Category Archives: Heavy Metal Toxicit

Unique Properties of Stem Cells

May 3, 2015

What Are The Unique Properties Of All Stem Cells?

Stem CellsThe stem cells have been hailed for their efficacy in treatment of certain diseases especially those that are degenerative in nature like the Parkinson’s disease, osteoarthritis and even the Huntington’s disease. To accomplish all its medicinal capabilities the stem cells must have certain properties that are not present in other body cells. They therefore differ from other cells in the body. The stem cells are available majorly in the bone marrows and the adipose tissues but can also be harvested from placentas after a safe delivery. The stem cells have three general properties regardless of their source. These properties are; they are capable of dividing and renewing themselves for long periods; they are unspecialized; and they can give rise to specialized cell types. It is these distinct characteristics of the stem cells that make them effective in treatment of degenerative diseases.

The other cells found in the body like the nerve cells, the muscle cells and the blood cells are not able to replicate themselves unlike the stem cells that are able to proliferate after long periods of time. Typically, a starting population of stem cells that proliferates for many months in the laboratory can yield millions of cells. What is more is that the daughter cells are capable of long term self-renewal giving rise to more unspecialized cells.

Despite the vast research that has been done on the stem cells and their ability to treat certain diseases there are some information that are still required which we can only hope that researchers will one day find an answer to. These questions are as follows:

  • Scientists are trying to understand two fundamental properties of stem cells that relate to their long-term self-renewal:
  • Why can embryonic stem cells proliferate for a year or more in the laboratory without differentiating, but most adult stem cells cannot; and
  • What are the factors in living organisms that normally regulate stem cell proliferation and self-renewal?

When these answers are addressed there will be a valid explanation to how cell proliferation is regulated during normal embryonic development or during the abnormal cell division that leads to cancer. Such information would also enable scientists to grow embryonic and non-embryonic stem cells more efficiently in the laboratory to help in treatment of diseases.

The stem cells are unspecialized

Stem cells remain unspecialized even after long hours in the laboratory after getting harvested. The scientists have spent years of research trying to find out factors that make the stem cells unspecialized and differentiating into different cell types. It took two decades to learn how to grow human embryonic stem cells in the laboratory following the development of conditions for growing mouse stem cells. In a similar manner the scientists must first understand the signals that enable adult stem cell population to proliferate and remain unspecialized before they will be able to grow large numbers of unspecialized adult stem cells in the laboratory for medicinal use.

The stem cells are not specialized and hence are not able to perform specific functions. Unlike heart muscle cells, the stem cells are not able to pump blood through the body, they can neither carry oxygen molecules through the bloodstream like red blood cells nor can they kill pathogens like the white blood cells but they can give rise to more of all these cells; they can form bone, heart muscle cells, blood cells and even nerve cells. So they are then unspecialized cells that have the unique ability to give rise to specialized and more vital functional specialized cells.

Stem cellsThe process through which undifferentiated stem cells give rise to specialized cells is known as differentiation. It is through this process of differentiation that the stem cells become even more specialized. Scientists are just beginning to understand the signals inside and outside cells that trigger each step of the differentiation process. The internal signals are controlled by a cell’s genes, which are interspersed across long strands of DNA and carry coded instructions for all cellular structures and functions. In contrast, the external signals for cell differentiation include chemicals secreted by other cells, physical contact with neighboring cells, and certain molecules in the microenvironment. The interaction of signals during differentiation causes the cell’s DNA to acquire epigenetic marks that restrict DNA expression in the cell and can be passed on through cell division giving rise to more specialized cells.

There are however some questions that should be addressed and these may include; Are the internal and external signals for cell differentiation similar for all kinds of stem cells? Can specific sets of signals be identified that promote differentiation into specific cell types? Finding answers to these questions may help scientists to find new ways to control stem cell differentiation in the laboratory, thereby growing cells or tissues that can be used for specific purposes such as cell-based therapies or drug screening.

