Mitochondrial dysfunction and obesity

February 12, 2014

Mitochondrial dysfunction and obesity-In action

Mitochondrial diseases result from failures of the mitochondria, specialized compartments present in every cell of the body except red blood cells

Dysfunction means that something is not working or functioning in the correct way. Mitochondrial dysfunction refers to a situation in which the mitochondria are not working properly.

Mitochondrial diseases result from failures of the mitochondria, specialized compartments present in every cell of the body except red blood cells. Mitochondria are responsible for creating more than 90% of the energy needed by the body to sustain life and support growth.

When they fail, less and less energy is generated within the cell. Cell injury and even cell death follow. If this process is repeated throughout the body, whole systems begin to fail, and the life of the person in whom this is happening is severely compromised. The disease primarily affects children, but adult onset is becoming more and more common.

Depending on which cells are affected, symptoms may include loss of motor control, muscle weakness and pain, gastro-intestinal disorders and swallowing difficulties, poor growth, cardiac disease, liver disease, diabetes, respiratory complications, seizures, visual/hearing problems, lactic acidosis, developmental delays and susceptibility to infection

Mitochondrial dysfunction -Approaches to Resuscitate Aging Mitochondria

Understanding the proposed mechanisms by which mitochondrial dysfunction can contribute to aging and aging related diseases suggests several potential interventions. These include:

Maintenance of optimal Krebs cycle and respiratory chain efficiency.
Restoration of mitochondrial membrane fluidity.
Reduction in deleterious free radical activity.

CoQ10

Coenzyme Q10 is probably the most widely used cofactor for treating mitochondrial-related diseases. CoQ10 functions as the electron carrier in the inner mitochondrial membrane, transferring electrons from complexes I and II to complex III. In addition to increasing biosynthesis of ATP (the universal energy molecule), and acting as a potent free radical scavenger, CoQ10 also reduces lactic acid levels, improves muscle strength, and decreases muscle fatigability.¹

Mitochondrial dysfunction-restoration will cause weight loss

The role of your metabolism is to take the oxygen we breathe and the food we eat and process it to make energy, the fuel for life. (The fuel for your car is called gas. The fuel for your body is called ATP and it is produced from the combustion of food and oxygen.)

When they are not working properly, you suffer all the symptoms of low energy: fatigue, memory loss, pain, rapid aging, and more. Along the way, many things can go wrong that may impede your metabolism, make it run less efficiently, or practically shut it down.

Fatigue is the most common symptom of poorly functioning mitochondria. We need to keep them in top shape. The reason we poop out as we age is the constant insult and injury we give our mitochondria.

We have over 100,000 trillion of these powerhouses in our body, and each one contains 17,000 little assembly lines for making ATP, our major fuel. They use over ninety percent of the oxygen we breathe. They take up forty percent of the space inside the heart cells. The only problem is they are very sensitive to damage.

And the injury is from uncontrolled oxidative stress, which results from toxic insults, infections, allergens, stress, and just eating too much poor quality food.

Dr. Bruce Ames, the renowned scientist from the University of California at Berkeley, has spent the last decade discovering how we can give ourselves a metabolic tune up.

In one study he gave old rats who were tired, wouldn’t get on the treadmill anymore, and couldn’t find the cheese in the maze, or swim very far, two molecules that boost metabolism, that make the mitochondria run better. They are alpha lipoic acid and acetyl-L-carnitine.

Overnight these rats became young rats. They got up on the treadmill themselves, swam long distances without fatiguing and could easily find the cheese in the maze like young healthy rats. How could that happen?

Well, he simply gave the cells the raw materials they need for optimal function. As we age, our metabolism burns out from a lifetime of damage and insults. So again, the way to get healthy, the way to ultra-Wellness is very simple.

Depending on which cells are affected, symptoms may include loss of motor control, muscle weakness and pain, gastrointestinal disorders and swallowing difficulties…

Ultimately the goal of Ultra Wellness is to give everyone a metabolic tune up.

