Tag Archives: Inflammation

Mechanisms of Inflammation in Aging

December 30, 2014

Mechanisms of Inflammation in Aging – The redox stress hypothesis

Mechanisms of Inflammation in Aging

Mechanisms of Inflammation in Aging. Numerous complex inter-related mechanisms contribute to age-related inflammation. The redox stress hypothesis of aging is based on age-related changes in cellular redox balance.

We have just introduced the effects of inflammation in aging in our pervious article and now we want to progress with the discussion focusing on the mechanisms of inflammation in aging. If you are joining us for the first time in this life changing site, I would recommend that you get to the introduction for a better flow of information on this worthy topic. Numerous complex inter-related mechanisms contribute to age-related inflammation. The redox stress hypothesis of aging for example is based on age-related changes in cellular redox balance supplemented by age-related deregulation of the immune system. However other processes like endocrino-senescence and declining levels of sex hormones also likely contribute to high inflammation in older age. In addition, a number of diseases, especially age-related diseases such as atherosclerosis and dementia, have strong inflammatory components. Meanwhile in view of the experts at AWAREmed Health and Wellness Resource Center under Doctor Akoury’s care, the following are some of the components that are likely to affect your skin into premature aging.

  • Redox stress
  • Mitochondrial damage
  • Immunosenescence
  • Endocrino-senescence
  • Epigenetic modifications and
  • Age-related diseases

With the help of experienced experts at this facility founded by doctor Akoury, we will make certain emphasis about each of the above mechanisms of inflammation in aging as follows.

Mechanisms of Inflammation in Aging – The Redox stress

Endogenous reactive oxygen species (ROS) are hypothesized which play a key role in molecular, cellular, and structural damage of your skin over time. Under normal physiological conditions, reactive oxygen species like hydrogen peroxide (H2O2) have vital roles in signal transduction cascades and function to reversibly oxidize or reduce protein cysteine thiol groups as molecular on/off switches. However, age-associated increases in reactive oxygen species may lead to over-oxidation and irreversible changes in protein structure and function. The biological process to remove these accumulated damaged proteins stimulates inflammatory responses leading to a chronic inflammatory state.

Mechanisms of Inflammation in Aging – The Mitochondrial damage

Mitochondria, the primary sites for chemical energy (ATP) production, are essential for normal cell function and maintenance of redox homeostasis as well as regulating programmed cell death. Mitochondria are the main source for reactive oxygen species therefore; they are key components in redox stress. The mitochondrial free radical theory of aging is based on oxidative damage to mitochondrial DNA (mtDNA) due to overproduction of reactive oxygen species. This damage results in dysregulation of cell and organ function leading to the overall system decline recognized as aging. mtDNA alterations have been reported to accumulate with age; the ensuing loss of energy production likely underlies sarcopenia. Other tissues affected by age-related mtDNA alterations include ovary, testis, and adrenal organs with noted loss of function with age. In addition, apoptosis, or programmed cell death, is a highly regulated process that leads to cell death without stimulation of the inflammation response and damage to surrounding tissue. With age, mismanagement of apoptosis due to mitochondrial dysfunction results in increased inflammation and tissue injury.

Mechanisms of Inflammation in Aging – Immunosenescence

Oxidative stress and energy dysregulation are also hypothesized to play a key role in immunosenescence, the gradual decline of the immune system with age. Immunosenescence results from the accumulation of molecular and cellular defects due to oxidative damage and thymic involution the age-related reduction in thymus size and activity, and hyper stimulation of both the innate and adaptive immune systems. The ultimate result of these processes is increased exposure to diseases and increased morbidity and mortality due to infections and other age-associated diseases.

Thymic involution results in significantly reduced levels of naive T cells at older ages. While the adaptive immune response to previously seen antigens dependent on memory T cells remains functional, although in a reduced capacity, the ability to respond to new infectious agents, requiring naive T cells, is severely impaired. Poor immune function combined with continued exposure to antigens, results in chronic activation of macrophages and other pro-inflammatory cells and contributes to chronic low level inflammation common in older age. In addition, senescent cells demonstrate significant increases in production and secretion of many pro-inflammatory cytokines. Chronic inflammation, therefore, not only results from, but also drives immunosenescence.

