Tag Archives: Dementia

Allogeneic Stem Cells For Neurodegenerative Diseases

Allogeneic Stem Cells Role in Neurodegenerative Diseases

stem cellThe stem cells are the precursors of all cells in the body. They are very essential for formation of new tissues and healing of damaged tissues as a result of diseases or even accidents. The stem cells are available in adequate quantities in the bone marrow and in the adipose tissues as well. They have the ability to turn into the red blood cells, platelets or even the white blood cells. They can also form the muscles cells, the bones and even cartilage and hence help in keeping your body healthy. naturally you should be having the healthy amounts of these stem cells, unfortunately due to diseases and accidents that may result in bone marrow destruction and damage you may have too little of these essential stem cells and so you will need a stem cell transplant. In most cases the stem cell transplant is done through an IV, supplementing the little stem cells you have left and hence enabling the body to work right.

When the stem cells are harvested from the same person, the transplant is termed as autologous stem cell transplant. the autologous stem cell transplant is the most popular as the cells are harvested from the patient’s own body and this rules out any chance of the transplant being rejected or causing any pathological reactions that may warranty serious medical attention. however there are cases when the stem cells can’t be sourced from the patient’s own body and this will dictate that the stem cells be sourced from a different person who is not genetically identical to the patient; this is termed as allogeneic stem cell transplant. For safety of any recipient in allogeneic stem cell transplant, it is important to match closely the immune system markers to reduce chances of any reaction that may inhibit the healing process.

Stem cells and neurodegenerative diseases

Neurodegenerative diseases are numerous and each has distinctive effects on the patient but all are caused as a result of neurodegeneration. Neurodegeneration refers to the damage of the nerves in that are essential for transmission of messages within the nervous system. When the nerve cells are destroyed and deformed, they lose their original structure they will begin to malfunction. In most cases this damage is done gradually but at the end of it all the patient will suffer from cognitive disabilities such as memory loss and poor decision making. There are numerous neurodegenerative diseases, however basing on their debilitating effects, just a few have been known and are being currently focused on. Some of the famous neurogenerative diseases includes; Huntington disease, Parkinson’s disease and Alzheimer’s disease. Apart from these diseases listed above there are others that have not been in the medical literature and are less publicized, this doesn’t mean that they are not worth the mention. They are.

The greatest danger of all neurodegenerative diseases is that they lead to progressive brain damage and neurodegeneration. The major three diseases may show different features and effects but they progress in similar manner at the cell level. take Parkinson’s disease for example, it affects the basal ganglia of the brain, depleting it of dopamine hence causing stiffness, rigidity and tremors in the major muscles of the body which are distinctive features of the disease.

In Alzheimer’s disease, it is characterized by deposits of minute protein plaques that damages different brain parts thereby leading to gradual memory loss while Huntington’s disease is known to corrupt the genetic make-up affecting muscles of the body thereby resulting in motor restriction and eventual death.

Allogeneic stem cells transplant

Allogeneic stem cellsThe cell is harvested from the bone marrow of a suitable donor by use of a needle. This maybe done repeatedly to draw the sufficient amounts needed for the transplant. After harvesting the cells from the marrow the blood is passed through a machine that separates the stem cells from the blood leaving the rest of the blood flowing back into the donor through the needle into the donors arm. The harvested stem cells can then be transplanted into the patient through a central venous catheter that is inserted into the patient’s chest. The stem cells flow through the catheter into the patient’s blood and into the bone marrow where they will give rise to other stem cells between one to three weeks.

After transplant the stem cells will begin to work in repairing and replacing the worn out tissues caused by various degenerative diseases. All this is made possible since they can form any cell in the body and help restore the normal body functions.

The neurodegenerative diseases have very debilitating effects; the inception of stem cell therapy seems to be a light at the end of the tunnel for those suffering from these diseases. Anyway you need to be updated on how well you can regain your health and vitality back even after suffering from these diseases.

conference

Get in contact with Dr. Dalal Akoury an experienced doctor in integrative medicine at www.awaremednetwork.com as well as http://www.integrativeaddiction2015.com and learn more about the upcoming Integrative Addiction Conference 2015. The conference will focus on the unique approaches to identifying symptoms of addiction and how to help addicts.

Allogeneic Stem Cells Role in Neurodegenerative Diseases

 

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St. John’s Wort Helps in Depression and Insomnia Treatement

St. John’s Wort Powers: The Treatment of Depression and Insomnia during Addiction Withdrawals

St. John’s Wort is a wonder plant that has been used in treatment of many conditions for quite a long time. The most used part of this herb is the flowers and the leaves. This herb has many medically active components but its known most active components are two; hypericin and hyperforin. Although hypericin was formerly thought to be the component of St. John’s wort principally responsible for its action, it is now understood that hyperforin, adhyperforin, and several other related compounds are the primary active constituents. Both hyperforin and adhyperforin appear to modulate the effects of serotonin, dopamine, and norepinephrine and may inhibit reuptake of these neurotransmitters. This herb has been found to be very useful in treatment of conditions that are caused as a result of imbalances in the neurotransmitters.

