Tag Archives: Neurotransmitter imbalance

Dopamine Rush

Neurotransmitter role in drug addiction

October 10, 2016
Neurotransmitter role

Neurotransmitter role in drug addiction includes the treatment of cancer related pain

Neurotransmitter role in drug addiction: Risk and reward that trigger for the release of dopamine

Dopamine is neurotransmitter in the brain that plays vital roles in a variety of different behaviors. The major behaviors dopamine affects are movement, cognition, pleasure, and motivation. Dopamine is an essential component of the basal ganglia motor loop, as well as the neurotransmitter responsible for controlling the exchange of information from one brain area to another. However, it is the role that dopamine plays in pleasure and motivation that attracts the most neurobiologists attention. And that is why our discussion is focusing on dopamine the neurotransmitter role in drug addiction in this article. We would appreciate if you can stay with us on the link so that together we can learn and take action where necessary in order to defeat addiction. Nonetheless for a better understanding of this topic, we are going to be relying on the expert opinion of doctor Dalal Akoury (MD) who is also the founder of AWAREmed Health and Wellness Resource Center. This is a facility that she founded primarily to make a difference in the life of people who are suffering from the various forms of drug addiction which is very rampant in the current societies we live in.

For better understanding of this point doctor Dalal Akoury says that in certain areas of the brain when dopamine is released it gives one the feeling of pleasure or satisfaction. These feelings of satisfaction become desired, and the person will grow a desire for the satisfaction. To satisfy that desire the person will repeat behaviors that cause the release of dopamine. For example food and sex release dopamine. That is why people want food even though their body does not need it and why people sometimes need sex. These two behaviors scientifically make sense since the body needs food to survive, and humans need to have sex to allow the race to survive. However, other, less natural behaviors have the same effect on one’s dopamine levels, and at times can even be more powerful. Often these behaviors can result in addiction due to their effect on dopamine, and that addiction can have negative effects on a person’s well-being.

Neurotransmitter role in drug addiction: Cocaine

Cocaine is by far more severe in relation to other substances in terms of addiction. Cocaine chemically inhibits the natural dopamine cycle. Normally, after dopamine is released, it is recycled back into a dopamine transmitting neuron. However, cocaine binds to the dopamine, and does not allow it to be recycled. Thus there is a buildup of dopamine, and it floods certain neural areas. The flood ends after about 30 minutes, and the person is left yearning to feel as he or she once did. That is how the addiction begins and with time adaptation builds up due to the fact that the person is consistently behaving in the same way that he or she had the first time. However, the individual cannot, because dopamine is also released when something pleasurable yet unexpected occurs. During the first time, the person expects the effect, thus less dopamine is released, and the experience is less satisfying. This cause explains why gambling releases dopamine.

Many studies have been done which targeted neural response to rewards. The findings were in agreement that when one performed an action repeatedly, and is given a reward randomly, the dopamine levels rises. If the reward is administered for example every four times the action was performed, the dopamine levels remained constant. Whereas when no reward is given dopamine levels dropped. These random rewards can be seen in gambling and since the outcome is based on chance, one may not know prior if he or she will win. Therefore, if he or she wins, dopamine levels increases. However, unlike cocaine, gambling causes addiction in relatively low levels of participants. This is because Cocaine’s chemical input is much more influential on dopamine levels than gambling’s behavioral input meaning that only people whose dopamine levels are low, become addicted to gambling. This may sound technical and complicated, but a phone call to doctor Dalal Akoury will make it much easier for you if only you can schedule for that appointment today.

