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Alcohol Abuse Escalates Liver Cancer Risk

Alcohol Abuse and Liver Cancer

Liver cancerLiver cancer is a problem that has affected many people and lots is being done to help alleviate its effects on the world’s population. According to the American cancer society about 24,550 people (17,030 men and 7,520 women) will die of liver cancer. The number of people dying of liver cancer has increased greatly over the past decades. However, this disease has been found to affect men more than it affects women. On average a man’s lifetime risk of getting liver or intrahepatic bile duct cancer is about 1 in 81, while an average woman’s risk is about 1 in 196. On average people who are diagnosed with liver cancer are aged 63 with most of them being 45 years of age or older, the statistics state that more than 95 percent of those affected are aged 45 and above. About 3% are between 35 and 44 years of age and about 2% are younger than 35.

Liver cancer can affects anybody anywhere but researchers have found that it is more common in countries in sub-Saharan Africa and Southeast Asia than in the US. In fact in most of the countries in these regions it has become the most common type of cancer. In the entire world it is reported that more than 700,000 people are diagnosed with liver cancer each year throughout the world. Liver cancer is also a leading cause of cancer deaths worldwide, accounting for more than 600,000 deaths each year.

Basing on the statistics above, it is therefore safe to say that liver cancer is a cause for alarm, with the risk of liver cancer growing everyday bearing on the toxins that are present in our environments, it is important to eliminate all the possible risk factors to liver cancer. Alcohol drinking has been linked to liver cancer. It is therefore reasonable to reduce the rate of alcohol you take or better quit it completely, of course you will need professional help to quit it but all the effort will be worth it.

Despite these statistics that have shown that liver cancer is a serious disease that ought to be fought at all costs, there has been controversy on the subject of liver cancer being linked to alcohol use. Past researchers established that drinking alcohol moderately has very many health benefits. The National Institute on Alcohol Abuse and Alcoholism (NIAAA) defines moderate drinking as consumption of 14 drinks per week for men and 7 drinks per week for women. Exceeding these limits increases your risk to other diseases, liver cancer included.

There has been controversy on this topic and this may be because of the fact that alcohol itself doesn’t cause liver cancer but when consumed beyond healthy limits and hence abused for many years it will cause liver cirrhosis. Liver cirrhosis is a major cause of liver cancer and so if alcohol abuse causes liver cirrhosis then it will cause cancer in the long run.

Liver Cirrhosis to Liver cancer

Usually, a person who is addicted to alcohol will drink up to a point that he gets to suffer liver cirrhosis after stopping drinking he will develop liver cancer. Researchers opine that it is somewhat unusual for an actively drinking alcoholic to develop liver cancer. What happens is that when the drinking is stopped, the liver cells try to heal by regenerating. It is during this active regeneration that a cancer-producing genetic change (gene mutation) can occur, which explains the occurrence of liver cancer after the drinking has been stopped.

Alcohol abuse has far more ways to contribute to cancer however its links to liver cancer can majorly be apportioned to development from liver cirrhosis. The fact that alcohol is converted into a toxic chemical called acetaldehyde in our bodies may be considered though it hasn’t been linked specifically to liver cancer. Acetaldehyde can cause cancer by damaging DNA and stopping our cells from repairing this damage. The International Agency for Research on Cancer have classified acetaldehyde formed as a result of drinking alcohol as being a cause of cancer, along with alcohol itself. It also causes liver cells to grow faster than normal. These regenerating cells are more likely to pick up changes in their genes that could lead to cancer.

Liver CancerAlcohol is made up of other carcinogens and these carcinogens interacts with the liver, the liver being a vital filter organ through which every pint of alcohol consumed passes through. When these toxins overburden the liver, it becomes easier for infections that may later escalate into liver cancer to be initiated.

Drug addiction is a vice that should be fought by all means that is why we at AWAREmed Health and Wellness Resource Center are committed to availing help to addicts and offering them a place to call home. We offer NER Treatment and Amino acid therapy that are the most effective approaches to addiction treatment and recovery. You call on Dr. Dalal Akoury (MD) today and begin your journey to victory against addiction.

