Drug addiction and the brain-Effects of dopamine on addiction

why dopamine-producing drugs are so addictive is that they have the ability to constantly fill a need for more dopamine.

In the previous article we stated that dopamine is an inhibitory neurotransmitter, meaning that when it finds its way to its receptor sites, it blocks the tendency of that neuron to fire. We also noted that it is strongly associated with reward mechanisms in the brain. That aside new research on the brain is showing that addiction is a matter of memories, and recovery is a slow process in which the influence of those memories is diminished.

Further studies have also shown that addictive drugs stimulate a reward circuit in the brain. The circuit provides incentives for action by registering the value of important experiences. Rewarding experiences trigger the release of the brain chemical dopamine, telling the brain “do it again.” What makes permanent recovery difficult is drug-induced change that creates lasting memories linking the drug to a pleasurable reward.

Drug addiction and the brain-Brain circuits

Addiction involves many of the same brain circuits that govern learning and memory. Long-term memories are formed by the activity of brain substances called transcription factors. All perceived rewards, including drugs, increase the concentration of transcription factors. So repeatedly taking drugs can change the brain cells and make the memory of the pleasurable effects very strong. Even after transcription factor levels return to normal, addicts may remain hypersensitive to the drug and the cues that predict its presence. This can heighten the risk of relapse in addicts long after they stop taking the drug.

Knowing more about how addiction works in the brain has not yet given us any effective new treatments, but it has suggested new possibilities while providing a better understanding of how the available treatments work. The hardest job will be finding substances that lower the risk of addiction but do not interfere with responses to natural rewards. So far there is little evidence that any one type of therapy works better for addiction than another.

Drug addiction and the brain-Brain Chemistry

It has been demonstrated times and again that drug addiction is a powerful force that can take control of the lives of users. In the past, addiction was thought to be a weakness of character or just misbehavior, but in recent decades research has increasingly found that addiction to drugs like cocaine, heroin and methamphetamine is a matter of brain chemistry.

Experts at the National Institute on Drug Abuse, says that the way a brain becomes addicted to a drug is related to how a drug increases levels of the naturally-occurring neurotransmitter dopamine, which modulates the brain’s ability to perceive reward reinforcement. The pleasure sensation that the brain gets when dopamine levels are elevated creates the motivation for us to proactively perform actions that are indispensable to our survival for example eating or procreation. Dopamine is what conditions us to do the things we need to do.

Drug addiction and the brain-Neurochemical reward

Using addictive drugs floods the limbic brain with dopamine taking it up to as much as five or 10 times the normal level. With these levels elevated, the user’s brain begins to associate the drug with an outsize neurochemical reward. Over time, by artificially raising the amount of dopamine our brains think is normal, the drugs create a need that only they can meet.

For instance, when a drug produce increases in dopamine in these limbic areas of the brain, then your brain is going to understand that signal as something that is very reinforcing, and will learn it very fast so that the next time you get exposed to that stimuli, your brain already has learned that reinforcing instantly. Over time, the consistently high levels of dopamine create plastic changes to the brain, desensitizing neurons so that they are less affected by it, and decreasing the number of receptors. That leads to the process of addiction, wherein a person loses control and is left with an intense drive to compulsively take the drug.

According to experts the reason why dopamine-producing drugs are so addictive is that they have the ability to constantly fill a need for more dopamine. So a person may take a hit of cocaine, snort it, it increases dopamine, takes a second, it increases dopamine, third, fourth, fifth, sixth. So there’s never that decrease that ultimately leads to the satiety. Addiction has to do with the brain’s expectations. An emerging idea is that drugs basically hijack the brain’s normal computational enjoyment and reward mechanisms.

For example let’s say you’re happy about a great chocolate ice cream and over time you learn to expect that the chocolate ice cream is really great and you have no more dopamine released in expectation of that when you receive it. Nevertheless if you take an addictive drug you can never learn to expect it because the drug itself will release an extra kick of dopamine. And when that happens, the value of that drug keeps increasing because now you’re learning that wow my expectations were violated, therefore this must be much more valuable than what I thought before. So what ends up happening is that dopamine system gets hijacked by these drugs.

It must be noted that there are other components to addiction like genetics and age of exposure which is why not everyone who takes drugs becomes an addict. Approximately 50% of the vulnerability of a person to become addicted is genetically determined, and research indicates that if a person is exposed to drugs in early adolescence they are much more likely to become addicted than if they were exposed to the same drugs as an adult.

Drug addiction and the brain-Take away

One of the key functions of the neurotransmitter dopamine is to create feelings of pleasure that our brains associate with necessary physiological actions like eating and procreating. We are driven to perform these vital functions because our brains are conditioned to expect the dopamine rush that accompanies them.

Addictive drugs flood the brain with dopamine and condition us to expect artificially high levels of the neurotransmitter. Over time, the user’s brain requires more dopamine than it can naturally produce, and it becomes dependent on the drug, which never actually satisfies the need it, has created.

AWAREmed Health and Wellness Resource Center under Doctor Akoury is a facility run by experts headed by doctor Akoury, for proper care and healing of whatever kind of addiction and whatever the level of addiction you need caring experts who will focus on Neuroendocrine Restoration (NER) to reinstate normality through realization of the oneness of Spirit, Mind, and Body, Unifying the threesome. This kind of treatment can only be found at AWAREmed. Reach out for help and get your life back with real professionals.

Drug addiction and the brain-Effects of dopamine on addiction