Category Archives: Cytochrome P450

hormones and weight gain

Female hormones and weight loss

Female hormones

Female hormones and weight loss that corrects lost waistline and stomach fats problems

Female hormones and weight loss: Gender based distinctions in weight loss

A quick observation at the male gender versus the female body tells you forthright that they are not the same. Nonetheless, even though we can make these distinctions, we have ignored them when addressing issues relating to diet and exercise for fat loss. According to the experts at AWAREmed health and wellness resource center under the leadership of doctor Dalal Akoury MD, the standard health and fitness advice of eat less and exercise more does not work once people get out of their twenties and into their thirties, forties and beyond, and women are especially vulnerable. So what are the difference between male and female hormones, what determines where women store fat, and what can women do to address the fitness and fat loss issues that are unique to them?

Women usually have smaller waists and more fat storage on the hips, thighs, and breasts. Estrogen and progesterone have much to do with this. Estrogen is largely responsible for greater fat storage around the hips and thighs while both estrogen and progesterone impact larger breasts. Because women experience monthly hormone fluctuations through the menstrual cycle, they know from experience that hormones impact how they feel, function, and look. They seem to intuitively get the fact that hormones play a role in determining whether they store fat or burn fat and where on the body it is lost or gained. To understand why women are so different, you have to understand their hormones.

Menstrual cycle

No discussion of female fat loss can take place without understanding the normal female menstrual cycle. The first day of bleeding for a woman represents day one of the menstrual cycle.

The menstrual cycle can then be divided into two phases, the follicular phase (named for the maturing of the ovarian follicle) and the luteal phase (named for the corpeus luteum which ovarian follicles become after ovulation). Ovulation, the release of an egg from the ovaries separates these two parts of the cycle.

The follicular phase is associated with higher estrogen levels compared to progesterone, while the luteal phase is the reverse. The relative ratios of these two hormones can have an impact on female related fat loss and health.

Female hormones and weight loss: Estrogen and progesterone balance

A key fat loss measure in women is the estrogen and progesterone balance and how those hormones interact with other hormones like cortisol or insulin. Bigger hips and thighs on a women suggest greater estrogen levels relative to progesterone. The reverse of that, larger breasts and smaller hips and thighs, may indicate the opposite balance of these hormones. The menstrual cycle is another key indicator of hormone balance. Since the time just before menses is usually a progesterone dominant time, PMS is a strong indication there is a progesterone deficiency relative to estrogen.

A woman can have higher than normal progesterone levels but still have a relative deficiency if estrogen levels are much higher in comparison. Many women with low progesterone relative to estrogen will report feeling like a completely different person before ovulation the first two weeks of cycle vs. after ovulation last two weeks of cycle, where they feel much worse. This ill feeling usually manifests as depression, breast tenderness, moodiness, fatigue, lack of motivation, bloating, and other complaints. All these are effects of female hormones which have direct impact on weight management which can be corrected professionally at AWAREmed health center.

Female hormones and weight loss: Gender based distinctions in weight loss

http://regenerativepotential.com/wp-admin 

 

Facebooktwitterpinterestlinkedin
stop drinking

Acetaldehyde poison and Alcohol consumption

Acetaldehyde poison

Acetaldehyde poison and Alcohol consumption if not addressed in good time can be catastrophic

Acetaldehyde poison and Alcohol consumption: Cytochrome P450 2E1 (CYP2E1)

In light social drinkers nearly all the alcohol consumed is taken care of by alcohol dehydrogenase. However, the enzyme Cytochrome P450 2E1 (abbreviated CYP2E1) becomes quite active in metabolizing alcohol in chronic heavy drinkers. CYP2E1 does its work in the liver. The hydrogen released by this reaction is bound to oxygen and to NADPH to form water and NADP+. This reaction takes energy rather than producing it. CYP2E1 does its work in the microsomes of the cell. This is sometimes referred to as MEOS (Microsomal Ethanol Oxidizing System). CYP2E1 is a member of the Cytochrome P450 enzyme family. The next enzyme is the catalase.

Acetaldehyde poison and Alcohol consumption: Catalase

Catalase is found in tiny organs inside of cells called peroxisomes. Catalase is found all over the human body. When catalase turns alcohol into acetaldehyde the hydrogen which is released is bound to hydrogen peroxide molecules which then become water. Although catalase is active everywhere in the body, catalase is of particular interest to researchers because it metabolizes alcohol in the brain. The acetaldehyde released into the brain by the metabolism of alcohol by catalase has the potential to combine with neurotransmitters to form new compounds known as THIQs (tetrahydroisoquinolines, also sometimes called TIQs). Some researchers believe that THIQs are the cause of alcohol addiction and that the presence of THIQs distinguishes addicted drinkers from social drinkers. Other researches strongly dispute the validity of the THIQ hypothesis of alcohol addiction. The actual role of THIQs remains controversial and calls for further research.

Acetaldehyde poison and Alcohol consumption: How acetaldehyde dehydrogenase works

Acetaldehyde dehydrogenase does its work in the mitochondria of cells and removes a hydrogen atom from acetaldehyde to produce an acetic acid radical. This hydrogen atom combines with NAD+ to form NADH.

There are several varieties of aldehyde dehydrogenase found in the human body. The one which normally breaks down acetaldehyde is called ALDH2. There is another variety aldehyde dehydrogenase found in the human body which is called ALDH2*2. ALDH2*2 is only about 8% as efficient as ALDH2 in metabolizing acetaldehyde. Some East Asian people have ALDH2*2 instead of ALDH2 in their bodies. These individuals find the effect of alcohol to be very unpleasant as we discuss below. Doctor Dalal Akoury MD, President and founder of AWAREmed Health and Wellness Resource Center reiterates that the aldehyde dehydrogenase enzymes are found in many tissues of the body, but are at the highest concentration in the liver

The problem with too much NADH

Finally, it is important to appreciate that alcohol metabolism produces excess amounts of NADH (Nicotinamide Adenine Dinucleotide plus Hydrogen). This excess of NADH can lead to acidosis from lactic acid build-up and hypoglycemia from lack of glucose synthesis. It can also lead to weight gain, fatty liver, and heart attack. It is because of these health risks that made doctor Akoury to formulate this health facility to offer meaningful and professional treatment that yield absolute result. This is not a simple problem and therefore, if you are struggling with alcoholism, help is just a phone call away. As soon as you make that call, an appointment will be schedule and your life will be transformed positively and for real productivity.

Acetaldehyde poison and Alcohol consumption: Cytochrome P450 2E1 (CYP2E1)

http://www.integrativeaddictionconference.com/wp-admin

 

 

 

 

Facebooktwitterpinterestlinkedin