Alcohol Abuse and Liver Cancer

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Restoring Dopamine and Serotonin Levels after Opioid Abuse

How to Naturally Increase Dopamine and Serotonin Depleted By Opioid Abuse

SerotoninOpiates are fancied for their euphoric feelings; they affect the normal production of brain chemicals. At the beginning they may induce a sudden hike in the production of feel good brain chemicals, however when you have used the drugs for some time they will lead to depletion in the levels of the brain chemicals such as serotonin and dopamine. In the brain the production of neurotransmitter happens naturally without intervention of any other drug. These basic neurotransmitters include; dopamine, serotonin, GABA, acetylcholine. The body also produces other chemicals known as endorphins which work as the body’s own opiates functioning to fight pain naturally.

These neurotransmitters have specific functions that they accomplish in the body. Each function is important and works in conjunction with the functions of the other neurotransmitters to make life what it ought to be. These functions are; Serotonin regulates sleep and appetite, Acetylcholine for processing information and memory, GABA acts as your calming neurotransmitter while dopamine is the feel good chemical, plays an important role in mood, energy, attitude, motivation.

When you use these drugs of pleasure thy hike the levels of dopamine in the brain beyond the accepted levels. This will force the brain to find a means by which to suppress the production of the neurotransmitter that has been hiked by drug use. naturally, the production of dopamine will be reduced by the brain after sensing that the hike in the levels of dopamine is caused by factors out of the body, therefore when a person who has been using drugs stops using them, the levels of dopamine and serotonin will be too low below the normal levels and this beckons such feelings of depression, anxiety, nervousness and lack of interest in everything.

Some natural ways to increase dopamine after opiates use

Healthy Eatinggood nutrition goes a long way in increasing the levels of serotonin and dopamine. you can eat the following foods to help you in this noble cause; foods rich in carbohydrates, vegetables, whole grains, whole grain pasta, rice, broccoli, spinach, lettuce among other healthy foods. Eating fat processed foods will do the opposite. You may also eat sweet foods like chocolate, only a couple squares of good quality chocolate with a high percentage of Cocoa in it can raise these chemicals. Serotonin is naturally occurring in foods like pineapples, bananas, nuts and plums. You can also get an adequate supply of B vitamins, folic acid and vitamin C because these vitamins play a role in transmitting brain chemicals. Spicy foods like chili peppers and jalapenos. The heat triggers the release of endorphins, so the spicier the better. You may get help from a nutritionist who may give you a list of foods that may be of benefit.

Meditation- through meditation the fatigue in the nervous system is mitigated and so their performance is enhanced. Doing meditation right helps in production of serotonin and endorphins at required levels. At AWAREmed Dr. Dalal Akoury will help you achieve this.

Herbal supplements – Some herbs like St John’s Wort, 5-HTP and L Tyrosine can all increase serotonin and dopamine in the brain, thus easing withdrawal symptoms and shortening withdrawal duration after use of opiates.

Exercise – The benefits of exercise has been echoed by many doctors. It has been applauded as one of the best natural ways to produce serotonin, dopamine and endorphins. However, vigorous exercise is recommended over light exercise that most people seem to enjoy. This is because the stronger the physical demand you place on your body, the greater the release of endorphins. You should try weight training and high and low intensity exercises. Hit the gym and reap big.

Music – Music is good for emotional relief and energy. A person who is suffering from opiate withdrawal symptoms is more sensitive to touch and sound. Listening to good music can help his body to get the brain chemicals work again and boost his moods. Even with different tastes music therapy offers a natural relief from opiate withdrawal.

Sex – sex is helps in boosting the endorphins. A long session can dramatically increase endorphins. When you’re in withdrawal sex can be a very nice escape.

Acupuncture – acupuncture increases circulation and stimulates the release of endorphins. If you haven’t looked into acupuncture while in withdrawal you might want to try it out, it can be very helpful during healing.