First, find the things that damage your metabolism and mitochondria.
Second, give your body the things that help the mitochondria function optimally.
Getting rid of toxins in the body will give you more energy. So here’s another reason to exercise: Exercise accelerates the detoxification process.
Exercise pushes the blood to circulate more efficiently through the body, allowing nutrients to move easily to reach all the organs and muscles.
Exercise helps lymph fluids circulate through the body, which removes toxins and other harmful materials. When you exercise, you naturally take in more oxygen; to make room for the added oxygen, your cells kick out toxins that are taking up space. When you exercise properly, your build up a sweat and toxins are released through the pores of the skin.
Playing at anaerobic levels is a great way to get in peak shape. It doesn’t do anything for longevity, or probably for overall health, but it’s great for vim, vigor and pure fitness.
Regular exercise is one of the most important things you can do for health. Participation in physical activity improves several body functions. These include: weight control, decreased risk of cardiovascular disease, decreased risk of diabetes, reduced risk of cancer, improved strength of bones and muscle, enhanced emotional status, decreases the natural degenerative changes that come with aging, and increases your chances to live longer.
That said, being consistently active can actually cause degeneration. Rest and recovery periods are essential as these periods allow the body to repair and rebuild itself.

Mitochondrial dysfunction –and exercise

It must be noted that consistent exercise can lead to overuse injury. Be sure to discern between consistently exercising and regular exercise.

Mitochondrial dysfunction and obesity-In action

Neurotransmitters dysfunction and obesity

February 11, 2014

Neurotransmitters are the naturally occurring chemicals inside your body that transmit messages between nerve cells. In the brain alone there are 183 different neurotransmitters. Two major neurotransmitters are…..

Neurotransmitters

Neurotransmitters are naturally occurring chemicals that “transmit” electrical messages between nerve cells, called “neurons” hence the name neurotransmitters. They are produced in the body by amino acids with the help of vitamins and minerals. We get these amino acids, vitamins and minerals from the food we eat. However, if we are not getting enough of these or in an imbalanced ratio a deficiency occurs and over time can lead to the development of diseases and illnesses associated with low levels of neurotransmitters.

What diseases are associated with neurotransmitter dysfunction?

According to Neuro-Research a list of diseases or illnesses are caused by or associated with neurotransmitter dysfunction. Neurotransmitter dysfunction leads to obesity and the diseases resulting from obesity, as well as other diseases not associated with obesity. Causes of neurotransmitter dysfunction There are four known primary causes of neurotransmitter dysfunction. 1: Nutritional Deficiency 2: Prescription drugs 3: Damage to the neurons of the brain 4: Excess excretion of neurotransmitters by the kidneys

Neurotransmitter dysfunction -Why is lab testing only used after starting amino acid therapy?

This is a common question. We are used to a medical community that runs tests first and then treats based on the test. However with neurotransmitters, hyper excretion is a common problem. Hyper excretion results when the kidneys are excreting excessive amounts of neurotransmitters so that the urinary values don’t match up with the systemic values. Once treatment starts with amino acids this problem doesn’t seem to occur. Therefore testing is NOT performed prior to supplementation with amino acids.

Neurotransmitter dysfunction -How many supplements are involved in treatment and what is each doing?

There are two different programs available for treatment. The first specifically treats neurotransmitter dysfunction resulting in the “conditions related to obesity and neurotransmitter deficiency” listed right. The second program treats neurotransmitter dysfunction as well as weight loss by incorporating an appetite suppressant in the formula. This will assist in controlling your appetite, however, calorie restriction is still necessary to accomplish long-term weight loss. This second program can also be used to treat symptoms associated with Parkinsonism. If only one neurotransmitter system is not functioning properly, why do I have to take supplements that affect both systems? The reason is simple, according to Neuro-Research’s extensive research, they have found that 5% of patients have only serotonin dysfunction, 5% of patients have only catecholamine dysfunction and 90% of patients are a mixture of both. Both systems must be functioning properly for the entire system to be healthy and free of neurotransmitter disease. After you have started the program we will monitor your symptoms and lab test results and adjust the supplements accordingly. So in the end you may take more of one supplement than another to achieve an appropriate “balance”. More about the Neurotransmitter Support Supplements available! Proteins, minerals, vitamins, carbohydrates, and fats are the essential nutrients that make up your body. Proteins are the essential components of muscle tissue, organs, blood, enzymes, antibodies, and neurotransmitters in the brain. Your brain needs the proper nutrients every day in order to manufacture proper levels of the neurotransmitters that regulate your mood. Neurotransmitter Effects:

Control the appetite center of the brain.
Stimulates Corticotrophin Releasing Factor, Adrenocorticotropic Hormone, & Cortisol.
Regulate male and female sex hormone.
Regulates sleep.
Modulate mood and thought processes.
Controls ability to focus, concentrate, and remember things.
The Mind Body Connection.
The chemistry of our bodies can alter, and be altered by our every thought and feeling. Our bodies and our minds are truly interconnected; the health of one depends on the health of the other.

