Tag Archives: Inflammation

Inflammation Linked To Cancer

July 19, 2014

Research Proves That Inflammation Causes Cancer

InflammationThere are very many causative agents to cancer but still with the global climate change and pollution to our environment, deforestation that has changed air composition in most parts of the world, even more cancer causative agents are yet to be known. Current research studies have linked inflammation to cancer.

 

Inflammation is one of the most effective defense mechanisms that our bodies use to protect us against the invasion of disease causing pathogens. Inflammation helps our bodies to eliminate bacteria and other chemicals that may cause disease in our bodies. Scientists say that without inflammation we can barely survive especially during infancy. So inflammations are typically beneficial to us but it also has a negative effect in our bodies. Inflammations can help in the formation as well as in the growth of cancerous cells. It may also help in metastasis.

 

When our bodies are invaded by foreign bodies, the bodies will react to counter the effects of the foreign body. An example is an open wound will open a path through which bacteria and other disease causing pathogens enter the body. As the bacteria enters through the open wound, the white blood cells respond by coming to the site of injury and initiates a war against the bacteria by the help of toxins that it uses to kill the bacteria. During this fight it can be seen that a swelling is developing around the injury, the area becomes red and painful. This condition should not last for long as it may cause damage to the healthy cells. After this the fighters leave the site leaving space for tissue repair and recovery agents to promote healing. This is how helpful inflammation is.

 

However incase the inflammation becomes too much, it may cause serious health problems. When inflammation becomes persistent, it may lead to diseases such as the rheumatoid arthritis as well as psoriasis. It may also cause cancer. Chronic inflammation leads to diseases such as pancreatitis and the Crohn’s disease which have been proved to increase one’s risk to cancer. Chronic inflammation has also been found to be the root cause of certain types of cancers stomach cancer and liver cancer.

 

How does inflammation cause cancer?

 

A new research study has proved that inflammation may cause cancer. The study done by researchers at the Ohio State University Comprehensive Cancer Center — Arthur G. James Cancer Hospital and Richard J. Solove Research Institute (OSUCCC — James) found that inflammation triggers a rise in levels of a molecule called microRNA-155 (miR-155). The rise in levels of microRNA-155 (miR-155) causes a drop in the protein that are used in DNA repair and this results in higher rates of spontaneous gene mutations which finally leads to formation of cancer cells.

“Our study shows that miR-155 is unregulated by inflammatory stimuli and that over expression of miR-155 increases the spontaneous mutation rate, which can contribute to tumorigenesis,” explains Dr. Esmerina Tili a post-doctoral researcher who also authored the research findings.

 

“People have suspected for some time that inflammation plays an important role in cancer, and our study presents a molecular mechanism that explains how it happens.”

“Our findings also suggest that drugs designed to reduce miR-155 levels might improve the treatment of inflammation-related cancers,” Tili explains.

 

 

The researchers have so far proved that inflammation can cause cancer, so what next? How can we limit inflammations? You need not to worry nature has provided most of the powerful anti inflammation vegetables and fruits that will help you to avoid chronic inflammations and reduce your risk to inflammation induced cancers. Some of these are curcumin and Boswellia.

 

Anti-inflammation properties of Curcumin and Boswellia

 

Turmeric (Curcumin)

Turmeric is a member of the ginger family, turmeric has been highly valued for its many medicinal abilities, among most of its medicinal abilities is that it is very effective in reducing inflammations. Turmeric is a common spice to Indians who value it for its health benefits. Curcumin is the most active component of turmeric.  Curcumin is effective in reducing inflammations. It exerts its anti-inflammatory activity by inhibiting the enzymes and prostaglandins that are essential for inflammation.

Researchers at Baylor University Medical Center in Dallas conducted a research that involved dividing 45 patients with rheumatoid arthritis into three groups. One group received curcumin, the second group was given a standard rheumatoid arthritis drug and the third group was given both. After eight weeks, both the group who took curcumin alone and the group that got both the drug and the spice had a greater reduction in symptoms such as joint swelling and pain compared with those who only took the drug devoid of curcumin. It was also noted that those who were on the curcumin did not suffer any side effect as was the case with those who were under the standard drugs.