Massage – During a massage the release of endorphins get stimulated. Massaging your own scalp and shower massager’s can provide an affordable alternative to expensive treatments. Massage therapy has been used for centuries to help heal certain diseases and its application here may really help you.

SerotoninLaughter – Laughter is a good way to release endorphins naturally. By Watching a good comedy movie or have a laugh with friends you will stimulate the release endorphins which are helpful in the long run.

Sunlight – bright light increases the production of Serotonin in the body. Basking in the sunlight can absolutely improve your mood and also soothe muscle aches. In case there is no sunshine you may use tanning beds which may also help greatly.

There might be other ways of improving the production of these crucial neurotransmitters in the body. But these natural ways above are simple and inexpensive and so can apply to anyone. The bottom line is that by boosting the production of these neurotransmitters you will make it easier for yourself to recover from opiate addiction. However, these problems need to be treated effectively through integrative medicine. Dr. Dalal Akoury (MD) is an expert at this. Call her on (843) 213-1480 for help.

How to Naturally Increase Dopamine and Serotonin Depleted By Opioid Abuse

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Alcohol and Breast Cancer

Alcohol Abuse Increase the Risk of Breast cancer

Breast CancerThe risks of alcohol abuse are well known by even elementary school kids. However the link between breast cancer and alcohol abuse is something ma y people have never known. This is not so appropriate given that most recent research findings have shown the clear link between these two conditions. Studies have proved the links between alcohol use and breast cancer. Research findings points out that one in five (21.6%) of all alcohol-related deaths are due to cancer globally. Breast cancer is one of the leading causes of death in women coming second after lung cancer.

According to Drinkaware’s Chief Medical Advisor, Professor Paul Wallace, people should know that alcohol abuse can increase women’s risk of getting breast cancer.

“My impression is that my patients don’t know about the link between alcohol and breast cancer any more than they do about the association between alcohol and fertility. We can do more to increase awareness.” he says

The professor continued to give the following details on the link between alcohol abuse and breast cancer. True to his words there seems to be a lot of evidence that alcohol abuse increases the risk of breast cancer. However, he made it clear that drinking alcohol does not guarantee that you will get breast cancer but it increases your risk of getting the disease. How much you drink over your lifetime is what increases the risk.

He opines that although alcohol does increase the risk, taken with all the other factors, its contribution to overall causation of breast cancer is estimated to be about 4%. The advice is that if you do regularly drink it should be within the government’s lower risk guidelines.

However the evidences availed by Dr. Wallace aren’t the only ones available to back up this link between alcohol abuse and breast cancer. There are older evidences which show that alcohol increases the risk of developing breast cancer. Professor Wallace confirms that they have known for years that your risk of developing breast cancer increases when you overindulge in alcohol consumption. Overall, women have a 9.5% chance of getting breast cancer before they are 75.In one of these studies it was found that drinking every day even a small amount raises that risk to 10.6%. (4) Professor Wallace says, though, that the overall risk (anything that affects your chance of getting a disease) is based on how much you drink on average each day over a lifetime.

According to Professor Wallace, this link is real based on past research findings which have been reinforced by a recent research that was even done on a larger scope to establish the link between alcohol abuse and breast cancer. This study however is still going on. This study is done on 1.3 million women across the United Kingdom. This study has indicated that the overall risk of a woman to develop breast cancer increases by 7.1 percent for each 10 grams of alcohol drank

Despite the evidences that have been availed, the exact ways alcohol increases the risk of developing breast cancer are still not fully understood but researchers have made known some of the highly potential mechanisms through which alcohol consumption links to breast cancer. one of the mechanism that is suspected to be the major contributor here is the fact that ethanol is broken down into a toxic substance known as acetaldehyde, which can cause genetic mutations, a permanent change in the DNA sequence that makes up genes. This can trigger a response from the body leading to the development of cancerous cells.

