Tag Archives: Ahmet Davutoğlu

Circulating Stem Cells And Opiate Addiction

Deficit of Circulating Stem Cells-In Opiate Addiction Cause Major Illnesses in the Body

Circulating Stem cellsA new research has pointed out that deficit of circulating stem cells-in opiate addiction cause major illnesses in the body. This however is not much of a surprise since past researchers were able to discover the fact that slow cell growth and apoptosis were major reasons for the different capacities of addictive drugs. To people who have slow cell growth, the chances addiction is much higher of Couse within a shorter lifespan than those who had optimum cell growth levels.

Deficit of circulating stem cells-in opiate addiction cause major illnesses in the body The stem cell hypothesis of ageing suggests that ageing at the organismal level is reflected by impaired cell health at the cellular level including reduced function, reduced growth, increased senescence, and cell loss by apoptosis, necrosis. The often disorganized and disheveled body habitus of many drug addicts is well known, as is their predisposition to a variety of unusual disorders.

A rising body of knowledge suggests that disorders common in aged populations occur at an increased frequency in addicted populations as a result of stem cell deficiencies. Stem cells dysfunctions in addicts apply to:

  • Osteoporosis,
  • Neuropsychiatric disorders,
  • Depressed sperm counts,
  • Calcific arteriosclerosis,
  • Premature graying of the hair,
  • Severe mental disorders.

These problems have in common a failure in stem cell physiology. The high mortality accompanying chemical addictions is also well recognized.

New Research

Currently, the field of stem cell biology is mushrooming with many investigations centered on a host of prospective applications in regenerative medicine and including particularly bone marrow transplantation, tissue regeneration and immune and gene therapy. Several recent developments make these advances of particular interest to the field of addictive medicine particularly to its toxicology. Stem cells exist at low frequency in the peripheral circulating blood and may be quantitated there. Several methods have been recently described for the quantitation of various lines of stem and progenitor cells in peripheral blood, a tissue which is regularly accessed in routine clinical care. Secondly the endothelial progenitor cell has been said to be of enormous importance to the regeneration of the vasculature and has be noted to be a superior predictor of cardiovascular outcomes including mortality than commonly used classical cardiovascular risk factors. Similarly counts of the circulating osteoblastic progenitor cell have been shown to correlate with bone density studies. Finally the cellular theory of ageing suggests that stem cells and their health should be a special focus of ageing medicine and the deficits associated with ageing, and this has been confirmed by recent reports.

Given the importance of the circulating stem cells in the blood, it is therefore necessary to examine the peripheral blood for circulating stem cell numbers in addicted and control populations so as to find out the relationship between suppressed levels of the circulating stem cells and illnesses that are common in opiate addicts.

In a research that was done recently by substance abuse prevention policy it was found that patients who were addicted to opiates had decline in stem cells circulating in the peripheral blood appears to be three or four times as fast in addicts as in the general population.

In this research the patients were chosen from normal clinical primary care population. Medical patients were representative of those seen typically in primary care clinics. Opiate addicted patients were maintained on buprenorphine/naloxone combination and are gradually reduced. They were not in clinical withdrawal at any time. Blood was obtained with patient consent. Blood was drawn for standard clinical indications in the course of routine patient care. Peripheral venous blood was sampled from patients and processed fresh without storage by flow cytometry. Absolute lymphocyte counts were taken, and CD34+ CD45+ double positive cells were counted as haemopoietic stem cells (HSC’s), and CD34+ KDR+ (VEGFR2+) cells were denoted endothelial progenitor cells (EPC’s). Progenitor cells were standardized against the lymphocyte fraction as these were believed to be of the most appropriate nuclear cytoplasmic ratio.

Based on the data presented the decline in stem cells circulating in the peripheral blood appears to be three or four times as fast in addicts as in the general population. This therefore indicates that opiates addicts are more likely to suffer the symptoms of low circulating stem cells than those who are not addicted to opiates.

This research however was small but if these results are confirmed by other researches that are done on a much larger scope then they would have very significant potential implications for understanding the cumulative toxicology of indefinite maintenance therapies and programs both for opiate dependency and the notion presently widespread in medicinal chemistry, clinical, research funding and other circles that agonist medication is functionally superior to sustain patient compliance in the long term to antagonists. If confirmed the present results are likely to have far reaching implications for clinical practice and hence public policy, particularly as an increasing number of long acting depot preparations of antagonists are currently entering the marketplace.

Circulating Stem CellsThis research as said earlier is a preliminary study and its researchers are still suggesting that further investigations be done for on-going research in this important field as it has significant future implications for drugs policy administrations and long term patient treatment development.

