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Mesenchymal Stem Cells for Treatment of Cardiovascular Diseases

June 3, 2015

Mesenchymal Stem Cells Role in Cardiovascular Diseases

Cardiovascular diseaseThe use of stem cells in treatment of various diseases has been given lots of consideration in the recent past. scientists have been busy doing researches trying to find out if the stem cell therapy which is termed by many as the medical miracle of the 21century can be a break in treatment of the diseases that have proved stubborn to conventional treatment methods. Stem cells have various properties that other cells do not have and this is the major reason why they have been in the lips of every regenerative doctor. There are different types of stem cells but the mesenchymal stem cells have been the major focus of integrative medicine practitioners.

Degenerative diseases are known to wreak havoc in the body’s ability to self-renew and rejuvenate. They affect the way the nervous system works causing a breakdown in the communication between the nerves which eventually causes various ailments. Degenerative diseases have not been very easy to treat in the past but with stem cell therapy, there is hope for not only degenerative diseases but also the much dreaded cardiovascular diseases as well.

Why mesenchymal stem cells?

The mesenchymal stem cells are not sought after for nothing. They have a lot to offer especially in this age when degenerative diseases are enslaving many people and the conventional medicine is not offering the much needed break. Mesenchymal stem cells are sourced from either the adipose tissues or from the bone marrows and are described as a rare type of cells which are multi-potent and rich in medicinal properties. The unique properties of the mesenchymal stem cells have made them a target as therapy for various diseases and currently they have been used for treatment of arthritis among other conditions. They have been found to be also very effective in moderating the functions of dendritic cells, immune cells, B cells, natural killer cells, monocyte or macrophages, T cells, and neutrophils.

Just like the rest of the Stem cells, the mesenchymal stem cells are precursors of all cells and have the ability of forming cells of other types such as the hematopoietic, bone, endocrine organs, nervous and cardiovascular system, and cartilage and muscle tissue. It is the unique ability of the mesenchymal to shift shape and form other cells that they have been targeted for treatment of cardiovascular diseases.

Research on Mesenchymal stem cells for cardiac diseases treatment

Cardiac diseases have caused many deaths and are still among the leading causes of death worldwide. however the conventional medicine such as myocardial infarction haven’t helped much in treatment of these diseases and this led to the research on the possibility of the stem cells being used for this course. The Hematopoietic stem cells were the first to be researched on and used for clinical trial. In some trials the therapy worked while in others they didn’t give the much expected results and this led to consideration of other stem cell types.

The mesenchymal stem cells were the most promising of all the types owing to their strong paracrine function, which gives them potential immunomodulatory effects via anti-inflammatory and antiapoptotic actions. It is this property that may give them the ability to counteract the pathological mechanisms that are involved in various cardiac diseases. They can also be trans-differentiated into cardiomyocytes.

In 1999, Makino S and his colleagues first demonstrated the differentiation of MSCs into cardiomyocytes in vitro. Their research concluded that Cardiomyocytes can be generated from marrow stromal cells in vitro. Makino and his colleagues aren’t the only scientists to have worked on viability of MSCs ability to treat cardiac diseases, Wang JA and his colleagues did a trial that involved transplanting Allograftic bone marrow-derived mesenchymal stem cells into heart infarcted model of rabbit to renovate infarcted heart, they found out that the rabbits who had mesenchymal stem cells transplant had a lower mortality rate of 16.7% as opposed to the controls whose mortality rate was at 35%.

cardiovascular diseaseAnother study was done in 2005 by Hatton N and his counterparts, it involved transplanting purified cardiomyocytes differentiated from bone marrow MSCs in vitro into adult mouse hearts, after three months the transplanted cells had survived and were sloping in parallel to the cardiomyocytes of the recipient heart. These and other animal trials have all showed the ability of mesenchymal stem cells in treatment of cardiovascular diseases.

Through research, there has been a growing body of evidence that the mesenchymal stem cells have the multiple paracrine effects that even without cell replacement can affect cardiac remodeling, angiogenesis and cytoprotection hence are clinically beneficial.

The hopes were held even higher after another researcher; Ohnishi S showed that the mesenchymal stem cells have a role in inhibiting cardiac fibrosis by regulation of collagen synthesis by cardiac fibroblasts, as well as their effects on fibroblast proliferation.

conference

The mesenchymal stem cell therapy are the medical miracle of the 21century, you need to be updated their applicability in treatment of various diseases, visit www.awaremednetwork.com for more information about bone marrow transplant and stem cell transplantation. Dr. Dalal Akoury is an experienced doctor in integrative medicine; she will be able to assist. From the same website you can also visit http://www.integrativeaddiction2015.com and be updated on upcoming Integrative Addiction Conference 2015. The conference will deliver unique approaches to telling symptoms of addiction and how to assist patients of addiction.