Several studies have also reported that alcohol can potentially increase the production of the female hormone estrogen in pre-menopausal and post-menopausal women. One characteristic of a cancer cell is that it multiplies out of control and in certain types of breast cancer; high circulating levels of estrogen can make this more likely to happen. Alcohol also weakens the immune system leading to nutritional deficiencies, including folic acid, vitamins A, B6, D and E and zinc, all of which may make it more difficult for the body to fight cancerous cells making a person more vulnerable to breast cancer.

The risk of developing breast cancer as always known is much higher in women than in men; this can be attributed to the higher levels of hormone estrogen in women which has been known to increase risks of developing breast cancer. Professor Wallace therefore advices women to stop indulging in excessive drinking and to drink below statutory drinking regulation limits as that is the only way they can reduce this risk of breast cancer apart from dropping alcohol use entirely.

Breast CancerDrink within the government’s lower risk guidelines. When taken overall, looking at all the things alcohol does, the risk at these levels is minimal. Life isn’t about zero risk. Even if you lived in a bubble and didn’t ever go outside, you would still be likely to get osteoporosis because you didn’t exercise!” He adds.

Even men are at risk

The risk of breast cancer is not only to worry women but men as well. Though breast cancer is synonymous to women, men also are at a high risk of getting this disease especially later as they age since that is the time when their levels of hormone estrogen increases. It is therefore advisable for men to reduce the amounts of drinks they take and reduce this risk.

Finally, Alcohol abuse, addiction and cancer are problems that people cope with every day. These problems need to be treated effectively through integrative medicine. Dr. Dalal Akoury (MD) is an expert at this. Call her on (843) 213-1480 for help.

Alcohol Abuse and Breast cancer

 

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Supplements That Replenish Dopamine and Serotonin Levels

Supplements That Can Rebuild and Replenish Depleted Dopamine and Serotonin Levels after Opioid Addiction

SupplementsThe benefits of the brain chemicals such as serotonin and dopamine can never be underestimated. In the previous articles we explored their specific functions and therefore repeating them here will be scratching your ears. However I would like to remind you that the use of opiates has a negative effect on these neurotransmitters and after a person has been using opiates it is important that he find ways to restore the levels of these neurotransmitters failure to which he will suffer undesired consequences related to opiate withdrawal.

Here are some supplements that can be used to restore dopamine and serotonin levels after opiate use

L-Tyrosine– The conditionally essential amino acid tyrosine is a precursor of catecholamine neurotransmitter, dopamine included. L-Tyrosine is available in the foods we eat such as egg, meat and fish. It can also be synthesized in the body. Tyrosine forms DOPA, which is then converted to dopamine, and this, in turn, forms norepinephrine, another neurotransmitter related to mood. By supporting production of neurotransmitters like dopamine, L-tyrosine supplements can enhance mood, sleep, emotional well-being, and mental function, especially under situations involving environmental and emotional stress or when dopamine levels require additional support in most cases after long periods of opiate use resulting in depleted dopamine. As for some people they are born with low levels of dopamine and hence a genetically inherited problem but just like people with depleted dopamine and serotonin from opiates use, they can also eat foods rich L-tyrosine.

Mucuna pruriens– commonly known as velvet bean, murina naturally contains up to 5% L-Dopa often referred to as levodopa. Lovedopa is the same biochemical that is made in humans from the amino acid L-tyrosine and is then synthesized into dopamine. When it is taken as a supplement, the L-DOPA from Mucuna can cross the blood-brain barrier to elevate brain dopamine levels. The Indian traditional medicine champions the use of powdered mucuna seeds in treatment of myriad illnesses including the Parkinson’s disease. Recently, studies utilizing Mucuna supplements have shown promising results not just for Parkinson’s but for other conditions related to dopamine deficiency, including depression and psychological stress. Mucuna extract has been shown to increase not only dopamine concentrations, but also other neurotransmitters that affect mood, such as serotonin and norepinephrine too. Look for an extract of Mucuna pruriens standardized to contain 15% L-DOPA. Take 300 mg twice a day and you will be amazed at how effective this extract can be.

