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Severe Mental Illness and Substance Abuse

Persons with Severe Mental Illness Are Prone To Substance Use

Severe Mental illnessPeople with severe mental illness (SMI) are more prone to substance abuse than those who are not suffering from severe mental illness. Both epidemiological and clinical studies that have been done on this have attested to this fact. The findings of these researches have also pointed out that Individuals diagnosed with SMI are also at greater risk of hospitalization, homelessness and suicide and experience more difficulty in different spheres of their lives. Most studies have shown that individuals with SMI are more prone to substance abuse. However other studies that have been done on the same issue have not linked the two phenomena. The substances used most frequently by persons with SMI are alcohol, followed by cannabis and stimulants. Sedatives and hallucinogens are used less frequently by those with SMI. Amphetamine use is greater in persons with psychotic disorders compared with the general population. Studies have shown that both cannabis and, to a greater extent, amphetamines can provoke psychosis. Because individuals do not use cannabis or amphetamines alone, but use them in combination with several other substances, examining the effects of the use of a specific substance on mental illness is particularly challenging. A review showed that substance use has adverse long-term effects on cognitive functions in persons with SMI. The substance that has been found to affect the individuals most negatively is alcohol while cannabis use has little influence on the cognitive functions of the individuals.

Several studies have shown that many people with SMI tend to achieve full remission of their substance use while others relapse frequently. Research from different treatment settings indicate that 30 per cent of those with less severe mental illness and heavy substance use attain sustained remission, while up to 60 per cent of those with SMI and less severe substance use attain sustained remission.

There is however a lack of studies on how persons with SMI experience abstaining from substance use. Nevertheless, research on substance use by clients without the comorbidity of mental illness indicates that social support is important to successful change in behavior of these people. Clients claim that they benefit from interventions that address their multiple recovery issues as opposed to ones that emphasize recovery strictly in sobriety terms. Another qualitative study has noted the participants’ view that highly structured programs and cognitive behavioral techniques are crucial to achieving abstinence. Not only is sobriety a lifelong struggle for many clients, but also is perceived as a challenging state because of the risk that the person becomes complacent after achieving sobriety. This may indicate a need for substitute dependency to maintain the abstinence.

It is of importance to examine how individuals with a psychotic disorder experience quitting substance use and to investigate reported experiences of former abstinence periods by participants still using substances. Two qualitative studies with a primary focus on how persons with SMI experience abstaining from substance use have reported that clients view substance use as one of many sources of difficulty over a troubled life course and that social support is critical to staying clean, lack of support in most cases makes it difficult for these individuals to quit using these drugs. One ethnographic study of clients’ perspectives showed that giving up substances was seen as a source of both pleasure and pain, and presupposed a certain level of rationality.

Study findings

In a study done by Henning Pettersen, Torleif Ruud, Edle Ravndal and Anne Landheim with an objective to find out experiences of abstaining from substances of persons diagnosed with SMI. They examined both the reasons given and the requirements and strategies used when abstaining. The main reasons for quitting substance use were social relationships and meaningful activities. It was found that the stated requirements and strategies used in the search for sobriety were detachment towards people and places, positive thinking, controlling feelings and emotions, and fear of dependency. A qualitative study with semi-structured interviews was conducted, and a descriptive and explorative design was applied. This study included a purposeful sample of 11 patients with SMI and substance use being treated by assertive community treatment teams. Henning et al concluded that the results from this study are consistent with those from other qualitative studies on the importance of social relationships and meaningful activities as expressed reasons for abstaining. The strategy of actively avoiding a former adverse milieu to reach sobriety is consistent with findings from one similar study. The strategies of fear of adverse consequences, positive thinking, and controlling feelings and emotions found in the present study have not been reported by other qualitative studies.

The study had eleven participants of which nine were men and two were women. The ages of the participants were between 27-63 years. Most of the participants had a diagnosis of schizophrenia or schizoaffective disorder, but persons diagnosed with bipolar disorder or an unspecified psychotic disorder also participated. For most participants, SMI had preceded their substance use. The treatment of the participants took duration of between 14-30 months after the first interview.