Finally drug addiction is effectively fought through integrative care. If you are battling with addiction and you need help call Dr. Dalal Akoury of AWAREmed Health and Wellness Center on (843) 213-1480 for help.

Deficit of Circulating Stem Cells-In Opiate Addiction Cause Major Illnesses in the Body

 

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MicroRNA Quells Cocaine Craving

MicroRNA May Suppress Cocaine-Seeking Behavior

microRNA Currently there are very many people who are tripped in the use of drugs of abuse despite their life threatening effects. Drug addiction is a jail that many addicts find hard to evade. It is important to note that addicts do not use the drugs they abuse because they like using them, the honest truth however is that most addicts have tried to stop using their drugs of choice but they can’t just fight against their own craving. The cravings for drugs like cocaine that are known for their euphoric effects are one of the challenges that addicts face.

Typically, a person will use the drug once as an escapade to all the stress that he may be exposed to or as a result of mere curiosity having been misled by their peers that using cocaine is cool as they say it. However after getting the euphoric effects one is bound to go for more of this drug and this in the long run may result to cocaine addiction and even dependence. It has never been easy quitting the use of cocaine and many people even after going to rehab centers will still for the drug when exposed to triggers after they come back from the rehabs. It is this cocaine seeking behavior that is adopted by the addicts that makes it hard for them to quit. If this cocaine seeking behavior can be reduced then a person may win the fight against cocaine addiction easily.

The recent discovery by scientists that a minute snippet of genetic material called microRNA may suppress cocaine-seeking behavior presents hope to the medical fraternity as well as cocaine addicts. As a known fact the use of cocaine will cause both structural and functional alterations to the brains’ reward system. These changes cause a drift in the behavior of the users of cocaine. Through experiments and lab tests it has been found that these alterations results in increased drug-seeking behavior in both humans and rats. The desire to use cocaine become uncontainable hence overindulgence in drug use.

Just like with any other drugs of leisure, long-term use of cocaine will result in reduced response to the effects of cocaine which will force the user to use more of cocaine so as to achieve the sought euphoric feeling. After a long time of use of this drug the response will be lessened again and this will reduce the motivation of a user to continue using the drug. Researchers suspect that these differing influences may be why only about 15% of cocaine users ultimately lose control and compulsively seek the drug.

MicroRNAs are small pieces of RNA that don’t code for proteins but they regulate how much of a protein is made instead. Over the past decade, microRNAs have been linked to various cancers, degenerative disorders and other conditions. It was until recently that the contribution of these tiny molecules to drug use and addiction were brought under scrutiny.

Paul J. Kenny led study

In a research team that was led by Dr. Paul J. Kenny of the Scripps Research Institute in Jupiter, Florida, the team decided to explore how brain levels of specific microRNAs change when rats have extended or limited access to cocaine. The study was funded by NIH‘s National Institute on Drug Abuse (NIDA).

In the issue of Nature published on July 8, 2010, the scientists reported that rats given 6 hours of extended access to cocaine each day had markedly increased levels of a molecule called microRNA-212 in a particular brain region. The levels were nearly double those in rats with access to cocaine for an hour or less daily. The brain region, called the dorsal striatum, helps to regulate the development of habit formation.

After this discovery the researchers next tested the effects of elevated microRNA-212. The Researchers used a genetically altered virus to boost microRNA-212 expression in the dorsal striatum. A control group received an “empty” virus. When given extended access to cocaine, both groups predictably escalated their intake. But over time, cocaine intake plummeted in the rats with elevated microRNA-212. Cocaine consumption in this group continued to drop even as their exposure to the drug increased. Their cocaine intake became so low that they seemed to have a growing dislike for the drug.

MicroRNATo contrast the effects of this microRNA-212 in the brain, the researchers blocked the action of microRNA-212 in the brain and this led to sharp increase in cocaine intake and the rats began to self-administer the drug at exaggerated rates, similar to compulsive drug users. These results suggest that microRNA-212 may play an important role in preventing out-of-control drug use.

“The results of this study offer promise for the development of a totally new class of anti-addiction medications,” says Kenny. “Because we are beginning to map out how this specific microRNA works, we may be able to develop new compounds to manipulate the levels of microRNA-212 therapeutically with exquisite specificity, opening the possibility of new treatments for drug addiction.”

the fact that Cocaine consumption in the group of rate with elevated microRNA-212 continued to drop even as their exposure to the drug increased is a clear indication that that this minute component of genetic material may be used to quell the craving for cocaine in cocaine users. Dr. Dalal Akoury of AWAREmed Health and Wellness Center has dedicated her life to helping addicts restore their lives by use of integrative medicine. Call her on (843) 213-1480 for help.

