Tag Archives: Neuroplasticity

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Addiction chemical alteration to the brains functions

Addiction chemical alteration

Addiction chemical alteration to the brains functions a great danger for health

Addiction chemical alteration to the brains functions: The brains communication system

New neural pathways are formed as addiction develops. This is because addiction chemical alteration to the brain’s communication system takes effect with such intoxications. In other words when you take drugs away, the brain will revert again to form new neural pathways. Neuroplasticity explains why the initial period of recovery is difficult and uncomfortable. But the good news is that, this difficulty is only temporal. Speaking to the experts at AWAREmed Health and Wellness Resource Center about addiction chemical alteration, doctor Akoury MD registers that this piece of information is very helpful to especially when attempting recovery. From our previous illustration where a tree fell on the usual path way and so you needed to navigate to get through, some difficulties could be experience. In the same way when undertaking the recovery journey in addiction treatment, it can be difficult and uncomfortable while these new neural pathways are forming. As long as the recovering person does not give up during this initial period of discomfort, new neural pathways will form that support recovery. These new pathways will become more established and better developed over time. As they do, recovery becomes easier and more comfortable thereby defeating any addiction chemical alteration to the functions of the brain.

Addiction chemical alteration to the brains functions: Effects of addictive substances on the brain

Going by the facts mentioned above about the adaptive and the dynamic qualities of our brains to ensure our survival, I want to be persuaded that you are now somewhere as far as keeping your brain healthy. The next point I want to raise on how addiction changes the brains communication pathways may be quite unfortunate. Why do I say so, it is because the brain’s ability to be so adaptive is also at the root of addiction. Doctor Akoury says that the brain has the ability to adapt not only to the harmless substances and activities but also to the strong effects of addictive drugs and activities. And when it does, there will be damaging changes happening in the brain regions which are associated with reward including the memory and emotion, decision-making and stress regulations. These changes to our brain make the repeated use of addictive substances or activities very compelling. The good news is that our brains’ neuroplasticity allows us to correct these changes! Therefore, although addiction chemical alteration leads to structural changes in the brain, we are capable of learning new coping skills. The brain’s plasticity allows these new coping skills to be imprinted.

Finally we will be discussing these structural changes in the next series of articles and we want to urge you not to go away but to stay with us on the link and where possible invite a friend too. In the meantime having such powerful information about the most sensitive organ in your body the brain is very helpful in keeping you healthy. I am saying so because when you know, you will not do things that will cause harm to your health, and if you have already caused an injury, then you can take measures to remedy the situation by scheduling for an appointment with doctor Dalal Akoury to professionally take your through the recovery treatment process today.

Addiction chemical alteration to the brains functions: The brains communication system

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Addiction: A Neuroplasticity Disease

Addiction: A Neuroplasticity Disease

Had an accident or stroke? Developed amnesia? Lost consciousness for some reason? Well maybe not you. You may be wondering however how a friend or neighbor is recovering from such incidences of short or long term memory losses. Well thanks to technology now we know the brain has a way to self-regenerate in its functions through a process called neuroplasticity.

Neuroplasticity and Addiction Defined

Neuroplasticity is the brain’s ability to adjust to new environments or needs by developing new nerve cells throughout the body. it is the brain’s way of recovery. neuroplasticity allows the cells to compensate for any injuries or diseases in the nerve system. It also allows the neurons reorganize themselves to perform new functions of the brain depending on changes in their working environment.

One of the most common mechanisms in neuroplasticity is axonal sprouting. This is the process whereby active axons develop new nerve endings to connect with those their links were severed. Inversely, the damaged one can also grow new nerve endings to reconnect to the active neurons. Neuroplasticity is a term derived from the words; “neuron” and “plasticity”. A neuron is a nerve cell of the brain. Plasticity on the other hand means ability to remold. The process is at times referred to as brain malleability. Other times it is simply called brain plasticity.

Addiction on the other hand is an intricate condition of the brain, usually categorized as a disease that involves reward and motivation cerebral systems structurally and chemically altered. It is a mental condition characterized by a compulsive urge to indulge in rewarding stimuli despite possible dire consequences. Addiction is both reinforcing and rewarding. It manifests itself in the form of repetitive, intrinsic behavior including; gambling, food, exercises, shopping and substance abuse.

neuroplasticity

Influence of Neuroplasticity on Addiction

At one time Aristotle said: “We are what we repeatedly do.” Even though the Greek coined the phrase in the context to advice his readers of making a habit of excellence, the great philosopher had his brain develop a pathway around his successes over time. See, that is what the brain does. It creates a path of neurons to support our habits. A weight lifter for instance develops stronger muscles as a result of repetitive action. Similarly the brain may develop a path around addiction.

Once such pathways are created, addiction takes control of the brain. Eventually the addiction becomes the only thing that matters to the addict. Once the addiction hijacks the brain’s centers of pleasure it becomes the only thing that brings the addict a sense of joy or happiness. Soon his/her brain recognizes more of the addiction and less of other socio economic aspects of life including: friends, relatives, family, responsibilities, and work among other normal forms of social interactions and activities.