Severe Mental illnessCannabis and amphetamine were the main substances used in the study but alcohol and other prescription drugs were also used to a lesser extent. However most of the participants used a combination of the substances. At the time of the study four of the participants were abstaining from substance use. Their abstinence periods ranged from 3 to 18 month. At the time of the first interview seven of the participants were still using substances. By the second interview, the abstainers were still abstinent and the users had continued their use. The abstaining group and the group of users did not differ significantly in their psychiatric diagnosis or history of substance use. The 11 participants shared their experiences of shorter and longer periods of abstaining from substances. Some of them talked of their abstaining periods retrospectively, and some were abstaining at the time of the interview. From the findings of this study it is therefore safe to conclude that people suffering from SMI are more prone to substance abuse than people who don’t.

Finally, We at AWAREmed Health and Wellness Resource Center are committed to availing help to addicts by availing some of the most integrative approaches to healing an addict. We advocate for natural healing to all kinds of addiction. Call on Dr. Dalal Akoury (MD) at Myrtle Beach, South Carolina for help.

Persons with Severe Mental Illness Are Prone To Substance Use

 

 

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Addictions and the Internet

The Potential of Web 2.0 Internet Technologies in Enhancing Treatment for Alcohol/Other Drug use Problems

Addiction and the internetOver the past decade there has been proliferation of e-health applications across disease categories. With the emergence of the next generation of Internet-based applications, Web 2.0, there are increasing opportunities for integrating these technologies into treatment approaches for alcohol/other drug use problems, in a way that engages and empowers like never before. No evidence currently exists to demonstrate the benefits of Web 2.0 applications, such as social networking and social media, on alcohol/other drug use problems. However, social learning and influence theories point to the possible mechanisms of action and effectiveness. More research is urgently required to examine the potential of Web 2.0 applications on alcohol/other drug use problems.

The internet has become very useful today. All information is sought online and medical information is no exception. As is evident the social platforms that came with the digital age are not only used to chat and catch up on social issues but have become a very valid platform through which professionals seek ideas and debate on crucial issues that are very important to their careers. The internet has become unequalled hub of information where professionals seek information and share ideas. Likewise patients have also found the internet a good place to air their concern and this has been boosted by the fact that you can be anonymous and still have your problems solved by professionals who may question and answer columns on their websites or blogs. The internet has the advantage of speed, unlike looking for information in a library full of books where you have to go through table of contents of many books to find what you want you just write the keywords on the search pane on the search engines like Google, Bing or Yandex and then the information will be brought within seconds. Even with many choices to select from you can still refine your search by keying in specific keywords that will make your search more local hence very effective. Today most internet users seek health information from the internet, it is estimated that 80% of internet users in America seek health information from the internet and 59% of them are adults.

The youth form the majority of the internet users, it is estimated that 71% of these youths seek health information online. Right now apart from email and search engines use, health information searching is the most popular activity for adults. There are also many forums that are created on online communities like Facebook and twitter that people use to access health information. On these sites people of like mind come together discuss their health problems and find solutions to their problems and drug addicts are no exception. The internet is a platform for seeking information but as it stands right now drug and alcohol addicts can get computerized treatments. Research testing the efficacy of computerized psychological treatments for alcohol and drugs addiction revealed that when coupled with weekly therapist support the computer-delivered alcohol and drugs treatment can be as effective as face to face treatment. With technology based for depression, it has been found that coupled with guidance it works twice better.

The web 2.0 technology

The emergence of web 2.0 technology may find the best solution that incorporates all the convenience and efficacy to the internet based treatment delivery while providing a platform for the development and maintenance of social connectedness and support which is key in achieving effectiveness in online computer-delivered treatments. However as stated earlier there is still little research reports that have been published on the subject of alcohol and other drug use and how they can be treated. But scientists opine that the web 2.0 has applications such as the social influence tool that can be useful in alcohol and other drugs use and treatment. This application allow individuals to learn in a more social context with changes in opinions, feelings , attitudes, thoughts and behavior as a result of group discussion. Interacting with like-minded individuals in the group helps in educating a person more on the issues of alcohol and other drugs abuse and how they can be treated.

