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Gut Inflammation and Cytokines

Gut Inflammation

The digestive system plays a major role in food digestion as well as absorption of nutrients into the blood stream. It is important for the overall functioning of the body. When the digestive system is not working properly it can lead to development of gastrointestinal diseases and illnesses.

The bowel wall can be destroyed by conditions such as Crohn’s disease, inflammatory bowel diseases and ulcerative colitis. The conditions lead to poor absorption of nutrients, weight loss, abdominal pains, rectal bleeding among others. To correct the situation a patient is required to undergo surgery in most cases.

Cytokines

They are chemical messenger that act as signals for the immune system and neuromodulators. Cytokines can be either anti-inflammatory or pro-inflammatory. An imbalance in cytokines cause autoimmune disorders.

Cytokines are in form of proteins as well as glycoproteins that regulate immune functions and inflammation. They enhance the growth of cells as well as their differentiation and death.

Homeostasis in the intestines highly depends on the ability of the immune system of the intestines to withstand micro flora while at the same time providing protection against bacterial invasion. Normally, the dendritic cells of the gut induce T-cells differentiation.

Gut Inflammation

T-cells produce secretions that enhance suppression of cytokines that in turn prevent abnormal immune responses. Pathogens enhance a response that triggers activation of immune cells and this ends up causing inflammation.

Inflammatory cytokines like IL-1ß, IL-2, IL-6, IL-15, IL-21 and TNFa stimulate T-cells that are cytotoxic. These are the ones that attack the gut mucosa. The mucosa is the lining of the small intestines. When cytokines attack the mucosa it can lead to conditions such as inflammatory bowel syndrome, Crohn’s disease. It can also lead to leaky gut syndrome.

The small intestines are useful not only in food digestion but absorption of nutrients from the digested food into the blood stream. When the small intestines re affected the digestive and nutrition functions are affected too.

Some immune system aspects aid in the suppression of inflammation aspects and thereby inhibiting destruction of tissues that is caused by active T-cells. This is made possible by T regulatory cells that work to counterbalance the active T-cells that attack the mucosa. T regulatory cells reduce the risks of getting immune diseases that end up attacking the tissues of the body like Crohn’s disease and rheumatoid arthritis.

Natural Compounds That Target Pro-inflammatory Cytokines

Besides the T-regulatory cells, there are several natural compounds that can also work to suppress the cytokines that cause gut inflammation.

Curcumin: studies have shown that curcumin acts as an agent of anti-inflammation. Curcumin works by targeting a number of cytokines that are responsible for gut inflammation. These cytokines include among others IL-1, IL-2, IL-6, IL-21 and TNFα. Curcumin combines with cyclosporine to bring about this effect.

Fish Oil: it contains properties of anti-inflammation. These properties have been shown to have the ability of suppressing cytokine that cause inflammation like IL-1, IL-2, IL-6, IL-15 and TNFα. The Omega-3 property in fish oil is responsible for this.

Studies have shown that Omega-3 suppresses these inflammatory cytokines that lead to gut inflammation. In addition to this, fish oil stimulates the body to produce anti-inflammatory cytokines that enhances a decrease of cytotoxic T-cells.

Resveratrol: just like the other natural compounds, resveratrol works by suppressing inflammation causing cytokines. Such cytokine include; IL-1β, IL-2, IL-6 and TNFa. It works by reducing the ability of the T-cells to reach the gut mucosa. This thereby inhibits gut inflammation.

Trans-Resveratrol: it is used to reduce the activation of T-cells in the body. This is by suppressing cytokines involved in activating inflammation agents.

Tea Polyphenols: both black and green tea contains compounds that have been shown to act as strong agents of anti-inflammation. The compound in the tea inhibits the activations of cytokines such as IL-1β, Il-2, IL-6 and TNFα which cause inflammation of the gut.

inflammation

Quercetin: this natural compound is found in things like onions, citrus fruits, apples and grapes. The compound inhibits the activation of inflammatory cytokines like IL-1β, IL-2, IL-6, IL-15 and TNFα.

Vitamin D3: Vitamin D3 works as an anti-inflammatory compound when it comes to gut inflammation. It has been shown to control inflammatory toxics like IL-1β, IL-6 and TNFα which affect the mucosa causing inflammation.