Integrative Addiction Conference 2015

With these distinct characteristics of the stem cells especially their ability to give rise to different specialized cell types, the stem cells are a cutting edge to treatment of diseases. Degenerative diseases have debilitated many people but it is treatable. Dr. Dalal Akoury (MD) is an expert in integrative medicine and a founder of AWAREmed Health and Wellness Center located at Myrtle Beach South Caroline. Visit her for more information on most lifestyle diseases.

What Are The Unique Properties Of All Stem Cells?

 

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Understanding Alzheimer’s disease and The Healthy Brain

February 5, 2015

Understanding Alzheimer’s disease and The Healthy Brain

Alzheimer’s disease is the most common form of dementia that affects the older generation. Dementia is simply the loss or decline of thinking ability. People with dementia have problems thinking, internalizing information and remembering. The behavior of a person changes with dementia in such away the quality of their life is affected. A person may suffer from either mild or severe dementia. In mild dementia, the disease is in its starting stage and only affects a few aspects of their life. In severe dementia, the person’s functioning is completely affected to an extent that they rely on other people to complete even the basic tasks. Studies have it that Alzheimer’s disease affects over 70% of people who suffer from dementia.

Alzheimer’s disease is characterized by a significant decline of brain cells also known as neurons and deposits of beta-amyloid in the blood vessels located in the brain. In the case of Alzheimer’s disease, plaques and neurofibrillary tangles develop in the brain area. These changes take place in three areas of the brain from the hippocampus, cerebral cortex as well as the mid and temporal lobes. These are accompanied by declined acetylcholine concentration which is a neurotransmitter in the brain. Studies reveal that antioxidant deficiency promotes to the acceleration of the Alzheimer’s disease. Change of diet and taking plenty of supplements reduces a person’s risk to Alzheimer’s disease.

Alzheimer’s disease

The Healthy Brain

Naturally the brain receives oxygen from veins, arteries and capillaries that network their way through it. The vascular system is controlled and it separates the brain form the rest of the circulatory system. This barrier keeps the brain from infections that may come along. If the brain however happens to be infected treatment is difficult since the antibiotics administered are too big to penetrate through this barrier. This is similar in the treatment of Alzheimer’s disease since the medication must be able to pass through the barrier.

One area that Alzheimer’s disease affects is the middle and temporal lobes. These lobes are located behind the ears and the temples. This region is responsible for speech and memory as well as emotions like empathy and molarity. The hippocampus is also an area that is affected by the disease. This area of the brain is responsible for creation of new memories.

The cerebellum is located in the brain and is responsible for the storage of memories of the muscles which makes it easier for us to do things without thinking. The mid brain together with the brain stem is the most sensitive part. This is because body functions such as digestion and the heart rate are controlled by these parts. They also act as a border between the spinal cord and the other parts of the brain.

The brain contains over 100 million cells which are interconnected to form one complex system. Each day a healthy brain makes new connections which keep the brain in function. These connections change every day and this makes it possible for storage of memories, shaping personalities, changing f habits and reinforcements of different brain activity patterns as others are lost. The cells receiving the neurotransmitters send them to other cells to complete communication and an impulse is achieved.

Communication in the brain is made possible through synapses. Signals are sent from one synapse to another. The signals are inform chemicals known as neurotransmitters. These neurotransmitters are received by receptors located in the synapses

Alzheimer ’s disease And the Brain

One characteristic of the Alzheimer’s disease is the death of brain cells. Patients with Alzheimer’s disease usually have plaque and neurofibrillary tangles are deposited in the brain. The plaque deposits cause the impairment of synapses so that signals do not effectively pass through the brain cells. On the other hand the neurofibrillary tangles kill the cells in the brain making it difficult for energy and food to be normally transported through the cells in the brain.