internet
This application will help individuals to know more about drugs and alcohol before they begin using them. It is a known fact that most people who are now addicted to alcohol and other drugs of abuse were exposed to environments where these drugs were used, having a social forum where adolescents can seek information and learn about the dangers of alcohol and other drugs abuse they will stay away from the abuse of alcohol and other drugs. Many youths now stuck in the use of drugs began using the drugs when they were cajoled by friends who told them that using drugs of abuse is ‘cool’ and so they knew all the good things associated with drug abuse but no one ever told them the dangers of these drugs on friendly and in social context as they will learn on the web 2.0 applications. It is a known fact that adolescents listen to their peers more than they do to their parents and therefore the adolescents are led into using these drugs by their peers. The internet therefore presents an alternative interactive platform where these adolescents can seek information and guidance from health practitioners.

Finally, We at AWAREmed Health and Wellness Resource Center are committed to availing help to addicts by availing some of the most integrative approaches to healing an addict. We advocate for natural healing to all kinds of addiction. Call on Dr. Dalal Akoury (MD) at Myrtle Beach, South Carolina for help.

The Potential of Web 2.0 Internet Technologies in Enhancing Treatment for Alcohol/Other Drug use Problems

 

 

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Dopamine and RDS

Dopamine Genes Affect Clinical Outcomes in Reward Deficiency Syndrome

dopamineDopamine is crucial neurotransmitter and hormone in the body. This hormone serves many purposes. It plays a role in the pleasure and reward pathway of the brain as well as in memory and motor control. And any decline in this hormone presents the body with myriads of ill-health conditions. This hormone however is greatly affected by drugs of abuse, most drugs that are taken to produce induced euphoric feelings in a person works in such a manner that they increase the production of the dopamine neurotransmitter, when this neurotransmitter is produced up to certain levels it will get depleted in the long term and hence the problem sets in. Specifically, the euphoric properties of cocaine and other drugs of leisure lead to the development of chronic abuse, and appear to involve the acute activation of central dopamine (DA) neuronal systems. They proposed that DA depletion results from overstimulation of these neurons and excessive synaptic metabolism of the neurotransmitter. When this happens may suffer ill-health conditions. These may include; poor nutrition, stress, lack of sleep and the habitual use of antidepressants, symptoms such as depression, mood swings, poor attention and food cravings will also occur. Some of the major symptoms of dopamine deficiency are depression, chronic boredom, and a loss of satisfaction, apathy, chronic fatigue and low physical energy with no desire to exercise the body. To correct these problems, it is necessary for this hormone to be supplemented so that the normal levels are restored. In addicts the use of buprenorphine to treat opioid dependent individual is common and is approved by the FDA. While to many people it has been working well with many studies supporting its use has now been reported that using buprenorphine for a long time will jeopardize the life a person as cases of severe withdrawal symptoms have been common. Researchers have found it necessary to embrace genetic testing to reveal reward circuitry gene polymorphisms especially those related to dopaminergic pathways as well as opioid receptor(s) as a way of improving treatment outcomes.

Researchers have currently proposed the use of dopamine agonists instead of antagonists like buprenorphine that is mostly used with naloxone can offer long term solution to dopamine deficiency. While it is well established that dopamine deficiency or a hypodopaminergic trait leads to aberrant substance seeking behaviors (RDS) and intact mu opiate receptors are important for maintaining “dopamine homeostasis”, scientists have suspected that opioid-dopaminergic interaction must be involved in buprenorphine response. In this regard they have provided some evidence that a putative dopamine agonist, KB220Z shows long-term potential as an opioid replacement compound especially in subjects having a genetically determined hypodopaminergic trait like RDS.

In a research study done by Kenneth Blum, Marlene Oscar-Berman, William Jacobs, Thomas McLaughlin and Mark S. Gold, it was found that dopamine genes can affect clinical outcomes in reward deficiency syndrome and therefore it is safe to use less powerful dopamine agonist dopaminergic genes in helping patients with low dopamine levels on a long-term basis.

