Tag Archives: Reward system

Can Dopamine Depletion Cause Cocaine Addiction

Research Shows Dopamine Depletion Causes Cocaine Addiction

Dopamine depletionThe importance of dopamine in our bodies can never be underestimated. This is one of the most crucial neurotransmitters in the body. Dopamine has very many functions in the body but to many people it is famous for its good feeling effects that it is always identified with but this should not be the case as it has functions beyond the mesolimbic pathway. In the brain dopamine plays such roles as: It plays a big role in starting movement, and the destruction of dopamine neurons in an area of the brain called the substantia nigra is what produces the symptoms of Parkinson’s disease. Dopamine also plays an important role as a hormone acting to inhibit prolactin to stop the release of breast milk. Back in the mesolimbic pathway, dopamine can play a role in psychosis, and many antipsychotics for treatment of schizophrenia target dopamine. Dopamine is involved in the frontal cortex in executive functions like attention. In the rest of the body, dopamine is involved in nausea, in kidney function, and in heart function.

For emphasis, dopamine isn’t only associated with good feelings but in itself has many functions. This neurotransmitter is involved in many different important pathways. However, most people can only identify dopamine with such aspects as motivation, addiction, attention, or lust, their knowledge of dopamine is limited to the mesolimbic pathway. It is a pathway which starts with cells in the ventral tegmental area, buried deep in the middle of the brain, which send their projections out to places like the nucleus accumbens and the cortex.

Whenever a person engages in any pleasurable activity like sex, use of drugs or partying the brain will respond by increasing the levels of dopamine released in the nucleus accumbens .However during addiction the dopamine signaling in this area is changed. For any drug to have any pleasurable feeling to the user then the level of dopamine must be increased and this is what causes euphoric feelings that drug users will do anything to achieve.

Cocaine abuse and dopamine surges

Cocaine is one of the drugs of pleasure that are largely used even today despite its unpleasant effects on the user. Cocaine abuse is known to trigger large surges of dopamine extracellular in limbic areas, specifically, nucleus accumbens. Researchers have shown that human imaging studies correlate descriptors of reward, for instance, the “high” and euphoria with cocaine induced increases in dopamine nucleus accumbens. There is also the issue of saliency of the reward, which seems to be driven by the novelty or unexpectedness of the activity. It is the euphoric properties of cocaine that lead to the development of chronic abuse, and appear to involve the acute activation of central dopamine neuronal systems. This is based upon known effects of cocaine on dopamine neurons, and the role played by dopamine in reward states and self-stimulation behavior. When a person uses cocaine for a long time his neurotransmitter and neuroendocrine alterations will eventually occur. Dopamine depletion is hypothesized to result from overstimulation of these neurons and excessive synaptic metabolism of the neurotransmitter. It is this depletion of dopamine that may underlie dysphoric aspects of cocaine abstinence, and cocaine cravings.

Some scientists have opined neurochemical disruptions caused by cocaine are consistent with the concept of physical rather than psychological addiction. Possible pharmacological interventions in cocaine addiction are outlined and the psychological approach to these patients is discussed. With many research findings on cocaine relations with dopamine, it is clear that cocaine addiction stems from the depletion of synaptic dopamine in the mesolimbic dopamine reward system, leading to a dysphoric withdrawal state that drives cocaine seeking to restore dopamine to normal, drug-naïve level.

Owing to its euphoric feelings, people who use cocaine find it hard to quit. When your brain has been conditioned to produce high levels of dopamine only when you are using cocaine then it will be hard for you to quit using this drug as every time you try to quit all the withdrawal symptoms, some of which may be too severe sets in and that ties a person to cocaine abuse thereby causing addiction and dependence thereafter. These cravings contribute not only to addiction but to relapse after a hard-won sobriety. A person addicted to cocaine may be in danger of relapse when he interacts with the people he used to take it with. These triggers do something to his brain that awakens his cravings for cocaine.

Dopamine depletionUsing dopamine antagonists to treat cocaine addiction

Today there is evidence that cocaine exerts its rewarding effects through the acute activation of dopamine pathways in the brain. Chronic cocaine administration is hypothesized to lead to dopamine depletion, which results in cocaine craving and cocaine abstinence states. This is a condition that has chained many to cocaine use but there is hope as treatment of cocaine addiction with bromocriptine which is a dopamine antagonist has been found to be effective in quelling all the cravings associated with cocaine addiction.

