Tag Archives: Interleukin 6

Obesity and weight lose

Leptin concentration in relation to obesity

January 24, 2017
Leptin concentration

Leptin concentration in relation to obesity. In fact, Leptin concentrations adjust in response to obesity and contribute to insulin resistance

Leptin concentration in relation to obesity: Insulin resistance

Leptin regulates energy metabolism and balance in conjunction with the brain’s hypothalamus. Leptin is currently being touted as having cardio-protective benefits among its others roles in metabolism. Leptin concentrations adjust in response to obesity and contribute to insulin resistance. Besides that, doctor Dalal Akoury MD, President, and founder of AWAREmed health and wellness resource center register that, the changes in leptin concentration have also been associated with the risk factors for coronary heart disease. In the same way, increased resistin concentrations correlate with obesity-related inflammation and may be associated with the initiation and progression of atherosclerotic lesions. Resistins also promotes insulin resistance, although the actual mechanism is still not very clear.

Insulin resistance due to adipokines dysfunction is further influenced by free fatty acids liberated directly into the liver from the visceral fat tissue. Visceral fat releases chemicals and fatty acids into the portal system where they act on the connecting organs. The portal circulation system is a specialized network of blood vessels that connect the visceral organs to the liver. The excess fat in the portal circulation has detrimental effects on insulin action, which is worsened by sympathetic hyperactivity in response to obesity. Sympathetic hyperactivity causes heightened lypolytic action resulting in excess free fatty acids in the blood. These actions combined with beta cell hypersecretion and reduced insulin clearance resulting in hyperinsulemia, lead to early stage diabetes.

Leptin concentration in relation to obesity: Interleukin-6 (IL-6) 

Interleukin-6 (IL-6) is possibly another factor associated with inflammatory detriment within the portal system. High levels of IL-6 are a marker for inflammation and vascular pathology. Obese subjects demonstrated a 50% greater portal vein IL-6 concentration, demonstrating, again, the profound effect visceral fat has on pathogenic indicators. Portal vein IL-6 correlates with systemic C-reactive protein concentrations. And remember that the C-reactive protein is associated with cardio and peripheral vascular disease. C-reactive protein and oxidative stress are now presumed to interact in the early inflammatory processes of atherosclerosis. This is significant for young obese individuals. Although more research is necessary for a conclusive association, the C-reactive protein may be a new risk factor for CAD in individuals under 25 years of age.

The imbalance between increased inflammatory stimuli with a concurrent reduction in anti-inflammatory activity may be the foundation for the accelerated endothelial dysfunction and insulin resistance associated with obesity and the comorbid disorders of metabolic disease. However, more research is needed to clearly delineate the particular relationships, though it seems evident that the low-grade inflammation caused by obesity and visceral adiposity lead to the premature development of the disease. This, more so than ever before, identifies the importance of weight management during the developmental years and ongoing efforts to control weight throughout one’s lifespan.

Finally, for current obese people, there is still plenty of hope. Weight loss is related to the reduction of oxidative stress and inflammation, and these beneficial effects are likely to translate into the reduction of cardiovascular risk in obese individuals. Likewise, exercise and dietary management, along with pharmacologic intervention can lead to the atherosclerotic reversal in the earlier stages of CAD. Individuals with central adiposity, poor blood lipid profiles, hypertension, or insulin resistance should seek immediate professional assistance to prevent further health detriment by scheduling an appointment with AWAREmed health center now.

Leptin concentration in relation to obesity: Insulin resistance

http://www.integrativeaddictionconference.com/wp-admin

Facebooktwitterpinterestlinkedin

EPCs Role in Cardiovascular Diseases

June 4, 2015

Endothelial Progenitor Cells Role in Cardiovascular Diseases

EPCsCurrently, regenerative medicine is on focus with hopes that it can be used in treatment of cardiovascular diseases. The circulating endothelial progenitor cells have been shown to possess an ability to form mature endothelial cells that can be useful in the process of vascular repair as well as neoangiogenesis. In preclinical studies, it has been shown that the circulating endothelial progenitor cells (EPCs) have the potency for cardiovascular regeneration. With this said, it is god to admit that there is still a lot needed to be done in this area to show the effectiveness of the regenerative activities of these EPCs. Here we look at how the EPCs relate to cardiovascular diseases.

Endothelial Progenitor Cells are biomarkers of cardiovascular diseases

Just like other stem cells the circulating endothelial progenitor cells have the ability to proliferate, migrate, and differentiate into mature endothelial cells. First discovered from the human peripheral blood, the EPCs were shown to incorporate into sites of physiological or pathological neovascularization. Ever since the EPCs were discovered, a lot has improved in the understanding of the blood vessel formation. There is a growing body of evidence that EPCs helps in providing postnatal vasculogenesis mechanism for neovascularization and vascular remodeling.

These cells have also been shown to possess diverse physiological functions and helps in the recovery process of myocardial ischemia and infarction, limb ischemia, wound healing, atherosclerosis, endogenous endothelial repair, and tumor vascularization. Earlier clinical trials have proved that EPC therapy is safe and feasible for the treatment of cardiovascular diseases. Plus, the circulating EPCs are also considered as biomarkers for coronary and peripheral artery disease. In spite of the medicinal abilities of these EPCs, there is still a lot to be done in order for the mechanism by which these cells work can be fully understood and be applied.