The area that is initially affected by Alzheimer’s disease is the outer brain part. This is the part that is responsible for storage of short term memory. Therefore, the first symptom in a patient suffering from the disease is the loss of short term memory. As the disease continues to eat its way through the brain, eventually even the long term memory is lost. Behavioral aspects of a person also change because other parts of the brain get affected and their functioning impaired. This also affects the neurotransmitter concentration.

Alzheimer’s disease

Alzheimer’s disease treatment

Lifestyle: a change in lifestyle will do you good by reducing the risk of getting the disease. Changing diet and taking regular exercises ensures that your brain and body remain healthy and strong.

Supplements: there are supplements available in the market known to reduce the risk of Alzheimer’s disease or cure it for example ginkgo biloba . Visit your physician for advice about such supplements.

Medication: currently there is no cure for Alzheimer’s disease. However, drugs like cholinergic provide temporary improvements in cognitive abilities of the brain. This improves memory and ability to retain things.

At AwareMed we believe that a healthy you is equal to a healthy society. We not only give you information about diseases but we help cure them. Dr. Akoury helps patients dealing with Alzheimer’s disease improve their life as well as lessen the symptoms.

Understanding Alzheimer’s disease and The Healthy Brain

 

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Natural Approaches to Diabetes, Obesity and Metabolic Syndrome

February 1, 2015

Natural Approaches to Diabetes, Obesity and Metabolic Syndrome

Diabetes

Diabetes is a medical condition that continues to affect a number of people in the world. It claims millions of lives around the globe and costs countries billions in treatments. Studies show that one in every four Americans today aged above 65 suffers from diabetes. It affects the quality of your life as well as that of people around you.

So what exactly is diabetes? The condition also referred to as diabetes mellitus is a health conditions that arises when the body’s blood sugar levels are too high. The food we eat contributes to the glucose we need. Insulin is a hormone that is used in the body to assist the glucose into getting into our cells. Cells require this energy to perform different body functions.

Diabetes arises when something goes wrong with either the production or utilization of insulin in the body. For one, the body may be producing inadequate levels of insulin, which means that glucose absorption is inefficient. This leaves too much glucose in the blood resulting in diabetes.

On the other hand, the cells in the body may not be responding as they should to the insulin produced. This condition is known as insulin resistance. Insulin resistance results in the body not making use of the insulin produced. No matter how much is produced by the pancreas, it is not able to perform its functions because the body is sort of rejecting it. This results in accumulation of glucose as we continue eating resulting in high glucose levels or simply diabetes.

metabolic_syndrome

This leaves us with different forms of diabetes. In type 1 diabetes, the body is unable to produce insulin which means that glucose is not absorbed into the cells. Type 2 diabetes is the most common type of diabetes affecting a majority of people today. In this case the pancreas is able to produce insulin but the body does not make use of it. This results in more insulin production and less utilization leading to increases glucose levels. Prediabetes is a health condition where your blood glucose level seems higher than usual but it is not high enough to be termed as diabetes. Normally, prediabetes is a risk factor of type 2 diabetes. The most common symptoms of diabetes are increased thirst and hunger as well as frequent urination.

Metabolic Syndrome

Metabolic syndrome can be said to be a combination of diabetes, obesity and high blood pressure. It is a common condition that continues to affect many people today. It comes by due to insulin resistance by the body. Naturally diabetes is caused by either insulin resistance or the body not being able to utilize the insulin produced. On the other side, studies show that insulin resistance is a risk factor for obesity while blood pressure may arise for high levels of glucose.

Metabolic syndrome puts you at risk of diseases like heart attack, diabetes, several types of cancers and excess fat in the liver. The disease has been connected to low grade inflammation a kind of inflammation that results in loss of bones.

Metabolic syndrome can be caused by either inheritance of a gene responsible for insulin resistance or excess weight gain and failure to exercise. Some of the symptoms that are exhibited by people suffering from metabolic syndrome include hypertension, abnormal obesity, hyperglycemia, reduced lipoprotein, shortness of breath, and chest pains among others.