Drug addiction is a vice that should be fought by all means that is why we at AWAREmed Health and Wellness Resource Center are committed to availing help to addicts and offering them a place to call home. We offer NER Treatment and Amino acid therapy that are the most effective approaches to addiction treatment and recovery. You call on Dr. Dalal Akoury (MD) today and begin your journey to victory against addiction.

Dopamine Depletion Causes Cocaine Addiction

 

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Addiction Treatment for High Executives

Addiction Treatment for High Executives

Drug addiction knows no social classes; anybody in the society is at risk of becoming an addict. Just like people in lower cadre the high class executives may also be addicted to drug use and therefore seek help. The very nature of their life style demand that they be availed certain privileges and luxury even at their time of struggles with drugs. Firstly, they are people who love privacy and acquiring addiction treatment in any public Rehab center with no adequate equipments may not be the best of place for them.

Needless to mention these people have spent their lives developing their careers, putting in the hours and climbing the corporate ladder to increase their success. They’ve worked incredibly hard, often enduring an inconceivable amount of stress in their pursuit of professional advancement.  Therefore it is only logical that they can be assured a conducive environment even in the time of treatment to track the work going on in their organizations, the organizations that view them as indispensable assets due to their long years of experience. Offering them an opportunity to keep in touch with the organization through their personal computers can be a great strategy to enhance the camaraderie with his workmates. This not only helps the organization but helps the patient to cope with the treatment as it reduces his feeling of stress and so eases his travel to recovery.

addiction treatment

Rehabs that provide addiction treatment for high executives knows just how valuable they are to the company staff who might be dependent on their directions and so allows the patients to work in the course of their recovery through their personal computers when they are not on treatment. This helps them to view the situation as normal which is good for a recovering addict. This also limits the chances of their professional setbacks in the course of treatment that may be a course of stress in their lives.

Some of these rehabs that offer addiction treatment to high executives have fully operational business centers that the recovering executives may take full advantage of and communicate with their staff and even conduct researches before or after they have received the treatment of the day. They can also enjoy the privacy of their residences to hold even Skype conferences with their staff teams. The impact of drug addiction on an executive career is clearly understood by these facilities and thus all is done to ensure they maintain climbing their professional ladders while treatment is going on.

Any executive who need help finding a facility that best suits him can do an online search where there are myriads of these facilities and then choose the best judging from services they offer  this will get you started. In most, executive programs differ from non-luxury ones as you might think, though some may not be so evident. You or your family member will have not only the ultimate therapy but a level of one-on-one treatment that can have a sizable impact on your ability to remain addiction-free. You can expect the top-rated amenities, from high-end private rooms, to four-star meals, to massage and acupuncture services. Added attention will be given to your desire for privacy and comfort. These facilities are the best places for high executives as they have even the best professionals who will handle the patients better.

These facilities offer just so much that other public rehab centers cannot offer. They are not focused on healing symptoms alone but go beyond that. Here are some of the benefits that you can reap at a rehab offering addiction treatment for high executives.

Comprehensive Care

Patients can enjoy comprehensive care offered by these facilities. Focusing on the physical and behavioral science of chemical dependency, these facilities offer the best executive addiction treatment to help patients not only heal from the immediate symptoms of their addiction, but also form a comprehensive plan to develop a healthy and functional lifestyle. Many people mistakenly believe that once they successfully complete recovery, they are free and clear with no residual damage. Once they encounter stress or adversity in their regular lives, however, they wind up relapsing and are unclear as to why. With comprehensive treatment chances of relapse are reduced.

The brain is often adversely affected by drug addiction having caused chemical imbalances in both brain and body hence creating impacts on emotions and perception of environment, making it necessary for recovery patients to learn new coping skills. Without these new techniques, chances of successful long-term recovery are drastically diminished. The Executive Addiction Treatment program that these rehabs offer gives patients the skills they need to cope with these changes without the use of drugs or alcohol.

addiction treatment

Experienced and Qualified Experts

These rehabs employ a first-class team of licensed and credentialed addiction treatment professionals. The experts are divided in teams that work synergistically to ensure one common goal which is to help the addict to break off the chains of addiction. The teams include; clinical psychologists, counselors, licensed clinical social workers, spiritual advisers, fitness instructors, and professional detox specialists. These professionals have an intimate understanding of the issues that you will face during and after treatment, and help you develop the strength and independence to stay successful in your recovery.