There are many biochemical neurotransmitter imbalances that result in mental health symptoms such as:

Adrenal dysfunction
Blood sugar imbalance
Food and Chemical allergy
Heavy Metal Toxicity
Hormone imbalance
Nutritional Deficiency
Serotonin/Dopamine/Noradrenalin imbalance
Stimulant and drug intoxication
Under or overactive thyroid

Neurotransmitter Imbalances Disrupted communication between the brain and the body can have serious effects to one’s health both physically and mentally. Depression, anxiety and other mood disorders are thought to be directly related to imbalances with neurotransmitters. The four major neurotransmitters that regulate mood are Serotonin, Dopamine, GABA and Norepinephrine.

Neurotransmitter dysfunction -The Inhibitory System

Neurotransmitter system dysfunction may contribute to the borderline personality disorder traits of impulsive aggression and affective instability

This is the brains braking system, it prevents the signal from continuing. The inhibitory system slows things down. Serotonin and GABA are examples of inhibitory neurotransmitters. GABA (Gamma amino butyric acid) GABA is the major inhibitory neurotransmitter in the central nervous system. It helps the neurons recover after transmission, reduces anxiety and stress. It regulates norepinephrine, adrenaline, dopamine, and serotonin; it is a significant mood modulator. Serotonin imbalance This is one of the most common contributors to mood problems. Some feel it is a virtual epidemic in the United States. Serotonin is key to our feelings of happiness and very important for our emotions because it helps defend against both anxiety and depression. You may have a shortage of serotonin if you have a sad depressed mood, anxiety, panic attacks, low energy, migraines, sleeping problems, obsession or compulsions, feel tense and irritable, crave sweets, and have a reduced interest in sex. Additionally, your hormones and Estrogen levels can affect serotonin levels and this may explain why some women have pre-menstrual and menopausal mood problems. Moreover, daily stress can greatly reduce your serotonin supplies. The Excitatory Neurotransmitter System This can be related to your car’s accelerator. It allows the signal to go. When the excitatory neurotransmitter system is in drive your system gets all raved up for action. Without a functioning inhibitory system to put on the brakes, things (like your mood) can get out of control. Among other things, the following should be in place to restore neurotransmitters in attempt to achieve weight loss. Epinephrine It’s also known as adrenaline is a neurotransmitter and hormone essential to metabolism. It regulates attention, mental focus, arousal, and cognition. It also inhibits insulin excretion and raises the amounts of fatty acids in the blood. Epinephrine is made from norepinephrine and is released from the adrenal glands. Low levels have been can result in fatigue, lack of focus, and difficulty losing weight. High levels have been linked to sleep problems, anxiety and ADHD. Dopamine It’s responsible for motivation, interest, and drive. It is associated with positive stress states such as being in love, exercising, listening to music, and sex. When we don’t have enough of it we don’t feel alive, we have difficulty initiating or completing tasks, poor concentration, no energy, and lack of motivation. Dopamine also is involved in muscle control and function. Low Dopamine levels can drive us to use drugs (self-medicate), alcohol, smoke cigarettes, gamble, and/or overeat. High dopamine has been observed in patients with poor GI function, autism, mood swings, psychosis, and children with attention disorders. Glutamate It’s the major excitatory neurotransmitter in the brain. It is required for learning and memory. Low levels can lead to tiredness and poor brain activity. Increased levels of glutamate can cause death to the neurons (nerve cells) in the brain. Dysfunction in glutamate levels are involved in many neurodegenerative diseases such as Alzheimer’s disease, Parkinson’s, Huntington’s, and Tourette’s. High levels also contribute to Depression, OCD, and Autism. Neurotransmitter Levels Neurotransmitter levels can now be determined by a simple and convenient urine test collected at home. Knowing your neurotransmitter levels can help you correct a problem today or prevent problems from occurring in the future.

Neurotransmitters dysfunction and obesity-Exposition

Sleep deprivation causes weight gain and obesity

February 10, 2014

Sleep deprivation is the condition of not having enough sleep it can be either chronic or acute

Sleep deprivation causes weight gain and obesity-Find out

Sleep deprivation is the condition of not having enough sleep it can be either chronic or acute

Think about it: If you’re feeling sleepy at work, you may be tempted to reach for a cup of coffee or may be more and a doughnut for a quick shot of energy. Later you may skip the gym and pick up take away on your way home to your family no time to cook. When you finally find yourself back in your bed, you are too wound up to sleep.

