Circadian Rhythms and Melatonin Go Hand-in-Hand

November 10, 2014

Circadian Rhythms and Melatonin Go Hand-in-Hand

You go to bed every day at almost a specific time and wake up around the same time daily. Have you ever imagined how come this happens almost in a rhythmic fashion?

Imagine if you could not be able to set standard waking time. You may miss going to job in time. You may be late for conferences. You may delay certain crucial arrangements meant to take place within specific times.

Fortunately that is not likely to happen because our lives are naturally programmed like the clock. From the time you wake up to the time you retire to bed. There are things that just happen spontaneously, like going for meals will follow a quest for it: you are hungry.

If you have a pre-set time for going to bed then immediately that time reaches you begin to feel tired. At that moment all your body needs is the rest. You give it to your body and you won’t even need an alarm to wake you up in the morning. You just find yourself waking up when the time your body is programmed to wake reaches.

All these rhythms of activities are controlled by systems inside our bodies. It is not us who decide the things we wish to feel. Neither do we decide exactly what to want. There are systems which do that inside our bodies, making us programmed like the clock.

This controlled daily cycle of rhythmic activity that is essentially based on the 24 hours period available every day is what is referred to as the circadian rhythm. These rhythms are not just exhibited by humans alone, rather, plants and animals also exhibit the circadian rhythms.

The rhythms relate to the 24 hour cycle of the solar and applies even to microbes like bacteria and fungi. All physiological responses are controlled within this system of activities: strength of the muscles, blood pressure, body temperature, hormonal circulation, neurotransmitter circulation and a number of other metabolic and physiological processes all follow the cycle of circadian rhythms.

Circadian Rhythms

With that background it becomes easier to understand therefore that diseases and wellbeing are channeled into these circadian rhythms. The diseases also follow their particular rhythms in the body. They are also controlled variously. For instance, studies indicate that certain breast cancer tumors grow faster at daytime that during the night.

Melatonin and the Body Processes

Melatonin, a substance produced by the brain, plays a critical role in not only growth but almost all essential processes in your body.

Some accumulating proof is indicating that interference with circadian rhythms has a close link to the growth of cancer, particularly the breast cancer. This is related to a complex network of interrelated physiological or neuroendocrineimmune processes controlled and regulated in distinct ways. In the middle of these processes is the chemical component Melatonin. Research has found that Melatonin produced in highest amounts at night during dark hours is perhaps the most crucial endogenous component in the actual regulation of these circadian rhythms and the clocks.

It works variously to ensure control of these processes including the suppression of the production of estrogen which are related to the causes of cancer. As such Melatonin has a key role in the treatment of cancer among other serious diseases.

Circadian Rhythms and Melatonin Go Hand-in-Hand

Whole Body Hyperthermia

August 2, 2014

The Role of Whole Body Hyperthermia In Cancer Care

Hyperthermia is a condition in which the body temperatures are higher than the normal degrees. Hyperthermia can be caused by certain diseases but it can also be created by medical experts to help in treatment of certain diseases especially cancer. In this case it is referred to as heat treatment. Higher than normal temperatures are known to cause various health complications but in hyperthermia the heat is under careful control of qualified medical personnel hence cannot kill the patient but only kill the cancerous cells.

Use of hyperthermia which is also called thermal therapy in cancer treatment involves exposing the patient’s body tissues to high temperatures of up to 113°F.Thermal therapy is used to kill or damage the cancerous cells without or with minimal hurt to the healthy cells.

Thermal treatment helps in making the cancer cells more vulnerable to treatments like chemotherapy and radiation therapy. High temperatures may also kill the cancer cells instantly. Hyperthermia is very effective in treatment of cancer but it may also lead to the death of healthy cells for this reason it needs to be handled by doctors who are well versed in the area and can take good control of the heat so as to avoid harm to the patient.