High Proanthocyanidin Grape Seed Extract: grape seed contain a certain compound that is used to reduce the level of Th17 in the body. It also controls immune responses that tend to be aggressive in nature. It controls the differentiation of active T-cells serving as an autoimmune disease and inflammatory agent.

N-Acetyl Cysteine: this compound when combined with vitamin B lowers the levels of homocysteine thus improving the functioning of endothelial. It also works by suppressing the active inflammatory cytokines like TNFα in patients who receive lung transplants. TNFa makes a patient’s body reject transplants but in combination with vitamin B this is no longer a problem.

Contact Dr. Dalal Akoury today, for more information about gut inflammation. For more wellness and awareness tips just visit www.awaremednetwork.com today. AwareMed is the place to be to find any information about health.

Gut Inflammation and Cytokines

 

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Skin Irritants: How to Get that Glowing Look

Fighting Common Skin Irritants for a Glowing Look – Prevention & Treatment of Irritants

Fighting Common Skin Irritants

Fighting common skin Irritants for a glowing facial look. And once you’re no longer exposed to the irritant or allergen, redness usually vanishes.

The beauty of the skin can easily be affected by a simple skin irritation and the sooner we get to serious business of fighting common skin irritants the better for a glowing and radiant looking skin. It is important to note that individuals with sensitive skin can easily trigger an irritation even by changing the kind of soap they use leading to an outbreak of redness, stinging and itching. Things that cause skin irritations are all around us even in our homes. In fact our homes harbor most of these common skin irritants including triple-antibiotic ointments, bandage adhesives, and jewelry that contains metals such as nickel. When your skin becomes inflamed after coming in contact with one of these substances or many more the condition is called contact dermatitis. People with sensitive skin can get two types of this condition:

Irrespective of the kind of dermatitis you’re suffering from doctor Akoury will be there to help you get well as well as fighting other common skin irritants for a glowing look.

Fighting Common Skin Irritants for a Glowing Look: Irritant Contact Dermatitis

This form of skin irritants is the most common one affecting about 80% of all reported cases. Like for instance when your skin get into contact with an irritating substance, you’ll often get a reaction that resembles a burn with red, chapped, and dry skin. This skin reaction tends to be more painful than itchy. Skin irritants contact dermatitis is naturally triggered by common substances we are exposed to in our day today life like:

  • Strong soaps
  • Acetone in nail polish removers
  • Drain cleaners
  • Acids
  • Detergents
  • Plants

How this affects vary depending on the sensitivity of individual patients skin. Individuals with high skin sensitivity can develop irritation from even mild soaps and detergents they use regularly. Besides that doing house activities where your skin can be exposed to cleaning products like detergents and waxes, this can wear down the protective barriers of your skin making your skin to be vulnerable for an attack by all these irritants. Typical irritant contact dermatitis symptoms include:

  • Dry, cracked skin
  • Mild skin swelling
  • Blisters or painful ulcers on the skin
  • Stiff, tight-feeling skin

Fighting Common Skin Irritants for a Glowing Look: Allergic Contact Dermatitis

This less common form is a true allergic reaction. In allergic contact dermatitis, the immune system responds to a substance that touches the skin. You can become allergic to the substance after one exposure or many. In fact, people can be exposed to a substance for long periods, even years, before developing an allergy. Common sources of allergic contact dermatitis include:

  • Fragrances
  • Preservatives
  • Cosmetics
  • Poison ivy
  • Topical antibiotics
  • Rubber or latex
  • Metals in jewelry, such as nickel

Some people are also allergic to over-the-counter topical triple-antibiotic ointments. All told, thousands of substances can cause allergic dermatitis. When a person who has become sensitized to an allergen becomes exposed by touching the substance, symptoms, such as itching and skin inflammation, are often delayed. They can show up anywhere from a few hours to as many as four days after contact. Symptoms of allergic contact dermatitis include:

  • Reddened skin
  • Darkened, leathery, cracked skin
  • Dry, scaly patches of skin
  • Burning or intense itching
  • Blisters that ooze
  • Hives
  • Sun sensitivity
  • Swelling in the eyes, face or genital area

In addition, some people get a form called photo allergic contact dermatitis. This type happens only after the skin touches certain substances and then comes in contact with sunlight. These substances may include:

Fighting Common Skin Irritants for a Glowing Look: Finding the Source of Skin Irritnts

If you suspect that a certain product or substance is causing your dermatitis, avoid it and watch whether your rash improves.

