Acetaldehyde poison and Alcohol consumption
Acetaldehyde poison and Alcohol consumption if not addressed in good time can be catastrophic
Acetaldehyde poison and Alcohol consumption: Cytochrome P450 2E1 (CYP2E1)
In light social drinkers nearly all the alcohol consumed is taken care of by alcohol dehydrogenase. However, the enzyme Cytochrome P450 2E1 (abbreviated CYP2E1) becomes quite active in metabolizing alcohol in chronic heavy drinkers. CYP2E1 does its work in the liver. The hydrogen released by this reaction is bound to oxygen and to NADPH to form water and NADP+. This reaction takes energy rather than producing it. CYP2E1 does its work in the microsomes of the cell. This is sometimes referred to as MEOS (Microsomal Ethanol Oxidizing System). CYP2E1 is a member of the Cytochrome P450 enzyme family. The next enzyme is the catalase.
Acetaldehyde poison and Alcohol consumption: Catalase
Catalase is found in tiny organs inside of cells called peroxisomes. Catalase is found all over the human body. When catalase turns alcohol into acetaldehyde the hydrogen which is released is bound to hydrogen peroxide molecules which then become water. Although catalase is active everywhere in the body, catalase is of particular interest to researchers because it metabolizes alcohol in the brain. The acetaldehyde released into the brain by the metabolism of alcohol by catalase has the potential to combine with neurotransmitters to form new compounds known as THIQs (tetrahydroisoquinolines, also sometimes called TIQs). Some researchers believe that THIQs are the cause of alcohol addiction and that the presence of THIQs distinguishes addicted drinkers from social drinkers. Other researches strongly dispute the validity of the THIQ hypothesis of alcohol addiction. The actual role of THIQs remains controversial and calls for further research.
Acetaldehyde poison and Alcohol consumption: How acetaldehyde dehydrogenase works
Acetaldehyde dehydrogenase does its work in the mitochondria of cells and removes a hydrogen atom from acetaldehyde to produce an acetic acid radical. This hydrogen atom combines with NAD+ to form NADH.
There are several varieties of aldehyde dehydrogenase found in the human body. The one which normally breaks down acetaldehyde is called ALDH2. There is another variety aldehyde dehydrogenase found in the human body which is called ALDH2*2. ALDH2*2 is only about 8% as efficient as ALDH2 in metabolizing acetaldehyde. Some East Asian people have ALDH2*2 instead of ALDH2 in their bodies. These individuals find the effect of alcohol to be very unpleasant as we discuss below. Doctor Dalal Akoury MD, President and founder of AWAREmed Health and Wellness Resource Center reiterates that the aldehyde dehydrogenase enzymes are found in many tissues of the body, but are at the highest concentration in the liver
The problem with too much NADH
Finally, it is important to appreciate that alcohol metabolism produces excess amounts of NADH (Nicotinamide Adenine Dinucleotide plus Hydrogen). This excess of NADH can lead to acidosis from lactic acid build-up and hypoglycemia from lack of glucose synthesis. It can also lead to weight gain, fatty liver, and heart attack. It is because of these health risks that made doctor Akoury to formulate this health facility to offer meaningful and professional treatment that yield absolute result. This is not a simple problem and therefore, if you are struggling with alcoholism, help is just a phone call away. As soon as you make that call, an appointment will be schedule and your life will be transformed positively and for real productivity.
Acetaldehyde poison and Alcohol consumption: Cytochrome P450 2E1 (CYP2E1)
http://www.integrativeaddictionconference.com/wp-admin
