Tag Archives: Journal of Neuroscience

Addiction: A Neuroplasticity Disease

Addiction: A Neuroplasticity Disease

Had an accident or stroke? Developed amnesia? Lost consciousness for some reason? Well maybe not you. You may be wondering however how a friend or neighbor is recovering from such incidences of short or long term memory losses. Well thanks to technology now we know the brain has a way to self-regenerate in its functions through a process called neuroplasticity.

Neuroplasticity and Addiction Defined

Neuroplasticity is the brain’s ability to adjust to new environments or needs by developing new nerve cells throughout the body. it is the brain’s way of recovery. neuroplasticity allows the cells to compensate for any injuries or diseases in the nerve system. It also allows the neurons reorganize themselves to perform new functions of the brain depending on changes in their working environment.

One of the most common mechanisms in neuroplasticity is axonal sprouting. This is the process whereby active axons develop new nerve endings to connect with those their links were severed. Inversely, the damaged one can also grow new nerve endings to reconnect to the active neurons. Neuroplasticity is a term derived from the words; “neuron” and “plasticity”. A neuron is a nerve cell of the brain. Plasticity on the other hand means ability to remold. The process is at times referred to as brain malleability. Other times it is simply called brain plasticity.

Addiction on the other hand is an intricate condition of the brain, usually categorized as a disease that involves reward and motivation cerebral systems structurally and chemically altered. It is a mental condition characterized by a compulsive urge to indulge in rewarding stimuli despite possible dire consequences. Addiction is both reinforcing and rewarding. It manifests itself in the form of repetitive, intrinsic behavior including; gambling, food, exercises, shopping and substance abuse.

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Influence of Neuroplasticity on Addiction

At one time Aristotle said: “We are what we repeatedly do.” Even though the Greek coined the phrase in the context to advice his readers of making a habit of excellence, the great philosopher had his brain develop a pathway around his successes over time. See, that is what the brain does. It creates a path of neurons to support our habits. A weight lifter for instance develops stronger muscles as a result of repetitive action. Similarly the brain may develop a path around addiction.

Once such pathways are created, addiction takes control of the brain. Eventually the addiction becomes the only thing that matters to the addict. Once the addiction hijacks the brain’s centers of pleasure it becomes the only thing that brings the addict a sense of joy or happiness. Soon his/her brain recognizes more of the addiction and less of other socio economic aspects of life including: friends, relatives, family, responsibilities, and work among other normal forms of social interactions and activities.

Neuroplasticity on Addiction Treatment

For a long time detoxification has been used as a treatment mechanism against addiction. This is the removal of the substance of abuse from the body. Victims however fell back on to substance abuse shortly afterwards. The billion dollar question then was how this still happened sometimes way after the victim’s blood had been cleaned of the same. This was one very interesting aspect of scientific state of quandary.

It is however through neuroplasticity scientists discovered treatment of an addiction needed more than mere detoxification. The brain actually needed to be retrained back to its normal functions. It required an intensive psychotherapy among other medical interventions to remold the recovery process. Also, it required an intense psychotherapy to reconfigure the brain’s recognition of what initially seemed normal and of the person as a whole especially in terms of behavior change. The nerve cells needed to rebuild a connection along initial, rather former normal pathways.

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Neuroplasticity and Drug Abstinence

The process, neuroplasticity however does not take away the addictive neuron pathways like probably in the case of severe brain damage usually by accidents. It only retrains the brain to develop new ones along the old clean pathways. It is therefore often advisable to abstain from drugs completely during recovery. This is so as to avoid reinforcing the addictive path.

It is the same case each time you reread your favorite novel. You might have read it last twenty years ago. And you could have forgotten a few characters already. However if you picked that same book today you would remember a lot more, the story would begin to unfold in your sub conscience mind even without rereading the whole story yet again. You would remember the chapters more clearly, vividly the characters, deeply their roles and or attributes without going into it a whole other time.

Relationship between neuroplasticity and addiction is not a simple support of addictive habit and recovery alone. It is an inter-disciplinary connection of varied other fields; computer technology, anthropology, and psychology among others. Want to learn more on this? This year’s August integrative addiction medicine conferences could just be the answer you are looking for. Click on: http://www.integrativeaddiction2015.com and sign up for the upcoming event where you will have a chance to meet various medical experts, and listen to speakers on the neuroplasticity and integrative addiction recovery.

Addiction: A Neuroplasticity Disease

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Opioids and Cancer

How the use of opioids disturbs the cancer balance

OpioidsWhat are opiods?

