Tag Archives: Addictive behavior

Prefrontal cortex in addiction: The Executive Brain

Prefrontal cortex in addiction-Effect of Right and Left PFC

The Prefrontal cortex in addiction

Studies around problems in the brains prefrontal cortex have been associated with Impulsive action; a trait of addictive behavior.

The prefrontal cortex in addiction (PFC) is that portion of the brain located in the very front of the brain, just behind the forehead. It’s in charge of abstract thinking and thought analysis it is also responsible for regulating behavior. This includes mediating conflicting thoughts, making choices between right and wrong, and predicting the possible outcomes of actions or events. This brain area also governs social control, such as suppressing emotional or sexual urges. Since the prefrontal cortex is the brain center responsible for taking in data through the body’s senses and deciding on actions, it is most strongly implicated in human qualities like consciousness, general intelligence, and personality

Prefrontal cortex in addiction-Function

This vital region of the brain regulates thought in terms of both short-term and long-term decision making. It allows humans to plan ahead and create strategies, and also to adjust actions or reactions in changing situations. Additionally, the PFC helps to focus thoughts, which enables people to pay attention, learn, and concentrate on goals. This area is also the part of the brain that allows humans to consider several different yet related lines of thinking when learning or evaluating complex concepts or tasks. The prefrontal cortex in addiction also houses active, working memory.

The Prefrontal Cortex in Addiction

Chemical addiction is classified as a mental illness, such that addiction changes the brain in fundamental ways. An addiction disturbs a person’s normal hierarchy of needs and desires and substitutes new priorities connected with using drugs or alcohol. The resulting compulsive behaviors that override the ability to control impulses despite the consequences are similar to hallmarks of other mental illnesses.

Prefrontal cortex in addiction-Signs of Prefrontal Cortex Damage

  • Studies around problems in the brains prefrontal cortex have been associated with Impulsive action; a trait of addictive behavior.
  • Lack of dopamine in the prefrontal cortex is also associated with Attention Deficit Disorder (ADD).
  • Lack of serotonin is a common problem with juveniles who lash out.

Some believe that impulsive behavior says more about an addicts approach to their addiction rather than the addiction itself. If one asked, “Why would anyone use drugs knowing that they lead to suffering?”  The impulsiveness argument is a good answer, because it suggests that the thinking person is not in control, which reinforces the argument that the addict is powerless.

Prefrontal cortex in addiction-Signs of Addictive Behavior
  • Addicts differ in their capacity to exercise judgment and inhibit impulses.
  • The brain’s prefrontal cortex helps to determine the adaptive value of pleasure recorded by the nucleus accumbens and checks the urge to take the drug when it would be unwise.
  • If the prefrontal cortex is not functioning properly, an addictive drug has more power to monopolize the reward circuit.
Prefrontal cortex in addiction-Depression

Though depression involves an overall reduction in brain activity, some parts of the brain are more affected than others. In brain-imaging studies using PET scans, depressed people display abnormally low activity in the prefrontal cortex in addiction, and more specifically in its lateral, orbitofrontal, and ventromedial regions. And the severity of the depression often correlates with the extent of the decline in activity in the prefrontal cortex.

  1. Orbitofrontal cortex
  2. Lateral prefrontal cortex
  3. Ventromedial cortex
  4. Limbic system

The prefrontal cortex in addiction is known not only to be involved in emotional responses, but also to have numerous connections with other parts of the brain that are responsible for controlling dopamine, norepinephrine, and serotonin, three neurotransmitters that are important in mood regulation. More specifically, the lateral prefrontal cortex seems to help us choose a course of behavior by letting us assess the various alternatives mentally. The orbitofrontal cortex seems to let us defer certain immediate gratifications and suppress certain emotions in order to obtain greater long-term benefits. And the ventromedial cortex is thought to be one of the sites in the brain where we experience emotions and the meanings of things.

The two halves of the prefrontal cortex in addiction also seem to have specialized functions, with the left half being involved in establishing positive feelings and the right half in establishing negative ones. And indeed, in depressed people, it is the left prefrontal cortex that shows the greatest signs of weakness. In other words, when people are depressed, they find it very hard not only to set goals in order to obtain rewards, but also to believe that such goals can be achieved.

In healthy people, the left prefrontal cortex might also help to inhibit the negative emotions generated by limbic structures such as the amygdalae, which show abnormally high activity in depressed patients. In patients who respond positively to antidepressants, this over activity is reduced. And when the amygdalae remain highly hyperactive despite antidepressant treatment, the likelihood of a patient’s relapsing into depression is high.

It is also interesting to note that when someone’s left prefrontal cortex is operating at full capacity, the levels of glucocorticoids in their blood are generally very low. This follows logically, considering the harmful effects that high levels of glucocorticoids have on mood.

Brain-imaging studies have also shown that in patients with severe depression, the volume of the two hippocampi is reduced. This atrophy may be due to a loss of neurons that is also induced by the toxic effects of the high levels of glucocorticoids associated with recurrent episodes of depression. The extent of atrophy in the hippocampus even seems to be proportional to the sum of the durations of the episodes of depression, and depressions that are treated rapidly do not seem to lead to this reduction in hippocampal volume

Prefrontal cortex in addiction-Effect of Right and Left PFC

 

 

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None is immune to stress and addiction

None is immune to stress and addiction-All are at risk

.Addiction

Professionals work in very stressful environment and many of them are suffering from addiction secretly

It’s easy to think only the less privilege in the society is the possible candidates for stress and addiction. This school of thought is in the mind of the majority and everyone wants to believe it however this is not always the case. Everybody is at risk of being addicted to any substance or being stressful in any environment. If you go to health institutions you will find medical staff trying to offer treatment to addicts, you may be tempted to believe that they themselves aren’t suffering from the same. Some are, and some definitely aren’t. In fact one out of 10 physicians have problems with alcohol or drugs at some point during their careers.