Mechanisms of Inflammation in Aging – Endocrino-senescence

In addition to immunosenescence, the endocrine system also experiences age-related declines in function (endocrinosenescence) most notably affecting sex steroid production. Levels of growth hormone and dehydroepiandrosterone (DHEA) and its primary circulating form dehydroepiandrosterone sulfate (DHEAS) decrease with age as well. However, cortisol production is increased due to over-stimulation of the hypothalamic-pituitary-adrenal (HPA) axis.

Chronic over-stimulation of the hypothalamic-pituitary-adrenal axis leads to immune dysregulation and contributes to immunosenescence. Decreased levels of DHEA and growth hormone also likely play a role in immunosenescence. Both DHEA and growth hormone enhance the proliferation and activity of cellular mediators of immunity and DHEA reduces inflammatory cytokine production. Reduction in levels of these hormones and increasing levels of cortisol with age would therefore lead to increased.

Sex hormones also modulate the production of inflammatory cytokines. Studies indicate that interleukin-6 gene transcription and secretion are inhibited by both estrogen and androgen. Many studies show an increase in interleukin-6 and other pro-inflammatory cytokines in women subsequent to menopause. Similar inverse relationships have been reported for testosterone levels and inflammatory markers in older men. As levels of these steroid hormones decrease with age, levels of inflammatory cytokines are increased contributing to chronic inflammation, cellular senescence, and other age-related diseases.

Mechanisms of Inflammation in Aging – Epigenetic modifications

Epigenetic modifications are modifications to phenotypes or gene expression resulting from changes other than changes in the underlying DNA sequence. These changes may be retained by the cell throughout its lifespan and, for germ line cells, may be passed to future generations. DNA methylation is one of the most well characterized epigenetic changes.

DNA methylation is essential for normal development and survival. During aging, however, the DNA methylation pattern can change resulting in a global decrease in methylation with hyper methylation of some promoter regions, most notably promoters of several tumor repressor genes. Histone modifications lead to both gene activation and suppression. Histone modifications and changes in DNA methylation near telomeric regions correlate with telomere attrition and cellular senescence. In addition, these epigenetic changes are associated not only with activation of inflammatory genes, but also with cancer, dementia, atherosclerosis, and a number of other diseases.

Finally this article is very fertile with strong medical terms which may not sound clear to the ordinary man’s understanding. While appreciating the need for more clear view of the effects of mechanisms of inflammation in aging, the writings still had to be the way they are. However in a one on one with doctor Akoury in her office, you will be able to get clarity in all of your concerns. Remember that our target is to deliver beauty to you in the most professional way. Therefore on your part, what you need to do is to schedule for an appointment with the experts at AWAREmed Health and Wellness Resource Center under Doctor Akoury’s care and all your beauty concerns will be professionally addressed.

Mechanisms of Inflammation in Aging – The redox stress hypothesis

 

 

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Inflammation Control to Slow Premature Aging

December 28, 2014

Inflammation Control to Slow Premature Aging – Mechanisms of Inflammation in Aging

Inflammation

Inflammation control to slow premature aging is the way to go if you are to be in-charge of the aging process especially the premature aging

In our desire to keep the beautiful skin that everyone will admire, we are consistently faced with several challenges. Some of the challengers can be very devastating and will require the professionals to be involved if permanent solution is to be found. For this reason, we are going to be consulting with doctor Dalal Akoury from time to time as we progress into the discussion about calming chronic inflammation and slow premature aging. Just for the record, doctor Akoury is one of the few professionals with more than two decades experience in beauty and skincare management. She is also the founder of a health facility known as AWAREmed Health and Wellness Resource Center where we focus is on Neuroendocrine Restoration (NER) to reinstate normality through realization of the oneness of Spirit, Mind, and Body, Unifying the threesome into ONE.