Dopamine agonist therapy

Based on these earlier studies both Blum et al has continued to propose dopamine agonist therapy rather than dopamine antagonistic therapy currently favored by the approved FDA drugs as medical assisted treatment. Specifically, they proposed that D2 receptor stimulation can be accomplished via the use of KB220Z which is a complex therapeutic nutraceutical formulation that potentially induces DA release, causing the same induction of D2-directed mRNA and thus proliferation of D2 receptors in the human. This proliferation of D2 receptors in turn will induce the attenuation of craving behavior. In fact, this model has been proven in research showing DNA-directed compensatory overexpression which is a form of gene therapy of the DRD2 receptors, resulting in a significant reduction in alcohol as well as cocaine craving behavior in alcohol and cocaine preferring rodents.

This research done by Blum and his team suggested that utilizing less powerful dopaminergic repletion therapy to promote long term dopaminergic activation will ultimately lead to a common, safe and effective modality to treat Reward Deficiency Syndrome (RDS) behaviors including Substance Use Disorders (SUD), Attention Deficit Hyperactivity Disorder (ADHD), Obesity and other reward deficient aberrant behaviors. This concept is further supported by the more comprehensive understanding of the role of dopamine in the NAc as a “wanting” messenger in the meso-limbic DA system. This team had a hypothesis that D2 receptor stimulation signals negative feedback mechanisms in the mesolimbic system to induce mRNA expression causing proliferation of D2 receptors.

dopamineAs revealed by the researchers stress and dopamine D2 receptor levels play a significant role in alcohol seeking behaviors. Another researcher Delis and his team observed that in the presence of a stressful environment, low DRD2 levels are associated with increased ethanol intake and preference and that under this condition, increased ethanol consumption could be used as a strategy to alleviate negative mood this also supports dopamine agonist therapy not antagonistic. It is therefore safe to use dopamine agonists instead of dopamine antagonists in treating those with low dopamine levels as they are much safer.

Finally, We at AWAREmed Health and Wellness Resource Center are committed to availing help to addicts by availing some of the most integrative approaches to healing an addict. We advocate for natural healing to all kinds of addiction. Call on Dr. Dalal Akoury (MD) at Myrtle Beach, South Carolina for help.

Dopamine Genes Affect Clinical Outcomes in Reward Deficiency Syndrome

 

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Beta-Endorphins (Β-Ε) Levels and Alcoholism

The Effects Of Low Intensity Exercise On Beta-Endorphins (Β-Ε) Levels And Urge For Alcohol In Alcoholic Patients.

What are Beta-endorphins?

beta endorphinBeta-endorphins, or B-endorphins, are substances created by the pituitary gland. They specifically function as neurotransmitters, or conductors of messages between nerve cells. These substances are found around both the central nervous system and the peripheral nervous system. The Beta-endorphins is classified as a peptide since it contains 31 amino acids linked together. The beta-endorphins circulate around the brain, spinal cord, and secondary nerve systems in the body. Two glands, the pituitary gland and the hypothalamus, have a particular prevalence of the substance. The pituitary gland is responsible for releasing this endorphin into the blood, where it then travels to the central nervous system in the first legs of its journey. The beta-endorphins are agonists. They therefore connect to a cell and kick-starts a response. Beta-endorphins targets portions of a cell called opiate receptors in particular. The substance can reach these receptors in bodily tissue via a process called diffusion.

Beta-endorphins and alcohol

When alcohol is consumed at below risk levels it is known to be very rewarding health wise, it improves the quality of life but when a person begins taking alcohol in higher levels then there are problems that he will definitely have to suffer as a result of the severe effects of alcohol consumption. There are myriads of alcohol disorders needless to mention many accidents occur when people are drunken making alcohol a lead cause of accidental deaths.

