Tag Archives: Neurotransmitter

Catecholamine Fatigue Is Worse Than Adrenal Fatigue

September 7, 2014

Beware! Catecholamine Fatigue Is Worse Than Adrenal Fatigue

What is catecholamine?

These are hormones which are made by adrenal glands. These hormones are released by the adrenal glands found on top of the kidneys and go into the blood streams when a person becomes under physical or emotional stress. Catecholamine is found in the main three forms; dopamine, norepinephrine and epinephrine (also called adrenalin).

Catecholamine
What is the role of Catecholamine?

The role of Catecholamine can be understood by looking at the functions of the various components which form them. These compounds are dopamine, norepinephrine and epinephrine (also called adrenalin). Catecholamine especially dopamine and the norepinephrine are the principal neurotransmitters which mediates various activities or functions of the central nervous system.

The main function of catecholamine therefore is the regulation of functioning of the central nervous system. It sends signals which help the body to prepare to respond to stress or fright and adequately prepare the body to fight it.

How does catecholamine work?

When catecholamine gets into the body system via blood streams, it works by increasing the rates at which you heart beats, the blood pressure, breathing rate, the strength of your muscles, and also the mental strength. To ensure enough supply of blood to the main organs of the body (such as brain, kidneys, liver, lungs, heart etc.), it regulates the amount of blood going to the skin and intestines. This ensures that the main body organs are sufficiently supplied with blood.

What are the effects of catecholamine deficiency?

Just as we discussed earlier, catecholamine is a very important hormone. It is one of the two main neurotransmitters whereby the other is serotonin. Deficiency in catecholamine has been known for years to cause variety of diseases. The following are some of the diseases/ illnesses associated with deficiency in catecholamine:-

  • Depression or being moody – one of the effects of lowness in catecholamine which is known to be very common, is depression. This is one of the factors which make the catecholamine fatigue by far worse than that of adrenals. When a person who is addicted of a given substance and is also diagnosed with catecholamine fatigue, the problem becomes even more complicated to address. Before a successful addiction recovery program is undertaken, the problem of catecholamine fatigue needs to be first address. This is because it causes depression which makes it impossible for recovery from addiction to occur. The reason behind this difficulty is that for success in the addiction recovery to occur, your mind must be in good working condition. Depression in itself is a disease, and when adjoined with addiction it may make the recovery from addiction chances next to impossible.
  • A feel of anxiety – when a person is a victim of catecholamine fatigue or deficiency, the levels of excitement may be high. This is because the catecholamine is a component of neurotransmitter, which is the hormone responsible for regulation the brain’s reward system. This deficiency leaves the system un-regulated, and thus the levels of excitement may remain high, especially when initially triggered high. In this respect, catecholamine which supposed to regulate the levels of this excitement is low, and thus the levels of excitement remain high.
  • Insomnia may also occur – a state of sleep disorder is also very likely to occur. The principle behind it is that all the metabolic functions in our bodies are controlled from our minds and neurotransmitter plays the main role in this control. When there is a deficiency in catecholamine, it becomes very difficult for the brain to regulate the metabolic rates, which would facilitate sleep through activities such as regulation of the rate at which the heart beats.
  • Other common problems may include: – panic attacks, obesity, bulimia, anorexia, migraines, ADD/ADHD, Fibromyalgia just to mention a few.

What are the possible causes of depletion in catecholamine in the body?

There are several factors which have been attributed with causing depletion in catecholamine in our bodies. Some of these factors are:-

  • Simulants use – researches have shown that among the causers of depletion in catecholamine from our bodies is the use of stimulants. When one uses these stimulating substances, they lower the effectiveness of neurotransmitter and thereby creating resistance to the neurotransmitter.
  • Nutritional triggers – catecholamine (neurotransmitters) are made from proteins, and thus to ensure that they remain at a high level, we must take foods rich in proteins. When we take foods which are low in proteins for quite a long time. There is a likelihood of development of catecholamine deficiency. For a person who is an addict of a given food which is low in protein, catecholamine deficiency is a possibility.
  • Some medications especially SSRI, deplete catecholamine – research has shown that, administration of some SSRI medications can deplete serotonin receptors by 40 – 60%.
  • Stress – it has also been argued that stress can also contribute to the decline in the levels of catecholamine.