With that brief introduction, let’s get into the discussion. Chronic inflammation can destructively affect your health and even accelerate your skin’s aging. Therefore inflammation is a critical part of the body’s healing process: It occurs at the cellular level when the immune system tries to fight off disease causing germs and repair injured tissue. Inflammation can be invisible (if your body is battling an infection internally) or visible: Rashes or pimples, for example, occur when blood vessels widen near the skin’s surface to increase blood flow, which in turn expedites healing.

Redness, heat and swelling can also occur alongside inflammation. When the fight is over, the army of inflammation-triggering substances is supposed to withdraw, however in many cases they don’t. Besides that studies have implicated chronic inflammation with heart disease, diabetes, cancer and many more of such diseases. When it attacks the skin, it can accelerate fine lines, wrinkles and enlarged pores, as well as puffiness, sagging, blotchiness or reddening of the skin. All this impacts negatively on the health of the skin and the end result is premature aging. Therefore aging is a progressive degenerative process tightly integrated with inflammation. However the cause and effect are not very clear though a number of theories have been developed that attempt to define the role of chronic inflammation in aging including:

  • Redox stress
  • Mitochondrial damage
  • Immune-senescence
  • Endocrino-senescence
  • Epigenetic modifications and
  • Age-related diseases

We are going to discuss each of this aspects as we progress on but nonetheless, no single theory explains all aspects of aging, it is likely that multiple processes contribute and that all are entangled with inflammatory responses. Take for example human immunodeficiency virus (HIV)-infected individuals experiences premature aging phenomenon this may provide indicators to better explain the nature of inflammation in aging. Environmental and lifestyle effectors of inflammation may also contribute to variation of both inflammation and age-related dysfunction.

Inflammation Control to Slow Premature Aging – Inflammation and Aging

It must be noted that aging itself is not a disease. However it results from the accumulation over time of detrimental changes at the molecular and cellular levels, and ultimately at the level of tissues and organs, resulting in disease and increased risk of morbidity and mortality. Traditionally, robust immune and inflammatory responses allowed early humans to endure to reproductive age. However, these same response mechanisms lead to a variety of lethal consequences now that humans routinely endure to older age. In a highly elaborate process, organs lose functionality and structural integrity both deriving from and leading to age-related diseases like atherosclerosis, dementia, and cancer. While the etiology of the aging process is not fully understood, inflammation clearly plays a major role, inseparably linking inflammation and aging.

Nonetheless it is not clear whether inflammation causes age-related processes, results from these processes or both. For the purpose of this article we will concentrate on current theories about the nature of chronic inflammation associated with aging including the causes and effects of inflammation with a focus on the highly entangled nature of aging and inflammation and potential interventions to moderate the effects of inflammation in aging.

Inflammation Control to Slow Premature Aging – Chronic Inflammation

Subsequent to trauma or infection, the inflammatory response is initiated at a local, cellular level. A number of cellular mediators such as macrophages and monocytes are activated. These cells release cytokines like tumor necrosis factor-α and interleukin-6 which act as molecular mediators and are responsible for the progression of the response to a systemic level encompassing multiple organs. The inflammatory cascade is designed to:

  • Destroy microbial pathogens
  • Initiate tissue repair processes and
  • Promote a return to physiological homeostasis

Remember that at an acute level, this process is marked by easily discernible heat, swelling, redness, and pain. However, in terms of aging and age-related diseases, the inflammation response is a chronic, low level, subclinical process mediated by the same effectors, but opposing significantly in degree Inflammation as a function of age has been well characterized in numerous epidemiologic studies. Levels of inflammatory mediators typically increase with age even in the absence of acute infection or other physiologic stress. While levels are still in the sub-acute range, this chronic inflammation underlies many aging-related conditions. However, a key question remains. Is inflammation a cause of the aging process or an effect? We are going to be answering this question in our next article when we handle Mechanisms of Inflammation in Aging. You don’t want to miss this and so I asked you to stay on the link for a while as we unlock the truth about inflammation.