Drug addiction is a vice that should be fought by all means that is why we at AWAREmed Health and Wellness Resource Center are committed to availing help to addicts and offering them a place to call home. We offer NER Treatment and Amino acid therapy that are the most effective approaches to addiction treatment and recovery. You call on Dr. Dalal Akoury (MD) today and begin your journey to victory against addiction.

Addiction Treatment for High Executives

 

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Suicide and Drug Addiction

Suicide Rate in Drug Addiction and How to Naturally Prevent

Drug addiction has been known for its destructive effects on the addicts. Most of the side effects are known by many especially depression and other withdrawal symptoms that an addict faces whenever he tries to stop using the drugs. However there is also another serious problem that has now been linked to drug and substance addiction- suicide. Suicide among drug addicts has become a serious problem that have to be curbed as many addicts are finding it the easiest way to end their suffering and depression as they struggle to set themselves free from addiction. Most of the people who commit suicide do it under the influence drugs. The use of opiates like oxycodone and heroin are leading cause of suicides.

Cocaine Use Increased Odd of Suicide Attempt 

Suicide Student Overwhelmed Asking For Helphas been a problem that the society has been fighting with. It has very many causes, however as revealed by a study that was led by Richard Ries MD of Harborview Medical Center University of Washington Seattle, Wa, the major cause of suicide attempts are the use of drugs and substance. This study reveals that of all the major causes of suicide attempts, cocaine use leads by increasing suicide attempts 62 times more likely. This is followed by major depression which increases the odd of suicide attempts 41 times more likely. Alcohol use follows by increasing odd of suicide attempts 8 times more likely. This supports the notion that drug and substance addiction increases chances of a person committing suicide.

In this same study it was found that among other factors divorce and separation increased odd of suicide attempts 11 times more likely. A person may argue that now that divorce and separation also increases the likelihood of a person committing suicide then there is no way to link drug addiction to increased suicide cases. However if deviate from your view you will realize that drug and substance addiction has a bigger role in even divorce and separation. Most of the cases where married parties have to separate or divorce are often linked to drug abuse. A person gets drunk and becomes abusive needless to mention he may not be able to stand with his responsibilities causing the family to break. Socially, the use of drugs and getting addicted to them will even determine the people you relate with and what jobs you will even do. So drug and substance addiction will affect a marriage in many and may be the driving factor that leads to separation linked to increased suicide cases.

However it not reasonable to ignore other factors that may lead to divorce and separation such as infidelity, having abusive partners (some people get abusive even without using drugs), financial problems and other mere misunderstandings. In these cases it calls for counseling in order to rectify the problems before it results in divorce. As it turns saving a divorce may count in reducing the rate of suicide. Marriage counselors may help in restoring peace in a marriage.

What Predicts Suicide Attempts in Alcoholics?

Teen alcohol addiction (drunk teens with vodka bottle)Several studies have linked drug use to increase in suicide attempts. The addicts need to be helped through various ways to help them stay away from suicide thoughts. The doctors have found various ways through which they can predict whether a person addicted to alcohol may attempt suicide or not. These insights may help the doctors to find ways to counsel the addicts to be free from suicide thoughts. One of these pointers is the family history of attempted suicides. When a person has a family member who had committed suicide they are said to develop suicide thoughts. When these suicide thoughts become dominant in their minds they begin to view it as the best solution to end their addiction problems. By studying their family suicide attempt history they can be helped to adopt better ways of solving problems. Another pointer is adverse childhood experience. There are childhood experiences that keep haunting an individual. These thoughts may even be the cause why a person becomes alcoholic. Experiences such as rape, neglect or sodomy may leave a person feeling unworthy and such attitude may cause suicide. The doctors may find ways of helping such an addict to avoid suicide.