Obesity

Most people believe that obesity means being overweight. On the contrary obesity is a condition that arises from having excessive fat in the body.  Over weight on the other hand is simply weighing too much.  Obesity is a real menace that knows no age limit. It affects both the young to the old.

The condition may build up over time depending on your calories intake. There should be a balance between the calories you consume and those you lose. When the amount of calories you consume is higher than what you lose, then obesity is likely to arise.

Insulin resistance is major concern for a number of people and one stands a chance of being obese. Naturally the pancreas is supposed to produce insulin which is then used by the body to enhance absorption of sugars in the body. Insulin resistance occurs when the body does not utilize the insulin produced. When this happens it means than glucose is not absorbed into the cell to be used for various functions like energy production.

This leaves an excess of glucose in the blood. Because the glucose is not being used as it should, it is converted into fat which is stored in the tissue. More insulin resistance means more fat deposits which translate into obesity. The same scenario happens when the pancreas does not produce enough insulin.

Natural Approaches to Diabetes, Metabolic Syndrome and Obesity

Usually most dieses are caused by the kind of lifestyle we chose to lead. Maintaining a healthy diet is one way of preventing such diseases. Most of the foods we eat contain chemical compounds that may inhibit the production or utilization of insulin leading to obesity and diabetes. Also a reduction of polished grains prevents the three diseases by regulating the blood sugars.

metabolic_syndrome

Exercise is an essential part and parcel of healthy living. Without exercise we are prone to disease like obesity. Taking regular exercise is one of the ways of ensuring your boy remains healthy and strong. Also avoiding smoking can prove to be real helpful. Smoking messes up with your body system making it prone to such things as insulin resistance or blood glucose increase.

Grape seed extract has also been shown to reduce blood pressure in patients suffering from metabolic syndrome. Kudzu is also a herb that is used by patients with metabolic syndrome or obesity to help in weight loss. The herb facilitates shedding off of weight which leads to a healthy you.

To find out more about diabetes, metabolic syndrome and obesity visit AwareMed. The expert advice of Dr. Dalal Akoury has helped many patients. She will treat insulin resistance and utilization in order to correct obesity, metabolic syndrome and diabetes.  Join this network of healing at www.awaremednetwork.com today.

Natural Approaches to Diabetes, Obesity and Metabolic Syndrome

 

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Fibromyalgia and NAD Treatment

January 28, 2015

Fibromyalgia and NAD Treatment

There is often a thin line between chronic fatigue and fibromyalgia. The two conditions exhibit almost the same symptoms. Many are the times when patients suffering from chronic fatigue syndrome have been diagnosed and treated for fibromyalgia.

So what is fibromyalgia? It is a health disorder that is often characterized by intense and widespread pain in the muscles. These pains are accompanied by other symptoms like increased fatigue, insomnia, mood swings and impaired memory and concentration levels. Studies show that the intense pains in patients with fibromyalgia is as a result of manipulation of the way pain signals are processed by the brain.

The symptoms of this disorder begin to manifest themselves after an individual has undergone a major stressful situation, physical trauma, infection or surgery. In some other cases the symptoms will continue building up over a period of time.

Contrary to many beliefs that fibromyalgia is a disease of the old folks, the condition can affect anybody from the young to the old. However, women are more at risk of developing the disease as compared to men. This is probably because women are more exposed to psychological stress than men.

Fibromyalgia

Most people who are diagnosed with the disease suffer from conditions such as temporomandibular joint disorders, anxiety, irritable bowel movements, headaches as well as depression. While fibromyalgia remains without a cure, the patients are given medications which aim at controlling the symptoms. Also some physiological measures such as relaxation, exercises and reducing the amount of stress you are exposed to also help ease the situation.

NAD Treatment for Fibromyalgia

Some of the symptoms of fibromyalgia are like those of chronic fatigue syndrome. NAD treatment is one that is used on patients suffering from this condition.