Alcohol consumption has been reported to influence the activity of the endogenous opioid system. Reports indicate that acute exposure to ethanol leads to an enhanced release of brain Beta-endorphins (β-E) which through its interaction with μ and δ receptors mediates, at least in part, neurobehavioral effects such as reinforcement and acquisition of ethanol drinking behavior. Specifically, ethanol intake has been shown to increase β-E release by the pituitary and hypothalamus, an action that is mediated by the increase of corticotropin releasing hormone in a dose dependent manner. Furthermore, some reports indicate a biphasic effect of ethanol on hypothalamic Beta-endorphins release. However, the ethanol-induced increase of Beta-endorphins release is fast and transient, lasting about 15-20 minutes before normalizing again. Besides its effects on pituitary and hypothalamic Beta-endorphins, ethanol administration enhances Beta-endorphins release in the nucleus accumbens. This is a brain region important for the processes of reward and reinforcement. Therefore, the activation of μ and δ receptors by the increase in Beta-Endorphins levels due to ethanol intake may be pivotal in reinforcing properties of alcohol intake. On the other hand, chronic exposure to ethanol may cause adaptive responses of neuronal systems linked to negative reinforcement. Decreased Beta-endorphins production following chronic ethanol exposure may be responsible for some of the feelings of discomfort and the presence of negative reinforcement. Reports indicate that chronic ethanol abuse results in lower concentration of Beta-endorphins in the cerebrospinal fluid and plasma of male and female alcoholics. Therefore, chronic ethanol abuse might result in a central opioid deficiency. That deficiency might be related to decreased synthesis and release of Beta-endorphins in the hypothalamus and pituitary as well as lower density and activity of the opioid receptors.

A group of scientists conducted a research study to find out the effects of low intensity exercise on Beta-endorphins (β-E) levels and urge for alcohol in alcoholic patients. These researchers were Athanasios Z Jamurtas, Nikos Zourbanos, Kalliopi Georgakouli, Panagiotis Georgoulias, Eirini Manthou, Ioannis G Fatouros, Marios Goudas, Yiannis Koutedakis and Yannis Theodorakis.

This study used nine chronic alcoholic patients of whom 8 were males and 1 was female. These participants who were undergoing alcohol detoxification were recruited from a psychiatric hospital in Greece and 9 healthy controls volunteered to participate. Patients were diagnosed as being alcohol dependent according to the DSM-IV and the Alcohol Use Disorders Identification Test (AUDIT). AUDIT consists of 10 questions scored individually from 0 = never to 4 = 4 or more times per week. A total score of > 8 is an indication of alcohol abuse, a score of > 15 indicates serious abuse/addiction whilst a score between 8 and 10 is an indication of being at risk. Cronbach’s alpha coefficient was .73. Alcoholic patients were young and the medical exam revealed no presence of cardiovascular or metabolic disease in the participants. However, five patients were receiving antidepressant medicine, five were receiving anticonvulsant medicine and seven of them were receiving Thiamine, Pyridoxine, and Cyanocobalamine (three times a day) and folic acid (5 mg a day).

The findings of the study

beta endorphinsAll patients had a history of addiction of 10 years or more. All subjects were able to complete a 30-minute workout and the mean relative exercise heart rate was 61.1 + 4.9 % and 62.2 + 3.5% of their maximum heart rate for the alcoholic patients and healthy controls, respectively. Beta-Endorphins levels were significantly lower (p<0.001) in alcoholic patients whereas exercise resulted in significant increases (p<0.001, Cohen’s D: 3.31) only in the alcoholic group. Lactic acid at baseline was not significantly different between groups and increased significantly (p<0.001) after exercise in both groups. Analysis for CBC parameters revealed a significant time effect for red blood cells, hemoglobin and hematocrit. None of the remaining parameters was significantly different between groups nor was changed due to exercise. Pearson correlation analysis revealed non-significant relationships between Beta-endorphins and urge for alcohol (r = 0.23, p = 0.58). Finally, results on the Beta-Endorphins test revealed no significant changes in scores for alcohol urge in alcoholic patients (pre: 2.3 + 1.17; post: 1.87 + 1.17).

Finally, we at AWAREmed Health and Wellness Resource Center are committed to availing help to addicts by availing some of the most integrative approaches to healing an addict. Be it issues with Beta-Endorphins or general addiction treatment needs, we are here to help. We advocate for natural healing to all kinds of addiction. Call on Dr. Dalal Akoury (MD) at Myrtle Beach, South Carolina for help.

The Effects Of Low Intensity Exercise On Beta-Endorphins (Β-Ε) Levels And Urge For Alcohol In Alcoholic Patients.