Neuroplasticity on Addiction Treatment

For a long time detoxification has been used as a treatment mechanism against addiction. This is the removal of the substance of abuse from the body. Victims however fell back on to substance abuse shortly afterwards. The billion dollar question then was how this still happened sometimes way after the victim’s blood had been cleaned of the same. This was one very interesting aspect of scientific state of quandary.

It is however through neuroplasticity scientists discovered treatment of an addiction needed more than mere detoxification. The brain actually needed to be retrained back to its normal functions. It required an intensive psychotherapy among other medical interventions to remold the recovery process. Also, it required an intense psychotherapy to reconfigure the brain’s recognition of what initially seemed normal and of the person as a whole especially in terms of behavior change. The nerve cells needed to rebuild a connection along initial, rather former normal pathways.

neuroplasticity

Neuroplasticity and Drug Abstinence

The process, neuroplasticity however does not take away the addictive neuron pathways like probably in the case of severe brain damage usually by accidents. It only retrains the brain to develop new ones along the old clean pathways. It is therefore often advisable to abstain from drugs completely during recovery. This is so as to avoid reinforcing the addictive path.

It is the same case each time you reread your favorite novel. You might have read it last twenty years ago. And you could have forgotten a few characters already. However if you picked that same book today you would remember a lot more, the story would begin to unfold in your sub conscience mind even without rereading the whole story yet again. You would remember the chapters more clearly, vividly the characters, deeply their roles and or attributes without going into it a whole other time.

Relationship between neuroplasticity and addiction is not a simple support of addictive habit and recovery alone. It is an inter-disciplinary connection of varied other fields; computer technology, anthropology, and psychology among others. Want to learn more on this? This year’s August integrative addiction medicine conferences could just be the answer you are looking for. Click on: http://www.integrativeaddiction2015.com and sign up for the upcoming event where you will have a chance to meet various medical experts, and listen to speakers on the neuroplasticity and integrative addiction recovery.

Addiction: A Neuroplasticity Disease

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A Molecular Switch for Memory and Addiction?

Is This Real-Molecular Switch For Memory And Addiction?

Research has pointed out that learning and memory formations are based on the creation of new connections between neurons in all the brain. While examining the effects of some drugs, it has been found that behaviors such as nicotine addiction manifest themselves in long-term changes of neural connectivity. In this respect, can we think about what causes addiction? Since we are saying learning involves connections between neurons in the brain, and this is the same thing that addiction will do, then addiction can be viewed as a form of learning.

How does memory switch occur?

One of the fundamental explanations of how this occurs is by the fact that it involves joining of neurons in the brain. Scientists have discovered a molecular switch that plays a key role in the establishment of addictive behaviors and addiction. The success of their ideas may lead to new technologies in the control of loss of memory and probably treatment of addictive behaviors.

The process involves neural cells being sent from one cell to the next one in the form of chemical compounds known as neurotransmitters. This is usually the first step in the learning process in the brain. This prompts sequence of events which result in the changes in the neural connectivity and hence the memory consolidation. It is important to note that nicotine can equivalently have a similar behavior by triggering the rearrangement of the brain connections.

RyR2 and Calcium

How does the process flow?

Usually the first step is the introduction of neural plasticity, which is the formation of new connections in the brain. It involves calcium. Consequently as a response to neurotransmitters, cocaine or nicotine, calcium will increase the site of neuronal connection, known as the synapse.

The second step will be that the calcium will induce gene expression. Due the synthesis of proteins, it will lead to new and reinforced synaptic connectivity. It has been explained scientifically that this increase in calcium is only part of the first step in this process and thus does not depend on the gene expression.

Contrary to the argument above, some scientists have challenged it and tried to experiment the facts using mice. They realized that nicotine administration to mice induced the expression of a gene called type 2 ryanodine receptor (RyR2).

Is RyR2 involved in calcium release?

The RyR2 protein has been found to be involved in the release of calcium from a cell internal calcium store, the endoplasmic reticulum, thus leading to a sustained long-term signaling manner. This sustenance of calcium increase consequently leads to neuronal plasticity.

To be more specific, RyR2 is expressed in a number of critical brain areas associated with cognition and addiction as the cortex and ventral midbrain, suggesting that RyR2 induction plays a pivotal role in these given processes.

More and more researches were consequently done to confirm the idea. These experiments indicated that reduction in the RyR2 activation in animals were able to abolish behaviors associated with learning, memory and also addiction. This was absolutely a confirmation that RyR2 was required to develop long-term changes in the brain that could lead to addiction.

RyR2 and Calcium Release

What is the future of Molecular Switch for Memory and Addiction?

The results of those experiments were actually a milestone towards the understanding of the molecular processes which underlie our memory and addiction. This is an area that has not been exploited up to date though, and scientists are working tirelessly hoping they will soon come up with therapies based on these discoveries which will help in the treatment of addictions and also give counter measures to memory losses.

All we can hope is for this to happen soon than sooner, since the damage of addiction if already a concern all over the world and any success in this area will be a breakthrough for everyone in the world.

Is This Real-Molecular Switch For Memory And Addiction?

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