Meanwhile as I had mention in the introduction, this is not just any topic about healthcare. We are looking at the real issues that bring about premature aging. If you want to remain young even if you’re not, engage the experts at AWAREmed Health and Wellness Resource Center under the able leadership of Doctor Akoury’s care. Schedule for that appointment today and get to know your position with the effects of inflammation. You may never know until you get the experts opinion. It doesn’t matter where you are or what you do, our concern is to help you keep that glamorous appearance for a very long time. Give us an opportunity to help you keep that youthful look by calling doctor Akoury today.

Inflammation Control to Slow Premature Aging – Mechanisms of Inflammation in Aging

 

 

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Healthy Sleep Habits

December 7, 2014

Healthy Sleep Habits

Sleep is one aspect of life whose essence is often easily overlooked. You think about a ball game that you simply cannot miss. Yet it is taking place from midnight. You say, “Anything else counts not, but the game.” So you stay up late into the night watching it. 4.00 AM and you are not yet asleep, and it is the eve of a Monday!

You are in the news industry. As the editor, you have to leave the newsroom after everything newsworthy has been captured in the day’s paper. Or, you are sitting for your end semester exams that begin in the morning. You do not feel well backed so you stay up late going through your notes.

The list of reasons we give for not sleeping is long. Apparently when daytime comes you often feel that grumpiness and wish to lock yourself up in the office. If you are a student you always doze off in front of the computer or your books.

In other words, the lack of sleep takes away your productivity. Bad mood; you will not be the smiling face that draws even the most uninterested customer, no! Fatigued, you will not pay attention to details at all. You may easily miss out a very important detail. In that state your mind is always foggy and if it was an exam you were staying up late for, chances are that you might end up not producing much after all because you just cannot think that well.

Good thing, you can always catch a bed and compensate for the lost sleep so that you feel better again. At certain instances, you can always rush for a cup of coffee and keep up with the prevailing circumstance. But, have you ever asked yourself what that behavior of keeping sleep a distance away have on your health?

Quality-Sleep

After missing sleep for some time, the mental effects of this sleeplessness become more serious. The fogging of your brain will become more pronounced, rendering it difficult for it to concentrate and make needed decisions. You will probably begin feeling down and may drop off at daytime. You also risk getting injuries and causing accidents at work or at home. If you drive, it is catastrophic!

Yet that is not it all! The range of health problems related to sleeplessness may surprise you if you realize them. You may probably not want to ever miss a night of sleep ever again over some series of night vigils or ball games, whatever your convincing reason is.

Health Implications

Poor Sleep patterns increase the risk for Ulcerative Colitis and Crohn’s Disease. Ulcerative colitis is a chronic autoimmune disease of the large intestine in which the gastrointestinal lining becomes inflamed and develops ulcers.

This is caused by an abnormal response by the body’s immune system. In patients with inflammatory bowel diseases, the immune system mistakes food, bacteria and other substances in the intestine for foreign or invading substances.

Ulcerative colitis only affects the large intestine whereas Crohn’s disease can affect any part of the GI tract. In addition, both short and long durations of sleep have important health implications and are associated with increased overall mortality. You have probably experienced the bad mood thing, fatigue and tiredness associated with lack of sleep. But what you might have never realized is the long-term health consequences which include chronic health conditions such as diabetes, cardiovascular disease, high blood pressure, and obesity. And now you know that these conditions may lead to some really shortened life expectancy!

  1. Weight gain and obesity

Studies have found a link between no-sleep and weight problems. These people who deny themselves the essential requirement- sleep, are more likely to have a higher body mass index (BMI) than normal. Such people are susceptible to obesity. But, how does this happen?

When you sleep less, it all begins with your appetite. It goes up! You may begin to eat uncontrollably, not because you want to or because your stomach becomes larger, no. This is something to do with the hormonal behavior in your system.

Leptin is the hormone that usually notifies the brain that you have eaten enough food and it is time to put food aside. This hormone apparently is secreted when we are asleep. Deny yourself the sleep and your appetite will have nothing to control it. Instead, you face the risk of higher levels of the hormone responsible for appetite stimulation: ghrelin.

Poor sleep therefore leads to uncontrolled food cravings that may eventually cause overweight as your body gains too much calories but is too tired to burn them off through exercise.