Basically we all need energy to survive. Every process in our bodies relies on energy and that is what keeps us healthy from circulation, breathing to even digestion. The mitochondria are responsible for generation of energy used by cells to perform their functions. Without this energy we are prone to diseases and medical conditions like chronic fatigue and fibromyalgia.

Nicotinamide adenine dinucleotide (NAD) refers to a molecule whose function is to react with the oxygen found in the mitochondria. This reaction creates energy that is used by the cells to help you in breathing, movement, food digestion, blood pumping and thinking.  In short, this energy is what enables to live your life as it is.

Studies show that lack of this molecule is what causes chronic fatigue, fibromyalgia, anxiety, depression, weakening of the immune system, impaired memory and decline in concentration levels, sleeping problems, muscle aches and weakness and even drug and alcohol addictions. Deficiency in this molecule is a cellular disease epidemic that may go undetected.

How Does NAD Works?

NAD is basically and active form of vitamin B3. NAD is converted into a co-enzyme that binds with hydrogen to become NADH. Hydrogen combines with oxygen in the body to generate energy. Naturally when hydrogen and oxygen react in their liquid forms they generate energy like in the case of hot air balloons. This same reaction takes place in the body.

However due to the explosive power of hydrogen, during NAD treatment it must be carefully inserted into the NAD molecule so that it can generate energy for the body without causing harm to the patient. NAD in this case acts as the hydrogen carrier before it reacts with the oxygen to become NADH.

The process of converting NAD into NADH undergoes through a cycle called Citric Acid Cycle. The fats, carbohydrates and proteins that we eat in our diet provide the necessary chemicals that enter into the cycle. At this point the NAD molecule becomes loaded with the hydrogen which enters into the mitochondria generating a reaction with oxygen that ends up generating energy.

Fibromyalgia

The energy produced by this reaction in the mitochondria is in form of ATP and also a bit of water. The ATP is what is used by the body to assist in blood pumping, contraction of muscles and also the energy that is required by billions of cells in the body.

It is clear how important energy is for normal body function. The energy produced is utilized by body organs like the heart and brain. When there is a deficiency in the energy production the brain is the first organ that is affected. This leads to decline in concentration, memory problems and reduced attention.

If incase this shortage of energy lasts a bit longer, the brain is unable to produce neurotransmitters such as dopamine, serotonin and noradrenaline which are useful in maintain consciousness. We thereby start experiencing depression, anxiety, moods swings and lack of sleep.  It is afterwards that the muscles begin to ache and fatigue creeps in because processes like blood pumping have reduced.

At AwareMed we believe in health and wellness and genera body health. Dr. Dalal Akoury will provide more information about this topic and more. Just visit www.awaremednetwork.com today and she will answer any questions you may have about Fibromyalgia and other health conditions.

Fibromyalgia and NAD Treatment

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Gut Inflammation and Cytokines

January 9, 2015

Gut Inflammation

The digestive system plays a major role in food digestion as well as absorption of nutrients into the blood stream. It is important for the overall functioning of the body. When the digestive system is not working properly it can lead to development of gastrointestinal diseases and illnesses.

The bowel wall can be destroyed by conditions such as Crohn’s disease, inflammatory bowel diseases and ulcerative colitis. The conditions lead to poor absorption of nutrients, weight loss, abdominal pains, rectal bleeding among others. To correct the situation a patient is required to undergo surgery in most cases.

Cytokines

They are chemical messenger that act as signals for the immune system and neuromodulators. Cytokines can be either anti-inflammatory or pro-inflammatory. An imbalance in cytokines cause autoimmune disorders.

Cytokines are in form of proteins as well as glycoproteins that regulate immune functions and inflammation. They enhance the growth of cells as well as their differentiation and death.

Homeostasis in the intestines highly depends on the ability of the immune system of the intestines to withstand micro flora while at the same time providing protection against bacterial invasion. Normally, the dendritic cells of the gut induce T-cells differentiation.