Boswellia

Boswellia is also known as frankincense. It was highly valued in the ancient times so much that when Jesus was born, the wise men brought him boswellia as a gift. This wonderful product has proved its medicinal value in treating various conditions. It is useful in reducing inflammations as well as repairing degenerated muscle tissues. Researchers have showed that it contains boswellic acids that are useful in reducing inflammations. The boswellic acids are also less toxic and do not cause any harm on the patient.

A research that was done to determine the treatment abilities of boswellia proved that it was effective. The research involved 30 patients that were suffering from osteoarthritis of the knee that were taken through placebo for 8weeks after which they were treated to boswellia for another 8weeks. The research found out that the patients’ conditions improved on the boswellia treatment than when on placebo.

To tame cancer you need reliable information. Dr. Dalal Akoury (MD) has a commitment of making this information available to you so that you can take care of your health better. Visit her website regularly and learn more.

Research Proves That Inflammation Causes Cancer

 

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Drugs that can harm the Immune System

April 30, 2014

Drugs that can harm the Immune System-Their negative effects

Immune system

Help indeed, drugs which affects immune system are toxic and addictive, if affected seek professional help

We have in the past articles discusses the significance of immune system to the human body. As a center for protecting the body against injuries from pathogens and substances, it is very important that we get to know some of the drugs which may injure this center (immune system) and take precautionary actions to ensure that the fabric of immunity is safe. For-instance flu is rarely deadly, but even though this is true, pneumonia which kills comes as result of flu making it a serious point of concern. It is therefore necessary that prescription and over-the-counter drugs be seriously considered on the list of things that could potentially make people more susceptible to having a flu that morphs into a deadly pneumonia. The following are some of the drugs for consideration:

Steroids these are drugs from corticosteroids to anabolic steroids, suppress the immune system that defends against bacterial and viral infections such as pneumonia.

Chronic stress creates greater susceptibility to infection because it raises cortisol levels. Cortisol is a steroid hormone released by the adrenal glands that has many side effects when it’s chronically high. One side effect is that it reduces inflammation. This may appear good but at the same time it suppresses the immune system. Chronically high cortisol also disrupts blood sugar balance, often leading to high insulin, obesity and sometimes, diabetes. With these illnesses weak immune system is disastrous.

The most common route of steroid drug use, particularly in children, is through asthma inhalers.
Most asthma inhalers contain some form of synthetic steroid. These steroids help reduce the airway inflammation associated with asthma, but at the same time can reduce the ability of the lungs to fight bacterial and viral infections.

Steroid drug abuse among high school and college athletes is common. The National Institute on Drug Abuse estimates that 1 – 6% of high school athletes use steroid drugs to enhance their performance. This amounts to potentially hundreds of thousands of teens with suppressed immune systems who are more susceptible to viral and bacterial infection.

Steroid drugs such as prednisone are widely prescribed for people with painful inflammatory diseases such as arthritis, and for autoimmune diseases such as multiple sclerosis and lupus. They are also prescribed for those with organ transplants to suppress a rejection response by the immune system.

Even the regular use of cortisone creams for arthritis can raise cortisol levels enough to suppress the immune system.

Drugs that can harm the Immune System-PPI Heartburn Drugs that Suppress Stomach Acid
Proton pump inhibitors or PPIs such as Nexium, Prevacid and Prilosec powerfully block the secretion of stomach acid. This has the effect of reducing heartburn and nausea, but it also blocks one of the body’s main defenses against bacteria and viruses. According to a 2004 study published in the Journal of the American Medical Association (JAMA), 70% of the hospitalized patients in the study received a PPI or other stomach acid-suppressing drug within hours of being admitted. The study showed that patients who were given PPIs had a 30% higher risk of developing pneumonia.

Drugs that can harm the Immune System-Statin Drugs to Lower Cholesterol
A medical group in Switzerland found that organ transplant patients who were taking statin drugs (e.g. Lipitor, Mevacor, Pravachol) did better than those who weren’t taking the drugs. Laboratory studies showed that statins did indeed suppress parts of the immune system, and the authors concluded, “This unexpected effect provides a scientific rationale for using statins as immune-suppressors, not only in organ transplantation but in numerous other pathologies as well.”