L-theanine- L-theanine is an amino acid uniquely found in green tea that creates an alert state of relaxation without drowsiness. L-theanine is known to be able to cross the blood-brain barrier and increase dopamine levels in the brain. In animal studies it has been shown that L-theanine also increases brain serotonin and GABA. L-theanine has anti-depressant and anti-anxiety effects. It reduces mental and physical stress, and leads to improvements in learning and memory in humans and animals. Even just a single, small dose of L-theanine (100 mg) significantly improves the ability to pay attention and maintain focus compared to placebo. Take 200 mg of L-theanine 2-3 times daily.

RhodiolaRhodiola rosea, also known as golden root is a popular plant in traditional medicine in Eastern Europe and Asia, with good reviews for improving depression, enhancing work performance, eliminating fatigue and treating symptoms resulting from intense physical and psychological stress. It exerts its benefits via multiple effects on the central nervous system, including enhancing the stability of dopamine and supporting its reuptake. This leads to notable decreases in depression, anxiety, and fatigue, as well as an increased ability to handle stress. In human studies, rhodiola has been shown to significantly reduce depression, anxiety, and stress-related fatigue compared to placebo. Basing hope in past research findings you are encouraged to find its extract and use it daily to end your troubles with opiate withdrawal effects. For the standardized supplement just use 170mg per day.

Multivitamin- some minerals and B-vitamins are known for their effects on the neurotransmitters. These includes; Zink, folate, Vitamin B6. These are very necessary for dopamine synthesis and neurotransmission. These nutrients are often depleted in individuals due to medications, inadequate diets, excessive stress, and toxic environmental exposures, compromising the ability to properly synthesize neurotransmitters like dopamine. Therefore there is need to supplement these nutrients especially with high-potency, high-quality multivitamin and mineral supplements. This will help in enhancing neurotransmitter function and playing a complementary role in supporting emotional wellness that is required for a recovering addict.

SupplementDespite the benefits of having a high level of dopamine, too much of it is dangerous and needs to be avoided. You therefore need to work with the supplements strictly as instructed to avoid any problem that may arise in case of overdose. It is also advisable that you desist from getting and using these supplements without the help of a doctor specialized in the area. For better outcome you should seek the services of an experienced integrative doctor as they are more versed in this kind of treatment. You should not use different supplements at a time without consulting your integrative doctor as some supplements may react and therefore bear even more grave consequences.

Drug addiction is a vice that should be fought by all means that is why we at AWAREmed Health and Wellness Resource Center are committed to availing help to addicts and offering them a place to call home. We offer NER Treatment and Amino acid therapy that are the most effective approaches to addiction treatment and recovery. You call on Dr. Dalal Akoury (MD) today and begin your journey to victory against addiction.

Supplements That Can Rebuild and Replenish Depleted Dopamine and Serotonin Levels after Opioid Addiction

 

 

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Nicotine Addiction in Females

Role Of Progesterone In Nicotine Addiction In Females

Nicotine addictionProgesterone is a found in good quantities in women and is often thought of as a female hormone. this hormone is important for the regulation of ovulation and menstruation. however current research findings have indicated that this hormone has a role in inhibiting nicotine addiction.

today many people are using drugs with nicotine content and nicohtine addiction is on the rise. it has been causing death that could rather be prevented especially in the developed countries. this stimulant is used by all genders and is appreciated for a feel of high sensation and relaxation after sometime but researchers have noted that women and teen girls appear to be more vulnerable on certain aspects of nicotine addiction compared with men and boys. However the mechanism of gender differences in nicotine addiction is not yet clear, but there is evidence that endorses the suggestion that progesterone may protect females against nicotine addiction unlike estrogen that some researchers have linked to enhanced vulnerability in females to nicotine addiction. Therefore, progesterone may have therapeutic use for nicotine addiction, especially in female smokers. Researchers are working to establish the reason for this gender variation in nicotine addiction and the discovery will provide a greater understanding of the role of progesterone in nicotine addiction. this is important not only from a treatment purposes but also from a prevention perspective. The changes in hormones in the body of women such as those that occur at adolescence and during pregnancy and following birth. The changes in hormones that are also caused by hormonal manipulation like using methods of hormonal birth control may all contribute to changes in vulnerability to nicotine addiction.