St. John’s Wort for Depression during addiction withdrawals

Imbalances in the neurotransmitters such as serotonin and dopamine cause depression. This imbalance may be caused by use of drugs of pleasure or by other diseases. Apart from these two causes, a person may also have a family history of depression and so predisposed to depression a case which makes it rather complicated for the brain to produce the neurotransmitters in required amounts. The brain has a great role to play in inhibiting depression; it has to produce the millions of chemicals it produces in the right amounts everyday failure to which you will be depressed. It’s that complicated.

In the long-term, all drugs and alcohol are brain depressants. In moderate amounts, alcohol does not lead to depression, but abusing drugs or alcohol will definitely lead to depression. This is because they deplete your brain of serotonin and dopamine. Researchers warn that it may take quite a long time for depleted dopamine to be restored and so it is important to avoid abusing drugs.

Alcohol abuse almost doubles the risk of depression. In one study that looked at 2,945 alcoholics. Fifteen percent were depressed before they began abusing alcohol, and that number jumped to 26 percent after they started abusing alcohol. Once they stopped drinking for an extended period, 15 percent remained depressed. This study showed that alcohol almost doubles the risk of depression.

St. John’s Wort

Marijuana has also been linked to depression. It is reported that marijuana users are four times more likely to develop depression. In one study which monitored a large group of people for 16 years, it was discovered that people who smoked marijuana were four times more likely to develop depression.  Another study followed later with 1601 students and confirmed the findings. Depression is a serious illness that may make it hard for an addict to stop taking the drugs of pleasure to boost the dopamine levels for a moment. Fortunately this can be helped by use of St. John’s Wort. Taking St. John’s wort extracts improves mood, and decreases anxiety and insomnia related to depression.  This herb seems to be effective in treatment of mild depression than some of prescription drugs.  According to the American College of PhysiciansAmerican Society of Internal Medicine, St. John’s wort can be considered an option along with antidepressant medications for short-term treatment of mild depression.

St. John’s Wort for Insomnia during addiction withdrawals

According to National Sleep Foundation, insomnia is difficulty falling asleep or staying asleep, even when a person has the chance to do so. People with insomnia can feel dissatisfied with their sleep and usually experience the symptoms of poor sleep that may deter them from enjoying healthy lifestyles. This disease can affect people of all ages but adults are the major victims.

A person suffering from insomnia may show the following symptoms

  • Irritability, depression or anxiety
  • Difficulty paying attention, focusing on tasks or remembering
  • Increased errors or accidents
  • Tension headaches
  • Distress in the stomach and intestines (gastrointestinal tract)
  • Ongoing worries about sleep
  • Difficulty falling asleep at night
  • Awakening during the night
  • Awakening too early
  • Not feeling well rested after a night’s sleep
  • Daytime tiredness or sleepiness

insomnia

Insomnia may be caused by depression and stress but it may also be caused by the imbalances in the neurotransmitters as a result of long term use of drugs of pleasure.  Some other causes of insomnia include;

Anxiety– Anxiety is a common everyday problem. However there are more serious anxiety disorders like PTSD which will never give your brain a rest. Anxiety beckons insomnia and so should be avoided to help you sleep soundly and reap huge health benefits from it.

Medical conditions-there are conditions that cause insomnia. These conditions may include; chronic pain, chest problems and even frequent urination. These conditions may cause difficulty in sleep. Diseases like cancer, arthritis, heart disease, stroke, Alzheimer’s disease and even Parkinson’s disease have been linked to insomnia.

St. John’s wort has been found to be very effective in treatment of depression that might cause difficulty in sleep and this is owed to its effects on serotonin may be primarily responsible for its antidepressant activity. Apart from being an anti-depressant this herb works on the neurotransmitters in unlimited ways it affects many neurotransmitters that are key to good sleep health.

Drug induced Insomnia may not be easy to treat. However there are also medical approaches to treating drug induced Insomnia but of all these going the natural way is much better since it has less side effects and is more effective.  We at AWAREmed health and wellness center are dedicated to finding the best natural solutions to health problems. You can visit us at Myrtle Beach South Carolina where you will be attended to by Dr. Dalal Akoury (MD) who has vast experience in integrative medicine for lifestyle diseases.

St. John’s Wort and treatment of depression and insomnia during addiction withdrawals

 

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