There are several important things about opiods that you need to know at this stage. First, it is important to note that strictly speaking, the term ‘opioids’ is used to describe a group of chemical compounds that are defined by two important characteristics: having chemical action that is similar to that of morphine and being made of a distinct chemical structure. For many of the compounds that are categorized under this umbrella, their structures vary. Whereas some have distinct alkaloid structures, others occur in the form of peptides.

The second thing is about the occurrence of opioids. Naturally, opioids are found in two distinctive forms: occurring freely in the environment and within the body of human beings. Although initially the possibility of occurrence of opioids within the body of humans was strongly refuted, rigorous research has indicated that indeed the human brain contains specific endogenous opioids that play important role in different functions.

The third thing regards the interaction of opioids with complementary chemical compounds. Further studies have indicated that there are compounds whose actions contradict that of opioids. Known as antagonists, such compounds play a highly important role in their interaction with opioids in relation to influencing particular processes in the body. We shall examine this subject later.

How are opioids used?

For years, opioids have been used for a range of functions. Basically, the use of opioids has been in the form of morphine, which is a commonly occurring plant. Morphine has been used for medicinal as well as recreational purposes for long. Since the use of the plant for medicinal purposes is what matters with regard to our discussion, we shall focus on it.

At the commercial level, morphine has actually been used to relieve pain in chronically ill patients. Take cancer for example, the disease has been known to produce intense pain in patients. To relieve patients of this, morphine-based painkillers are extensively used. This is one common and formal way in which morphine (a common source of opioids) is used for commercial purposes.

The ability of opioids in general and morphine in particular to act as a strong analgesic has been a subject of research for long. Studies have indicated that the compounds have specific effects on the nervous system which translates to drastic reduction in pain. This explains the popularity of morphine-based painkillers as the standard therapy for cancer patients who have undergone an operation as part of the therapy or simply those in advanced stages of cancer.

Therefore, whether for recreation or medicinal use, opioids, have been extensively used to relieve cancer patients of pain in the course of treatment.

How opioids act

Basically, the action of opioids on the body can best be understood when you understand what opioid receptors are. Your body is made of special compounds which act as receptors for opioids. The receptors are distributed in several parts of your body, with many of them being in the central nervous system. It is this phenomenon that explains why opioids have a very strong effect on the nervous system. Others are distributed in different parts of your body such as the lungs, liver and other internal organs.

There are several types of receptors. It is the interaction between specific opioids and receptors that causes particular feelings in the body. Whereas some receptors are meant to trigger feelings of relief when they come into contact with opioids, others are designed to trigger changes in other physiological processes when opioids are introduced. The interaction between opioids and receptors is an important process when it comes to how opioids may disturb the cancer balance in the body.

How do opioids disturb cancer balance?

Simply put, cancer balance is a situation in which the process of metastasis, angiogenesis and invasion of healthy body cells by cancerous ones is completely inhibited. Research has indicated that use of opioids as painkillers can disturb this balance, thus leading to development of cancer in the body. On the other hand, other studies have indicated that morphine, in particular, may have anti-cancer properties by inhibiting the cancer development process mentioned above.

One way in which opioids used as painkillers can disturb the cancer balance is by altering the normal functioning of the immune system. Since cancer development largely depends on the state of the immune system, any compound that alters the immune system can indirectly influence the possible occurrence, development and spread of cancer. From several studies conducted, it can be concluded that particular opioids are able to alter the normal functioning of the immune system, thus exposing a patient on whom they are used to cancer development.

On the other hand, some studies have indicated that morphine is able to induce natural cell death and, as a result, control the growth of cancer cells in the body. However, this property, which highly depends on a number of different factors such as the concentration of the morphine that is used and the state of the opioid receptors in the body, remains a subject of research. What you need to know is that there has been concrete evidence to the effect that the use of opioids for relief of pain in cancer patients may actually disturb the cancer balance and trigger fresh development of cancer. This happens because of the effect that opioids have on the immune system of the patient in the form of production and inhibition of production of important hormones.

OpioidsConcluding remarks

Here at AWAREmed Health and Wellness Resource Center, we use the best approaches to administer alternative and complementary treatment of cancer to patients. Dr. Dalal Akoury is a specialist in this field. One thing, though, that sets her apart is her devotion to helping cancer patients successfully fight the devastating effects of the disease. Feel free to visit us in Myrtle Beach, South Carolina for a completely personalized administration of alternative and complementary therapies for cancer.

How the use of opioids disturbs the cancer balance

 

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