Here, we will explore in reference to recent evidences from clinical studies how progesterone affects the health of a woman in relation to nicotine addiction. Depending on the data already availed from past researches we will find out the effects of progesterone during the initiation stage and even during the later stages of nicotine addiction process as a potential relapse prevention treatment.

Several studies have indicated that in spite of the public knowledge that nicotine addiction can be dangerous to one’s health, tobacco use has been on the rise especially on young women and teens. In a 2007 study results on National Survey on Drug Use research done by Substance Abuse and Mental Health Services Administration often shortened as SAHMSA found that Females aged 12–17 are also more likely than males initiate smoking. It has also been found out that women take shorter time to develop tobacco dependence syndrome after their initial use of tobacco.

Similar reports of enhanced vulnerability in females versus males have been reported among adult smokers. For example, among adults (18 years and over), although more men than women smoke, women take less time to become dependent after initial use, report shorter and less frequent abstinence periods and smoke for longer periods of time in their lives compared with men with the median cessation age of 33 years for males versus 37 years for females. This finding was reported by a research done by Pierce and Gilpin in 1996 in a study titled: How long will today’s adolescent smoker be addicted to cigarettes?

Of all the studies that have been available on tobacco use it has been found that women are more vulnerable to nicotine addiction as they also appear to respond less favorably to smoking cessation treatments.

Donny and Clark study on rats

A preclinical study on rats done by Donny and Clark with other researchers provided information that is Consistent with the above findings. In preclinical studies, adolescent and adult female rats showed faster acquisition of intravenous nicotine self-administration and higher break points on a progressive-ratio schedule compared with adolescent and adult males. Similarly, female mice showed a greater preference for nicotine in a two-bottle choice task compared with male mice indicating greater sensitivity of females to nicotine’s reinforcing effects. These studies point to important gender differences in initiation and maintenance of nicotine use that may contribute to smaller gains in curbing nicotine addiction in women.

Progesterone and GABA receptors

Several research findings point out that Progesterone and its metabolites interact with multiple neurotransmitter receptors including GABA, glycine, sigma1, kainate, serotonin3, and nicotinic cholinergic receptors. However, most relevant for nicotine addiction are interactions with GABA. Progesterone’s active metabolites, pregnanolone and allopregnanolone, have positive modulatory effects on GABA receptors which enhance GABAergic transmission. GABA is the main inhibitory neurotransmitter in the brain and has significant influence on multiple central nervous system (CNS) function. The positive modulatory effects of progesterone metabolites on the GABA receptors have been proposed to weaken drug reward. Remarkably, the effects of progesterone and its metabolites on GABAergic signaling vary with menstrual cycle phase and at hormone transition phases including during adolescence and during pregnancy. For instance, during puberty, allopreganolone’s effects on GABAergic transmission are opposite to those seen before and after puberty with results showing a reduction in GABAergic transmission.

nicotine addictionIt has also been reported that progesterone also affects signaling at nicotinic receptors. Specifically, both progesterone and allopregnanolone are negative modulators of the α4β2 nicotinic receptors. Progesterone has also been reported to increase mRNA expression of α5 nicotinic receptors.

Despite the research findings that have been published on this issue, the available literature is still insufficient to anchor a strong decision on the use of progesterone hormone in fighting nicotine addiction. Dr. Dalal Akoury (MD) of AWAREmed Health and Wellness Center is an expert in integrative medicine for addiction. Call her on (843) 213-1480 for help.

Role Of Progesterone In Nicotine Addiction In Females

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