The little sleep may also upset the balance of other related hormones, for instance, little sleep will result in an increased production of cortisol. Hormone cortisol is normally referred to as the stress hormone. The secretion of insulin hormone may also increase following a poor sleep. Insulin which regulates glucose processing while promoting fat storage will therefore exist in large quantities, a condition that is associated with weight gain. This is a risk factor for diabetes.

  1. Immunity failure

With the altered behavior of the endocrine system, the body’s defense mechanism against infections is likely to be highly affected. This augments to the reason why doctors recommend bed rest for people who are sick. When you sleep, your body’s immunity has the advantage over invading microbes.

How do you identify a disturbed sleep then?

The signs and symptoms of a disturbed sleep include constantly feeling tired ranging from mild to severe cases, an irritable temper and feelings of moodiness, you could lose concentration and at times feel hallucinations and even memory loss, loss of coordination is common; and in severe cases the individual may encounter auto accidents. Other symptoms and signs include relationship problems, loss of appetite, absenteeism or tiredness at work and use of stimulants.

sleeping

How do you build good sleeping habit?

You could improve your sleep hygiene by establishing a regular bed time. You constantly retire to bed when that time reaches. It involves going to bet a specific time and waking up at an established regular time. For adults this interval should be about 7 to 9 hours of sleep.

You may also get rid of stimulants in your routine. Do not go for caffeine to boost your level of alertness. If you feel drowsy, just get yourself a nap. The rest will come later. In addition, you need a regular exercise schedule to get you tired so you can get some deep sleep.

When you are ready to go to bed, avoid computer games, TV or watching movies. These will rip you of your sleep. Other healthy steps include an improved diet and a cool sleep environment.

AwareMed uses the cognitive behavioral therapy as one of the principal treatments for insomnia and sleep disorders for our patients. This treatment is non-pharmacologic and addresses the sleep problems at the psychological and behavioral levels. Part of these include the above mentioned behaviors.

Healthy Sleep Habits

 

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Inflammation, Cancer and health

November 29, 2014

Inflammation, Cancer and health – Why your diet is important

Inflammation

Inflammation, Cancer and health. Actually inflammation can lead to several health complication more so if it is chronic inflammation.

The body defense mechanism is always under certain threats despite the measures put in place to defend it from both external and internal attacks. The body immune system and the white blood cells are such defense mechanism the body relays on for protection against diseases and infections. Whenever they are under attack the whole body organs including the skin are at risk of various infections. We are therefore going to discuss the effects of inflammation on human health generally before we can get to specific areas of the body.

What is inflammation?

There are two different kinds of inflammations and they include the following:

  • Acute inflammation
  • Chronic inflammation

Acute inflammation – this is actually your body’s natural and helpful immune response to tissue damage. Like for instance when you get a bruise or wound either from a minor accident or otherwise, the wound or the cut swells, reddens and feels inflamed. These are all signs that your immune system is busy at work sending white blood cells to the site of your injury to repair the tissue. In situation like this, inflammation is our friend and we couldn’t live without it.

Chronic inflammation – this is a situation where your body’s confused and damaging immune response to a bombardment of environmental, physical and mental invaders, which come in the form of things like poor diet, toxic chemicals and stress. Therefore this article will be focusing on the type of inflammation. Here’s chronic inflammation in a nutshell:

What does inflammation have to do with cancer?

Like I have indicated in the introduction that the body’s immune system is facing threats of being weaken by several health complications. For example the prolonged inflammation can harm your body’s healthy cells and tissue thereby causing the deterioration of your immune system. This deteriorated state can escalate your risk of diseases like cancer.

Nevertheless, it is important to note that not all inflammation is bad. Your body’s inflammatory response is essential for you to heal. This response communicates with your body’s immune system to send white blood cells and chemicals to help fight off infection or repair an injury.

But when inflammation persists, or when your body triggers a response when you don’t have an infection or injury, its cause for concern.

Other causes of chronic inflammation can include obesity, smoking and even the second hand smoking, stress, lack of exercise, exposure to secondhand smoke and diet choices. And worse, chronic inflammation often shows no signs.