Sleep deprivation-Recommended Related Disorders

Narcolepsy Resources

Left untreated, narcolepsy may be devastating both psychologically and socially. However, with proper management and treatment, people with narcolepsy usually lead meaningful and productive personal and professional lives. If you are diagnosed with narcolepsy, consider joining a support group.

By becoming a member of a support group, you’ll get emotional support from people who are having similar problems. This will alleviate isolation and the feeling that you are the only one with this condition. The exchange of ideas with people of the same situation will go a long way in helping you make corrections and evaluate progress.

It’s important to note that it’s is a vicious cycle, and eventually this sleep deprivation can sabotage your waistline and your health.

It starts out innocently enough. “When you have sleep deprivation and are running on low energy, you automatically go for a bag of potato chips or other comfort foods according to experts. The immediate result you may be able to fight off sleepiness. However the ultimate result would be unwanted weight gain as poor food choices coupled with lack of exercise set the stage for obesity and further sleep loss.

Experts say sleep debt is like credit card debt. If you keep accumulating credit card debt, you will pay high interest rates or your account will be shut down until you pay it all off. If you accumulate too much sleep debt, your body will crash.

Not getting enough sleep is common and we talked about it with pride. We brag about an all-night out not knowing that we do pay a price for staying up late and getting up early,” says Mark Mahowald, MD, director of the Minnesota Regional Sleep Disorders Center in Hennepin County.

Sleep deprivation-Understanding the Sleep Diet Connection

The sleep-diet connection is regular fodder for diet books and magazine articles. Maybe you have even heard about the sleep diet, which suggests you can lose weight while you catch your ZZZs. And it’s true, sort of.

“It’s not so much that if you sleep, you will lose weight, but if you are sleep-deprived, meaning that you are not getting enough minutes of sleep or good quality sleep, your metabolism will not function properly,” explains Michael Breus, PhD, author of Beauty Sleep and the clinical director of the sleep division for Arrowhead Health in Glendale, Ariz.

On average, we need about 7.5 hours of quality sleep per night, he says. “If you are getting this already, another half hour will not help you lose 10 pounds, but if you are a five-hour sleeper and start to sleep for seven hours a night, you will start dropping weight.”

Exactly how lack of sleep affects our ability to lose weight has a lot to do with our nightly hormones, explains Breus.

The two most important hormones in this process are ghrelin and leptin. “Ghrelin is the ‘go’ hormone that tells you when to eat, and when you are sleep-deprived, you have more ghrelin,” Breus says. “Leptin is the hormone that tells you to stop eating, and when you are sleep deprived, you have less leptin.”

More ghrelin plus less leptin equals weight gain.

“You are eating more, plus your metabolism is slower when you are sleep-deprived,” Breus says.

The Sleep Deprivation-Weight Loss Solution

So what can you do about sleep deprivation?

A lot, says Breus. First, look at how much you sleep vs. how well you sleep. “Some people such as new moms may only get to sleep for a four-hour stretch. And there are some people who get 7.5 hours of sleep that is poor quality because of pain or an underlying sleep disorder, and this has the same effect as if they got less sleep,” he says.

Trouble-shoot both with improved sleep hygiene, he says.

Sleep deprivation information including symptoms and causes

Not sleeping enough and not sleeping well is not OK. As a matter of fact, there is quite a price to pay. It may surprise you to learn that chronic sleep deprivation

For starters, avoid any caffeine in the afternoon because it will keep you in the lighter stages of sleep which are associated with poor sleep at night. Breus recommends only decaf from 2 p.m. on. Exercise also helps improve sleep quality. How soon before bed should you exercise? It depends everyone is different. It’s more important that you exercise than it is when you exercise. Breus says to be safe, don’t exercise right before going to bed. “But some people exercise better before bed and it doesn’t affect their sleep,” he says.

Watch what you eat before bedtime. “Pizza and beer before bedtime is not a good idea,” says Breus. “Neither is eating a big meal close to bedtime.” He suggests eating a few healthy snacks and then having a light meal like a bowl of cereal if you’re running close to bedtime. Heavy, rich meals before bed can also increase risk of heartburn, which will certainly keep you up all night.