Today, suicide has become a major catastrophe. In America alone it is reported that suicide is among top 3 or 4 causes of death in the US from teens to 50. To reduce this rate, there are a lot that needs to be done. Fortunately several studies have shown the major causes of suicide and so an action plan can be developed to minimize the causes of suicidal deaths in both teens and adults not only in America but also in other continents.

Suicide Screen, Assessment Risk and Referral

Suicide is one of the major causes of deaths in teens. For this reasons there is need to screen the alcoholics and even teens for suicide risks. Unfortunately screening for suicide risks has not been utilized in the past majorly because many institutions lack these mental health resources. Risk assessment will be done after the screening to show probability of suicidal death occurring and after this probability is known then various measures can be taken to help the person before he becomes a victim of suicide. In most institutions there may not be abled professionals to handle a subject given the suicide risk factor may be high. In this case referrals become necessary where the person may be taken to more equipped centers with abled professionals who can help prevent such deaths.

Drugs and substance abuse contribute greatly to suicidal deaths and that is why here at AWAREmed we approach addiction integratively so that we not only deal with withdrawal symptoms but also assess other risk factors. Dr. Dalal Akoury (MD) has helped many addicts to retrace their steps and overcome addiction. You can call on her for more help.

Suicide Rate in Drug Addiction and How to Naturally Prevent

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Understanding Addiction as it is

Understanding Addiction as it is – Drug Addiction

Addiction

If only we can understand addiction as it is we would not do things that subject our health in to greater risk

There is nothing that happens without it roots, for example we all have our roots where we came from, who our parents, grandparents etc. are and so when we want to talk about us we are able to locate the roots and get into the story, in the same way the problem of addiction can also be understood from its known roots before we can talk of administering treatment. Understanding addiction will include looking at various triggers for an addiction and why some people appear to be more susceptible than others. In spite of what people say stopping an addiction is such an uphill task and many people do not understand why or how other people become addicted to drugs. It is often erroneously assumed that those who abuse drugs lack moral principles or willpower and they could stop using drugs if they want to simply by choosing to change their behavior.

The truth is that drug addiction is a complex and very complicated disease. Stopping abusing any substance is such an uphill task that takes more than good intentions or strong will. It is important to know that drugs changes the brain in ways that foster compulsive drug abuse. Nonetheless we are today luck that advancement in technology has simplified more about how drugs work in the brain and we are also aware that drug addiction can be successfully treated to help people stop abusing drugs and lead productive lives.

However before commencement of addiction treatment it is to comprehend what an addiction really is and the various factors which lead to the addiction. We can do this by looking at various triggers for an addiction and why some people appear to be more susceptible than others. Therefore:

What Is Drug Addiction?

Addiction is a chronic problem, often relapsing brain disease that causes compulsive drug seeking and use despite all known harmful consequences to the addicted persons and to people around them. When we are opting for drugs in most cases it is never done forcefully. The new user get in drugs on a willing basis, the problem that follows could be devastating in the sense that the alterations that take place in the brain over a period of time influences the addicts ability to practice self-control and hinder their will to resist intense impulses to take drugs.

Like I said we are today much more informed of the availability of treatment procedures tailored to help people counter addiction’s powerful disruptive effects. Several studies have also established that mixing addiction treatment medications with behavioral therapy is one of the best ways to ensure success for most patients. Treatment methods that are tailored to each patient’s drug abuse patterns and any co-occurring medical, psychiatric, and social problems can lead to sustained recovery and a life free of drug abuse. It is important noting that during treatment process just like any other chronic disease patients can relapse and begin abusing drugs again, when this happen, it does not indicate failure of treatment but rather it indicates that treatment should be:

  • Reinstated
  • Adjusted or that
  • An alternative treatment is needed to help the individual regain control and recover.

What Happens to Your Brain When You Take Drugs?

Drugs contain chemicals that tap into the brain’s communication system and disrupt the way nerve cells normally send, receive, and process information. There are at least two ways that drugs cause this disruption it can either happen by:

  • Imitating the brain’s natural chemical messengers and
  • Over-stimulating the “reward circuit” of the brain

Some drugs (e.g., marijuana and heroin) have a similar structure to chemical messengers called neurotransmitters, which are naturally produced by the brain. This similarity allows the drugs to confuse the brain’s receptors and activate nerve cells to send abnormal messages.