Why must catecholamine fatigue be addressed before addiction recovery program is embraced?

Catecholamine fatigue is more serious than the adrenal fatigue, although closely related. This is because unlike with adrenal fatigue, catecholamine fatigue is usually accompanied by depression and thus not unless it is addressed first, it becomes very difficult for the addiction recovery program to be successful.

Can catecholamine levels be restored?

CatecholamineRepletion of catecholamine is very easy. You just need to understand where it is synthesized from. Catecholamine and serotonin comes from the same source, which are the amino acids, vitamins and the minerals which are common in the foods we eat. These minerals are the ones which are converted into neurotransmitter, which catecholamine forms part. Therefore, to get your catecholamine restored into your body, you just need to eat much of the foods rich in these nutrients. Such foods may include: – bananas, pineapples, eggplants, red plum, tomatoes, walnuts, just to mention a few.

Alternatively, you can get these nutrients as supplements or seek advice from doctor for the administration of drugs rich in the nutrients.

From this discussion, we can clearly see the need for addressing catecholamine deficiency before we address the addiction recovery. Are you now thinking about where you can get help out of addiction or catecholamine fatigue? Your solution is here; call or visit us at Awaremed Resource And Wellness Center.

Beware! Catecholamine Fatigue Is Worse Than Adrenal Fatigue

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NATURAL REMEDIES FOR DOPAMINE

July 31, 2014

Natural Remedies for Dopamine Include IV Vitamin C, IV selenium, IV coq10, IV DNP

From the definition of dopamine, you will understand that dopamine is responsible for the reward system in the brain. This chemical is responsible for making us feel pleasure, motivated, drive, focus, concentration etc. Dopamine is therefore simply a chemical that is used by the brain to send signals. When dopamine is released by a nerve, it crosses a very small gap known as synapse and then attaches to a dopamine receptor on the next nerve. When the levels of dopamine are low in the brain, the nerve impulses or signals cannot be transmitted well and this can impair the brains functioning. This situation where the level of dopamine is low in the brain is known as dopamine deficiency.

What may affect the level of dopamine?

Dopamine is a chemical which is naturally produced by the human brain. This means that for the level of dopamine produced by the brain to remain optimum the brain must be functioning well. Any alteration in the functioning of the brain therefore can cause imbalance in the levels of dopamine in the brain. Addictive drugs are known to be in the frontline of the causers of this imbalance. The addictive drugs seem to alter the normal functioning of the brain and consequently affect the level of dopamine in our bodies. When the level of dopamine goes down, the person may become depressed. A common effect of low level of dopamine in the brain is depression.

How do I know that I have dopamine deficiency?

The common symptoms of low level in dopamine are the same symptoms associated with the clinical depression. This is because when the person has low level of dopamine; emotions cannot be correctly regulated and has mental impulses which mitigate intense feeling of sadness. The following are therefore the most common symptoms of dopamine deficiency;

  • Lowness in motivation – the person looks docile and doesn’t look to have any motivation towards activities around.
  • Lack of interest in life – the person doesn’t see reason to live.
  • Mood swings – the person looks moody and not willing to freely interact with the people around.
  • Sleep patterns become altered – if you are a victim of dopamine deficiency, you may exhibit altered sleep patterns.
  • Poor memory – the person has a very low retention and remembrance capacities. The chances of retaining information for long are very low since the person remains depressed.
  • The person may be addicted to caffeine or other stimulants
  • Fatigue may also be evident.
  • There may be weight loss in the person.
  • Inability to feel pleasure – since the dopamine is the one responsible for the feeling of pleasure, its deficiency means the person will experience diminish in pleasure feeling capacity.

The levels of dopamine sometimes may be extremely low. In this situation, it causes a permanent and degenerative diminishing motor skills and also muscle rigidity and tremor.

The Natural Remedies For Dopamine Deficiency

Balanced amount of dopamine in the brain is very important. Thus whenever one is diagnosed with its deficiency there should be measures to restore it back to the appropriate levels. The natural remedies have been proven to be much safer ways of increasing serotonin levels. This is particularly because these natural ways are not prone to side effects like the medical ways have.

The natural dopamine remedy doesn’t involve prescription medicine and thus it focuses on the nutrition, exercise and supplements.