Drugs that can harm the Immune System-SSRI Antidepressants
The selective serotonin reuptake inhibitor antidepressant drugs (SSRIs) such as Prozac, Zoloft and Paxil increase serotonin levels and in so doing also give the immune system a boost. This boost can be the good news or the bad news. According to expert researchers this boost can push the immune system into autoimmune disease, where the body starts attacking itself. These types of immune system over-reactions are also implicated in the “cytokine storms” that can create deadly inflammation in the lungs.

Opioid Drugs
Both short term and long term use of the pain killing opioid drugs such as hydrocodone, oxycodone, fentanyl, codeine and morphine block the immune system’s ability to attack viral and bacterial invaders. Some pain killers drugs such as Tramdol combine an opioid with acetaminophen (e.g. Tylenol), further compromising the immune system with acetaminophen’s toxic effects on liver function.

Acetaminophen
Acetaminophen (e.g. Tylenol) is very hard on the liver, the body’s major organ of detoxification. A simple dosage mix-up, such as giving a teaspoon of liquid acetaminophen vs. a dropperful can cause liver damage, particularly in children. When the body is invaded by a virus or bacteria, the debris of the battle is processed through the liver. A compromised liver cannot effectively remove toxins caused by infection.

Drugs that can harm the Immune System-Fakegrances
Fake fragrances, also known as fakegrances, such as the air fresheners, scented laundry soaps and personal care products, candles, and most perfumes are not drugs, but for many people they are certainly lung irritants and are thought to be a major cause of asthma in children.

Fakegrances often contain dozens if not hundreds of chemicals, many of them extremely toxic. Fakegrances remain unregulated in the U.S., the justification being that the toxic chemicals are present in such small amounts that they are not harmful. However, constant exposure through scented personal care products, wearing fakegranced clothing, sleeping on fakegranced sheets and living with air fresheners in the home and car, certainly has an impact on the lungs. There has been an explosion in the use of hand sanitizer gels, all of them containing fakegrances.

Drugs that can harm the Immune System-Strive for Immune Balance
The truth is this a journey you do not want to disengage in owing to the vitality of immune system. It will not be wrong to say that immune system is undisputed tool for good health and sine we both love life we have a duty to make sure that it is well maintained. I suggest that if you’re taking drugs of any kind, make a list of their brand names and generic names, and take an audit of each to a certain if they suppress the immune system. This knowledge is very important to you irrespective of whether you need to stay on an immune-suppressing drug or not, you will still need to know how it’s affecting your body.

All of us want a balanced immune system, which is best achieved by an overall healthy lifestyle which includes wholesome foods, moderate exercise, good sleep and stress management. Besides all these you will need to be inconstant touch with an expert to help you keep the promise. This is effectively available at AWAREmed Health and Wellness Resource Center under Doctor Akoury. With her you will be cared for professionally while focusing on Neuroendocrine Restoration (NER) to reinstate normality through realization of the oneness of Spirit, Mind, and Body, Unifying the threesome into ONE. Welcome to AWAREmed and experience the comfort of living life to the fullest.

Drugs that can harm the Immune System-Their negative effects

 

 

 

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Restoration of Immune System to heal addiction

April 28, 2014

Restoration of Immune System to heal addiction-Drug and Alcohol Addiction Wreak Havoc

Immune System to heal addiction

Immune system is an asset to keep by eating healthy food and physical activities. This will also help heal addiction

The body of a human being is a compound of many vital organs performing different functions that help keep the body well and healthy. The success of these functions is normally based on the total elimination of any substance that may work against these functions. When the body is functioning well we say the immunity system is strong. So what is immunity? It is the ability of an organism to resist a particular infection or toxin by the action of specific antibodies or sensitized white blood cells. We need to restore our immune system to heal addiction. The white blood cells are the defenders of the body from attacks by diseases however substance which weakens the body’s immunity does so by attacking the white blood cell. We will through this article be discussing majorly the proper healing of addiction through the restoration of immune system.

Your immune system is like a finely tuned orchestra whose purpose is to defend your body from unhealthy insults from the world around you. Like an orchestra, your immune system contains many different instruments that work harmoniously together with one goal, protecting you from foreign insults that can cause damage to your body. And, like an orchestra, the different parts of your immune system must be present to play their part at the right time, and then stop when they have completed their function. The main parts of your immune system to heal addiction are the immune cells, the structural barriers in your body in which the majority of these cells are localized, and the specific messenger molecules that call the cells to action or tell them to stop.