But it’s not always easy to pinpoint a specific cause. For example, your eyelids may be chronically dry, red and flaky, but what’s to blame: your eye shadow, eyeliner, makeup remover, or overnight eye cream?

Sometimes, people have no clue at all — they get a rash, but they can’t recall the substances that have touched their skin. Or their facial skin becomes inflamed, leading them to suspect a face product. In fact, they might have unwittingly transferred a substance from their hands to their face. The substance doesn’t affect the hands, but the more sensitive facial skin will react.

If you can’t figure out the source of irritation, see a dermatologist. He or she will quiz you about your job, household chores, hobbies, drug and cosmetics use, and other factors in order to gain clues about the root of the problem.

Your doctor may also do testing. No test can be performed for irritant contact dermatitis. But your doctor may do patch testing to see if you’re sensitive to various types of allergens that are known to cause dermatitis. Small patches of these substances are placed on your skin for one to two days so that your doctor can check if a rash develops.

Fighting Common Skin Irritants for a Glowing Look: Prevention & Treating Contact Dermatitis

To relieve itching, contact dermatitis is commonly treated with:

  • Oral or topical steroids
  • Oral antihistamines
  • Skin emollients
  • Oatmeal baths

Once you’re no longer exposed to the irritant or allergen, redness usually vanishes after a week. But itching, scaling, and temporary skin thickening may go on for days or weeks. You can also take steps to protect your sensitive skin from developing contact dermatitis. For example:

  • Once you’ve identified an offending substance, avoid it. Wear gloves or protective clothing to prevent exposing your skin to cleansers, weeds, and other substances during housework or yard work. If your skin makes contact, wash the substance off right away with soap and water.
  • Learn to recognize poison ivy and poison oak.
  • Use mild, unscented laundry detergent.
  • If you have sensitive facial skin, consider using gentle, soap-free, liquid cleansers. Or use a moisturizing soap that’s free of fragrance and dyes.
  • Don’t scrub your face vigorously with a rough washcloth or buff puff. Instead, cleanse gently and pat dry.
  • Avoid deodorant or antibacterial soaps.
  • Choose moisturizers, sunscreens, and cosmetics that are fragrance-free and don’t contain acids or botanical ingredients. Physical sun blocks that contain zinc oxide or titanium oxide are less likely to cause skin problems than chemical sunscreens.
  • Test cosmetics and personal care products before using. Apply a small amount of the new product twice a day to a small patch of skin near the inside of your elbow. If no irritation occurs in that spot after a week, you can try using the product.

Protect your skin by applying petroleum jelly or a thick, moisturizing cream two or three times a day. The objective of fighting common skin irritants may not be realized if the experts are not adequately involved. Therefore scheduling for an appointment with doctor Dalal Akoury an expert in skincare with over two decades experience of practice would be the starting point. The beauty of your skin is and must be your number one priority. Call doctor Akoury today for that very important appointment.

Fighting Common Skin Irritants for a Glowing Look – Prevention & Treatment of Irritants

 

 

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Estrogen Replacement Therapy

Estrogen Replacement Therapy

Estrogen replacement therapy (ERT)The estrogen hormone plays crucial roles in the life of a woman. Among other things this hormone is responsible for the maintenance of human skin. They improve collagen content and quality, increase skin thickness and improve blood supply to the skin, maintaining good moods in women. Estrogen has effects on other hormones too as it increases cortisol and Sex hormone binding globulin. Estrogens increase melanin and pheomelanin and reduce eumelanin.

The known basic roles of estrogen hormones in women is that it promotes the growth and health of the female reproductive organs and keeps the vagina moisturized, elastic and well supplied with blood. Moisturized vagina is safe for sex as it will not allow for bruises that may be a source of pain during sex. This hormone also makes the vagina elastic hence making it able to accommodate a good size of penis during intercourse without pain.  When this hormone declines all its functions will become unattended to making sex a rare practice for those in post menopause.

