Tag Archives: Oxidative stress

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Stress hormones response pathways

Stress hormones response

Stress hormones response pathways tailored at addressing the real problem

Stress hormones response pathways: Food addiction pathways

When individuals are confronted with stressful situations, specific hormones are produced, which help the body to cope with the situation. One of the body’s stress hormones response pathways is known as the limbic-hypothalamic-pituitary-adrenal (LHPA) axis. It generates a series of brain hormones that eventually leading to production of cortisol by the adrenal gland. Cortisol helps to make available more sugar to the brain and other parts of the body to help cope with the stressful event. Experts at AWAREmed health and wellness resource center under the able leadership of doctor Dalal Akoury MD reiterates that the individuals who are under chronic stress have an overactive LHPA axis.

Hyperactivity of this axis has been reported in individuals who are obese as well as alcoholics, drug users, smokers and victims of early abuse or trauma. Elevated cortisol levels on an ongoing basis are not only harmful to health, but also harmful to mood. It can cause depression. It also affects mood by interfering with the actions of one of the brain’s major messengers, serotonin. Serotonin defects cause depression and anxiety. Many alcoholics, smokers, drug addicts and obese individuals suffer from depression and anxiety. Nicotine, alcohol and certain drugs increase serotonin activities and temporarily improve mood. These addictions are a means of self-medication.

Stress hormones response pathways: Food as “Medication”

Carbohydrates also raise serotonin levels and enhance mood temporarily. Studies have established that the majority of individuals who are obese crave carbohydrates. Low serotonin and stress induced activation of the LHPA axis are also known to increase the risk for substance abuse and food addiction through another feel good pathway, the dopamine reward system. The pleasure derived from substances such as alcohol, nicotine and certain drugs are, in part, due to the stimulation of dopamine. Eating foods high in sugar, fat or even the smell or taste of an individual’s favorite food activates the dopamine reward system, producing pleasure and satisfaction. Frequent use of addictive substances, such as nicotine, alcohol and food, reduces the pleasurable effects of the dopamine reward system so that more and more of the substance is required to derive satisfaction.

Recent studies found that obesity can be associated with defects in dopaminergic responses to the smell and taste of food. It may be possible that some obese individuals may eat more and more food to increase dopamine activities and improve mood. Abstinence from the abused substance helps to reverse or improve many neurochemical defects associated with addictions. Bariatric surgery, by reducing the amount of food intake, and enhancing mood through weight loss, is effective in improving neurochemical defects contributing to the addictive behavior. However, such improvements can be short-lived. Food cravings as well as depression may reoccur over time, along with weight regain. The behaviors responsible for initiating the cascade of events leading to such defects are not resolved by the surgery. Low self-worth and poor stress coping skills must be addressed for these issues to resolve. Therefore, if this description suits your situation, you can schedule an appointment with doctor Dalal Akoury today for the commencement of your recovery program.

Stress hormones response pathways: Food addiction pathways

http://www.awaremednetwork.com/

 

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Obesity and weight lose

Leptin concentration in relation to obesity

Leptin concentration

Leptin concentration in relation to obesity. In fact, Leptin concentrations adjust in response to obesity and contribute to insulin resistance

Leptin concentration in relation to obesity: Insulin resistance

Leptin regulates energy metabolism and balance in conjunction with the brain’s hypothalamus. Leptin is currently being touted as having cardio-protective benefits among its others roles in metabolism. Leptin concentrations adjust in response to obesity and contribute to insulin resistance. Besides that, doctor Dalal Akoury MD, President, and founder of AWAREmed health and wellness resource center register that, the changes in leptin concentration have also been associated with the risk factors for coronary heart disease. In the same way, increased resistin concentrations correlate with obesity-related inflammation and may be associated with the initiation and progression of atherosclerotic lesions. Resistins also promotes insulin resistance, although the actual mechanism is still not very clear.

Insulin resistance due to adipokines dysfunction is further influenced by free fatty acids liberated directly into the liver from the visceral fat tissue. Visceral fat releases chemicals and fatty acids into the portal system where they act on the connecting organs. The portal circulation system is a specialized network of blood vessels that connect the visceral organs to the liver. The excess fat in the portal circulation has detrimental effects on insulin action, which is worsened by sympathetic hyperactivity in response to obesity. Sympathetic hyperactivity causes heightened lypolytic action resulting in excess free fatty acids in the blood. These actions combined with beta cell hypersecretion and reduced insulin clearance resulting in hyperinsulemia, lead to early stage diabetes.

Leptin concentration in relation to obesity: Interleukin-6 (IL-6) 

Interleukin-6 (IL-6) is possibly another factor associated with inflammatory detriment within the portal system. High levels of IL-6 are a marker for inflammation and vascular pathology. Obese subjects demonstrated a 50% greater portal vein IL-6 concentration, demonstrating, again, the profound effect visceral fat has on pathogenic indicators. Portal vein IL-6 correlates with systemic C-reactive protein concentrations. And remember that the C-reactive protein is associated with cardio and peripheral vascular disease. C-reactive protein and oxidative stress are now presumed to interact in the early inflammatory processes of atherosclerosis. This is significant for young obese individuals. Although more research is necessary for a conclusive association, the C-reactive protein may be a new risk factor for CAD in individuals under 25 years of age.

The imbalance between increased inflammatory stimuli with a concurrent reduction in anti-inflammatory activity may be the foundation for the accelerated endothelial dysfunction and insulin resistance associated with obesity and the comorbid disorders of metabolic disease. However, more research is needed to clearly delineate the particular relationships, though it seems evident that the low-grade inflammation caused by obesity and visceral adiposity lead to the premature development of the disease. This, more so than ever before, identifies the importance of weight management during the developmental years and ongoing efforts to control weight throughout one’s lifespan.

Finally, for current obese people, there is still plenty of hope. Weight loss is related to the reduction of oxidative stress and inflammation, and these beneficial effects are likely to translate into the reduction of cardiovascular risk in obese individuals. Likewise, exercise and dietary management, along with pharmacologic intervention can lead to the atherosclerotic reversal in the earlier stages of CAD. Individuals with central adiposity, poor blood lipid profiles, hypertension, or insulin resistance should seek immediate professional assistance to prevent further health detriment by scheduling an appointment with AWAREmed health center now.

Leptin concentration in relation to obesity: Insulin resistance

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