The cells of your immune system are found circulating in your bloodstream or in the lymph nodes, which are located throughout your body; therefore, the immune cells themselves are spread throughout your tissues and can travel quickly when called upon. This way, your immune system is positioned so that it can minimize the entrance into your body of foreign invaders that can cause infection and disease and can quickly respond to any invaders that do manage to gain entrance into your body.

Restoration of Immune System to heal addiction-The foundation for defense

Your immune system also relies upon specific structures in your body that provide a foundation for defense. The most important structures are the barriers between the inside of your body and the outside. These barriers keep unwanted organisms and molecules from entering your body where they can do damage. Since your skin is in contact with the outside world, it is probably not surprising that your skin is an important barrier; however, it is only one part of your defensive barrier. Your gastrointestinal tract is actually the largest barrier between you and the outside world. Restore your gut and your immune system to heal addiction.

Restoration of Immune System to heal addiction -The soluble factors

Your immune system also includes molecules called soluble factors. These are molecules that can recognize when your barrier has been compromised by a foreign invader or toxin and then try to heal the area of damage and remove the insult from your body rapidly. Factors such as the complement cascade, a complex group of proteins, can form an immediate response to an insult. Your immune system also can deploy signaling molecules, which are soluble factors that send messages to the immune cells located further inside the tissue that has been compromised, or into your bloodstream. These messenger soluble factors call immune cells to the site of damage and activate the cells, bringing them in full force to the infected area. These messenger molecules are called cytokines. So we need to restore our immune system to heal addiction.

Your cytokines not only signal immune cells to take up action, but they also often promote an inflammatory response. The inflammatory response at a site of infection is one way your body secludes, or walls-off, an infected area. For example, if you have ever had poison ivy, or gotten a rash from eating a food to which you are allergic, you may have noticed the signs of inflammation — redness and swelling — surrounding the affected area. So, when we talk about the immune system, it is not one organ; it is really the types of immune cells, structures, and soluble factors, like cytokines, which are present throughout all your organs that constitute the immune system. And, your immune system gets help from your inflammatory response.

Restoration of Immune System to heal addiction -Addictive substances

Having understood the proper functionality of our immune system it will be necessary that we take a moment and look at some of these substances that work against the well-being of the body and causes addiction. While there are some serious consequences, the impact substances have on the body can extend much further. Consider how these illicit substances commonly associated with addiction can impair health of regular users:

Cocaine

From a basic standpoint, those sniffing cocaine on a regular basis will likely cause severe damage to their sinus cavities. This repetitive aggravation can heighten risk of developing cold or other circulatory issues. While seemingly minor, these health issues can be indicative of a much larger loss of strong immune response. A 2003 study found that cocaine use can limit the production of IL-6 cytokines, a “hormone of the immune system” that plays a major part in prompting recovery when the body is damaged. We should avoid cocaine to restore the immune system to heal addiction.

Opioids

Opioids that come in the form of prescription drugs are commonly marketed as medications tailored to help improve the health of patients experiencing chronic pain. While these pills may be able to relieve pain under strict use, these medications are highly addictive and can lead patients to use them on a regular basis. Regular use of opioids can impair daily function a great deal, but what many may not notice is a progressive decline in immune response. Therefore we need to stop opioid use to restore the immune system and heal addiction.

Alcohol

This is the most abused addictive drug globally and we are all aware of the dramatic health consequences of drinking even in non-alcoholic scenarios. For instance, drinking is often identified with the unpleasant side effects of nausea, vomiting, slurred speech, impaired movement and headache. However, those who abuse alcohol regularly or binge drink could be doing a great deal of harm to their immune system.

Noting that many alcoholics struggle with binge-drinking, it is important to learn what long-term damage is being done to the body beyond blacking out. Exhaustion as a result of binging on drugs or alcohol can be a significant cause of illness. When a person binge drinks, they may cause their body to go into toxic shock from the large amount of alcohol in their bloodstream.