Despites its benefits, after menopause the ovaries of women stops producing certain hormones and this lead to lower levels of these hormones in the body. The hormones; progesterone, estrogen and testosterone plays certain crucial roles in the body of a woman.

The decline in the levels of this hormone leads to low sex drive among other problems. The person loses interest in sex and sexual intercourse becomes a once in a while indulgence as opposed to a regular activity that it was before menopause.

Low Estrogen Symptoms

Low estrogen levels are low moments for every woman. During this time women will suffer varied symptoms that lasts for varied length of time however few women will be able to know that they are suffering the symptoms as a result of decline in the levels of estrogen hormone. It is advisable that every woman should have her levels of estrogen hormone checked frequently to shun the chances of being debilitated by these symptoms. Symptoms of low estrogen hormones include the following

  • Vaginal dryness
  • Loss of libido
  • Mood swings
  • Hot flashes
  • Night sweats
  • Anxiety
  • Thinning hair
  • Weight gain
  • Arthritis
  • Difficulty concentrating

Estrogen replacement therapy (ERT) 

During menopause the production of estrogen hormones stops but the need for estrogen hormone still stands therefore the need to supplement this crucial hormone sets in, besides with low levels of this hormone women suffer such symptoms as hot flashes, vaginal dryness and osteoporosis among other conditions. Going for estrogen replacement therapy may help fight against the symptoms of menopause in women.

Estrogen Replacement Therapy has helped many women to win fight against post menopause symptoms. Here are some benefits of Estrogen Replacement Therapy.

  • Help prevent postmenopausal osteoporosis by slowing bone loss and promoting some increase in bone density.
  • Reduce the risk of dental problems, such as tooth loss and gum disease.
  • Maintain the lining of the vagina, reducing irritation.
  • Reduce the frequency and severity of hot flashes.
  • Improve moodiness and sleep problems related to hormone changes.
  • Increase skin collagen levels, which decline as estrogen levels decline. Collagen is responsible for the stretch in skin and muscle.

Risks associated with ERT

Despite its many benefits there are also risks associated with ERT. These risks may include;

  • Vaginal discharge.
  • Fluid retention.
  • Weight gain.
  • Breast tenderness.
  • Spots on skin may appear
  • In rare cases, an increased growth of preexisting uterine fibroids or a worsening of endometriosis.

Natural Estrogen Replacement

There are some risks associated with ERT, however the good news is that both diet and the right supplements provide some of the safest and most effective hormone balancing remedies. One of the favorite and best-researched foods for menopausal symptoms is flaxseed. Flaxseeds offer a high content of essential fatty acids and large quantities of a natural hormone-balancing substance known as lignins. Lignins are very potent anti-cancer agents for cancers that are hormone sensitive and extensive studies on both colon and breast cancer show that as little as 2 tablespoons per day is highly effective in reducing tumor growth. The best news of all: Lignins possess both anti-estrogen and estrogenic properties. With regard to menopausal symptoms, they are as effective as traditional HRT in lessening hot flashes and sweating. Grind up a couple of tablespoons a day and put it in your smoothie, yogurt, or cereal. You’ve then got one of the best sources for health, healing, and taking charge of your menopausal symptoms naturally.

Estrogen replacement therapy (ERT)

Another nature given remedy for low estrogen symptoms is the evening primrose oil, which is a source of GLA, an essential fatty acid has been found to be mostly helpful for getting rid of cramping, irritability, headaches, and water retention that are so common with PMS. But its benefits don’t just stop with PMS. It can also be used in a natural hormone replacement therapy in menopause. It works to suppress hot flashes and triggers the production of serotonin, the feel good hormone in the brain. Skin conditions like eczema, psoriasis, and plain old dry skin are marvelously helped with evening primrose oil and other GLA-containing botanicals. It is one of the most potent inner and outer menopausal and skin care treatments known.

Dr. Dalal Akoury of AWAREmed wellness and resource center is an expert in integrative treatment and has helped many women fight menopause symptoms naturally. If you’re struggling with menopause or dealing with low estrogen symptoms like hot flashes, joint pain and depression, estrogen hormone replacement therapy (ERT) may be the answer. Please call (843) 213-1480 to contact her.

Estrogen Replacement Therapy

 

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