Neurotransmitter role in drug addiction: Risk and reward that trigger for the release of dopamine

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neurotransmitters-and-mood-symptoms

Dopamine levels variance and the feelings of satisfaction

October 10, 2016
Dopamine levels variance

Dopamine levels variance and dopamine reward master. The neurotransmision and substance abuse needs immediate treatment

Dopamine levels variance: Neurotransmitter role in drug addiction

This is may be due to genetics, environment related or a combination of factors. A study concluded that pathological gamblers most often experienced traumatizing experiences when they were younger. Since most people who became addicted to gambling have low dopamine levels, and also that same group usually has endured a traumatic experience, it was concluded the overall dopamine levels can change due to environmental factors. This supports the opinion that both the mind and the brain can change due to environmental factors. However in yet another study it was established that a gene related to dopamine is sported twice as often in pathological gamblers than non-gamblers. To this effect, doctor Akoury says that this view seems to supports the observation that dopamine levels are genetic. We can therefore come up with two possible observations. Either both genetics and environmental factors affects ones brain anatomy and mind simultaneously, or that environmental factors can affect genes which in turn affect ones brain and mind.

Dopamine levels variance: Why is risk and reward a trigger for the release of dopamine?

It’s scientifically logical that sex and food release dopamine, because they are essential for the life of human beings. Risk and reward are not.  It is believed that everything happens for a reason; meaning, there must be a scientific explanation for the increase of dopamine levels as a result of risk and reward. Like for instance the human race is different from other species on this planet not only by its ability to reason, but also its ability to create and be innovative. Therefore nature dictates that humans are creative and innovative, and for this to happen a person should have some level of satisfaction when one accomplishes an innovation. Doctor Akoury agrees that for one to accomplish an innovation he/she must take certain risks. It is risky to try to do something that no other being on earth has ever accomplished. Therefore, there must be a reward other than material that one gets when he or she accomplishes the innovation, otherwise that person would not take the risk. The reward here is the release of dopamine and the feeling of satisfaction. The problem with this process is that not only can one be satisfied after a major risk and accomplishment, but that one can also be satisfied through constant minute risks and accomplishments.

The feeling of satisfaction that dopamine exhibits are so strong that one can often lose his or her ability to reason in order to achieve satisfaction. It is that unconscious state of mind that takes over and begins to make certain decisions. The brain develops neural circuits that unconsciously assess reward. Since dopamine plays an active role in these circuits, people will act in what they think is in their best interest, when in fact the only interest it satisfies is the release of dopamine. This can be exemplified in gambling where one insists on gambling even though he or she knows that the odds are against them. Finally we appreciate that there is a lot of scientific explanations in this topic which may not be very clear to many people and if you are one of them then we are more than ready at AWAREmed Health and Wellness Resource Center to listen and help you be on the know. All you have to do is to call doctor Dalal Akoury (MD) who is also the founder of the facility for an appointment and all your concerns will be addressed professionally.

Dopamine levels variance: Neurotransmitter role in drug addiction

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stem cell therapy

Neurons communication signals and addiction

October 4, 2016
Neurons communication

Neurons communication signals and addiction when interfere with can really stress your health

Neurons communication signals and addiction:  The brain chemistry

The neuron is the primary unit of communication within the brain. A single neuron is extremely tiny. Experts are estimating that there are over 100 billion neurons in the human brain. With that you can imagine just how complex and distinct your brain is from the person next to you. And because good communication is of two ways where we both listen (receive information) and at the same time we also speak (send information). The same is applicable to the brain’s communication system with the neurons having the ability to both send and receive communication signals. The dendrite is the portion of a neuron that typically receives information (listens) while the axon is portion of the neuron that sends out information (speaks).

Neurons communication signals and addiction: Neurotransmitters

Therefore when humans communicate with each other, we typically use words and gestures. The different parts of the brain communicate with each other using electrical signals. Neurons use electrical pulses to send their communication signals. These electrical impulses are called action potentials. When a neuron fires, the action potential travels down the neuron’s axon where it ends. At the end of the axon is the axon terminal or pre-synapse. In this area, special chemical messengers called neurotransmitters and neuromodulators lay in wait. These are stored in specialized capsules called vesicles. The action potential causes the release of these chemical messengers into an open space between one neuron’s axon and the next neurons’ dendrites. This open space is the synaptic cleft. At the other side of the synaptic cleft is the post synapse that is formed by the dendrites of connecting neurons. In the post synapse, there are special receptors that receive the neurotransmitters.

