cells have various properties that other cells do not have and this is the major reason why they have been in the lips of every regenerative doctor. There are different types of stem cells but the mesenchymal stem cells have been the major focus of integrative medicine practitioners.

Degenerative diseases are known to wreak havoc in the body’s ability to self-renew and rejuvenate. They affect the way the nervous system works causing a breakdown in the communication between the nerves which eventually causes various ailments. Degenerative diseases have not been very easy to treat in the past but with stem cell therapy, there is hope for not only degenerative diseases but also the much dreaded cardiovascular diseases as well.

Why mesenchymal stem cells?

The mesenchymal stem cells are not sought after for nothing. They have a lot to offer especially in this age when degenerative diseases are enslaving many people and the conventional medicine is not offering the much needed break. Mesenchymal stem cells are sourced from either the adipose tissues or from the bone marrows and are described as a rare type of cells which are multi-potent and rich in medicinal properties. The unique properties of the mesenchymal stem cells have made them a target as therapy for various diseases and currently they have been used for treatment of arthritis among other conditions. They have been found to be also very effective in moderating the functions of dendritic cells, immune cells, B cells, natural killer cells, monocyte or macrophages, T cells, and neutrophils.

Just like the rest of the Stem cells, the mesenchymal stem cells are precursors of all cells and have the ability of forming cells of other types such as the hematopoietic, bone, endocrine organs, nervous and cardiovascular system, and cartilage and muscle tissue. It is the unique ability of the mesenchymal to shift shape and form other cells that they have been targeted for treatment of cardiovascular diseases.

Research on Mesenchymal stem cells for cardiac diseases treatment

Cardiac diseases have caused many deaths and are still among the leading causes of death worldwide. however the conventional medicine such as myocardial infarction haven’t helped much in treatment of these diseases and this led to the research on the possibility of the stem cells being used for this course. The Hematopoietic stem cells were the first to be researched on and used for clinical trial. In some trials the therapy worked while in others they didn’t give the much expected results and this led to consideration of other stem cell types.

The mesenchymal stem cells were the most promising of all the types owing to their strong paracrine function, which gives them potential immunomodulatory effects via anti-inflammatory and antiapoptotic actions. It is this property that may give them the ability to counteract the pathological mechanisms that are involved in various cardiac diseases. They can also be trans-differentiated into cardiomyocytes.

In 1999, Makino S and his colleagues first demonstrated the differentiation of MSCs into cardiomyocytes in vitro. Their research concluded that Cardiomyocytes can be generated from marrow stromal cells in vitro. Makino and his colleagues aren’t the only scientists to have worked on viability of MSCs ability to treat cardiac diseases, Wang JA and his colleagues did a trial that involved transplanting Allograftic bone marrow-derived mesenchymal stem cells into heart infarcted model of rabbit to renovate infarcted heart, they found out that the rabbits who had mesenchymal stem cells transplant had a lower mortality rate of 16.7% as opposed to the controls whose mortality rate was at 35%.

cardiovascular diseaseAnother study was done in 2005 by Hatton N and his counterparts, it involved transplanting purified cardiomyocytes differentiated from bone marrow MSCs in vitro into adult mouse hearts, after three months the transplanted cells had survived and were sloping in parallel to the cardiomyocytes of the recipient heart. These and other animal trials have all showed the ability of mesenchymal stem cells in treatment of cardiovascular diseases.

Through research, there has been a growing body of evidence that the mesenchymal stem cells have the multiple paracrine effects that even without cell replacement can affect cardiac remodeling, angiogenesis and cytoprotection hence are clinically beneficial.

The hopes were held even higher after another researcher; Ohnishi S showed that the mesenchymal stem cells have a role in inhibiting cardiac fibrosis by regulation of collagen synthesis by cardiac fibroblasts, as well as their effects on fibroblast proliferation.

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The mesenchymal stem cell therapy are the medical miracle of the 21century, you need to be updated their applicability in treatment of various diseases, visit www.awaremednetwork.com for more information about bone marrow transplant and stem cell transplantation. Dr. Dalal Akoury is an experienced doctor in integrative medicine; she will be able to assist. From the same website you can also visit http://www.integrativeaddiction2015.com and be updated on upcoming Integrative Addiction Conference 2015. The conference will deliver unique approaches to telling symptoms of addiction and how to assist patients of addiction.

Mesenchymal Stem Cells Role in Cardiovascular Diseases

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Why are Stem Cells Important?

May 3, 2015

What are stem cells, and why are they important?

