Category Archives: Insulin Potentiation Therapy

Glycolysis Inhibitors Help in Fighting Cancer

August 4, 2014

 

The Role of Glycolysis Inhibitors In Fighting Cancer

The best way of killing cancer cells is to starve them. This is the safest way of killing cancer cell as the normal healthy cells are not affected by this way of killing the cancerous cells. In the past it was a big problem finding a way of killing the cancerous cells without affecting the healthy body cells. This is because all the cancer cells as well as the healthy body cells depend on glucose as their energy source that they need to survive. However very many researchers have done work on the subject of cancer cell metabolism and the discovery by Otto Warburg that the cancer cells depended entirely on glucose for source of energy unlike the healthy body cells that can adapt to other sources of energy like fats helps a lot in selective killing of cancer cells without hurting the healthy body cells. The cancerous cells undergo increased glycolysis and rely on this pathway for generation of ATP energy as their sole source of energy for growth and survival.

Basing arguments on the Warburg effect, doctors have come up with different cancer therapies to help in killing the cancer cells effectively without hurting the healthy body cells. The cancer cell overdependence on the glycolitic pathway for generation of ATP energy as the sole source of survival has provided a great loophole through which the cancer cells can be selectively killed without affecting any other healthy cell by inhibiting glycolysis.

There are Glycolytic inhibitors that can be used in maiming the cancer cells by denying them their source of livelihood. By inhibiting glycolysis they exert an anticancer effect on the cancer cells hence help in killing the cancer cells.

Glycolytic inhibitors can be used mostly in fighting cancer cells that have mitochondrial defects or in hypoxic conditions. These cells often become resistant to conventional medication such as chemotherapy or radiation therapy. However increased glycolysis is a common characteristic of all tumor cells and glycolysis inhibition can be used in wide range in treating cancer patients.

Though it may be difficult to understand the molecular and biochemical mechanisms that lead to increased aerobic glycolysis in the cancer cells, the metabolic repercussions of this increased glycolysis is very clear. The malignant cells become dependent or other addicted to the glycolysis pathway as the sole source of ATP energy. Researchers opine that the increased glycolysis in cancer cells may be caused by such factors as; hypoxia, oncogenic signals as well as mitochondrial dysfunction.

The cancer cells have to access a reliable supply of glucose in order to live. Unlike oxidative phosphorylation which generates more ATP energy per glucose the ATP generation of ATP through glycolysis is too little. Typically oxidative phosphorylation produces 36 ATP per glucose while glycolysis produces 2 ATP per glucose. This therefore forces the cancer cells to eat more glucose for effective metabolism as well as to accomplish other activities. The cancer cells therefore need to maintain glycolitic activities in order to grow and live on.

This metabolic characteristic of the cancer cells has availed a better way of killing cancer cells. Researchers have now proved that by inhibiting glycolysis the cancer cell will stop production of the ATP energy that they depend on and so they will die out of starvation.

When there is glycolysis inhibition the normal body cells will be able to adapt to other metabolic pathways to generate the ATP energy through the TCA cycle and oxidative phosphorylation in the mitochondria. The cancer cells however cannot adapt to other sources of ATP as they have defects hence will die as they will not be able to live without another source of ATP energy. The healthy body cells will be able to adapt to new sources of energy like fatty acids and amino acids to produce metabolic intermediates channeled to the TCA cycle for ATP production through respiration. Glycolysis inhibition is therefore a clever way of killing the cancer cells without harm on the healthy body cells.