Mesenchymal Stem Cells Role in Cardiovascular Diseases

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Medical Tourism And Treatment of Addiction

March 11, 2015

The Role of Medical Tourism in Treatment of Addiction

Basically medically tourism can be defined as the act of a person leaving his country to seek medical care in a different country or simply beyond the country’s borders. In the past medical tourism involved patients from third world countries traveling to developed countries in search of qualified medical doctors to treat their diseases. This meant that the patient had good money to spend in treatment in the country he was visiting for medical care. However today medical tourism has taken a new dimension with patients traveling from the developed countries to developing countries for affordable medical care. These patients are evading heavy financial crisis that they may plunge into if they opt to treat the diseases in their own countries where the cost of treatment is higher than in the countries they are visiting.

It is important to appreciate the fact that the patients who leave their countries to come and seek medical attention in developing countries are not destitute. In their countries they may form part of the middle class but they certainly have higher purchasing power than the citizens of the countries they visit for medical attention. They are therefore welcomed in these countries by the governments who view medical tourism as a chance to create more national income from it therefore it is greatly encouraged.

Medical Tourism

Medical tourism is a multimillion business that is known worldwide. However medical tourism if not well managed may result in some problems to the countries the medical tourist visit. Just like the common tourism you always know of, I mean that of adventure and leisure that has both positive and negative impacts on the countries the tourists visit the medical tourism is also a double edged sword. It therefore needs to be well managed for the benefits to be enjoyed. Apart from all the benefits that a country visited by a medical tourist will get, we need to look at the role of medical tourism in treatment of addiction.

Medical Tourism avails effective treatment for addiction

Medical tourism has far many benefits to an addict seeking help. To begin with we know that that the biggest hurdle to addicts in overcoming addiction is the presence of triggers that lie just outside the rehab walls. A change in the environment especially leaving a country to a different provides an addict with an opportunity to evade these triggers that may make him to fall back into drug use. These triggers may include the people they were drinking with or even some type of music that is usually played in bars and other places of leisure as people drink and use other drugs. When a person is receiving treatment in a different country, not only the location changes but also the culture which places learning and adventure at the top of the list while pulling the triggers out of the way of an addict.

The addict will also have access to some of the most unique addiction treatment practices across the world, treatments that have been used for centuries in treatment of addiction and have been proved to be very effective. Without the limits of the addicts country’s borders, a whole new world of variety of effective treatments open up for the addict to explore and choose from, of course with help from highly qualified doctors and healers. An example of a unique treatment of addiction that medical tourism avails for an addict is the Ayurvedic herbal Treatment;

Ayurvedic Herbal Treatments of addiction

Ayurvedic treatments are one of the oldest therapies in the world with its roots in India. It is based on the belief that health and wellness depend on a delicate balance between the mind, body, and spirit. The primary focus of Ayurvedic medicine is to promote good health, rather than fight disease. But treatments may be recommended for specific health problems. The best thing with ayurvedic treatment is that it is holistic. That is to say that it focuses more on the wellness of the patient other than on treating the patient of the symptoms of the disease. It focuses on uprooting the disease by maintaining the delicate balance of the mind, the body and the spiritual being of the patient.

Medical TourismOne of the greatest Ayurvedic theories is that everything in the universe be it living or not are not is connected. Good health is achieved when your mind, body, and spirit are in harmony with the universe. Even the slightest disruption of this harmony can lead to poor health and sickness. A person should therefore coexist with the universe. To begin with you need to appreciate the fact that anything that affects your physical, spiritual, or emotional well-being can cause you to be out of balance with the universe and therefore bring you lots of diseases. Ayurvedic treatment is also known as Ayurveda. Through medical tourism addicts from all over the world have been travelling to India for Ayurvedic herbal treatments. This can be credited to its effectiveness in treatment of addiction. Ayurvedic medicine works through these mediums to help an addict overcome addiction and offer complete healing.

Ayurvedic Diet– through ayurvedic diet, a patient will get lost nutrients restored; ayurvedic healers will tailor a diet aimed at recovery for every patient.

Meditation – this is a crucial part of Ayurveda. Meditation helps addicts in the path of self-discovery and also helps them deal with stress and depression better. It effectively addresses depression which is common in addicts as a withdrawal symptom.

Yoga– this involves a series of exercise and postures that will help in deep purification that is needed in getting drug debris out of the system of the patient. It only improves good health and restores the balance of energy in the body.

Achieving Balance– when a person has recovered from drug addiction, ayurvedic medicine will help him to achieve and maintain the physical, mental, and spiritual health balance.

Finally, addiction is a disease that should be approached integratively just in order to be won. Medical tourism avails an opportunity for an addict to find integrative medicine that may not be in their countries. Here at AWAREmed we are dedicated to offer the best treatment available to addicts. Contact Dr. Dalal Akoury (MD) for more help in any kind of addiction you may be wrestling with.