Hyperthermia had been used in the past however, back then the tools used in hyperthermia were not as effective and so the results were not constant. The reason to this was that the doctors were finding it hard to maintain that heat on a specific area of the body for a certain time without affecting the remaining parts of the body that was not subject to the treatment. This means the other body parts that did not have cancerous cells also got affected adversely. Nevertheless there are no hopes lost as today’s tools used in hyperthermia are more effective and it is now easy to control the heat on a certain area without affecting the rest of the body. Today very many health institutions are using hyperthermia in treatment of cancer worldwide.

There are different types of hyperthamia depending on the area the heat is concentrated. I had tackled the different types of hyperthermia in the past and today we are going to learn about the whole body hyperthermia and how it can be effectively used in cancer treatment.

Whole-body hyperthermia

The whole hyperthermia as used in cancer treatment involves the application of heat on the entire body of the cancer patient. Whole body hyperthermia mainly used in treating cancer that has spread to other body parts in other words it is used in treatment of metastatic cancer. There are varieties of methods through which the heat can be applied to the whole body. These methods may include but not limited to: hot-water blankets, special coiled devices or special thermal chambers that are like large incubators.

The whole body hyperthermia involves increasing the body temperatures but the heat used in local hyperthermia is much higher than the heat used in whole body hyperthermia. In whole body hyperthermia the temperatures are raise above 43 degrees Celsius. The whole body thermal therapy is mostly used with other conventional treatments like chemotherapy and radiation therapy.

Thermal therapy does lots to kill the cancer cells. when the proteins in the cancer cells gets coagulated and the blood vessels that supply the cancer cells with nutrients are destroyed, the cancer cells remains with no food source and so they die out of starvation and damage caused by the thermal therapy. The thermal therapy literally cooks the surrounding of the cancer cells depleting all the proteins in the cancer cells and destroying the blood vessels they rely on for supplies of the necessary nutrients.

To retain the heat the cancer patient may be placed in a tent that is made of a very flexible thermal insulator. The tent which is placed over a patients bed or treating table helps in keeping the heat. The tent is spacious enough to let the patient move about in it during the treatment. The tent is also fitted with transparent windows to help the patient keep in touch with relatives who might have come to visit him or her during the treatment. This heat will be retained up to the time that it has been used effectively in killing the cancerous cells.

The whole body hyperthermia helps the body in fighting cancer in several ways. Today very many cancer patients are going through whole body hyperthermia as a treatment to their disease. Here are some of the ways through which it helps in fighting cancer.

The whole body hyperthermia stimulates the body’s natural immune system to fight the cancer cells.
It helps in increasing the cancer cell recognition by the body’s immune system hence can be easily targeted and killed.
It also increases the immune system chemicals that fight the cancer cells
Increases the strength of macrophage, lymphocyte, cytotoxic T cells and dendritic cells in the body. These help the immune system in fighting cancer.
increases the more beneficial heat-shock proteins
The whole body hyperthermia also increases blood flow-oxygen to the more low oxygen tumors. Cancer cell do not thrive where there is lots of oxygen.
It also weakens the tumor cell walls hence making them more vulnerable to chemotherapy
Whole body hyperthermia also helps in reducing cancer cell resistance to chemotherapy and radiation therapy.

Dr. Dalal Akoury is an experienced integrative cancer doctor who has seen very many cancer patients journey to victory in their fight against cancer. She is available for consultations. Just call her now and begin your journey to victory against cancer.

The role of Whole body hyperthermia in cancer care

Hyperthermia and Cancer Treatment

July 1, 2014

Hyperthermia widely used in Treating Cancer

Hyperthermia is a condition in which the body temperatures are higher than the normal degrees. Hyperthermia can be caused by certain diseases but it can also be created by medical experts to help in treatment of certain diseases especially cancer. In this case it is referred to as heat treatment. Higher than normal temperatures are known to cause various health complications but in hyperthermia the heat is under careful control of qualified medical personnel hence cannot kill the patient but only kill the cancerous cells.

Use of hyperthermia which is also called thermal therapy in cancer treatment involves exposing the patient’s body tissues to high temperatures of up to 113°F.Thermal therapy is used to kill or damage the cancerous cells without or with minimal hurt to the healthy cells.