DCA as a Glycolysis inhibitor

The way DCA works as a glycolysis inhibitor is very interesting; it forces the cancer cells to generate ATP through glucose oxidation but the cancer cells are not able to do this and they get starved and die. The healthy body cells can adapt to metabolic changes unlike the cancerous cells. The first way through which the body cells get energy is through glucose oxidation which happens in the mitochondria of every cell in the body and requires oxygen. Glucose respiration is the mostly utilized form of metabolism in the healthy cells. However in absence of oxygen the cells turn to glycolysis which takes place in the cell cytoplasm for energy generation. Glycolysis does not avail adequate ATP energy for normal cells; however it is the best for cancer cells. Glycolysis depends on sugar. This gives the healthy cell advantage as they have a backup plan in case the oxygen supply is interrupted. However to oxidize glucose there must be pyruvate. Pyruvate entry into the mitochondria is inhibited by an enzyme known as pyruvate dehydrogenase kinase (PDK). In case the PDK is strong then it will limit the transportation of pyruvate into the mitochondria and the healthy cells will have to depend on glycolysis even in presence of oxygen but incase its weak the pyruvate will be transported with ease to mitochondria even when the oxygen is low.

Cancer cells have the most active PDK than the healthy cells and they are adapted to glycolysis. When PDK is weak then the cancer cells are disadvantaged and this is what the DCA does. It weakens PDK forcing the cancer cells to rely on glucose oxidation which does not favor them. Hence they will starve and die.

Dr. Dalal Akoury is an experienced integrative cancer doctor who has seen very many cancer patients journey to victory in their fight against cancer. She is available for consultations. Just call her now and begin your journey to victory against cancer.

The Role of Glycolysis Inhibitors In Fighting Cancer

 

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Off-label Drugs and Cancer

August 3, 2014

Use of off-label Drugs in Cancer Treatment

off-labelIn the past, there was a belief that when you had gone for cancer diagnosis then the only options of treatment you had were only chemotherapy, radiation therapy and surgery. This belief seemingly has refused to leave the minds of very many people even after medical researchers and other oncologists have done lots of work to avail various alternatives to cancer treatments. The researchers are giving us better ways of treating cancer everyday and all we ought to do is find an integrative cancer doctor who can make the best out of the discovered cancer treatment alternatives. The reason to why so many alternatives to cancer treatment are sought everyday is not because there is no cancer cure, no cancer unlike HIV has known cures all the doctors and researcher are trying to do is to find us a better cancer treatment that is free from all the severe and life threatening side effects that cancer patients have to embrace while undergoing the conventional cancer treatments. Some of these alternatives also work better when used alongside conventional cancer treatments like chemotherapy and radiation therapy. They also increase the effectiveness of the chemotherapy treatment as they induce the cancer cells to consume poisoned food particles, an example of this is the Insulin potentiation therapy that has been used to effectively target the cancer cells, killing them without causing any severe hurt to the healthy body cells. Other alternative cancer treatments have also proved their effectiveness in fighting cancer and so it is time to shift this belief in conventional cancer treatments and accept the new inventions that can help cancer patients to get better treatments. There are very many alternatives to cancer treatments and that is one of the reasons why AwareMed exists; to let you know of all the available options that you can utilize in case you become a victim of this dreaded disease. Here is one of the alternatives.

Use of Off-label Drugs

The off label use of drugs is to use medicine for another reason other than the intended purpose for which it was approved by the United States FDA or any other regulatory body. It is the use of drug for the purpose that is not on the official label, hence “off-label”. There are very many drugs that are meant to treat other diseases but can work very well in cancer treatment. The utilization of these off-label drugs is not something unusual, though they are not as common as they ought to be. The regulatory bodies have not supported the use of drugs approved for treatment of a particular disease to be used in treatment of another disease and this may explain why the use of off-label drugs is not that common. Cancer is a disease that is caused by many factors and so is it treatment facilitated by many factors. There are conditions that cancer shares with other diseases and so the treatment that works in those other diseases will work rather perfectly in cancer treatment. The integrative doctors knows the relationship between cancer and other diseases and whether the off-label drugs can work better in suppressing the tumor growth and restore the health of the cancer patient. Experienced integrative cancer doctors like Dr. Dalal Akoury (MD) can help personalize the use of off-label drugs to help in healing the cancer patient better.

The off-label drugs can work in different ways to help in fighting the cancer. The avenues through which the off-label drugs work to treat cancer are numerous and are based on the common features that cancer shares with the said diseases. It is not strange to hear that diabetes drugs are used for cancer.