Restoration of Immune System to heal addiction -Healing the Immune System

From this discussion it’s clear that immune system does a lot for us to keep us as healthy as possible, but in order to be in our best state, it is imperative that we do everything we can to protect and heal our immune system, in other words the restoration of immune system to heal addiction is a must. While enrolling in an addiction recovery can be a great way to spark this healing process and create a healthier and brighter future, the choice of the expert and facility can be a challenge to many. As for you my dear reader this won’t be a problem because you have doctor Dalal Akoury the founder and MD of AWAREmed Health and Wellness Resource Center. At her center you will be attended by highly qualified and caring professionals who will focus on Neuroendocrine Restoration (NER) to reinstate normality through realization of the oneness of Spirit, Mind, and Body, Unifying the threesome into ONE. It will not matter the problem you have whether you are an addict or your immune system is the problem, this is the place to be and you will have your life back. Restore the immune system to heal addiction cannot be easier here at AWAREmed.

Restoration of Immune System to heal addiction -Drug and Alcohol Addiction Wreak Havoc

 

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Leaky gut Syndrome and Inflammation will make weight loss impossible

February 19, 2014
Leaky Gut and Inflammation

With leaky gut not only is the digestive lining more porous and less selective about what can get in, but normal absorption can also be affected

 

 

 

 

 

 

 

 

Leaky gut Syndrome and Inflammation will make weight loss impossible-How?

With leaky gut not only is the digestive lining more porous and less selective about what can get in, but normal absorption can also be affected

Leaky gut Inflammation can be a difficult diagnosis to establish for a number of reasons: It’s associated with a wide range of seemingly unconnected symptoms; it has a lot of different causes; there’s no specific test to confirm it; and evidence tying it to other conditions can be murky. As a result, there’s a fair amount of skepticism in the mainstream medical community about the legitimacy of leaky gut as a diagnosis. But as the evidence that this is indeed a real and recognizable condition grows, opinions are slowly changing. That’s a good thing, because leaky gut is likely to emerge as one of the most significant medical concepts of our time.

Leaky gut Syndrome and Inflammation-How Leaky Gut Affects You

The digestive lining serves is an important barrier function. It’s like a sieve with very tiny holes allowing only small substances to go through, while keeping out larger undesirable particles. With leaky gut, also known as increased intestinal permeability, the net becomes damaged, resulting in bigger holes that allow more things to pass through that ordinarily couldn’t.

When the barrier function becomes compromised, then bacteria, viruses, undigested food particles and toxic waste products can leak from the inside of your intestines through the damaged digestive lining into your bloodstream, where they’re transported throughout your body and can trigger your immune system to react. The end result is inflammation in various parts of your body, leading to a wide variety of symptoms of Inflammation like bloating, cramps, fatigue, food sensitivities, flushing, achy joints, headache and rashes.

With leaky gut not only is the digestive lining more porous and less selective about what can get in, but normal absorption can also be affected. Nutritional deficiencies may develop as a result of damage to the villi – the finger-like projections in the small intestine that are responsible for absorbing nutrients.

Multiple food sensitivities are another hallmark of leaky gut, because partially digested particles of protein and fat may leak through the intestinal wall into the bloodstream and cause an allergic response as a result of inflammation. Increased intestinal permeability may potentially cause or worsen a number of other conditions, including Celiac disease, inflammatory bowel disease (IBD, which includes Crohn’s disease and ulcerative colitis), irritable bowel syndrome (IBS), arthritis, psoriasis, eczema and asthma.

Leaky gut Syndrome and Inflammation –Causes

So what causes increased intestinal permeability? There’s still much to be learned, but diet, chronic stress, certain medications and bacterial imbalance seem to play important roles. Eating a diet high in refined sugar can lead to overgrowth of yeast species, which has been associated with leaky gut. Preservatives and chemicals in processed foods can damage the lining, and so can consumption of gluten – a protein found in wheat, rye and barley.

Chronic stress can lead to a weakened immune system, affecting your ability to fight off invading bacteria and viruses and worsening the symptoms of leaky gut. Medications like aspirin and non-steroidal anti-inflammatory (NSAIDs) that can damage the lining of your gut, as well as antibiotics that kill off your essential good bacteria are also associated with increased intestinal permeability. In fact, an imbalance between beneficial and harmful species in your gut called dysbiosis is one of the leading theories about what causes increased intestinal permeability. Excessive alcohol consumption, infection with parasites, radiation and chemotherapy can damage the lining of the intestine and are also risk factors.