Receptors and neurotransmitters function in a way that is similar to a keyhole and key. Receptors are like keyholes and neurotransmitters are like the keys. When neurotransmitters fit into the receptors it is called binding. Once a neurotransmitter is bound to a receptor, the key turns the lock. Once the lock opens, it communicates with the receiving neuron’s dendrites. In the post synapse, there may be many different receptors (many different shaped keyholes). However, a particular neurotransmitter may be able to fit into (bind to) several different receptors types. This is similar to the way a single key can open several different locks. The particular receptor type determines the type of signal that is transmitted. Thus, the receptor type is often more critical to the communication than the particular neurotransmitter.

It may be easiest to visualize this communication as a single chain of events: First, a neuron sends an electrical impulse (action potential) down the axon. Next, the electrical impulse causes chemicals (neurotransmitters and neuromodulators) to be released into the space between two neurons. Then these chemicals can signal the next neuron to send an electrical impulse and so on. This electro-chemical process forms the brain’s communication system. In conclusion, it is evident that the functions of the brain in communication are very sensitive and any alteration caused by drugs addiction can have far reaching effects. Therefore before we get there, we must do all it takes to prevent or correct as soon as it is necessary. For this reason it will be prudent for you to schedule for an appointment with doctor Dalal Akoury MD a veteran addiction expert who is also the founder of AWAREmed Health and Wellness Resource Center for the commencement of your addiction recovery process. This is very important more so if the most sensitive organ of the body is involved. So waste no time and make that call now.

Neurons communication signals and addiction: The brain chemistry

 

 

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brain

Central nervous system depressants

August 15, 2016
Central nervous system

Central nervous system depressants and a balance neurotransmitters for good management of your health.

Central nervous system depressants: What are depressant?

It is amazing how drugs abuse can accumulate so many names. And irrespective of the name used, their effects in human life still remain the same. We want to discuss about the depressants which are also known as central nervous system depressant besides other street names like barbs, reds, red birds, phennies, tooies, yellows, or yellow jackets, candy, downers, sleeping pills, or tranks, A-minus, or zombie pills. Central nervous system tranquilizers derails the normal activities of the brain and even that of the spinal cord say doctor Dalal Akoury MD, President and founder of AWAREmed Health and Wellness Resource Center which is a health facility founded with soul objective of offering addiction solution to the suffering communities and the globe at large.

From her experience of over two decades in this profession, doctor Akoury agrees that medical doctors often prescribe depressants to people who are anxious or are just struggling getting quality sleep. This is a common practice and nothing is wrong with that. Depressant when taken religiously as prescribed by the doctor are beneficial to patients. However when central nervous system depressants are abuse or used wrongly, the consequences can be very severe. Doctor Akoury reiterates that when depressants are misused, dependence and addiction are inevitable risks. As individual users continues abusing these prescription drugs either by taking someone else medication or just taking your own inappropriately to get high, all the other chronic health conditions that are associated with drug addiction can easily attack such users.

As we continue exploring on the effects of depressants, it is important to note that, these drugs can be divided into three primary groups: barbiturates, benzodiazepines, and sleep medications. Each of these groups will equally cause harm if not used appropriately. Careful attention needs to be taken in ensuring that the right prescription is used and the doctors instructions followed religiously. In the meantime if for whatever reason you did not follow instructions well and you’re now suffering from its addiction, all is not lost. You can still get your life back if only you can schedule for an appointment with doctor Akoury today for professional guidance.

Central nervous system depressants: How are depressant abused?

Depressants usually come either in pill or capsule form. They can be abused in different ways including some of the following:

  • Taking someone else’s prescription depressant medication.
  • Taking a depressant medication in total disregard of the doctor’s advice.
  • Experimenting with or taking depressants just for fun or to get high.
  • Taking a depressant while under the influence of other drugs.