What if you are getting enough hours of sleep but wake up and feel sleepy the next day? “Talk to your doctor about seeing a sleep specialist,” Breus says. After conducting a thorough evaluation and sleep study, in which you are monitored while sleeping, the sleep specialist can help identify any underlying problem. Together you can develop a treatment plan so that you get more high-quality sleep — and maybe even slim down.

Sleep deprivation causes weight gain and obesity-Find out

Health & Fitness – Article 15
Adrenaline, Stress and Obesity-All you need to know
Toxins and Neurotoxicity Pathogenesis of Obesity
Leptin and adinopectin roles in obesity and weight loss
Healthy Rapid Weight Loss Begins with Safe Detox
Body inflammation causes obesity
Testosterone Pellets Treat Chronic Fatigue
Take Charge Lose Fat Weight Fast With Knowledge
Obesity in America: Safe Rapid weight loss, Obesity is preventable
Female hormones and weight loss

Female hormones and weight loss

February 10, 2014

Female hormones and weight loss-what you need to know

Female hormones and their sites

A quick observation at a male versus a female body tells you right away something is different. While we can certainly recognize the obvious, we ignore these differences when we talk about diet and exercise for fat loss. The standard health and fitness advice of eat less and exercise more often does not work once people get out of their twenties and into their thirties, forties and beyond, and women are especially impacted.

So what are the difference between men and women, what determines where women store fat, and what can women do to address the fitness and fat loss issues that are unique to them?

The differences between men and women:

Women usually have smaller waists and more fat storage on the hips, thighs, and breasts. Estrogen and progesterone have much to do with this.

Estrogen is largely responsible for greater fat storage around the hips and thighs while both estrogen and progesterone impact larger breasts.

Because wom en experience monthly hormone fluctuations through the menstrual cycle, they know from experience that hormones impact how they feel, function, and look. They seem to intuitively get the fact that hormones play a role in determining whether they store fat or burn fat and where on the body it is lost or gained. To understand why women are so different, you have to understand their hormones.

Brief review of the menstrual cycle.

No discussion of female fat loss can take place without understanding the normal female menstrual cycle. The first day of bleeding for a woman represents day one of the menstrual cycle.

The menstrual cycle can then be divided into two phases, the follicular phase (named for the maturing of the ovarian follicle) and the luteal phase (named for the corpeus luteum which ovarian follicles become after ovulation). Ovulation, the release of an egg from the ovaries separates these two parts of the cycle.

The follicular phase is associated with higher estrogen levels compared to progesterone, while the luteal phase is the reverse. The relative ratios of these two hormones can have an impact on female related fat loss and health.

Estrogen and progesterone balance

A key fat loss measure in women is the estrogen and progesterone balance and how those hormones interact with other hormones like cortisol or insulin. Bigger hips and thighs on a women suggest greater estrogen levels relative to progesterone. The reverse of that, larger breasts and smaller hips and thighs, MAY indicate the opposite balance of these hormones.

The menstrual cycle is another key indicator of hormone balance. Since the time just before menses is usually a progesterone dominant time, PMS is a strong indication there is a progesterone deficiency relative to estrogen.

A woman can have higher than normal progesterone levels but still have a relative deficiency if estrogen levels are much higher in comparison. Many women with low progesterone relative to estrogen will report feeling like a completely different person before ovulation (the first two weeks of cycle) vs. after ovulation (last two weeks of cycle), where they feel much worse. This ill feeling usually manifests as depression, breast tenderness, moodiness, fatigue, lack of motivation, bloating, and other complaints.

Female fat distributions

Progesterone & estrogen both play a role in keeping the waist of women smaller. This is because estrogen works against the action of insulin (and testosterone a belly fat storing hormone in women) while both estrogen and progesterone oppose the action of cortisol. Insulin and cortisol, together with testosterone and low estrogen, are implicated in belly fat deposition in women.

Estrogen is the biggest factor in increasing fat storage at the hips and thighs providing the hour-glass shape. Progesterone with estrogen halts the storage of fat around the waist, but stress can have more of a negative impact on progesterone’s action. High stress has been shown to negatively impact progesterone, so women who see fat accumulating around the waist may want to work to reduce stress and raise progesterone.

Estrogen is a little different. Estrogen works to increase fat storage by up-regulating what is known as alpha-adrenergic receptors in female fat depots around the hips and thighs. Adrenergic receptors are like the gas and brake peddles on your car and work to accelerate or decrease fat usage. Beta-adrenergic receptors increase fat burning while alpha adrenergic receptors block it. The hips and thighs of a woman have higher amounts of alpha adrenergic receptors compared to men. This is also the major reason it is so difficult for some women to lose fat from the hips and thighs.

It is interesting to note here that one of the best ways to decrease the action of these alpha receptors is by using a low carb diet. This is why many women find fantastic results when they switch from the standard high carb diets and adopt more low carb eating patterns.

Many women have plenty of fat to spare in the hips and thighs but instead of burning it, they will become smaller in the torso and breast first and remain bigger on the bottom. This is a very frustrating scenario for many. Estrogen increases alpha-adrenergic receptor numbers while progesterone decreases it. Progesterone, like testosterone in men, MAY increase beta-adrenergic receptors. In this way, estrogen and progesterone work to influence the ability to burn fat and determine from which areas it will be taken from. This is an issue of hormone balance not calories.

Female hormone changes: age, lifestyle, and the environment

Female hormones have a great contribution to loosing weight

Women are often duped into believing the low calorie diet and aerobic exercise myth. This approach to weight loss rarely works and often creates damage to their body as a consequence. As a woman ages, as a consequence of stress, or because of environmental estrogen mimicking compounds several things begin to occur. The ovaries decrease their production of estrogen and progesterone. This exacerbates estrogen and progesterone balance, further pushing the body more towards estrogen dominance.

There are also many estrogen mimickers in our food and environment. At the same time, fat cells continue to produce estrogen through an enzyme called aromatase present in fat cells. This also leads the estrogen/progesterone balance to shift more towards estrogen. At the same time slimming and muscle building hormones, like human growth hormone (HGH) and DHEA, decline. Together this creates the perfect storm for female related fat gain and most of it occurs in the mid-section.

DHEA, HGH and progesterone are all hormones that act to keep a woman lean and block the storage of fat in the middle of her body. The tricky part is that a low calorie diet and a focus on aerobic exercise makes this worse because they do nothing to restore these powerful hormones and may actually worsen the estrogen progesterone imbalance in the long run.

Solutions to the problem:

Women should be focused on eating more of the right things and exercising smarter. This means eating higher amounts of vegetables and “estrogen free protein as well as engaging in weight training over cardio. There are only three ways to reliably restore HGH in the body: sleep, adequate protein, and intense exercise using weights.

Weight training is perhaps the most important aspect of this and is critical for female health especially to stop the belly fat that accumulates during aging. HGH is to women what testosterone is to men. It keeps them looking young, lean, and firm. Once progesterone levels fall due to stress, menopause, or other factors, HGH is all that is left to keep belly fat in check

Women falsely believe less intense exercise like walking and yoga will give them the desired “look” of their younger years. While these activities are exceedingly healthy, they will not be adequate to generate the hormonal effect needed to raise HGH. However, they will work synergistically with more intense exercise to lower the negative impact of cortisol.

Female hormones and weight loss-what you need to know

Healthy Rapid Weight Loss Begins with Safe Detox

January 14, 2014

Effect of toxins and neurotoxicity in pathogenesis of obesity

Healthy Rapid Weight Loss Begins with Safe Detox; Obesity is a metabolic disorder that can be characterized by abnormal accumulation of fat with associated co-morbidities. According to World Health Organization (WHO, 2010), over 300 million adults and 12 million children are obese, globally. Obesity is a complex disorder that involved several causatives including genetic, environmental and other factors. Obesity results in impaired energy homeostasis that is regulated by the higher centers. Studies have confirmed the role of hypothalamus in obesity (Kennedy 1953). However, the complete role of hypothalamus on fat regulation is unknown. Environmental toxins could contribute to neuronal damage, neurotoxicity and obesity in humans (Chung and Yoon 2008; Edwards and Myers 2008). Obesity due to environmental toxins is often less studied by the research community.

Industrial heavy metals and biotoxins exposure could cause obesity in humans. A study conducted by Turunen et al (2008) has suggested that increased marine fish consumptions are linked with higher exposure to environmental toxins and obesity risk. Obesity could increase the susceptibility of metal-induced cardiovascular effects (Chen et al. 2007; Lant and Storey 2010). Neuronal control is the main component of fat regulation and energy homeostasis maintenance. Gross anomalies in the frontal lobe could contribute to obesity (Pannacciulli et al. 2006; Taki et al. 2008; Ward et al. 2005). Experimental studies have demonstrated the direct association between increased adiposity and exacerbated neurodegeneration (Chen and Lipton 2006; Moroz et al. 2008; Sriram et al. 2002). Diabetic experimental animals fed with high-fat diet have exhibited symptoms of obesity with reduced brain weight and brain substrates including tau proteins (Moroz et al. 2008).

In experimental animals, methamphetamine induce dopaminergic neurotoxicity with reduced levels of striatal dopamine, dopamine transporter and tyrosine hydroxylase (Deng and Cadet 1999; Kogan et al. 1976; Sonsalla et al. 1989) and marked degree of neurodegeneration. When compared to lean experimental animals, the neurotoxic insult effects of methamphetamine were exaggerated in obese animals. Administration of methamphetamine could result in up-regulation of mitochondrial uncoupling protein-2 in the obese animals. These effects reduce ATP yield and cause obesity. Increased adipocyte apoptosis was reported in obese individuals with progressive neurodegeneration (Bharathi et al. 2006; Hirata 2002; Koh 2001; Ong and Farooqui 2005). In experimental animal studies, neurotoxins induced polyQ aggregation that was mediated by daf-16 and insulin-signaling pathway that contributes to obesity (Voisine et al. 2007; Ayyadevara et al. 2008; Gami et al. 2006; Grad and Lemire 2004; Inoue et al. 2005; Tullet et al. 2008). These studies have confirmed that obesity aggravates or induce neurodegeneration with impaired release of neurotransmitters such as norepinephrine (Belsare et al. 2010).

Healthy Rapid Weight Loss Begins with Safe Detox. Addictive substances such as MPTP are highly lipophilic in nature that readily cross the blood-brain barrier and cell membranes. The neuroactive chemical is metabolized intra-cellularly into MPP+. Due to polarity, the xenobiotic is released and taken up by dopamine metabolizing cells via the DAT ((Russ et al. 1996; Javitch et al. 1985). MPP+ inactivates complex I of mitochondrial respiratory chain in the dopaminergic neurons (Mizuno et al, 1988) and reduce ATP levels with increased free radical generation. These molecular changes contribute to neurodegeneration of dopaminergic neurons and obesity.

Healthy Rapid Weight Loss Begins with Safe Detox; * Detoxification and weight loss

Proper detoxification is vital for prevention of obesity and to promote weight loss among obese individuals. Detoxification process significantly reduces white adipose tissue storage in the vital organs and prevents generation of excessive fatty acids which are toxic to biological membrane.

Exposure to fat soluble toxins such as mold, PCB’s, formaldehyde, alcohol, pesticides and acetaldehyde due to digestive toxicity or overgrowth of intestinal candida could increase the risk of neurotoxicity and obesity. In low levels of toxicity, these environmental toxins cause thyroid dysfunction, liver degeneration and cellular health (Koob GF & Volkow ND, 2010; Spooren W et al, 2010; Purzycki CB & Shain DH, 2010; Hiestand PC et al, 2008).

Excessive exposure to these toxins could cause rapid weight gain with impaired defense mechanisms. Toxic challenges could contribute to neurotoxicity and metabolic crash. The role of fat-soluble toxins on neurotoxicity is mediated by activation of immune system and brain cell damage. These changes contribute to obesity and addictive behaviours with risk of Parkinsonism and Alzheimer’s disease (Russell L et al, 1991; Barone R et al, 2007).

Healthy Rapid Weight Loss Begins with Safe Detox under the supervision of a trusted qualified physician who understands proper and safe detox. Dr. Dalal Akoury the Founder of AWAREmed can coach through Healthy detox. Call 843-213-1480

The aim of the detoxification is to reduce the accumulation of fat-soluble toxins in the vital organs and circulation that contributes to obesity. Detoxification process promotes weight loss in a natural way by preventing neurotoxicity associated with dopaminergic and leptin pathways. Generally, detoxification includes tailored diet such as Leptin diet with moderate exercise regimen to meet the individualized needs and to relive stress. Detoxification programmes could be organ-specific including liver, bowel or general. Healthy weight loss programme should include proper detoxification with healthy and balanced diet.

Healthy Rapid Weight Loss Begins with Safe Detox * Liver detox and its effect on weight loss

Modern lifestyle with stress is a major contributing factor for obesity and unhealthy lifestyle. In the recent days, detoxification as a potential weight loss method is gaining steam among the health conscious individuals. Detoxification programme includes healthy diet with balanced nutritional supplements to flush out the toxins. Liver detoxification process includes drinking of adequate levels of water with organic foods such as fresh fruits, raw and nutritious vegetables to aid liver health.

During active liver detox process, consumption of alcohol, caffeinated beverages, refined and/or processed food or tobacco are not allowed. These changes could improve the liver health; help the tissues to purge the toxin and to regenerate.

Liver detox diet mostly comprised of antioxidants, fiber rich diet with lifestyle changes and exercise. Physical activity including moderate exercising is recommended to aid toxin elimination via the sweat and stools. Liver cleansing diets generally promote intestinal health with proper elimination of the waste substances including urine and stools.

Liver detox aids weight loss by reducing the stress mechanisms and negative neural feedback mechanisms that are linked with obesity. Liver detoxification cleanses the liver toxins and aids proper functioning including normal synthesis of enzymes, optimization of food assimilation and cholesterol regulation.

Healthy Rapid Weight Loss Begins with Safe Detox * Proper elimination of stool, urine, skin to achieve weight loss

Proper detox programme should aid complete elimination of stool, urine and sweat to improve weight loss among obese individuals. In addition with body’s own natural detoxification process, detox diets comprised of high-fiber diet, complex carbohydrates, proteins, vitamins and minerals improve the excretory system to function properly.

Adequate water consumptions regulate the renal system and aids elimination of waste substances including urea, salts, creatinine and uric acid. Normal fluid elimination could optimize fluid retention/balance and prevents obesity. Proper elimination of urine and sweat prevents edema and improve weight loss among obese individuals. Daily defecation is vital for weight loss. Weight loss diet should promote colonic microbiome that detoxify food wastes and strengthen intestinal walls against the entry of pathogenic microorganisms.

Liver aids detoxification process and converts lipid-soluble chemicals into water-soluble compounds and promotes renal excretion. Lipid-soluble toxins are the main contributors of neurotoxicity and obesity. Some toxins are also eliminated via the lungs and skin during moderate physical activities including exercise.

Proper elimination of waste substances as urine, sweat and stools acts a natural detoxification process and reduce the effects of naturally-derived toxins in the body. To promote proper elimination of urine, sweat and stools it is important to consume required levels of water with balanced, fiber-rich diet. These steps can increase satiety and maintains optimal blood glucose with proper elimination of waste substances. Normal blood glucose homeostasis with balanced food could reduce the obesity risk in humans.

Healthy Rapid Weight Loss Begins with Safe Detox What is *The Proper detoxification and mechanisms that facilitate weight loss?

Proper detoxification is important for balance of body mechanisms to lose weight. Some processes including treatment of hormonal imbalances, neutralization or enzyme potentiated desensitization with exercise could facilitate weight loss.

Treatment of hormonal imbalances, particularly adrenal and thyroid functions could improve the metabolic rate. Hormonal imbalances could delay the metabolic rate and also the detoxification process

Neutralization or Enzyme Potentiated Desensitization could reduce the sensitization against harmful chemicals and to reduce toxic load in the body. Decreased free radicals generation could prevent the onset of metabolic syndrome, a key causative of obesity. Normalization of glucose and other metabolic pathways could facilitate weight loss among obese individuals. (McEwen LM, 1973; McEwen LM, 1975)

When combined with patient-specific exercises, the metabolic rate could be increased with reduced gut transit time. These mechanisms lower the food clearance rate from the gut and increase satiety. Improved glucose metabolism with food control could facilitate weight loss.

Healthy Rapid Weight Loss Begins with Safe Detox addresses the* Links between detoxification pathways and weight loss

Detoxification promotes healthy weight loss by intake of nutrients with less calories, sugar and salt which are addictive in nature that contributes to obesity. Detoxification reduces dopaminergic cellular neurotoxicity and obesity.

Detoxification processes directly affects the leptin, insulin and dopamine pathways that contributes to food addiction and cravings. Fiber-rich diets with nutrients increase plasma ghrelin levels that regulate insulin and leptin pathways. Controlled and healthy weight loss can be achieved by regulation of white adipose tissue formation which depends on insulin and leptin pathways. Ghrelin controls satiety and appetite and promotes weight loss among obese individuals.

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