Despite the haze that still clouds the mechanism with which the EPCs work, it has been shown that EPCs locating to damaged tissues and organs proceeding vascular regeneration do not only help in the formation of the neovasculature but also produce a variety of proangiogenic cytokines and growth factors thus promoting proliferation and migration of pre-existing Endothelial Cells and activating angiogenesis to contribute to vascular regeneration. it is suggested that the EPCs owes their ability to contribute to vascular regeneration to the presence of cytokines and other secreting pro-angiogenic factors in them such as VEGF, stroma derived factor (SDF)-1α, angiopoietin-1 (Ang-1), hepatic growth factor (HGF), insulin-like growth factor (IGF)-1, and eNOS/iNOS (inducible nitric oxide synthase). Thus, EPCs can mediate tissue-protective effects and contribute to neovascularization via direct vasculogenesis in ischemic tissues and indirect production of proangiogenic factors to pre-existing endothelial cells.

Research has shown that there are reduced numbers of EPCs in clinical conditions like diabetes mellitus, heart failure, chronic kidney disease and hypertension. In such conditions these EPCs also become impaired and malfunctioning. It has also been shown that the number of peripheral EPC is significantly reduced and their functions impaired in patients with established coronary artery disease and stroke. In contrast the number of EPCs has been found to be on the increase in patients with acute coronary syndrome such as acute myocardial infarction or unstable angina since they are mobilized from the bone marrow into the bloodstream.

The levels and migratory capacity of EPCs is also highly reduced in those suffering from hypertension with coronary artery disease. Besides, the concentration of circulating EPCs is considerably reduced in refractory hypertension as compared to healthy subjects. Imanishi T and his colleagues reported that EPC senescence is augmented in both experimental hypertensive rats and patients with essential hypertension, which may be related to telomerase inactivation. The team found that the hypertension-induced EPC senescence may affect the process of vascular remodeling.

Another researcher, Delva P in his research; Endothelial progenitor cells in patients with essential hypertension, reported that there was no alteration in the number or functional activity of EPCs in 36 patients with essential hypertension. Some research studies have also demonstrated that the numbers of EPCs are decreased in pulmonary hypertension while others that the number of EPCs are increased or remain normal in pulmonary hypertension. With these available literature that are somehow conflicting there isn’t a clear relationship between EPCs and hypertension

EPCs and Heart Failure

EPCsTo show the relationship between heart failure and the number of circulating EPCs, Valgimigli M and his counterparts tested the level of EPCs in patients suffering from heart failure and they discovered that EPC mobilization occurred in heart failure and showed a biphasic response, with elevation in early stages while depression in the advanced stages. The increased EPCs was shown as a replication of a functional bone marrow response to diffuse and severe endothelial damage during the early stages of heart failure but an additional and significant increase of tumor necrosis factor (TNF-α) counteracted and overwhelmed the elevation of EPC mobilization in advanced disease phases by exerting a possible suppressive effect on hemopoiesis.

conference

With the above findings, it is clear that there is a relationship between the EPCs and the cardiovascular diseases. For more information about bone marrow transplant and stem cell transplantation, visit www.awaremednetwork.com Dr. Dalal Akoury, a doctor with years of experience in integrative medicine will be able to help. Don’t hesitate to check on http://www.integrativeaddiction2015.com  and learn about the upcoming Integrative Addiction Conference 2015. The conference will dwell on unique approaches to telling symptoms of addiction and how to help addicts.

Endothelial Progenitor Cells Role in Cardiovascular Diseases

Related articles
Facebooktwitterpinterestlinkedin

Restoration of Immune System to heal addiction

April 28, 2014

Restoration of Immune System to heal addiction-Drug and Alcohol Addiction Wreak Havoc

Immune System to heal addiction

Immune system is an asset to keep by eating healthy food and physical activities. This will also help heal addiction

The body of a human being is a compound of many vital organs performing different functions that help keep the body well and healthy. The success of these functions is normally based on the total elimination of any substance that may work against these functions. When the body is functioning well we say the immunity system is strong. So what is immunity? It is the ability of an organism to resist a particular infection or toxin by the action of specific antibodies or sensitized white blood cells. We need to restore our immune system to heal addiction. The white blood cells are the defenders of the body from attacks by diseases however substance which weakens the body’s immunity does so by attacking the white blood cell. We will through this article be discussing majorly the proper healing of addiction through the restoration of immune system.

Your immune system is like a finely tuned orchestra whose purpose is to defend your body from unhealthy insults from the world around you. Like an orchestra, your immune system contains many different instruments that work harmoniously together with one goal, protecting you from foreign insults that can cause damage to your body. And, like an orchestra, the different parts of your immune system must be present to play their part at the right time, and then stop when they have completed their function. The main parts of your immune system to heal addiction are the immune cells, the structural barriers in your body in which the majority of these cells are localized, and the specific messenger molecules that call the cells to action or tell them to stop.