The good news is you can reduce chronic inflammation and lower your cancer risks. “It starts with your diet”. An anti-inflammatory diet also can help you avoid diabetes, heart disease and Alzheimer’s.

The following are some of the anti-inflammatory diet tips.

Add more plant foods to your plate

Plant foods are the only foods that contain anti-inflammatory phytonutrients. Plus, they are high in the antioxidants and fiber your body needs to stay cancer-free. Fiber also can lower levels of C-reactive protein (CRP), a protein in the blood that signals inflammation.

The experts in nutrition recommend filling at least two-thirds of your plate with foods realized naturally from the vegetation. Like for instance:

  • It is advisable that you serve half of your plate with non-starchy vegetables and fruits of all colors.
  • Make one-quarter of your plate whole grains or starchy vegetables, like potatoes, corn and peas.
Limit processed foods

Choosing whole, fresh foods and doing your own prep maximizes nutrients and phytonutrients. These nutrients keep us healthy in many ways, while reducing inflammation.

Processed foods are lower in nutrients and higher in refined sugars, flours and fats. These foods are usually loaded with artificial ingredients that can increase CRP levels.

  • Avoid highly processed foods, like fast food, packaged and instant foods.
  • Steer clear of processed meats, like deli-meats, bacon, sausage, hotdogs and pepperoni.
  • Sodas and other sport drinks are to be no go zones.
Balance fatty acids

Omega-3 fatty acids can help protect your body from chronic inflammation. On the other hand, omega-6 fatty acids increase inflammation.

Many Americans are trying to include more omega-3 fatty acids in their diet. But, they’re still eating too much omega-6 fatty acids.

The key is balance, so you’ll take in more omega-3 and less omega-6.

  • Eat foods high in omega-3 fatty acids, such as salmon, tuna, halibut, flaxseeds, chia seeds, walnuts, pecans and avocado.
  • Use oils high in omega-3, such as olive and canola.
  • Avoid or limit oils high in omega-6, such as corn, sunflower, peanut and soybean.
  • Read the ingredients on packaged foods. Limit foods made with refined vegetable oils high in omega-6. You’ll find these oils in most snack foods, cookies, crackers and sweets.

Reduce consumption of red meat

Eating too much red meat, like pork, beef, lamb, deer and buffalo, can increase your cancer risks. Try to limit red meat to 18 oz. or less each week to keep your cancer risks low.

The experts suggest replacing red meat with these high protein foods to help reduce chronic inflammation.

  • Choose animal proteins, such as skinless chicken, turkey and fish.
  • Replace animal proteins with plant proteins, such as beans and lentils, at some meals.
  • Choose meat, milk, cheese and eggs from pasture-raised and hormone-free animals.

Eat more fermented foods

Fermented foods such as yogurt, sauerkraut and miso contain probiotics that help reduce inflammation. To get the most health perks, eat at least one small serving of a fermented food each day.

  • Choose low-fat, plain organic yogurt and kefir.
  • Try fermented vegetables, such as sauerkraut and kimchi, with a sandwich or salad.
  • Enjoy a cup of miso soup or kombucha tea.

Foods that help prevent cancer also help reduce chronic inflammation, and vice-versa. So, following these guidelines will ultimately reduce your risk of a variety of chronic diseases, and improve your quality of life.

If you’re concerned you have chronic inflammation, speaking to doctor Dalal Akoury will be very helpful to you to unlock all the problems going through your mind. Doctor Akoury is an expert of more than two decades and has transformed many people’s lives through effective treatment which is precise and direct to the last solution. Remember that inflammation may not be friendly to you at all and so scheduling for an appointment the doctor Akoury is the best you can do for yourself, your family and even to the extended family.

Inflammation, Cancer and health – Why your diet is important

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Neural Prolotherapy and Cancer Pain Management

July 22, 2014

Neural Prolotherapy (NPT) For Cancer Pain Treatment

Neural Prolotherapy

Neural Prolotherapy

Neural Prolotherapy (NPT) is a new concept in the treatment of cancer but it is simple to implement and has had far reaching effect on managing chronic pain. The wonder therapy uses dextrose solution in sterile water to address a pain neuropeptide referred to as TRPVI. TRPVI is what triggers the release of pain and inflammatory peptides that lead to excessive pain.