  • The nutritional dopamine increase – this dopamine increasing strategy looks at the level of deficiency and offers plans to increase them appropriately. The book, “The Edge Effect” which is written by Dr. Eric Braverman gives us specific nutritional and supplement plans which can be used to increase the levels of dopamine to certain levels depending on the person’s deficiency.

dopamineThe principle that is used by the dopamine diet is that it offers the body the required raw materials for a steady supply of tyrosine and phenylalanine which are the two amino acids which are antecedents of dopamine. The source of these amino acids is foods which are rich in proteins. These foods convert their tyrosine to dopamine. Such foods include:-

  • Meat (Chicken, pork etc.)
  • Fruits like bananas, apples and watermelon.
  • Eggs
  • Black and green tea
  • Beans and legumes
  • Honey
  • Milk
  • Ricotta
  • Soybeans
  • Beets and many more other foods products especially those rich in proteins and IV Vitamin C.
  • Supplements which can increase dopamine

There are compounds which can be administered to the patient and then they raise the level of dopamine in the patient. Such supplements include Tyrosine and L-Phenylalanine. These are actually amino acids and hence they can make dopamine when administered to the patient. They should though be used for low energy type depression, addictive behavior, including depression (low mood), food craving and overeating phases.

Exercise plays an important role in dopamine level increasing. It is highly recommended that you regularly do exercise. Exercise increases the blood calcium which in turn stimulates dopamine production and uptakes in the brain. Doing exercises such as walking, gym, swimming, jogging extra can be very helpful in the dopamine level incrementing. Sleep is also another important ingredient, and thus ensure you get enough sleep.

NATURAL REMEDIES FOR DOPAMINE

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Amino Acids in Fighting Addiction

July 26, 2014

Amino Acids Aid in Treatment of Addiction

Addiction to drugs has been on a rise over the last century. It has therefore been a concern all over the world to develop medication which would address this problem. Through researches many prescription drugs were developed and many of them have proven to cure addiction. Another concern which has of late arisen is that some of the drugs that are given to us (patients) by doctors as prescription drugs have also turned to be addictive. A good example of these drugs is the opioids which are meant to cure pains. This has prompted need to device medication which can cure any kind of addiction, either resulting from legal and illegal drugs or over the counter drugs. One of the treatments which have proven effective is the amino acid treatment.

What is amino acid?

Amino acids are the building blocks of proteins. These acids are responsible for building the cells, repairing tissues, also responsible for the production of enzymes not forgetting their role in the mental health. Research has shown that about twenty percent of a human body is made up of proteins.

It is important to note that, although proteins are vital in the human body, the body cannot obtain them directly from the food. These dietary proteins must be broken into their constituent amino acids which the body then uses to build the specific proteins that it needs. In this respect, we can conclude that it is the amino acids rather than protein that are essential nutrients.

amino acids

Why are some amino acids referred to as essential?

There are basically two categories of amino acids. These are the Essential and non-essential amino acids. Yes, they are referred to as essential because the body needs them in plenty but it cannot synthesize in sufficient quantities to satisfy the nutritional requirements for good health and thus they must be included in our diets. On the other hand there are other amino acids which are regarded as non-essential because they do not have to be included in our diets since they are not required in plenty by our bodies and also the body can synthesize enough for itself.

How does amino acid cure addiction then?

Like we mentioned earlier, Neurotransmitters are made from amino acids which is the building block of proteins. The brain nervous system is almost entirely regulated by amino acids and their biochemical companions, vitamins and minerals. In this respect, before we look at how amino acids cures addictions is important to note that there are key neurotransmitters which are affected by addiction and needs to be restored to their normal state for the person to recover from drug addiction, and be free from craving and anxiety during the period of recovery. Amino acid treatment plays this role by restoring the affected neurotransmitters to their normal conditions. These neurotransmitters are responsible for good mental health and they include: – Serotonin, Catecholamine; GABA; and Endorphin. Amino acids in the treatment of addiction address the tyrosine pathway, the glutamine GABA pathway in the treatment of addiction, Tryptophan pathway, Serotonin and Melatonin Pathways, Taurine IV for
addiction

What is the Role of cofactors and coenzymes in Amino Acid treatment?