Thermal treatment helps in making the cancer cells more vulnerable to treatments like chemotherapy and radiation therapy. High temperatures may also kill the cancer cells instantly. Hyperthermia is very effective in treatment of cancer but it may also lead to the death of healthy cells for this reason it needs to be handled by doctors who are well versed in the area and can take good control of the heat so as to avoid harm to the patient.

Hyperthermia had been used in the past however, back then the tools used in hyperthermia were not as effective and so the results were not constant. The reason to this was that the doctors were finding it hard to maintain that heat on a specific area of the body for a certain time without affecting the remaining parts of the body that was not subject to the treatment. This means the other body parts that did not have cancerous cells also got affected adversely. Nevertheless there is no hopes left as today’s tools used in hyperthermia are more effective and it is now easy to control the heat on a certain area without affecting the rest of the body. Today very many health institutions are using hyperthermia in treatment of cancer worldwide.

There are two ways through which hyperthermia is done. All this are related to the surface that that the heat is concentrated on and the intensity of the heat. The heat can be concentrated in one area that is infested by the cancer cells especially on tumor. When the heat is focused on one small area it is referred to as local hyperthermia or thermal ablation. In local hyperthermia the heat used is much stronger and so helps in killing or damaging the cancer cells on that small area.

The cancer cells are killed when the proteins in them get coagulated and the blood vessels that supply them with nutrients are killed. This leaves a place that is cooked hence no living cancer cell. Various sources of energy can be used in this process including Radio waves, microwaves, and ultrasound waves.

Thermal ablation can be either internally or externally. When done external the source of heat is focused on a specific area of the patients body while in internal ablation involves using a needle that is pricked into the tumor. The needle releases lots of heat at the tip killing the cancerous cells.

Thermal ablation can be used in treatment of cancers that are deeply rooted In the internal organs. It is the method that is used in killing cancer cells in brain tumors. This technique is called Interstitial and it releases lots of heat than the external thermal ablation. Needles that release heat are used in the tumor to kill the cells in it.

At times the heat can be concentrated on whole body of the patient. This is especially when the cancer cells are well spread in the body of the patient. When the heat is concentrated on the patient’s whole body, it is referred to as whole body hyperthermia or regional hyperthermia.

Regional hyperthermia is not used with a lot of heat as in the thermal ablation. It is used on an entire organ or on a large surface affected by the disease. Regional hyperthermia is mostly used with other treatment methods like chemotherapy as well as radiation therapy

The regional hyperthermia can involve the following techniques in treating cancer:

Deep tissue hyperthermia– Deep tissue is used to heat a specific area that is affected by the cancer. It involves use of external applicators that are placed around the affected organ and then Radio waves, microwaves or ultrasound waves are focused on that area to heat it killing the cancerous cells.
- Whole body hyperthermia– whole body hyperthermia is an approach that is used to treat cancer that is widespread in the body. Metastatic cancer is mostly spread hence use of thermal ablation may not be very effective. Here the temperatures can be heightened upto108° Fahrenheit.

Regional perfusion– regional perfusion involves removal of some of the patient’s blood, heating it and then pumping it back into the system after the cancerous cells have been killed. It is useful in treatment of specific areas of the body for example the lung or the liver.

Are there risks Associated with hyperthermia?

Hyperthermia can be safe when it is used under the control of experts in the field it involves use of heat that can be dangerous if not well controlled and the patient needs to assess the credibility of the oncologists that is to control the heat. In most cases the healthy cells are rarely affected by hyperthermia. However side effects like burns, blisters and pain may occur due to the high temperatures. Perfusion may cause other problems like blood clot, tissue swelling and even bleeding. Generally these side effects are associated with hyperthermia: Vomiting, nausea and diarrhea.

Doctors are doing research daily to find better ways of treating cancer. Dr. Dalal Akoury (MD) is particularly committed to finding you the best information that can help you in staying away from cancer. Visit her website regularly for information about cancer and other diseases.

Hyperthermia widely used in Treating Cancer

Tag Archives: Thermoregulation