NPT works by adhering to the peripheral nerves, this are nerves that are very close to the surface of the skin and are the main cause of pain. A thin injection may be used to deliver 5% dextrose in sterile water. This water is delivered to all superficial nerves and eventually it leads to a complete freedom of pain especially in the area surrounding the injected part.  NPT targets areas with chronic constriction injuries that affects the nerves health and stimulates the pain.

The technique is simple and reliefs the patient from the pain. Once the superficial nerves are put under this treatment, the pain goes away almost immediately. The treatment targets the correct nerve and addresses it instantly. Once this has been done, the pain goes away immediately. The duration it takes before one starts feeling the pain again depends on the underlying tissue and the nerve constriction. It also depends on how long it will take the dextrose before it repairs the constrictions. Nevertheless, it may take 6 treatment days before the patient is fully cured.

Other than being used to manage cancer pain, NPT has been used in managing lower back pain, sciatica, carpal tunnel, stiff necks, Achilles tendonitis and many other ailments. It is an exciting treatment that can be used to react to chronic pain relief without necessarily resorting to use cortisone injection or medications.

More practitioners are acquiring more skills and knowledge on the use of Neural Prolotherapy NPT and this is expected to better cancer pain management.

Neural Phototherapy (aka Lyftogt Technique) is based on the premise that overuse or injury of the superficial nerves is the main cause of pain and dysfunction.  When Dextrose solution is injected under the skin, the dextrose is able to heal the nerves that lead to the sensation of chronic pain.  The dextrose solution heals the dysfunction that perpetuates the sensation of chronic pain.  It then allows the connective tissue and the nerves to heal and one ends up feeling much better.

The patients will get immediate relief from pain and may not require the use of anesthetics. it can be used to treat all trigger points  and requires a follow up of between 1 week or 2 months depending on the extend  of  the injuries  sustained.

When this method is used, the following outcomes will be expected

  • Elimination and decreased pain after between one and five treatment
  • Increased mobility
  • Increased stability of the joints
  • Reduced pain bites
  • Reduced swelling and tenderness
  • No need for surgery
  • Reduced inflammation.

How is Neural Prolotherapy done

In the treatment of cancer pain, sugar or glucose can be injected just below the skin to promote the healing of tissue damaged so as to rebuild them. There is intense research on using growth factors such as autologous platelet rich plasma, bone marrow aspirate and many other substances in the treatment.

There are still no properly conducted clinical trials although recent studies show that Dr. Lyftogt has been able to develop neural phototherapy treatment protocols for migraine.

Neural Prolotherapy

Neural Prolotherapy

The Neural Prolotherapy according to Dr. Lyftogt can be relied on in managing neurogenic inflammation. His assertion is based on the work by Douglas W. Zochodne who hypothesizes that prolotherapy treats pathological inflammation.  According to Dr. Lyftogt, injection of 0.1 % lignocaine induces proliferating peptidergic effectors while at the same time reduces vascular endothelial growth factor level that restores repair processes hence reducing or eliminates pain.  The injections target specific receptors TRPVI that are present in the nerve nervorum. These are the smallest nerve fibers that are responsible for pain and the swelling in the protective sheath of the nerve trunk (neurogenic inflammation)

According to Dr. Lyftogt, there is already evidence that neuropathic pain syndromes causes peripheral neurogenic inflammation that involves autonomic and sensory nerves. What the doctor needs to demonstrate on is how the neurogenic inflammation is enhanced and how the sugar injection reacts to it.

If you are suffering from neuropathic pain, or any chronic pain, Dr. Dalal Akoury one of very few trained in Neural Prolotherapy NPT by Dr. Lyftogt in this procedure can help you. Do not hesitate to call AWAREmed Health and Wellness Center for immediate pain relief.

Neural Prolotherapy (NPT) For Cancer Pain Treatment

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