In addition to bloating and digestive distress, a lot of the patients I see with leaky gut have a combination of other symptoms like food allergies, chronic sinus infections, achy joints, fatigue, brain fog or unexplained rashes. Typically they’ve been to multiple doctors trying to make sense of their symptoms, and conventional tests and imaging studies have been unrevealing. There can be a feeling of hopelessness and despair, because the symptoms seem so unrelated. With all these infections cropping in it becomes clear that the body becomes sick and as a result weight loss becomes practically impossible.

When you think of leaky gut not so much as a disease, but as a mechanism by which a number of different conditions can develop, it starts to make sense. A leaky gut is the pathway for how toxins enter the body through the GI tract and create all kinds of mayhem once they’re in, sort of like party crashers who slip through security and proceed to make a mess of the venue.

Leaky gut Syndrome and Inflammation-Solutions?

There’s no miracle cure for treating leaky gut, but there are things you can do if you’re suffering from it that can help heal inflammation and restore the integrity of your gut lining.

An anti-inflammatory diet that eliminates refined sugars, dairy, gluten, alcohol and artificial sweeteners – some of the biggest offenders when it comes to inflammation – can be very helpful. Consuming lots of anti-inflammatory essential fatty acids in fish and nuts, and filling up on green leafy vegetables, high-fiber and fermented foods that help to promote the growth of good bacteria is also crucial.

A robust probiotic that contains large amounts of good bacteria can help heal a damaged intestinal lining by restoring balance in the gut flora.

Supplements like glutamine have been shown in some studies to help with intestinal injury after chemotherapy and radiation and may be beneficial in leaky gut.

Most people will notice improvement within 6 weeks, although it may take several months and even years to heal a damaged intestinal lining in extreme cases of leaky gut. Because we’re still learning about leaky gut, many of the treatment guidelines are drawn more from anecdotal observation than from rigorous scientific studies. But they’re sensible recommendations that can lead to improvements in your overall health, whether or not you have increased intestinal permeability.

Leaky gut is one of those diagnoses that bridges the gap between conventional and alternative medicine, between what we can see and touch and what we can feel in our bodies. I refuse to believe that the hundreds of patients I see in my office with unusual and seemingly unrelated complaints are crazy, or just stressed out.

I believe them when they say they feel like they’re being poisoned, or that they think there’s a connection between all their symptoms, even though they don’t know what it is. My hunch is that as our knowledge grows, the theories behind leaky gut will become the foundation for lots of diseases that are widely prevalent in our society, and millions of people will be in a better position to find relief from their suffering.

Leaky gut Syndrome and Inflammation will make weight loss impossible-How?

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Body inflammation causes obesity

February 12, 2014

Body inflammation causes obesity-How it happens

Inflammation

When inflammation becomes chronic, as is the case with obesity, chemical mediators, derived from different cellular activities, change in dynamics causing a progressive state of decline

A common theme that links many diseases and chronic illness is uncontrolled cellular inflammation. It is a factor in diseases including cardiovascular disease, diabetes, cancer, arthritis and many autoimmune-related conditions. Obesity has recently been added to this group of diseases as it is now known to present a low grade inflammatory response within many of the body’s tissues, which cause deleterious effects, often leading to the development of cardiovascular and metabolic disease. It is well known that being overweight is detrimental to one’s health, but until recently the known mechanisms were limited. Scientists over the last decade have started to unravel the mystery of why obesity leads to premature death. Although there is still much to learn, it is valuable to comprehend the known effects of chronic inflammation, as the prevalence of obesity continues to be a rising problem among the American population, particularly in children.