Let’s start by understanding what cofactors and coenzymes refer to. Cofactors refer to non-protein molecules which are required for effective activity of Amino Acids. These cofactors can be organic or inorganic substances. The organic cofactors are the ones referred to as Enzymes. In this case therefore, enzymes can be seen as protein catalysts that are responsible for lowering the energy barriers of many biological reactions. They do this by lowering the activation energy of the reaction that they catalyze and this allows the metabolic reaction to occur faster that it would under normal temperatures.

What makes cofactors important?

Just like we have mentioned above, the cofactors will catalyze the reaction ensuring sufficient metabolic energy generation. One of the notable important cofactors is the metal ions. These include ions such as Magnesium (Mg++), Potassium (K+) and Calcium (Ca+). These cofactors bind the enzymes and participate in the reaction by removing electrons, protons, or chemical groups from the substrate. In reactions which involve oxidation-reduction, coenzymes remove electrons from the substrate and then pass them to the other molecules. Habitually, the electron is added to a proton to form a hydrogen atom before it is passed on. Through this way, coenzymes serve to carry energy in the form of electrons from one compound to the other.

Is amino acid treatment safe?

Yes, amino acid is a very safe treatment of addiction since it involves providing the body with all what it requires in the process of addiction recovery and allowing it to cure naturally. This treatment seeks to restore neurotransmitters to their initially healthy functioning state that they used to be at before addiction. This gives the patient a permanent solution to addiction. Another advantage of using amino acid treatment is that it ensures that the patient is free from craving effects and unlike some addiction medication methods which leaves behind addiction effects in the long run, amino acid treatment is not addictive. With all these advantages we can now conclude that amino acid treatment is a safe and a recommendable method of addiction treatment.

Amino Acids Aid in Treatment of Addiction

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Neurons and Neurotransmitters

June 12, 2014

Neurons and Neurotransmitters-The Brains of the Nervous System

Neurotransmitters

Neurotransmitters neuron is a specialized nerve cell that receives, processes, and transmits information to other cells in the body.

The body of a human being is presumed dead when the brain stops functioning. This is because all the functions of the body are controlled by the various segments of the brain. Majorly the nervous system is responsible for the body’s control and communication network. While discharging this function in humans, they do so in three ways and that is to say that they:

  • Senses changes both in and outside the body-the sensory function.
  • Interprets and explains the changes-the integrative function.
  • Responds to the interpretation by making muscles interact and glands secrete hormones or other chemicals into the bloodstream-the motor function.

The nervous system itself has two main parts:

The central nervous system includes the brain and spinal cord which acts as a control center.

The peripheral nervous system includes all other nerve elements. All these elements connect the brain and spinal cord to muscles and glands.

Neurons power their functions

It is important to note that the body of a human being is made up of billions of cells which are ordinarily the basic unit of all living things. This also applies to the single-celled organisms like the bacteria which can perform the basic functions needed to sustain life. These basic functions may include gathering energy from food, reproducing and producing waste materials. Looking at the cells, nearly all of them have three parts which are:

  • An outer wall also known as membrane
  • A nucleus that contains essential chemicals
  • A body of clear fluid called the cytoplasm

Plants, animals and human beings are multicellular meaning creatures with many-cells. Of these cells billions of them are specialize in certain specific functions. For example, some cells would become:

  • Part of muscle tissue and help us to move.
  • Other cells make up organs, glands, blood, veins, arteries, and bones.

Neurotransmitters cross the gaps between neurons

For it to effectively serve its three functions, the nervous systems which includes the vast circuits of delicate cells which are very much elaborately interconnected and in fact the brain, spinal cord and nerves all over the body are all made up of one kind of cell. These are the nerves cells and they are also known as neurons and as had been indicated that the brain of human beings has billions of neurons.  Now the question you need to ask yourselves is does your spinal cord and all the nerves that fan out from the spinal cord to your glands, organs, and muscles.

The specific functions of the neurons are to allow your brain to learn reason and be able to remember things. Through these activities the body responds and adjusts to changes in the environment. These changes are also called stimuli, they will set off impulses in our sense organs like: the eye, the ear and other organs of taste and smell and sensory receptors located in the skin joins, muscles and other parts of the body. Now having listened to all these it is important to note that every time you feel something including the effects of a drug, know that millions of neurons are firing messages to form one another.

Each neuron may have thousands of branches that connect it to other neurons and these branches are called dendrites or axons. Dendrites carry messages towards the cell body while axons carry messages away from the cell body to another neuron. Axons can extend as long as four feet in humans and in some animals even longer.