Stem cellStem cells are very special, powerful cells found in both humans and also in other animals. Stem cells are the precursors of all cells in the human body. What makes stem cells special is that they are regenerative and malleable. They have the ability to replicate themselves and to repair and replace other tissues in the human body. Some tissues, like skin, need constant renewal, which could not take place without skin stem cells. Other stem cells repair damage to the body’s tissues, for example, rebuilding damaged or degenerating muscle tissue. New research also indicates that stem cell malfunction or damage may be responsible for certain cancers and even muscular-degeneration diseases like Muscular Dystrophy.

Stem cells differ from other kinds of cells in the body. All stem cells have three general features that make them different from other body cells. These features are: they are capable of dividing and renewing themselves for long periods. They are unspecialized and they can give rise to specialized cell types. Stem cells are capable of dividing and renewing themselves for long periods. Unlike muscle cells, blood cells, or nerve cells which do not normally replicate themselves, stem cells may replicate many times, or proliferate.

The stem cells have a unique ability to divide and become more specialized cells forming cells like bone, blood, or muscle. It is this ability that makes them attractive agents in many areas of medicine. They can therefore be used to fight very many diseases in the regenerative medicine. Another advantage of stem cell therapy treatments is that autologous stem cell transport is made possible. This means that a person may be treated by doctors harvesting the stem cells from the patient and having the stem cells reimplanted into the same patient after finding out what was lacking in the patient. This reduces risks of infection as well as rejection which are helpful to the patient.

Importance of stem cells

the stem cells are very important cells in the body and have been since targeted for treatment of degenerative diseases. They have been called the center pieces of regenerative medicine. Medicine that involves growing new cells, tissues and organs to replace or repair those damaged by injury, disease or aging. there ability to proliferate into other cells of the body like the bone and muscle tissues have made them a priority in treatment of various degenative diseases like aging and even osteoporosis among others. here is how stem cells work in treatment of various diseases.

Rejuvenation– the stem cells can be used in rejuvenation process. through rejuvenation the bodies healing ability is boosted. Typically, the body is programmed to naturally repair itself that is why after you get a cut you can stay without going to hospital but still get healed within a very short time. However there other crucial organs that when damaged do not easily get repaired. When the body’s cells cannot get differentiated to give rise to new healthy cells and heal the damaged cell then there is a problem. According to Mayo clinic the cells that were once thought of as terminally differentiated including the heart, lungs and nerves which are more specialized are able to remodel as they possess ability to self-renew. However researchers are still working to come up with strategies through which the ability of these cells to self-heal can be enhanced.

Stem cellReplacement– here the stem cells can be used to replace the damaged cells.in degenerative diseases like osteoporosis the damaged tissues can be replaced with fresh stem cells that will proliferate into more functional bone issues and relieve the system of the damaged tissues. the stem cells can be transplanted in autologous manner where the stem cells will be harvested in the adipose or the bone marrow and be used to replace the affected cells in organ. with autologues stem cell transplant the issue of donor is not a problem neither are there issues of rejection nor the need for immunosuppression .

Regeneration- Through regeneration the stem cells are delivered to diseased tissues or organs, where they will ultimately restore tissue and organ function. This can be done through cell-based therapy or by using cell products, such as growth factors. Bone marrow transplants are an example of regeneration. Regeneration aims to awaken cells that are not functional or have malfunctions. With stem cell therapy there is hope for affordable healthcare solutions that heal the body whole without life threatening side effects.

Stem cells are a cutting edge

Stem cells are capable of self-renewing giving rise to several copies of themselves. They also have the capability of shifting shape and changing type, therefore they can be used to form the cells that are damaged and restore the functions of the damaged tissues. The stem cells can be used to replace the cells that have malfunctioned due to structural damage. The amazing part of the stem cell differentiation is that when a stem cell divides both the daughter cell and the parent stem cells have the potential to differentiate into different cells or to still remain as stem cells. Owing to this ability of stem cells to differentiate into more specialized cells, they can rebuild lost blood vessels, reverse scarring, regenerate damaged nerves, and bring back the healthy you.

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Stem cell therapy has a lot to offer to patients, Visit us at AWAREmed Health and Wellness Resource Centre at Myrtle Beach, South Carolina. Dr. Dalal Akoury (MD) an expert in integrative and regenerative medicine will be able to help.

What are stem cells, and why are they important?