The Role of Medical Tourism in Treatment of Addiction

 

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E-Cigarettes are Teen’s Favorite

January 5, 2015

 

E-Cigarettes Are More Popular Than Tobacco Cigarettes among Teens

E-cigarettesA recent research has found out that more teens use e-cigarettes than traditional, tobacco cigarettes or any other tobacco product. This research, a U.S national study showed that e-cigarettes surpass the traditional tobacco cigarettes in popularity especially among the teens.

The findings of this study came from the University of Michigan’s Monitoring the Future study, a study which tracks trends in substance use among students in 8th, 10th and 12th grades. It is not a once off study as it is done each year the nationally. This finding came as the body was working on its 40th year. This study surveyed 40,000 to 50,000 students in about 400 secondary schools throughout the United States.

“As one of the newest smoking-type products in recent years, e-cigarettes have made rapid inroads into the lives of American adolescents,” said Richard Miech, a senior investigator of the study.

In the survey the students were asked whether they had used an e-cigarette or a tobacco cigarette in the past 30 days. More than twice as many 8th- and 10th-graders reported using e-cigarettes as reported using tobacco cigarettes. This shows just how popular the e-cigarettes are to the U.S Teens.

The number of students who had used e-cigarettes in the post 30 days was even higher than those who had used traditional tobacco cigarettes. Of the 8th graders 9 percent had used e-cigarettes in the past 30 days while only 4 percent had used the traditional tobacco cigarettes within the same time. In 10th grade, 16 percent reported using an e-cigarette and 7 percent reported using a tobacco cigarette. Among 12th-graders, 17 percent reported e-cigarette use and 14 percent reported use of a tobacco cigarette. However the older teens report less difference in use of e-cigarettes versus tobacco cigarettes.

there might be other reasons why the e-cigarettes have gained so much popularity among the teens but as Lloyd Johnston, principal investigator of the project of the project puts it.; it may be because the e-cigarettes being relatively new. He opines that the 12th graders are not so much into the e-cigarettes as the lower graders since they were not introduced to the e-cigarettes while they were younger. He however relies on future surveys to reach a conclusion on this.

Battery-powered devices

E-cigarettes are battery-powered devices with a heating element. They produce an aerosol, or vapor, that users inhale. Usually, this vapor contains nicotine, although the specific contents of the vapor are proprietary and are not regulated. The liquid that is vaporized in e-cigarettes comes in hundreds of flavors. Some of these flavors, such as bubble gum and milk chocolate cream, are likely attractive to younger teens.

Despite their alluring characteristic, the e-cigarettes may serve as a point of entry into the use of nicotine, an addictive drug. The percentages of past 30-day e-cigarette users who have never smoked a tobacco cigarette in their life range from 4 percent to 7 percent in 8th, 10th and 12th grades. Nicotine is an addictive drug and the easy access of the e-cigarettes may propel the youths to nicotine addiction at younger age.

The e-cigarettes have become a primary source of nicotine to the teens; it is not a supplement to tobacco, most of the teens using e-cigarettes have never used the traditional tobacco cigarettes. The study is however yet to find out if the teens who use e-cigarettes exclusively later go on to become tobacco cigarette smokers. An insight in this will be of great help to the public health as lots will be done to mitigate nicotine addiction to the teens that may make them use tobacco cigarettes later.

The study reports that e-cigarette use among youth leads to a long-term decline in the use of tobacco cigarettes, which is at a historic low in the life of the study—now in its 40th year. In 2014, the prevalence of smoking tobacco cigarettes in the past 30 days was 8 percent for students in 8th, 10th and 12th grades combined. This is a significant decline from 10 percent in 2013, and is less than a third of the most recent high of 28 percent in 1998. The decline to the use of traditional tobacco cigarettes can be attributed to the fact that fewer young people today have ever started to smoke tobacco cigarettes. In 2014, only 23 percent of students had ever tried tobacco cigarettes, as compared to 56 percent in 1998. However the researchers are worried that the e-cigarettes may lead tobacco smoking and lead to increase in the use of tobacco cigarettes which are more harmful.

Perceived as harmless

E-cigarette“Part of the reason for the popularity of e-cigarettes is the perception among teens that they do not harm health,” Miech said.

Most students believe that e-cigarettes do not harm health. In this study only 15 percent of 8th-graders think there is a great risk of people harming themselves with regular use of e-cigarettes. This compares to 62 percent of 8th-graders who think there is a great risk of people harming themselves by smoking one or more packs of tobacco cigarettes a day. The teens are not quite aware of some of the health problems that may arise due to long-term use of e-cigarettes. This may be as a result of the fact that e-cigarettes are new and hence no comprehensive health impact assessment has ever been done on their use.

In spite of the rising use of e-cigarettes, it is good to note that it may lead to nicotine addiction which is just as harmful as any other addiction. Dr. Dalal Akoury of AWAREmed Health and Wellness Center has dedicated her life to helping addicts restore their lives by use of integrative medicine. Call her on (843) 213-1480 for help.

E-Cigarettes Are More Popular Than Tobacco Cigarettes among Teens

 

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