Those who admit they have an addiction to alcohol or drugs, as well as those who slip up and get reported, usually have to go through an intense substance abuse program before they can practice medicine again. Such physician health programs are pretty effective, helping around 80% of doctors recover from their problems. But these programs raise some ethical questions and I ask.

None is immune to stress and addiction-Is your doctor impaired?

Given that drug- or alcohol-impaired doctors aren’t rare, it’s possible you may come across one someday that is if you haven’t. You might suspect a drug or alcohol problem from your doctor if you notice some of these signs:

  • slurs words
  • stumbles
  • lacks coordination
  • forgets beyond what is reasonable
  • looks unusually disheveled
  • is irritable or easily angered
  • becomes overly emotional

It must be noted that these aren’t specific to drug or alcohol abuse, but they could be the result of drug or alcohol use. They could also be due to many other issues, such as a personal problem (marital difficulty or death of a loved one, among others), a medical illness (such as diabetes or the onset of dementia), or another mental health problem. Keep in mind that doctors, like the rest of us, can be very good about hiding an addiction. This drug problem is not affecting only the medics but it cuts across all professions.

None is immune to stress and addiction-Reporting

What should you do if you think one of your doctors has a drug or alcohol addiction? For your own protection, it would make sense to find a new doctor, though this might be difficult if there aren’t many in your area. If the doctor you are concerned about works in a group practice or a hospital setting, talk with the practice administrator, clinic chief, division head, ombudsman, or other doctor in the practice in an objective and matter-of-fact way. They are obligated to ensure that their colleagues are safe to practice medicine.

If your suspicions are strong enough, and you don’t trust the doctor’s colleagues to take appropriate action, voice your concerns to the state board of medicine. Someone there will then be obliged to do some investigating.

Who is an addict? With addictive tragedies striking every community in the nation – with many millions of Americans addicted to alcohol and drugs alone – legions of scientists are asking: What aspects of psychological makeup contribute to addiction? Are there common threads that weave through all addictions, from hard drugs to cigarettes, from gambling to overeating?

It is part of a much broader effort that has already seen progress in understanding the chemistry of addiction, as biochemists isolate the chemicals and mechanisms by which the brain gives itself pleasure. And the whole panoply of addiction research has led to insights that buttress a profusion of therapies. Though some of them hold great promise, all would benefit from an increased understanding of the addictive personality.

Despite the wide gulf between an addiction to drugs and an addiction to gambling, some mental health experts find it useful to view addiction as including all self-destructive, compulsive behaviors. Some even go so far as to include the relatively benign activity of compulsive television-watching.

In bringing together much of the existing knowledge on the personality’s role in addictions, with an emphasis on drugs and alcohol, a new study prepared for the National Academy of Sciences concludes that there is no single set of psychological characteristics that embrace all addictions. But the study does see common elements from addiction to addiction.

None is immune to stress and addiction-Factors contributing to addiction

The report finds that there are several ”significant personality factors” that can contribute to addiction:

  • Impulsive behavior, difficulty in delaying gratification, an antisocial personality and a disposition toward sensation seeking.
  • A high value on nonconformity combined with a weak commitment to the goals for achievement valued by the society.
  • A sense of social alienation and a general tolerance for deviance.
  • A sense of heightened stress. This may help explain why adolescence and other stressful transition periods are often associated with the most severe drug and alcohol problems.

Professionals believes that the continuing search for the personality traits that play a part in the development of addictions is an essential part of the broader fight against addiction, an opinion shared by others familiar with the field. ”If we can better identify the personality factors, ”they (doctors) can help us devise better treatment and can open up new strategies to intervene and break the patterns of addiction.”

Moreover, it’s believes that the insights provided by this kind of research could lead to much more effective preventive programs than those available today, to be used ”before problems reach the critical stage.” Supplementing the personality factors listed in the academy’s report, other behavioral scientists who have studied addicts point to additional often-found features of personality or background – a lack of self-esteem, marked depression or anxiety, physical or sexual abuse in childhood, and sharply conflicting parental expectations.

The broad approach to addiction is taken by Lawrence J. Hatterer, an associate clinical professor of psychiatry at the Cornell University Medical College who wrote in his book, ”The Pleasure Addicts” (Barnes) that ”Addictive behavior has invaded every aspect of American life today. We all feel the cloud of concern about becoming addictive – preoccupation with weight, smoking, drinking too much, or being caught in an excess of spending, acquiring, gambling, sex or work.”

Among other activities which, done in excess, have been characterized as addictive behavior are caffeine consumption, eating of chocolates or other sugar-laden foods, television watching, playing video games and even running.

None of these activities are considered to be addictions by doctors unless they involve excessive, repetitive use of pleasurable activities to cope with unmanageable internal conflict, pressure and stress. While such activity may begin pleasurably in a person’s life, the process in the addict involves increasing activity to achieve the same effect and eventually results in injury to the person’s health or to his work, family and social relationships. The addicted person typically denies that his activity is detrimentally affecting him. If the addict is forced to stop, he finds he suffers physical or psychological withdrawal pains, and often feels compelled to resume his excessive pattern.

None is immune to stress and addiction-All are at risk

 

 

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