March 16, 2017

Heart diseases connection to overweight knows nor age variances

Heart diseases connection to overweight: The epidemic levels of obesity

Obesity is reaching epidemic levels in most parts of the world. This is causing jittery in the medical profession. Currently, the greatest concern is the trail of destruction this condition leaves behind. I am addressing issues relation to the heart disease connection to being overweight. How does it happen? Experts at AWAREmed health and wellness resource center under the leadership of doctor Dalal Akoury MD explains:

Heart diseases connection to overweight: Obesity leads to blockage in the arteries

For a better understanding, let’s define insulin is, this is a hormone that helps the body metabolize blood sugar, or glucose. When one is obese the insulin resistance goes up causing the body to be less effective in digesting glucose. The result of this is high blood sugar which facilitates the formation of pre-diabetes or diabetes. This is a risk factor for heart disease. And due to the ineffectiveness of insulin operations in the liver, triglycerides (fats) increases in the blood causing the bad cholesterol, or LDL to go up and good cholesterol or HDL to come down.

Remember that cholesterol is vital to a number of functions in the body. However, too much level of cholesterol in the body can be harmful. LDL transport cholesterol from the liver and intestines to various parts of the body. During this transportation process, if we have excess cholesterol the excess will build up in the walls of arteries throughout the body, including those in the heart and brain. HDL takes cholesterol from the walls of the arteries and carries it back to the liver and intestines where it can be excreted. When there is too little HDL to carry away the excess LDL, it leads to atherosclerosis, which is hardening and narrowing of the arteries. This is a major risk factor for heart attack and stroke. Just to further on the relationship between obesity and heart diseases, obesity is also associated with increased risks of:

Coronary artery disease
Heart failure
Atrial fibrillation

Coronary artery disease

Various studies have shown that an increased risk of coronary artery disease (CAD) in the overweight is real and realistic. This is because while studying some 300 000 adults for 7 years, it was established that about 9% increase in ischaemic-heart disease events for each unit change in BMI.46 moreover, obesity was associated with both fatty streaks and raised atherosclerotic lesions in the right coronary and left anterior descending coronary arteries specifically in young men. Nonetheless as for those individuals with pre-existing heart conditions the link between obesity and cardiovascular mortality is not very strong.

Heart diseases connection to overweight: Heart failure

Doctor Akoury explains that the relationship between obesity and heart failure is complex. According to the Framingham Study where some 6000 individuals with no heart failure records in the past but of age 55 were followed keenly for some14 years. Up on concluding the study, it was established that, the risk of developing heart failure was two-fold higher in obese individuals, in comparison with subjects with a normal body-mass index. On multivariate analysis adjusting for risk factors including hypertension, coronary artery disease and left ventricular hypertrophy, there was an excess risk of 5% in men and 7% in women for each 1 point increase in BMI. It was estimated that 11% of the cases of heart failure in men and 14% in women could be attributed to obesity alone. These complications can be very chronic and the sooner you tackle them the better. To help you get lasting solutions of all these, you will need to call doctor Akoury for an appointment to commence treatment.

Heart diseases connection to overweight: The epidemic levels of obesity

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Leptin concentration in relation to obesity

January 24, 2017

Leptin concentration in relation to obesity. In fact, Leptin concentrations adjust in response to obesity and contribute to insulin resistance

Leptin concentration in relation to obesity: Insulin resistance

Leptin regulates energy metabolism and balance in conjunction with the brain’s hypothalamus. Leptin is currently being touted as having cardio-protective benefits among its others roles in metabolism. Leptin concentrations adjust in response to obesity and contribute to insulin resistance. Besides that, doctor Dalal Akoury MD, President, and founder of AWAREmed health and wellness resource center register that, the changes in leptin concentration have also been associated with the risk factors for coronary heart disease. In the same way, increased resistin concentrations correlate with obesity-related inflammation and may be associated with the initiation and progression of atherosclerotic lesions. Resistins also promotes insulin resistance, although the actual mechanism is still not very clear.

Insulin resistance due to adipokines dysfunction is further influenced by free fatty acids liberated directly into the liver from the visceral fat tissue. Visceral fat releases chemicals and fatty acids into the portal system where they act on the connecting organs. The portal circulation system is a specialized network of blood vessels that connect the visceral organs to the liver. The excess fat in the portal circulation has detrimental effects on insulin action, which is worsened by sympathetic hyperactivity in response to obesity. Sympathetic hyperactivity causes heightened lypolytic action resulting in excess free fatty acids in the blood. These actions combined with beta cell hypersecretion and reduced insulin clearance resulting in hyperinsulemia, lead to early stage diabetes.

Leptin concentration in relation to obesity: Interleukin-6 (IL-6)

Interleukin-6 (IL-6) is possibly another factor associated with inflammatory detriment within the portal system. High levels of IL-6 are a marker for inflammation and vascular pathology. Obese subjects demonstrated a 50% greater portal vein IL-6 concentration, demonstrating, again, the profound effect visceral fat has on pathogenic indicators. Portal vein IL-6 correlates with systemic C-reactive protein concentrations. And remember that the C-reactive protein is associated with cardio and peripheral vascular disease. C-reactive protein and oxidative stress are now presumed to interact in the early inflammatory processes of atherosclerosis. This is significant for young obese individuals. Although more research is necessary for a conclusive association, the C-reactive protein may be a new risk factor for CAD in individuals under 25 years of age.

The imbalance between increased inflammatory stimuli with a concurrent reduction in anti-inflammatory activity may be the foundation for the accelerated endothelial dysfunction and insulin resistance associated with obesity and the comorbid disorders of metabolic disease. However, more research is needed to clearly delineate the particular relationships, though it seems evident that the low-grade inflammation caused by obesity and visceral adiposity lead to the premature development of the disease. This, more so than ever before, identifies the importance of weight management during the developmental years and ongoing efforts to control weight throughout one’s lifespan.

Finally, for current obese people, there is still plenty of hope. Weight loss is related to the reduction of oxidative stress and inflammation, and these beneficial effects are likely to translate into the reduction of cardiovascular risk in obese individuals. Likewise, exercise and dietary management, along with pharmacologic intervention can lead to the atherosclerotic reversal in the earlier stages of CAD. Individuals with central adiposity, poor blood lipid profiles, hypertension, or insulin resistance should seek immediate professional assistance to prevent further health detriment by scheduling an appointment with AWAREmed health center now.

Leptin concentration in relation to obesity: Insulin resistance

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