Gut Inflammation

T-cells produce secretions that enhance suppression of cytokines that in turn prevent abnormal immune responses. Pathogens enhance a response that triggers activation of immune cells and this ends up causing inflammation.

Inflammatory cytokines like IL-1ß, IL-2, IL-6, IL-15, IL-21 and TNFa stimulate T-cells that are cytotoxic. These are the ones that attack the gut mucosa. The mucosa is the lining of the small intestines. When cytokines attack the mucosa it can lead to conditions such as inflammatory bowel syndrome, Crohn’s disease. It can also lead to leaky gut syndrome.

The small intestines are useful not only in food digestion but absorption of nutrients from the digested food into the blood stream. When the small intestines re affected the digestive and nutrition functions are affected too.

Some immune system aspects aid in the suppression of inflammation aspects and thereby inhibiting destruction of tissues that is caused by active T-cells. This is made possible by T regulatory cells that work to counterbalance the active T-cells that attack the mucosa. T regulatory cells reduce the risks of getting immune diseases that end up attacking the tissues of the body like Crohn’s disease and rheumatoid arthritis.

Natural Compounds That Target Pro-inflammatory Cytokines

Besides the T-regulatory cells, there are several natural compounds that can also work to suppress the cytokines that cause gut inflammation.

Curcumin: studies have shown that curcumin acts as an agent of anti-inflammation. Curcumin works by targeting a number of cytokines that are responsible for gut inflammation. These cytokines include among others IL-1, IL-2, IL-6, IL-21 and TNFα. Curcumin combines with cyclosporine to bring about this effect.

Fish Oil: it contains properties of anti-inflammation. These properties have been shown to have the ability of suppressing cytokine that cause inflammation like IL-1, IL-2, IL-6, IL-15 and TNFα. The Omega-3 property in fish oil is responsible for this.

Studies have shown that Omega-3 suppresses these inflammatory cytokines that lead to gut inflammation. In addition to this, fish oil stimulates the body to produce anti-inflammatory cytokines that enhances a decrease of cytotoxic T-cells.

Resveratrol: just like the other natural compounds, resveratrol works by suppressing inflammation causing cytokines. Such cytokine include; IL-1β, IL-2, IL-6 and TNFa. It works by reducing the ability of the T-cells to reach the gut mucosa. This thereby inhibits gut inflammation.

Trans-Resveratrol: it is used to reduce the activation of T-cells in the body. This is by suppressing cytokines involved in activating inflammation agents.

Tea Polyphenols: both black and green tea contains compounds that have been shown to act as strong agents of anti-inflammation. The compound in the tea inhibits the activations of cytokines such as IL-1β, Il-2, IL-6 and TNFα which cause inflammation of the gut.

inflammation

Quercetin: this natural compound is found in things like onions, citrus fruits, apples and grapes. The compound inhibits the activation of inflammatory cytokines like IL-1β, IL-2, IL-6, IL-15 and TNFα.

Vitamin D3: Vitamin D3 works as an anti-inflammatory compound when it comes to gut inflammation. It has been shown to control inflammatory toxics like IL-1β, IL-6 and TNFα which affect the mucosa causing inflammation.

High Proanthocyanidin Grape Seed Extract: grape seed contain a certain compound that is used to reduce the level of Th17 in the body. It also controls immune responses that tend to be aggressive in nature. It controls the differentiation of active T-cells serving as an autoimmune disease and inflammatory agent.

N-Acetyl Cysteine: this compound when combined with vitamin B lowers the levels of homocysteine thus improving the functioning of endothelial. It also works by suppressing the active inflammatory cytokines like TNFα in patients who receive lung transplants. TNFa makes a patient’s body reject transplants but in combination with vitamin B this is no longer a problem.

Contact Dr. Dalal Akoury today, for more information about gut inflammation. For more wellness and awareness tips just visit www.awaremednetwork.com today. AwareMed is the place to be to find any information about health.

Gut Inflammation and Cytokines

 

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