In the beginning it was believed that axons and dendrites simply run through the body continuously like a wire but letter on a space was discovered between each axon and dendrite. This space in known as a synaptic gap or synapse and it is the space between the axon of one neuron and the dendrite of the next neuron in a nerve pathway. This gap is negligibly small and it is about one millionth of an inch, it is that small.

Research finding originally believed that electrical impulses jumped these gaps like electricity does across the gap in spark plug but this theory has been ruled out as it is now known that this was never true. It is the chemicals which travel across the gap and not electrical impulses and these chemicals are also neurotransmitters.

A number of chemical building blocks for neurotransmitters such as amino acids come from the kinds of food we eat meaning that our bodies have the ability to manufacture or produce neurotransmitters. Neurons offer a storage package for neurotransmitters known as vesicles which are located very close to the endings of each axon. They (neurons) synthesize some neurotransmitters right in the vesicle while other neurotransmitters are synthesized in the body of the cell and transported to the vesicle. Most of the addictive substances have the ability to change the effects of neurotransmitters on neurons. We will be able to better comprehend how these substances work when we get to know about neurotransmitters and how they act as chemical messengers

Neurotransmitters meet three criteria

Neurotransmitters are molecules-groups of atoms joined by a chemical bond which act as a unit. For them to be called neurotransmitters a molecule must meet the following three criteria:

  • The molecule must be present and evenly distributed in the brain meaning that the molecules must not just concentrate in one segment but must spread out among different types of neurons and across all segments of the brain that have different functions.
  • Chemical criteria that is to say the enzymes which help in creating the neurotransmitter must be available in the brain. An enzyme is a catalyst protein which speeds up chemical reactions within the body. It is also important that these enzymes be available in areas where the neurotransmitters are found.
  • The criterion of mimicry assuming that we inject directly a neurotransmitter into a section of the brain known to contain certain neurons, this injection should be able to imitate the effects of electrically stimulating the same neurons.

Neurons and Neurotransmitters-The Brains of the Nervous System

 

 

 

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Neurotransmitters

April 25, 2014

Neurotransmitters-General Psychology

Neurotransmitter

the first neurotransmitter was discovered in early 1920s several others have since been discovered

Neurotransmitters are the chemicals which allow the transmission of signals from one neuron to the next across synapses. They are also found at the axon endings of motor neurons, where they stimulate the muscle fibers. Normally they together with their close relatives are produced by some glands such as the pituitary and the adrenal glands. For a couple of articles in the coming days I will dwell much about NAD being a neurotransmitter and it other functions. I would therefore want to kindly have you on board as we dig into this interesting topic, stay tuned and let us learn together, but for the purpose of article, I want us to byway of introduction review some of the most significant neurotransmitters we have as a basis of understanding ware we are heading to.

Neurotransmitters-Acetylcholine

This is one of the first neurotransmitter to be discovered in early ninety’s.  In 1921 it was isolated by a Nobel laurite German biologist called Otto Loewi for his work.  Some of its functions are;

  • It is responsible for much of the stimulation of muscles, including the muscles of the gastro-intestinal system.
  • It is also found in sensory neurons and in the autonomic nervous system, and has a part in scheduling REM (dream) sleep.

The plant poisons curare and hemlock cause paralysis by blocking the acetylcholine receptor sites of muscle cells.  The well-known poison botulin works by preventing the vesicles in the axon ending from releasing acetylcholine, causing paralysis.  The botulin derivative botox is used by many people to temporarily eliminate wrinkles. On a more serious note, there is a link between acetylcholine and Alzheimer’s disease:  There is something on the order of a 90% loss of acetylcholine in the brains of people suffering from Alzheimer’s, which is a major cause of senility.

Neurotransmitters–Norepinephrine

This was discovered by a Swedish biologist named Ulf von Euler in 1946 by then it was called Noradrenalin.  Ulf also won a Nobel Prize.

  • Norepinephrine is strongly associated with bringing our nervous systems into “high alert.”
  • It is prevalent in the sympathetic nervous system, and it increases our heart rate and our blood pressure.
  • Our adrenal glands release it into the blood stream, along with its close relative epinephrine (aka adrenalin).
  • It is also important for forming memories.