 

 

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Drug Abuse in London on the rise

Substance Abuse Trend in London Current Treatment Available

LondonDrug abuse is common in London with the major drugs that are commonly abused being cocaine, ketamine, heroine, alcohol, cannabis and designer drugs. The drugs that were commonly abused in the past decades were cannabis and cocaine but in 2012 there was rise in the use of other drugs probably because of the pressure that authorities put on the users of cocaine and cannabis as they are illegal in London just the same way they are in most countries of the world. Ketamine was purportedly being produced in India from where it was smuggled into the United Kingdom and most of the users of this drug were the Londoners. Other drugs were also reported to be in use and most designer drugs that were in use were not even known. This onslaught of readily available drugs had become a major worry to employers. In 2007, the City of London Corporation published a report titled Tackling alcohol and drugs in the workplace. Its research found that 22 per cent of London businesses reported absenteeism as a direct result of drug abuse. This is an illustration that if not looked into keenly and appropriate solution given then the economy of London will be adversely affected by drug abuse as the workforce are slowly but surely losing their lives to drug abuse.

In 2012 LondonlovesBusiness.com published The City’s toxic new drug trends, an expose of drug abuse in the City. The feature highlights the prevalent use of drugs such as GHB among City boys. In 2007 the City of London report cited ecstasy, cannabis, alcohol, cocaine and heroin as substances to watch out for, but neglected new drugs that were increasingly being used like GHB and even ketamine.

There were a whole host of other substances that were not listed in the 2007 report. These included 2CI, 2CB, 2CE, GBL, GBH, mephedrone, ketamine, methamphetamine, speed, crack and opium, all of which were increasingly being used in London. With these designer drugs creating hybrid-like mix and match highs (2CI, 2CB and 2CE are said to replicate acid-type trips but without the same intensity, or for the same period of time), those with demanding jobs can achieve shorter highs with shorter comedowns.

Cocaine capital of Europe

The use of drugs of abuse has been at an all-time rise in London with designer drugs contributing a good percentage of the drugs that are consumed in London. Unfortunately, as I stated above most reports about drug use in this city has emphasized the use of major drugs of abuse like cocaine and cannabis while ignoring the use of other equally dangerous drugs like ketamine and other designer drugs. There are today very many drugs of abuse in London but still according to the recent report on drug just in the United Kingdom, it has been found that cocaine is still the most abused drug in the London, in fact London is now referred to us the ‘cocaine capital of Europe’. Yeah you heard it right-London is the cocaine capital of Europe and has the highest use of the drug than any other city on the continent, new research published today is proof to this statement.

This report was from The European Drug Report 2014 that reached this conclusion having analyzed the sewage systems of 42 cities for traces of the drug and found the English capital had the highest cocaine use of any city tested, with consumption of the drug appearing to peak on a Tuesday. The samples, which were taken and tested during a week in 2013 to provide a forensic snapshot of drug use, found London was one of the cities with the highest use of ecstasy. Contained in the report was the information that the sewages water in London contained 711 mg of benzoylecgonine, the main chemical in cocaine, per 1,000 people, compared to 393 mg in Amsterdam and 233 mg in Milan.

LondonGenerally, cocaine and ecstasy were the more popular drugs in western and some southern cities, while crystal meth remained the most popular in Eastern Europe. However, overall use of the drug is continuing to decline in countries such as Denmark and the United Kingdom after a peak in 2008. Eleven out of the 12 countries also reported falls in cocaine use in surveys undertaken between 2011 and 2013.

The international report also warned against the increasing use of so-called ‘legal highs’, which are sold over the internet and often try to mimic the effects of drugs such as cocaine or LSD. The agency identified more than 80 new chemical drugs last year, making a total of almost 250 detected over the past four years.

Available treatment options for drug addicts in London

Here in London like any other part of the world addicts can mostly get help by visiting rehab centers. There are very many rehabs in the London and you may have to do a little research on which rehab can suit the case. In rehabs there are different ways through which an addict will be helped. One of the ways of fighting addiction is through drug and alcohol detoxification.

Finally, We at AWAREmed Health and Wellness Resource Center are committed to availing help to addicts by availing some of the most integrative approaches to healing an addict. We advocate for natural healing to all kinds of addiction. Call on Dr. Dalal Akoury (MD) at Myrtle Beach, South Carolina for help.

Substance Abuse Trend in London Current Treatment Available

 

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