Other drugs, such as cocaine or methamphetamine, can cause the nerve cells to release abnormally large amounts of natural neurotransmitters (mainly dopamine) or to prevent the normal recycling of these brain chemicals, which is needed to shut off the signaling between neurons. The result is a brain awash in dopamine, a neurotransmitter present in brain regions that control movement, emotion, motivation, and feelings of pleasure.

The overstimulation of this reward system, which normally responds to natural behaviors linked to survival (eating, spending time with loved ones, etc.), produces euphoric effects in response to psychoactive drugs. This reaction sets in motion a reinforcing pattern that “teaches” people to repeat the rewarding behavior of abusing drugs.

As a person continues to abuse drugs, the brain get used to the irresistible surges in dopamine by producing less dopamine or by reducing the number of dopamine receptors in the reward circuit. The result is a lessening of dopamine’s impact on the reward circuit, which reduces the abuser’s ability to enjoy not only the drugs but also other events in life that previously brought pleasure. This decrease compels the addicted person to keep abusing drugs in an attempt to bring the dopamine function back to normal, but now larger amounts of the drug are required to achieve the same dopamine high an effect known as tolerance.

Long-term abuse causes changes in other brain chemical systems and circuits as well. Glutamate is a neurotransmitter that influences the reward circuit and the ability to learn. When the optimal concentration of glutamate is altered by drug abuse, the brain attempts to compensate, which can impair cognitive function. Brain imaging studies of drug-addicted individuals show changes in areas of the brain that are critical to judgment, decision making, learning and memory, and behavior control. Together, these changes can drive an abuser to seek out and take drugs compulsively despite adverse, even devastating consequences that is the nature of addiction.

Why Do Some People Become Addicted While Others Do Not?

No single factor can predict whether a person will become addicted to drugs. Risk for addiction is influenced by a combination of factors that include individual biology, social environment, and age or stage of development. The more risk factors an individual has, the greater the chance that taking drugs can lead to addiction. For example:

  • Biology – The genes that people are born with—in combination with environmental influences—account for about half of their addiction vulnerability. Additionally, gender, ethnicity, and the presence of other mental disorders may influence risk for drug abuse and addiction.
  • Environment – A person’s environment includes many different influences, from family and friends to socioeconomic status and quality of life in general. Factors such as peer pressure, physical and sexual abuse, stress, and quality of parenting can greatly influence the occurrence of drug abuse and the escalation to addiction in a person’s life.
  • Development – Genetic and environmental factors interact with critical developmental stages in a person’s life to affect addiction vulnerability. Although taking drugs at any age can lead to addiction, the earlier that drug use begins, the more likely it will progress to more serious abuse, which poses a special challenge to adolescents. Because areas in their brains that govern decision making, judgment, and self-control are still developing, adolescents may be especially prone to risk-taking behaviors, including trying drugs of abuse.

Prevention Is the Key

Drug addiction is a preventable disease. Research findings indicate that prevention programs involving social networks like families, schools, communities, and the media are effective in reducing drug abuse. Although many events and cultural factors affect drug abuse trends, when youths perceive drug abuse as harmful, they reduce their drug taking. Therefore it is important to bring in experts like Dr. Dalal Akoury who is also the founder of AWAREmed Health and Wellness Resource Center where she is offering her exclusive NER Recovery Treatment to everyone including other physicians and health care professionals through training, clinical apprenticeships, webinars and seminars. Finally besides what we get from doctor Akoury the general public needs also to be educated and in this area a collective effort from Teachers, parents, medical and public health professionals will be very essential in creating awareness that drug addiction can be prevented if one never abuses drugs.

Understanding Addiction as it is – Drug Addiction

 

 

 

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Sugar Addiction & Dopamine

Sugar Addiction & Dopamine: Is there any relation?

In our everyday life in our diets we include sugary foods. Sugar is a source of sweetness that everyone will always want to get. Under normal circumstances, we take sugar in the form of food additive but some people will sometimes take it directly due to its sweetness satisfaction.

What is dopamine?