Central nervous system depressants: How do depressants affects the brain?

Most depressants affect the brain by increasing the activity of gamma-aminobutyric acid (GABA), a chemical in the brain that sends messages between cells. The increased GABA activity in turn slows down brain activity. This causes a relaxing effect that is helpful to people with anxiety or sleep problems. And like with other drugs, taking too much of GABA activity can be very harmful. Finally you can avoid all these harmful effects by seeking for help from the experts at AWAREmed Health and Wellness Resource Center today and you will not regret having done so.

Central nervous system depressants: What are depressant?

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cocaine-addiction1

Specific neurotransmitters affected by drugs

July 12, 2016
Specific neurotransmitters

With good treatment, Specific neurotransmitters affected by drugs can be eliminated for a greater freedom.

Specific neurotransmitters affected by drugs: What is neurotransmission?

For us to better understand the specific neurotransmitters affected by drugs, we must appreciate certain facts. Like for instance, any victim of substance abuse experiences directly reflects on the functional roles of a given neurotransmitter whose activity is being disrupted. Each individual neuron manufactures one or more neurotransmitters: dopamine, serotonin, acetylcholine, or any one of a dozen others that scientists have discovered to date. Each neurotransmitter is associated with particular effects depending on its distribution among the brain’s various functional areas. Dopamine, for example, is highly concentrated in regions that regulate motivation and feelings of reward, accounting for its importance in compulsive behaviors such as drug abuse.

A neurotransmitter’s impact also depends on whether it stimulates or dampens activity in its target neurons says doctor Dalal Akoury, MD, President and founder of AWAREmed Health and Wellness Resource Center. It is also worth noting that ordinarily, some drugs will disrupt one neurotransmitter or class of neurotransmitters. Like for instance, those individuals who are struggling with opioid may experience changes which are similar and more noticeable than those that accompany normal fluctuations in the brain’s natural opioid-like neurotransmitters, endorphin and enkephalin: increased analgesia, decreased alertness, and slowed respiration. Other drugs interact with more than one type of neurotransmitter.

Because a neurotransmitter often stimulates or inhibits a cell that produces a different neurotransmitter, a drug that alters one can have secondary impacts on another. In fact, the key effect that all abused drugs appear to have in common is a dramatic increase in dopamine signaling in the nucleus accumbens leading to euphoria and a desire to repeat the experience. For example, nicotine stimulates dopamine-releasing cells directly by stimulating their acetylcholine receptors, and also indirectly by triggering higher levels of glutamate, a neurotransmitter that acts as an accelerator for neuron activity throughout the brain.

Specific neurotransmitters affected by drugs: Changes which occurs with chronic drug abuse

During the early phase of an individual’s drug experimentation, specific neurotransmission normalizes as intoxication wears off and the substance leaves the brain. Eventually, however, drugs wreak changes in cellular structure and function that lead to long-lasting or permanent neurotransmission abnormalities. These alterations underlie drug tolerance, addiction, withdrawal, and other persistent consequences.

Some longer term changes begin as adjustments to compensate for drug-induced increases in neurotransmitter signaling intensities. For example, drug tolerance typically develops because sending cells reduce the amount of neurotransmitter they produce and release, or receiving cells withdraw receptors or otherwise dampen their responsiveness. Scientists have shown, for example, that cells withdraw opioid receptors into their interiors (where they cannot be stimulated) when exposed to some opioid drugs; when exposed to morphine, however, cells appear instead to make internal adjustments that produce the same effect reduced responsiveness to opiate drugs and natural opioids. Over time, this and related changes recalibrate the brain’s responsiveness to opioid stimulation downward to a level where the organ needs the extra stimulation of the drug to function normally; without the drug, withdrawal occurs.

Specific neurotransmitters affected by drugs: What is neurotransmission?

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