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Brain Coordination and The Reward System

Food, abused drugs and sexual interests share a common pathway within our brains’ survival and reward systems

Brain CoordinationStudies indicate that food, abused drugs and sexual interests share a common pathway within our brains’ survival and reward systems. This pathway leads into the area of the brain responsible for our higher thinking, rational thought and judgment. When an addict’s brain takes over that survival and reward pathway, it tells the person that having illicit sex and inappropriate thoughts are good for them the same way the brain tells a normal person that food is require when he is hungry. These changes in brain’s reward pathway translate into a sex addict’s obsession with sex and of other related activities such as obligatory sexual behavior despite understanding the ill effect of this behavior on oneself. This lack of sense of self harm is also followed my failed attempts to limit of completely terminated such sexual activities.

The idea that a person can be addicted to food has recently gotten more support from science. It is even perfectly fine to say that over eating and eating disorders are a form of addiction, obesity is not a life style, if it’s a food related obesity problem then it’s the outcome of addiction to over eating. Addiction plays weird games with our reward system; scientists have discovered that for some people the same reward system is activated through food (especially eatables rich in sugar and fat) which is generally activated by the consumption of addictive drugs such as heroin or cocaine. Like these addictive drugs, for these people certain foods trigger feel-good feelings resulting in the release a dopamine; a hormone that is associated with pleasure through reward system. The pleasures they get from high levels of dopamine make them feel the need to eat again and again to gain the same form of satisfaction.

Now comes drug addiction, many of us fail to understand how people get addicted to drugs, it’s a common misconception that drug addicts lack moral principles and will power because otherwise they could simply choose to change their behavior. That’s not how drug addiction works; drug addiction is a complex disease and quitting requires much more than a strong will power to change this behavior. In reality many of drug addicts really want to quit but they simply can’t. It is because of the change drugs have brought in their brain’s reward system that forces them to even commit compulsive drug abuse. It’s an established fact that the initial decision of taking drugs in most of the cases is voluntary but the later consequences and changes in brain that occur over period of time severely  compromises a person’s self control and hamper his ability to resist the strong urges of taking drugs.

Sexual addiction somehow follows the same patterns of addiction as food and drugs. It fools ones reward system into thinking that this is the ultimate pleasure and without this, survival is impossible. A sexual addict’s brain start making a person believe that sex is as important as food, just like a normal person have to eat three or more time a day, a sex addict has to do or plan such activities as many times to survive. What he fails to recognize is the lack of balance and control. Even eating more than necessary is detrimental to health, having sexual urges more than required are devastating for the addict as well as the society.

All of these forms of addictions manifest themselves in similar fashion however the mechanism and factor behind how a person gets addicted to food and sex and how the reward system is being changed are not very clear. In the case of drugs it’s comparatively easier to explain how our brain gets affected by drugs. Drugs contain certain chemicals that alter the brain’s communication system and interrupt the ways in which our nerve cells send, receive and process information signals. There are two major ways through which drugs can disrupt normal brain function. Firstly by mimicking the brain’s natural chemical messengers and secondly by over stimulation of our brain’s reward circuit.

Some drugs have similar structures like our chemical messengers called neurotransmitters. These neurotransmitters are naturally produced in the brain and are key role players in our chemical signaling pathways. The similarity of drugs allows them to fool brain receptors and stimulate nerve cells to send abnormal messages. Other drugs, such as cocaine have the ability to cause the nerve cells to release strangely hefty quantities of natural neurotransmitters such as dopamine. These signals also hinder the regular recycling of these brain chemicals, which is required to shut off the signaling between neurons. The result is a brain drenched in dopamine, which is present in those regions of brain that control movement, emotion, motivation, and feelings of pleasure. Due to the over activation of this reward system (normally responding to natural behaviors associated with survival such as eating and spending time with loved ones) certain euphoric effects are produced in response to psychoactive drugs. This reaction ensures a recurring pattern that teaches people to repeat the rewarding behavior of abusing drugs.

It is evident from the researches addictions apart from drugs, such as food and sexual, are caused by a greater tendency of impulsivity. Those individuals, who have been more impulsive easily fall prey to addiction. Once the addiction successfully alters the reward and survival pathways, the manifestation of addiction becomes exactly like someone is addicted to a substance. There is a pressing need of understanding these addictions and formulating integrated solutions that can counter addiction and related symptoms in more efficient way. For this purpose we are organizing a “Integrative Addiction Conference” whose sole focus is on addiction and its integrative solutions. If you are a health professional, a professor, a practicing psychologist or even a student, this conference is a great opportunity to contribute in these fields of knowledge. Our main topics deal with the same niche as of this article, so register right away and get maximum benefits through our link below

http://integrativeaddictionconference.com/

 

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Opioid abuse and its effects to the brain reward system

Opioid abuse and its effects to the brain reward system-How does the reward center in the brain work?