This is one of the principal neurotransmitters which are involved in the substance dependence. It is one of the hormones which play a very important role in the human brain and body. In the brain, this hormone works as a communication network to send signals to the other cells nerves. These hormones dominate the roles of the brain reward system which is responsible for behaviors. Most of the rewarding activities will increase the amount of the dopamine released in the brain and also some of the addictive drugs are known to also increase the dopamine neural activity.

Is sugar addictive?

Researches have been done to find out whether sugar addiction is a reality of fiction. The recent researches have shown that sugar is a “new tobacco”, worse than many addictive drugs we know and a secrete killer! It is argued according to the research done by Dr. Mark Hyman et al, that sugar is over eight times more addictive than cocaine.

sugar addiction

Sugar, unlike many other addictive drugs which are illegal in many countries, is a legal food substance all over the world. This makes sugar readily available and it is also cheap to acquire. The nature of its sweetness cannot also be underrated as this is what actually makes a sugar a highly rewarding substance in the human brain.

Among the known foodstuffs which have capability to stimulate the pleasure centers in the brain, sugar is one of them. This center of pleasure which sugar stimulates is known as dopamine, which is a neurotransmitter that controls the brain’s pleasure and reward centers. Research has shown that sugar acts on human brain in the same way as cocaine.

What makes sugar be regarded as addictive?

Before we conclude that a substance is addictive, we have to look at whether it poses the attributes of an addictive substance. Sugar has the following attributes which qualify it to be an addictive substance:-

  • Despite its negative effects or the desire to stop taking sugar, the person compulsively continues to eat it.
  • Just like the other addictive drugs such as alcohol and cocaine, sugar impacts the neurotransmitter in the brain.
  • When used continuously, tolerance occurs and hence the person must take more sugar to achieve the same experience.
  • Over time, sugar is required for the person’s body to function normally.
  • When someone stops taking the sugar, withdrawal symptoms are witnessed.

How does dopamine play part in sugar addiction?

Just like with any other dopamine producing substance, when sugar is taken it enters the brain system and activates the neurotransmitters responsible for pleasure. High amounts of dopamine are released to the system and hence the rewarding effects occur. This rewarding occurs in a form of pleasure that the person who is taking the sugar feels. With time, the number of dopamine which are released when the sugar is taken reduces and this results to the condition known as resistance. This eventually means in order to produce the pleasurable feeling, you have to consume more and more of sugar than that you used to consume before. This launches a viscous cycle of increased consumption of sugar leading to further desensitization and end up with an insatiable appetite for sugar.

Does sugar addiction have any negative effect to one’s health?

The fact that sugar is a common food substance acceptable all over the world makes it a common stuff in every kitchen. Under normal circumstances, a person will have a control over when it is necessary to take sugar in whichever form. This will though not be the case when the person becomes addicted with sugar. A sugar addict will unhealthily consume a lot of sugar which poses a lot of dangers to one’s health. Let’s look at some of the dangers that sugar addiction can cause to the addict.

  • Sugar addiction may cause diabetes

Diabetes is a complex disease attributed with high glucose level in the blood. It is also called high blood sugar. When a person becomes a sugar addict, the chances of high blood glucose becomes high and hence the chances of becoming diabetic.

  • Sugar addiction can cause obesity

The understanding of the relationship between sugar and obesity may look hidden unlike its direct relationship with diabetes. The main reason behind obesity is overeating. So, does it mean sugar addicts eat more than normal people? Let’s find out by asking another related question, “How do we know that we have eaten enough food and hence stop eating?”

sugar addiction

The reason why we will always know when we have had enough of food is that our brains have a hormone known as Leptin. This hormone sends a signal when one has had enough of a food and hence the person stops eating. This hormone is naturally produces in the fat cells and it functions well under normal healthy dieting. However, this hormone is easily interrupted by things such as ingesting too much artificial sweeteners, high levels of insulin and not forgetting excess sugar. When a sugar addict consumes excess sugar, this disrupts the hormone and hence it fails to function.

When Leptin hormones fail, the hunger homes begin to run rampantly and unopposed. This makes the addict feel hungry and hence want to eat every now and then. Every time such a person eats, there will be obviously overeating since there are no regulatory signals in the brain and this is why sugar addiction is highly associated with obesity.

Sugar Addiction & Dopamine: Is there any relation?

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