Diabetes Drugs for cancer

One of the great oncologist; Otto Warburg showed the dependence of cancer cells on glucose. In his experiments he proved that cancer cells depended solely on sugar sources of energy to survive and metastasize. Without sugar the cancer cell will be starved to death as they will not access the necessary nutrient supplies. Diabetes drugs are used to suppress the sugar level in the blood. These drugs work in favor of cancer treatment as they tend to reduce the amount of energy that is available for the cancer cells to survive on. An integrated oncologist may decide to use a diabetic drug to suppress the sugar level in a cancer patient and hasten the death of cancer cells out of starvation. As the cancer cell will be dying the healthy body cells will be using other sources of energy like fats to survive.

Apart from diabetes drugs, there are other medications that are useful in cancer treatment. Drugs used in enhancing immunity can be used to stimulate the white blood cells to fight cancer cells. Antibiotics that are not mentioned as cancer drugs may help in fighting cancer by inhibiting the enzymes that the cancer cells are dependent on.

Noscapine has also been found to be very effective in fighting cancer as it helps in cancer by preventing the division of cancer cells.

off-labelSome of the drugs used as anti-HIV can also be used in cancer treatment. Examples are ritonavir, nelfinavir and saquinavir. A test that was done by Dr. Phillip Dennis found that these drugs have an effect on the growth of cancer as they were found to kill cancer cells through apoptosis, necrosis and autophagy.

Dr. Dalal Akoury is an experienced integrative cancer doctor who has seen very many cancer patients journey to victory in their fight against cancer. She is available for consultations. Just call her now and begin your journey to victory against cancer.

Use of off-label Drugs in Cancer Treatment

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Stress Relief and Cancer

July 29, 2014

Stress Relief Is Essential in Cancer Care
StressCancer is a disease that has caused much pain and has made us victims in one way or the other. The moment a person receives a news that he has cancer, fear become his uninvited companion as no one is ever sure of surviving the disease even with availability of many alternative cancer treatments in the hospitals. Researchers have done lots of work to ease this feeling but history knows that very many people have lost their lives to the disease. Some of the people who lost their lives did not die because of the disease itself but because the treatment was not holistic enough to suppress all the tension that the patient had. Cancer treatment is not just about injecting the patient with drugs that are aimed at killing the cancer cells. This approach of cancer treatment may not succeed because a cancer patient goes through lots of psychological trauma that needs to be addressed as well during the treatment and this is the reason why having an integrative cancer doctor attend to your cancer patient can be very beneficial as they focus on the whole person healing that is the body, the spirit and the mind. Stress is a culprit in cancer treatment and so needs to be addressed well for the cancer treatment to be effective. The patient needs to obtain a peace of mind for the drugs to have effect on the patient. Stress has been mentioned by many researchers as a factor that may make cancer treatment even more complicated.

Stress causes cancer

Many medical research findings have linked stress to cancer. Researchers have found that a gene ATF3 is a crucial link between cancer and stress. The gene is activated during stressful conditions in all types of cells, in normal conditions the gene can protect the body since incase of dangerous stressors; the normal cells can commit suicide to avoid the spread of the poison to other cells.

The researchers however proved that the cancerous cells will coax the immune system that have been put in place closer to the tumors to influence the expression of the ATF3 gene hence makes the ATF3 to inhibit the activity of immune cells making them to act erratically and allow the cancer cells to spread from the tumor to other parts of the body. In that manner stress is linked to metastasis.

It is highly recommended for a cancer patient to engage in practices that helps in reducing the stress levels in the body which in a broader way will help in reducing your risk of getting cancer. The patient ought to be well taken care of by avoiding all stressful conditions.

Stress relief is not only important to those who are already sick of cancer, stress relief is necessary for those who are not sick as well. This is because stress may make a person to involve in unhealthy behaviors like smoking, drinking alcohol and having multiple sexual partners all in a bit to find relief. