Category Archives: Heavy Metal Toxicit

Food addiction

Food addiction-Fighting food addiction

food addiction

food especially sugar is becoming the biggest luring substance to food addiction

There is one common addiction for all mankind, we are all in one way or the other addicted to food. Visualize how it feels like when you aren’t able to eat. You will probably start to crave for food, and become more physically and emotionally uncomfortable. The longer the cravings go on for, until eating becomes the most important thing for you to do. This is the constant experience of people struggling with food addiction, even if they have plenty to eat.

However food is essential to survival, and unlike other addictive behaviors, it is normal to eat repeatedly every day, and to look forward to eating for pleasure. But several characteristics separate normal or occasional binge eating from a food addiction.

The first point, food addiction is maladaptive, so although people overeat to feel better, it often ends up making them feel worse, and gives those more to feel back about. Food addiction can threaten health, causing obesity, malnutrition, and other problems.

The second point, the overeating that people with food addiction do is persistent, so a person addicted to food eats too much food and most of the time it’s the wrong kinds of food taken repeatedly. Everybody overeat from time to time, but people with food addiction often overeat daily, and they eat not because they are hungry, but as their main way of coping with stress.

The Controversy of Food Addiction

As behavioral addictions, the concept of food addiction is a controversial one. Opinions differs between those who think that overeating can be a type of addiction, and those who think that true addictions are limited to psychoactive substances which produces symptoms such as physical and withdrawal. Although this has been demonstrated in research with sugar and fat (the two most common obesity-causing constituents of food), and other studies show that food produces opiates in the body, many think that this does not necessarily constitute an addiction.

However, the growing epidemic of obesity over the past years has raised public health concern. In almost all US states, one in five adults are obese. Childhood obesity was ranked as the top health concern for children in 2008, higher than either drug abuse, rated second, or smoking rated third, both of which were ahead of obesity in 2007.

This concern, along with effective treatments for addictions, which are being successfully applied to more and more problematic behaviors, is contributing to a movement towards understanding over-eating, and the consequences of obesity and related health problems, in terms of addiction.

Food addiction is now included in the Diagnostic and Statistical Manual of Mental Disorders (DSM-5), named as Binge Eating Disorder, and categorized with the Eating Disorders. Excessive eating is also a characteristic of another eating disorders outlined in the DSM, known as Bulimia Nervosa. Some controversy remains over whether eating disorders are actually addictions, but many experts believe that they are.

Food Addiction like Other Addictions

There are several similarities between food addiction and drug addiction, including effects on mood, external cues to eat or use drugs, expectancies, restraint, ambivalence, and attribution.

Neurotransmitters and the brain’s reward system have been implicated in food and other addictions. In animal studies, for example, dopamine has been found to play an important role in overall reward systems, and binging on sugar has been shown to influence dopamine activity.

Food, drugs and other addictive substances and behaviors are all associated with pleasure, hedonism, and social, cultural or sub-cultural desirability. When advertising or the people around us tell us that a food, drug or activity will feel good, it sets up a self-fulfilling prophecy. We are more likely to seek it out, and we are more likely to experience pleasure when we indulge.

Food addiction and Mental Health

Similarities between food addiction and other addictions suggest a universal process underlying food and other addictions. Some experts go further, theorizing that overlaps, similarities, and co-occurrences of mental health problems, including addictions, depression, obsessive-compulsive disorder and eating disorders, and the phenomenon of a new addiction or mental health problem developing when an old addiction is treated, indicate that they are expressions of related underlying pathologies. It has been argued that viewing these conditions separately hinders the development of a comprehensive view of addictions.

In the study involving 39 healthy women with different weights from lean to overweight or obese, the participants were asked to complete the Yale Food Addiction Scale, which tests for signs of food addiction. Women with full-fledged eating disorders of any type were not included in the study.

Then, using fMRI, researchers led by Yale’s Ashley Gearhardt and Kelly Brownell looked at the women’s brain activity in response to food. In one task, the women were asked to look at pictures of either a luscious chocolate shake or a bland, no-calorie solution. For another brain-scan task, women actually drank the shake made with four scoops of vanilla Häagen-Dazs ice cream, 2% milk and 2 tablespoons of Hershey’s chocolate syrup or the no-calorie control solution, which was designed to be as flavorless as possible (water couldn’t be used because it actually activates taste receptors).

The scientists found that when viewing images of ice cream, the women who had three or more symptoms of food addiction things like frequently worrying about overeating, eating to the point of feeling sick and difficulty functioning due to attempts to control overeating or overeating itself showed more brain activity in regions involved with pleasure and craving than women who had one or no such symptoms.

These areas included the amygdala, anterior cingulate cortex and medial orbitofrontal cortex — the same regions that light up in drug addicts who are shown images of drug paraphernalia or drugs.

Similar to people suffering from substance abuse, the food-addicted participants also showed reduced activity in brain regions involved with self-control (the lateral orbitofrontal cortex), when they actually ate the ice cream.

In other words, women with symptoms of food addiction had higher expectations that a chocolate shake would be yummy and pleasurable when they anticipated eating it, and they were less able to stop eating it once they started.

Interestingly, however, unlike drug addicts, the participants with more signs of food addiction did not show a decrease in activity in pleasure-related regions of the brain when they actually ate the ice cream. People with drug addictions tend to derive less and less pleasure from drug use over time — they want drugs more but enjoy them less, creating compulsive behavior. But it’s possible that this tolerance may be seen only in serious addictions, not in people with just a few symptoms.

Notably, the study also found that food addiction symptoms and brain responses to food were not associated with weight: there were some overweight women who showed no food addiction symptoms, and some normal-weight women who did.

That’s why addictions aren’t simple: they involve variations not only in levels of desire, but also in levels of ability to control that desire. And these factors may change in relation to social situations and stress.

Neither heroin nor Häagen-Dazs leads to addiction in the majority of users, and yet there are certain situations that may prompt binges in people who otherwise have high levels of self-control. So the answers to addiction may lie not in the substances themselves, but in the relationship people have with them and the settings in which they are consumed.

Food addiction-Fighting food addiction

 

 

 

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TOXINS AND NEUROTOXICITY PATHOGENESIS OF OBESITY

 

TOXINS AND NEUROTOXICITY PATHOGENESIS OF OBESITY-EXPOSED

UNDERLYING MECHANISMS

Toxins

Toxins can alter the hormonal regulation of weight, a process that involves insulin, leptin, thyroid, cortisol, adiponectin, resistin, sex hormones, and gut hormones

The influence of toxins on metabolism occurs through 5 key

  • Mechanisms
  • Hormonal regulation,
  • Neuro-regulatory mechanisms,
  • Immune-regulatory mechanisms,
  • Mitochondrial function, and
  • Oxidative stress.

Toxins can alter the hormonal regulation of weight, a process that involves insulin, leptin, thyroid, cortisol, adiponectin, resistin, sex hormones, and gut hormones, including ghrelin, peptide (PYY), and cholecystokinin (CCK).   Toxins alter thyroid hormone metabolism and receptor function leading to lowered metabolic rate. Important Neuro-regulatory mechanisms affected by toxins include hypothalamic satiety modulation through effects on peripheral and central inhibitors and stimulators of appetite, including leptin, cortisol, melanocyte stimulating hormone (MSH), and neuropeptide (NPY). Stress induced autonomic dysfunction it also alters appetite and weight-control mechanisms.   Toxins can influence weight through toxin mediated increases in inflammatory cytokines (TNF-α, IL-6) on the peroxisome proliferator activated receptor (PPAR) family of nuclear receptors promoting insulin resistance, and on themelanocortin receptor (MCR) system altering central appetite regulation.   Counter regulatory signals triggered by inflammation such as suppressors of cytokine signaling (SOCS) induce leptin resistance. Toxins alter mitochondrial energetics by damaging enzymes involved in fatty acid oxidation and thermogenesis. Oxidative stress influences weight via NFκ B-mediated mechanisms of gene transcription that control insulin resistance and inflammation. Other mechanisms may include direct effects of toxins on hepatic control of lipid and glucose metabolism, and on inflammatory cytokines  

WEIGHT REGULATION AND TOXINS -WHERE DO TOXINS COME FROM?

Exposure to toxins comes from two main sources: the environment (external toxins) and the gut (breakdown products of our metabolism, or internal toxins). Both can overload endogenous detoxification mechanisms.    External Toxins The Dangers from without the external toxins include chemical toxins and heavy metals. The heavy metals that cause the most ill health are lead, mercury, cadmium, arsenic, nickel, and aluminum.   Chemical toxins include volatile organic compounds (VOCs), solvents (cleaning materials, formaldehyde, toluene, and benzene), medications, alcohol, pesticides, herbicides, and food additives.   Infections (hepatitis C virus) and mold toxins (sick building syndrome) are other common sources of toxins. Our modern refined diet can be considered toxic because it places an extra burden on detoxification systems through excessive consumption of sugar, high fructose corn syrup (the two most important causes of elevated liver function tests),trans fatty acids, alcohol, caffeine, aspartame, foods made with genetically modified organisms (GMOs), and the various plastics, pathogens, hormones, and antibiotics found in our food supply. Internal Toxins: Danger from Within Internal toxins include microbial compounds (from bacteria, yeast, or other organisms), and the breakdown products of normal protein metabolism.   Bacteria and yeast in the gut produce waste products, metabolic by-products and cellular debris that can interfere with many body functions and lead to increased inflammation and oxidative stress. These include endotoxins, toxic amines, toxic derivatives of bile, and various carcinogenic substances such as putrescence and cadaverine. Lastly, by-products of normal protein metabolism, including urea and ammonia, require detoxification

WEIGHT REGULATION AND TOXINS-Detoxification Enzyme Polymorphisms and Obesity

The effect of toxins on an individual is determined, in part, by the polymorphisms of phase I and phase II detoxification enzymes. Highly prevalent single nucleotide polymorphisms (SNPs) of glutathione transferase enzymes predispose to increased toxic loads.   Detoxification of heavy metals is an important task for the body. It depends on specific proteins and enzymes that bind the metals and transport them out of the cells. In one recent study, mice bred without the protein (metallothionein) that is necessary for heavy metal detoxification gained more weight over their lifetime than mice that could eliminate the metals. They were more sensitive to the effects of toxic metals and oxidative stress.   Toxins Impair Central Appetite Regulation Toxins have many effects. Besides directly lowering thyroid hormone levels, metabolic rate, and fat burning (fatty acid oxidation), they can damage the mechanisms by which hormonal and Neuro-regulatory signals control our appetite and behavior. These signals are finely choreographed and sensitive to environmental inputs.   To briefly review, the hypothalamic appetite-control system is centered in the acute nucleus. It receives peripheral feedback from leptin, insulin, PYY, and adiponectin. Central inhibition of food intake is regulated by pro-opiomelanocortin (POMC) and cocaine-and amphetamine regulated transcript (CART). Central stimulation of intake is modulated by Neuropeptide Y and agouti related peptide (AgRP).   The melanocortin system and its receptors, MC3R and MC4R, play a crucial role in appetite control. Specifically, MSH binds to MCR, suppresses appetite, stimulates the thyroid axis, and increases energy expenditure, brown fat temperature, and sympathetic activity. It is inhibited by TNF. Other downstream control sites also exist in the related areas of the brain. Reward centers also play a role and are targets for new drug research including the end cannabinoid and serotonin receptors. Leptin resistance is found in obesity.   Leptin’s inhibitory effect on appetite is impaired by toxins, leading to leptin resistance and increased hunger. Hyperleptinemia increases mitochondrial reactive oxygen species monocyte chemo attractant protein-1 (ROS MCP-1). Leptin induces inflammation in a feed-forward cycle. Toxins may inhibit satiety effects of leptin, leading to increasing hyperleptinemia. Researchers treated rats with a neurotoxin that damaged another.

WEIGHT REGULATION AND TOXINS-What Are the Benefits of Detoxing Your Body?

Toxins

Toxins can influence weight through toxin mediated increases in inflammatory cytokines (TNF-α, IL-6) on the peroxisome proliferator activated receptor (PPAR) family of nuclear receptors promoting insulin resistance

Detoxification is the process of removing toxins from the body. The process to detoxify your body involves many different elements such as herbal detoxification regimens, change of diet and vitamin supplements. It is one of the best ways to rid your body of toxins, which can slow it down and make it unhealthy. The process of detoxification requires some discipline. Physical Benefits The most noticeable benefits from detoxification are the physical ones. Since the toxins store up in major organs, detoxification will help these areas the most. The organs which are affected, such as the liver and stomach, will begin to work more effectively. After the detox is completed, you may feel “lighter” and have more energy. Also, since a detox is used to clear away free radicals, your body’s immune system will be stronger and you will have a lower risk of getting cancer. Finally, a detoxification regimen will clear your blood, helping it circulate better.   Mental Benefits Toxins and free radicals that accumulate in the body can also affect brain functions. Before a detox, you may have trouble sleeping, chronic fatigue, and trouble with your concentration. Once you work through this process, many of these issues will gradually disappear. You will be able to sleep better and concentrate more. Lifestyle Changes A benefit which most people don’t think of can be the change to your lifestyle. As you progress through the body detox, you will begin to feel better physically and mentally. This feeling can be addictive and lead to changing your lifestyle to cut out bad elements which give your body those toxins. Quitting smoking, eating better, and getting more exercise are all actions which help protect the body. After a detox is a perfect time to begin these actions.

TOXINS AND NEUROTOXICITY PATHOGENESIS OF OBESITY-EXPOSED

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Mercury poisoning and your foods

Mercury poisoning

Mercury poisoning

Dr. Dalal Akoury

Mercury poisoning: Is it so common? Yes, we are constantly exposed to mercury in whatever small amounts. This is because it is there in soft drinks and snacks that we often enjoy. So, let us know more about this element and save our health. Mercury is naturally found everywhere which includes air, water and soil. It is released into the atmosphere due to coal burning. This mercury then settles on land and water sources like rivers. Its toxic form called methyl mercury accumulates in fish and shell-fish. These are the main sources of mercury poisoning in human beings though it does not mean that all fishes have high mercury levels. Their mercury level depends on what they eat. What are the health effects of mercury poisoning? Exposure to mercury affects multiple organs including brain, heart, lungs, immune system and kidneys. Methyl mercury is rapidly absorbed from the intestine into the blood circulation. The health effects depend on whether it is inorganic mercury salts or organic methyl mercury. Methyl mercury mainly affects the nervous system and brain. Inorganic mercury affects not only brain but also causes pneumonia, kidney damage and bleeding disorder. Some of the health effects of Mercury poisoning include:

  • Ataxia: Inability to maintain body balance while standing or walking due to lack of coordination of muscles.
  • Loss of vision and hearing
  • Memory loss
  • Emotional dysfunction occurs due to involvement of frontal lobes of brain.
  • Dysarthria: difficulty in articulation.
  • Neuropathy: Loss of function of nerves like sensory, motor and autonomic functions. They develop tingling sensation and numbness of limbs. Sensory loss involving hands and feet may occur. Tremors or uncontrolled vibratory movements of limbs may occur.
  • Psychiatric disturbance resulting in abnormal behaviour
  • Kidney damage: Reduced kidney function occurs due to death of renal tubules which form urine.
  • Contact dermatitis, hyperpigmentation, stomatitis or inflammation in oral cavity. Rash may also appear over palms.
  • Respiratory difficulty occurs in acute mercury exposure.

What are the common sources of exposure to mercury poisoning?

 mercury poisoning.

English: Element mercury (Hg), liquid form. (Photo credit: Wikipedia)

Seafood: Consumption of a lot of seafood from contaminated water is the most important cause of mercury poisoning. High-fructose corn syrup: Detectable levels of mercury have been reported in high fructose corn syrup. In a scientific study published in the Journal of Environmental Health, they reported that high fructose corn syrup may contain about 0.570 micrograms of mercury. The WHO has recommended that consumption of less than 0.2 micrograms of mercury per kilogram of body weight is within safe limits. Since the average American consumption of soft drinks and other snacks containing high fructose corn syrup is very high, it poses a risk of mercury poisoning. Soft drinks and snacks: High fructose corn syrup is used as a sweetening agent in soft drinks and other food products. Some of these favourite snacks which contain high fructose corn syrup include oatmeal, barbecue sauce, chocolate syrup, cereal bars, jellies, dressings, yogurt and other milk drinks. This probably comes from caustic soda which is used for manufacturing high fructose corn syrup. Soft drinks in which high fructose corn syrup is added as a sweetening agent are also a potential source of mercury poisoning.

What to do at home to avoid or reduce mercury poisoning? You should be careful in your selection of food that is consumed at home. Sharks and tuna are especially rich in mercury and are better avoided. Pregnant and lactating mothers should avoid consumption of large fishes. Avoid taking processed foods containing high fructose corn syrup. Read labels carefully at the time of shopping. It adds value to life. Being extra careful will go a long way to reduce and prevent further accumulation of mercury in your body. This also helps in weight loss as high fructose corn syrup consumption is associated with obesity and its complications like atherosclerosis, hypertension, ischemic heart disease, stroke and obstructive sleep apnoea.

 

 mercury poisoning.

Soft drinks on shelves in a Woolworths supermarket (Australia). Taken by myself. (Photo credit: Wikipedia)

How to get rid of mercury which is already there? In people with serious disease with symptoms described above, chelating agents are used. These are chemicals with bind with mercury or convert it into non-toxic substance which is then easily excreted. These chelating agents include dimercaptosuccinic acid (DMSA) and Penicillamine. DMSA is the agent of choice in people with mild or chronic poisoning. For people with acute poisoning, Dimercaprol is used. If there is recent ingestion, the decontamination of the gastrointestinal tract is done. For this, activated charcoal is consumed and is known to neutralize both organic and inorganic forms of mercury. The other agent of use here is Polyethylene glycol. This is a laxative with strong osmotic effects.

Mercury poisoning and you foods

 

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Do you know that you live in a polluted environment?

 Do you know that you live in a polluted environment?

We live in a polluted environment.
The METAL-FREE Heavy Metal Detoxification ProgramOur food, air and water are contaminated with hundreds of toxic chemicals, heavy metals, pesticides, and herbicides.Heavy metals are lead, mercury, aluminum, antimony, arsenic, barium, beryllium, bismuth, bromine, cadmium, nickel, thallium, tin and uranium. See the  for more on these heavy metals, and how one comes into contact with them.

Mercury is one of the worst environmental poisons. It can come from:

(a) leaking amalgam/silver fillings, which are about 50% mercury
(b) residues from volcanic ash
(c) coal burning
(d) heavy fish consumption
(e) from vaccines containing thimerisol (ethyl mercury)

Tragically, millions of children have been inoculated with toxic doses of mercury in vaccines. Many feel this has contributed to a modern day epidemic of hyperactivity and autism related disorders.

 

 

 

 

 

 

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