Inflammation and obesity-What is the meaning

Inflammation is, by design, a protective response leading to the repair of tissue. When inflammation becomes chronic, as is the case with obesity, chemical mediators, derived from different cellular activities, change in dynamics causing a progressive state of decline. Fat cells are now considered an immune organ that secretes numerous immune modulating chemicals. Visceral fat, in particular, is associated with the low grade inflammation that seems to be a contributing pathologic feature for metabolic disease through insulin resistance and the promotion of atherosclerotic build-up in circulatory vessels. When high levels of visceral fat are combined with physical inactivity, over nutrition, and advancement in age, the effect becomes more pronounced. Visceral fat is highly metabolic and contributes to cytokine hyperactivity. Adipokines secreted from fat tissue influence the metabolic process and contribute to proper function. The consequent low grade inflammation associated with obesity causes disturbance in the secretion and function of adipokines. Research has identified changes in adiponectin, leptin, and resistin that exhibit harmful effects upon the body in obese individuals. Adiponectin is an antiatherogenic agent, meaning it helps prevent the development of atheroschlerotic plaque in blood vessels and slows the progression of atherosclerosis in coronary vessels. It does this by acting directly upon the vessel wall, inhibiting adhesive molecules from contributing to plaque formation and acts as a blocking agent to the formation of foam cells. In the skeletal muscle and the liver, adiponectin serves to promote insulin sensitivity and a positive blood lipid profile. Visceral adiposity reduces adiponectin concentrations. Lowering the adiponectin concentrations lessens the cardio protective effect, leading to increased cardiovascular risk.   Leptin regulates energy metabolism and balance in conjunction with the brain’s hypothalamus. Leptin is currently being touted as having cardioprotective benfits among its others roles in metabolism Leptin concentrations adjust in response to obesity and contribute to insulin resistance. The changes in leptin concentration have also been recognized as a risk factor for coronary heart disease. Likewise increased resistin concentrations correlate with obesity related inflammation and may be associated with the initiation and progression of atherosclerotic lesions. Resistin also promotes insulin resistance, although the actual mechanism is not known. Insulin resistance due to adipokine dysfunction is further influenced by free fatty acids liberated directly into the liver from visceral fat tissue. Visceral fat releases chemicals and fatty acids into the portal system where they act on the connecting organs. The portal circulation system is a specialized network of blood vessels that connect the visceral organs to the liver.   The excess fat in portal circulation has detrimental effects on insulin action, which is worsened by sympathetic hyperactivity in response to obesity. Sympathetic hyperactivity causes heightened lypolytic action resulting in excess free fatty acids in the blood. These actions combined with beta cell hypersecretion and reduced insulin clearance resulting in hyperinsulemia, lead to early stage diabetes.

Inflammation-Interleukin-6

Interleukin-6 (IL-6) is possibly another factor associated with inflammatory detriment within the portal system. High levels of IL-6 are a marker for inflammation and vascular pathology. Obese subjects demonstrated a 50% greater portal vein IL-6 concentration, demonstrating, again, the profound effect visceral fat has on pathogenic indicators. Portal vein IL-6 correlates with systemic C-reactive protein concentrations. C-reactive protein is associated with cardio- and peripheral vascular disease. C-reactive protein and oxidative stress are now presumed to interact in the early inflammatory processes of atherosclerosis. This is significant for young obese individuals. Although more research is necessary for conclusive association, C-reactive protein may be a new risk factor for CAD in individuals under 25 years of age.

Inflammation-imbalances

inflammation

If your immune system and its ability to quell inflammation in your body are impaired, watch out. You are headed toward illness and premature …

The imbalance between increased inflammatory stimuli with a concurrent reduction in anti-inflammatory activity may be the foundation for the accelerated endothelial dysfunction and insulin resistance associated with obesity and the comorbid disorders of metabolic disease.   More research is needed to clearly delineate the particular relationships, but it seems evident that the low grade inflammation caused by obesity and visceral adiposity lead to the premature development of disease. This, more so than ever before, identifies the importance of weight management during the developmental years and ongoing efforts to control weight throughout one’s lifespan.   For individuals that are currently obese, there is still plenty of hope. Weight loss is related to reduction of oxidative stress and inflammation, and these beneficial effects likely translate into reduction of cardiovascular risk in obese individuals.   Likewise, exercise and dietary management, along with pharmacologic intervention can lead to atherosclerotic reversal in the earlier stages of CAD. Individuals with central adiposity, poor blood lipid profiles, hypertension, and/or insulin resistance should seek immediate professional assistance to prevent further health detriment.   The recent inclusion of obesity among chronic diseases makes Dr. Akoury of AWAREmed Health and Wellness Resource Center very resourceful for you. She will help you achieve optimal weight loss, the Dr. focus on Neuroendocrine Restoration (NER) to reinstate normality through realization of the oneness of Spirit, Mind, and Body, Unifying the threesome into ONE. What an opportunity, try and relieve yourself of this problem for good.

Body inflammation causes obesity-How it happens
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