MicroRNA May Suppress Cocaine-Seeking Behavior

 

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Drug Abuse in South Africa at Alarming Levels

The Magnitude of Drug Abuse in South Africa

South Africa is experiencing a rise in drugs abuse. In recent years the trend in alcohol abuse as well as other drugs has been alarming. Alcohol is still the primary drug of abuse and use is rising every day. In 2011 the world health organization (WHO) reported that South Africa has the highest per capita consumption rates in the world of alcohol in the world and it is quite insane that the rate is continuing to rise. In South Africa the citizens consume in excess of 5 billion litres of alcohol annually but this figure is likely to be higher still if sorghum beer is included, and equates to 9 – 10 litres of pure alcohol per person. Despite alcohol being the primary drug of abuse there are other drugs that are used by the South Africans as well. These drugs include Methaqualone (Quaaludes), cocaine, marijuana popularly known as dagga in South Africa, and heroin are all drugs that are becoming increasingly popular in the cities of South Africa.

There have been drastic political changes in  South Africa  that have been accompanied by social transitioning, rapid modernization, high unemployment rates, and a decline in social, cultural, and family values. As a result, drug use has flourished and new environments, such as night clubs, that promote drug use have been created. These environments appear especially promising for adolescents and young adults looking for an escape. It is in these places that drugs look cool and casual sex is acceptable. Unfortunately, these places are a haven for heavy drug abuse and diseases; such as, HIV and AIDS. Needless to mention, South Africa has become a major country involved in international drug trafficking networks over the past decade. Experts have agreed that it is becoming harder and harder to deal with the explosion of the drug trade and it links are becoming increasingly complex to tame.

South Africa

Here are statistics of the most abused drugs in South Africa over the past years. These statistics are from the World Health Organization (WHO). However there might be some changes on the statistics as the use of drugs of abuse in South Africa is increasing at such a rapid rate.

South Africa drugs of abuse stats according to WHO

The World Health Organization (WHO) reports that drug consumption in South Africa is twice the world norm. It is saddening to note that 15% of South Africa’s population has a drug problem. The cost associated with drug abuse is crippling the South Africa’s economy. This is evident as the country spends R20-billion a year and could pose a bigger threat to the country’s future than the Aids pandemic. According to SAPS figures, 60 percent of crimes nationally were related to substance abuse, this shows the cost of drugs of abuse in relation to the social ills they cause. Just as it happens everywhere, addicts will go through all odds to afford the drugs they have become dependent on and crime is the immediate step the youths take to buy their daily dosage of these drugs. In the Western Cape, the figure was closer to 80 percent that shows that Western Cape is the most affected area.  The perpetrators of these crimes are either under the influence of substances, or trying to secure money for their next fix. The use of drugs has also increased prostitution as most of the prostitutes have to sleep with 10-15 men daily to find enough money to buy their drugs of abuse.

 SANAB disbanded

The use of drugs and related crimes have increased greatly, by 30% to be exact after the government disbanded   SA Narcotics Bureau (SANAB) which was  a dedicated drug-fighting unit within the SAPS that had achieved some notable successes. The SANAB was disbanded in 2004 and no other body has sprung to fill the vacuum.

Recently the United Nations World Drug Report had named South Africa as one of the drug capitals of the world. The abuse of alcohol and usage of dagga has led to the country to being one of the top ten narcotics and alcohol abusers in the world. The CDA also reports that one Rand in four in circulation in South Africa is linked to the substance abuse problem. CDA is a drug control organization. The increase in drugs use is also evident in the increase of number of drug arrests from a mere 300 in 2006 to a staggering 1500 in 2012 in Cape Town.

Teenagers are not left out

The CDA reports that alcohol use is common in school kids and most kids who are involved in alcohol abuse are involved in violent crimes 3 times more than kids that are not involved in drug abuse.

South Africa

It also points at the increase in drug use among teens.  As from 1992 – 95 the use of drugs among teenagers increased by 600%. But the figure is still increasing as evident in 2007 when it stood 1100%.  Most kids begin using drugs of abuse at the age of twelve, the CDA report of 2009 revealed that schools have become a target for drug dealers.

A part from alcohol drugs that are widely abused in SA include;

Methamphetamine (Tik)

  • Crack
  • Heroine
  • Cocaine
  • Mandrax
  • Dagga
  • Ecstasy

Finally, We at AWAREmed Health and Wellness Resource Center are committed to availing help to addicts by availing some of the most integrative approaches to healing an addict. We advocate for natural healing to all kinds of addiction. Call on Dr. Dalal Akoury (MD) at Myrtle Beach, South Carolina for help.

The Magnitude of Drug Abuse in South Africa

 

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