Neurotransmitters-Dopamine

It is an inhibitory neurotransmitter, meaning that when it finds its way to its receptor sites, it blocks the tendency of that neuron to fire. It was discovered in 1950s by another Swede called Arvi Carlsson. Dopamine is strongly associated with reward mechanisms in the brain.  Drugs like cocaine, opium, heroin, and alcohol increase the levels of dopamine, as doe’s nicotine.  If it feels good, dopamine neurons are probably involved!

  • The severe mental illness schizophrenia has been shown to involve excessive amounts of dopamine in the frontal lobes, and drugs that block dopamine are used to help schizophrenics.
  • On the other hand, too little dopamine in the motor areas of the brain are responsible for Parkinson’s disease, which involves uncontrollable muscle tremors.
  • It was Arvid Carlsson mentioned above who figured out that the precursor to dopamine (called L-dopa) could elevate some of the symptoms of Parkinson’s. This would latter in 2000 see him being awarded the Nobel Prize.
  • Recently, it has been noted that low dopamine may related not only to the unsociability of schizophrenics, but also to social anxiety.
  • On the other hand, dopamine has been found to have relatively little to do with the pleasures of eating.

Neurotransmitters-GABA

Eugene Roberts and J. Awapara jointly discovered GABA (gamma amino-butyric acid) in 1950, which is also usually an inhibitory neurotransmitter.

  • GABA acts like a brake to the excitatory neurotransmitters that lead to anxiety.
  • People with too little GABA tend to suffer from anxiety disorders, and drugs like Valium work by enhancing the effects of GABA.
  • Lots of other drugs influence GABA receptors, including alcohol and barbiturates.
  • Luck of GABA in certain parts of the brain, results in epilepsy.

Neurotransmitters–Glutamate

It is an excitatory relative of GABA which is the most common neurotransmitter in the central nervous system as much as half of all neurons in the brain and is especially important in regards to memory.  Curiously, glutamate is actually toxic to neurons, and anything in excess will kill them.  Sometimes brain damage or a stroke will lead to an excess and end with many more brain cells dying than from the original trauma. ALS also known as Lou Gehrig disease comes as a result of excessive glutamate production. Many researchers believe it may be responsible for quite a variety of diseases of the nervous system, and are now looking for ways to minimize its effects

It was discovered 1907 by Kikunae Ikeda of Tokay Imperial Univ. while looking for the flavor common to things like cheese, meat, and mushrooms.  He was able to extract an acid from seaweed glutamate.  He went on to invent the well known seasoning MSG monosodium glutamate.  It took decades for Peter Usherwood to identify glutamate as a neurotransmitter (in locusts) in 1994.

Neurotransmitters–Serotonin

Serotonin is an inhibitory neurotransmitter that has been found to be intimately involved in emotion and mood. For instance:

  • Too little serotonin has been shown to lead to depression, problems with anger control, obsessive-compulsive disorder, and suicide.
  • Too little also leads to an increased appetite for carbohydrates (starchy foods) and trouble sleeping, which are also associated with depression and other emotional disorders.
  • It has also been tied to migraines, irritable bowel syndrome, and fibromyalgia.
Neurotransmitters-Endorphin

In 1973, Solomon Snyder and Candace Pert of Johns Hopkins discovered endorphin.  Endorphin is short for “endogenous morphine.”  It is structurally very similar to the opioids (opium, morphine, heroin, etc.) and has similar functions:  Inhibitory, it is involved in pain reduction and pleasure, and the opioid drugs work by attaching to endorphin’s receptor sites.  It is also the neurotransmitter that allows bears and other animals to hibernate.  Consider:  Heroin slows heart-rate, respiration, and metabolism in general – exactly what you would need to hibernate.  Of course, sometimes heroin slows it all down to nothing:  Permanent hibernation.

Having got the background of these neurotransmitters I want to seek your indulgence to stay on the link to continue getting the optimum benefits from doctor Dalal Akoury who is the founder and MD of AWAREmed Health and Wellness Resource Center. She is a professional training physicians globally to offer the best to patients. In her facility she take keen interest and focus on Neuroendocrine Restoration (NER) to reinstate normality through realization of the oneness of Spirit, Mind, and Body, Unifying the threesome into ONE while administering treatment to her patients.

Neurotransmitters-Psychology of neurotransmitters

 

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