Brain

The brain is the life controller and must not be affected by opioid addiction or abuse

Life is the most precious and price less gift humanity has. This is only useful and meaning full with proper functioning brain. We all understand that the brain is certainly a busy little organ yet it is on duty tirelessly for life without taking any vacation, the moment it possess for whatever reason life ends or serenity is rearranged. Despite it busy roles in driving the body; it knows fun and pleasure when it sees it. When an external stimulus, such as a particular food or a potential mate, has been encountered and deemed a pleasurable sensation, the cerebral cortex signals the ventral tegmental area of the brain to release the chemical dopamine into the amygdala, the prefrontal cortex and the nucleus acumens. These latter regions of the brain make up the reward system. These areas work in conjunction to deliver a sense of pleasure and focus the attention of the individual so that he or she learns to repeat the behavior once more. Researchers theorize that this is how behaviors necessary for survival, such as reproduction and eating, are learned.

Interestingly, the reward center doesn’t kick into gear only when we eat something delicious or meet a potential new love interest. It turns out that generosity can be quite a kick too! MRI studies have revealed that when we perform an act of kindness, the brain’s reward center is aroused and we experience feelings of pleasure. The brain is flooded with happiness-inducing dopamine whenever we give a homeless person some money or help out someone in need. A study conducted in 2008 confirmed the belief that spending money on other people can result in elevated feelings of happiness for the giver.

It might not be all fun and games for the reward center, however, a recent study came to a startling conclusion that the brain’s reward center responds to bad experiences as well as good. Doing something scary or even merely thinking about it can trigger a release of dopamine. In essence, dopamine isn’t just triggered by fun and pleasurable events. Negative things can do the trick too.

Opioid abuse and its effects to the brain reward system-Reward pathway

The most important reward pathway in brain is the mesolimbic dopamine system. This circuit (VTA-NAc) is a key detector of a rewarding stimulus. Under normal conditions, the circuit controls an individual’s responses to natural rewards, such as food, sex, and social interactions, and is therefore an important determinant of motivation and incentive drive. In simplistic terms, activation of the pathway tells the individual to repeat what it just did to get that reward. It also tells the memory centers in the brain to pay particular attention to all features of that rewarding experience, so it can be repeated in the future. Not surprisingly, it is a very old pathway from an evolutionary point of view. The use of dopamine neurons to mediate behavioral responses to natural rewards is seen in worms and flies, which evolved 1-2 billion years ago.

The VTA-NAc pathway is part of a series of parallel, integrated circuits, which involve several other key brain regions.

The VTA is the site of dopaminergic neurons, which tell the organism whether an environmental stimulus (natural reward, drug of abuse, stress) is rewarding or aversive.

The NAc, also called ventral striatum, is a principle target of VTA dopamine neurons. This region mediates the rewarding effects of natural rewards and drugs of abuse.

The amygdala is particularly important for conditioned forms of learning. It helps an organism establish associations between environmental cues and whether or not that particular experience was rewarding or aversive, for example, remembering what accompanied finding food or fleeing a predator. It also interacts with the VTA-NAc pathway to determine the rewarding or aversive value of an environmental stimulus (natural reward, drug of abuse, stress).

The hippocampus is critical for declarative memory, the memory of persons, places, or things. Along with the amygdala, it establishes memories of drug experiences which are important mediators of relapse.

The hypothalamus is important for coordinating an individual’s interest in rewards with the body’s physiological state. This region integrates brain function with the physiological needs of the organism.

Probably the most important, but least understood, are frontal regions of cerebral cortex, such as medial prefrontal cortex, anterior cingulate cortex, and orbitofrontal cortex, which provide executive control over choices made in the environment (for example, whether to seek a reward).

The locus coeruleus is the primary site of noradrenergic neurons in the brain, which pervasively modulate brain function to regulate the state of activation and mood of the organism.

The dorsal raphe is the primary site of serotonergic neurons in the brain, which, like noradrenergic neurons, pervasively modulate brain function to regulate the state of activation and mood of the organism.

Of course, these various brain regions, and many more, do not function separately. Rather, they function in a highly inter-related manner and mediate an individual’s responses to a range of environmental stimuli.

Opioid abuse and its effects to the brain reward system-What are opioids?

Opioids are medications that relieve pain. They reduce the intensity of pain signals reaching the brain and affect those brain areas controlling emotion, which diminishes the effects of a painful stimulus. Medications that fall within this class include hydrocodone (e.g., Vicodin), oxycodone (e.g., OxyContin, Percocet), morphine (e.g., Kadian, Avinza), codeine, and related drugs. Hydrocodone products are the most commonly prescribed for a variety of painful conditions, including dental and injury-related pain. Morphine is often used before and after surgical procedures to alleviate severe pain. Codeine, on the other hand, is often prescribed for mild pain.

Symptoms of opioid abuse can be categorized by physical state.

Opioid abuse and its effects to the brain reward system-Intoxication state

Patients with opioid use disorders frequently relapse and present with intoxication. Symptoms vary according to level of intoxication. For mild to moderate intoxication, individuals may present with drowsiness, pupillary constriction, and slurred speech. For severe overdose, patients may experience respiratory depression, stupor, and coma. A severe overdose may be fatal.

Opioid abuse and its effects to the brain reward system-Withdrawal state

Symptoms of withdrawal include the following:

  • Autonomic symptoms – diarrhea, rhinorrhea, diaphoresis, lacrimation, shivering, nausea, emesis, piloerection
  • Central nervous system arousal – sleeplessness, restlessness, tremors
  • Pain – abdominal cramping, bone pains, and diffuse muscle aching
  • Craving – for the medication

Opioid abuse and its effects to the brain reward system-How does the reward center in the brain work?

 

 

 

 

 

 

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