The cells of your immune system are found circulating in your bloodstream or in the lymph nodes, which are located throughout your body; therefore, the immune cells themselves are spread throughout your tissues and can travel quickly when called upon. This way, your immune system is positioned so that it can minimize the entrance into your body of foreign invaders that can cause infection and disease and can quickly respond to any invaders that do manage to gain entrance into your body.

Restoration of Immune System to heal addiction-The foundation for defense

Your immune system also relies upon specific structures in your body that provide a foundation for defense. The most important structures are the barriers between the inside of your body and the outside. These barriers keep unwanted organisms and molecules from entering your body where they can do damage. Since your skin is in contact with the outside world, it is probably not surprising that your skin is an important barrier; however, it is only one part of your defensive barrier. Your gastrointestinal tract is actually the largest barrier between you and the outside world. Restore your gut and your immune system to heal addiction.

Restoration of Immune System to heal addiction -The soluble factors

Your immune system also includes molecules called soluble factors. These are molecules that can recognize when your barrier has been compromised by a foreign invader or toxin and then try to heal the area of damage and remove the insult from your body rapidly. Factors such as the complement cascade, a complex group of proteins, can form an immediate response to an insult. Your immune system also can deploy signaling molecules, which are soluble factors that send messages to the immune cells located further inside the tissue that has been compromised, or into your bloodstream. These messenger soluble factors call immune cells to the site of damage and activate the cells, bringing them in full force to the infected area. These messenger molecules are called cytokines. So we need to restore our immune system to heal addiction.

Your cytokines not only signal immune cells to take up action, but they also often promote an inflammatory response. The inflammatory response at a site of infection is one way your body secludes, or walls-off, an infected area. For example, if you have ever had poison ivy, or gotten a rash from eating a food to which you are allergic, you may have noticed the signs of inflammation — redness and swelling — surrounding the affected area. So, when we talk about the immune system, it is not one organ; it is really the types of immune cells, structures, and soluble factors, like cytokines, which are present throughout all your organs that constitute the immune system. And, your immune system gets help from your inflammatory response.

Restoration of Immune System to heal addiction -Addictive substances

Having understood the proper functionality of our immune system it will be necessary that we take a moment and look at some of these substances that work against the well-being of the body and causes addiction. While there are some serious consequences, the impact substances have on the body can extend much further. Consider how these illicit substances commonly associated with addiction can impair health of regular users:

Cocaine

From a basic standpoint, those sniffing cocaine on a regular basis will likely cause severe damage to their sinus cavities. This repetitive aggravation can heighten risk of developing cold or other circulatory issues. While seemingly minor, these health issues can be indicative of a much larger loss of strong immune response. A 2003 study found that cocaine use can limit the production of IL-6 cytokines, a “hormone of the immune system” that plays a major part in prompting recovery when the body is damaged. We should avoid cocaine to restore the immune system to heal addiction.

Opioids

Opioids that come in the form of prescription drugs are commonly marketed as medications tailored to help improve the health of patients experiencing chronic pain. While these pills may be able to relieve pain under strict use, these medications are highly addictive and can lead patients to use them on a regular basis. Regular use of opioids can impair daily function a great deal, but what many may not notice is a progressive decline in immune response. Therefore we need to stop opioid use to restore the immune system and heal addiction.

Alcohol

This is the most abused addictive drug globally and we are all aware of the dramatic health consequences of drinking even in non-alcoholic scenarios. For instance, drinking is often identified with the unpleasant side effects of nausea, vomiting, slurred speech, impaired movement and headache. However, those who abuse alcohol regularly or binge drink could be doing a great deal of harm to their immune system.

Noting that many alcoholics struggle with binge-drinking, it is important to learn what long-term damage is being done to the body beyond blacking out. Exhaustion as a result of binging on drugs or alcohol can be a significant cause of illness. When a person binge drinks, they may cause their body to go into toxic shock from the large amount of alcohol in their bloodstream.

Restoration of Immune System to heal addiction -Healing the Immune System

From this discussion it’s clear that immune system does a lot for us to keep us as healthy as possible, but in order to be in our best state, it is imperative that we do everything we can to protect and heal our immune system, in other words the restoration of immune system to heal addiction is a must. While enrolling in an addiction recovery can be a great way to spark this healing process and create a healthier and brighter future, the choice of the expert and facility can be a challenge to many. As for you my dear reader this won’t be a problem because you have doctor Dalal Akoury the founder and MD of AWAREmed Health and Wellness Resource Center. At her center you will be attended by highly qualified and caring professionals who will focus on Neuroendocrine Restoration (NER) to reinstate normality through realization of the oneness of Spirit, Mind, and Body, Unifying the threesome into ONE. It will not matter the problem you have whether you are an addict or your immune system is the problem, this is the place to be and you will have your life back. Restore the immune system to heal addiction cannot be easier here at AWAREmed.

Restoration of Immune System to heal addiction -Drug and Alcohol Addiction Wreak Havoc

 

Related articles
Enhanced by Zemanta
Facebooktwitterpinterestlinkedin

  • Recent Posts

  • Blog Categories