 

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Treating Diabetes With Stem Cells

May 2, 2015

Stem Cell Therapy for Diabetes

DiabetesDiabetes is a serious disease that has continued to debilitate the human race. This disease comes in two forms namely the diabetes type 1 which is also known as juvenile and the type 2 diabetes which is also known as adult diabetes. The type 1 diabetes is an autoimmune disorder which occurs when the immune system mistakenly attacks and kills the beta cells of the pancreas. When this happens the release of insulin in the body will be interfered with adversely. Consequently, sugar builds up in the blood instead of being used as energy. About five to 10 per cent of people with diabetes have type 1 diabetes. Type 1 diabetes generally develops in childhood or adolescence, but can also develop in adulthood. Type 1 diabetes is always treated with insulin. However some dietary approaches can be used to help in keeping the sugar level right.

Diabetes is one of the top ten leading causes of death worldwide according to a recent WHO report; in 2012 the global prevalence of diabetes was estimated to be more than 10% among adults. The most prevalent type of diabetes is the type 2 and it is rampant in adult population. Diabetic patients develop hypertension and cardiovascular diseases, which account for high rates of morbidity and mortality among adult patients. In the past treatment of diabetes has been marred by different factors, oral medications that were the major form of treatment are not as effective as after sometime the patient may develop insulin dependence. Oral insulin medication is also not so effective since exogenous insulin cannot provide the tight glycemic control exerted by the pancreas-derived insulin secretion. Researchers consequently have been prompted to come up with better ways of addressing this menace. Stem cell therapy is the new effective way that is hoped to save the human race. It works by replacing the damaged cells and normalizing the blood sugar level.

Autologous stem cell transplant for treatment of diabetes

The stem cells are very important owing to their crucial functions in the body. These cells are present in the bone marrow and in the adipose tissues. Owing to their ability to form other cells and tissues, they can be harvested from either the bone marrows or the adipose tissues and be used to heal or replace cells in the affected places. When the harvest of the stem cells is done from the patient’s own body and the used within his body then it is called autologous stem cells transplant. Autologous stem cell transplant is safer since the cells are from the body and therefore there is no risk of them getting rejected neither to induce unpleasant allergic reaction nor require need for immunotherapy. The autologous stem cell therapy can be used to replace the affected cells and help restore proper functioning.

In autologous stem cell transplants, the doctors use peripheral blood stem cell transplantation. With peripheral blood stem cell transplantation, the stem cells are taken from blood. The growth factor G-CSF may be used to stimulate the growth of new stem cells so they spill over into the blood. G-CSF is a protein that is produced naturally in the body. The blood is removed from a vein and passed through a machine that separates the stem cells. The machine then returns the remaining blood through a needle in the person’s arm or through a central venous catheter. This way of collecting stem cells is called apheresis

Using mesenchymal cells yields best results

DiabetesBefore the use of autologous stem cell transplant, the islet transplantation was majorly used in cell based therapy for diabetes treatment. This method however successfully used in the past has its own disadvantages. Its major pitfalls included the following; limited donors, graft rejection, the need for continued immune suppression and exhaustion of the donor cell pool. To help fill these pitfalls that made this treatment unpleasurable, researchers targeted the stem cell therapy as a better alternative and they were not wrong, it has been noted that the stem cell therapy works better for diabetic patients who fail to control hyperglycemia even with insulin injection. This is because autologous cells are readily available and do not entail prolonged hospital stays or sustained immunotoxic therapy. Among autologous adult stem cells, mesenchymal stem cells therapy has been applied with varying degrees of success in both animal models and in clinical trials.

The cell based therapies had been introduced in treatment of diabetes for diabetes mellitus and it surely achieved success. It involved the use of islet transplantation. It was so successful especially in treatment of diabetes type 1 but it had some other failures that could not be overlooked and it’s these failures that are now addressed by the stem cell therapy. Stem cell therapy is a solution to some of the drawbacks of islet transplantation especially the shortage of donors. Autologous stem cell therapy allows for a person’s on organs to be used in the transplant.

The mesenchymal stem cells are used as they are able to proliferate and form new more effective cells replacing the damaged cells. They are mostly harvested in both the bone marrow and the adipose tissues where they are available in the highest amount. The mesenchymal stem cells help maintain the capacity of multilineage differentiation potential, both within and across lineage barriers. They are easy to cultivate and expand, and maintain pluripotentiality after prolonged culture conditions.

Diabetes is a killer disease; visit us at AWAREmed Health and Wellness Resource Centre at Myrtle Beach, South Carolina. Dr. Dalal Akoury (MD) an expert in integrative and regenerative medicine will be able to help.

Stem Cell Therapy for Diabetes

 

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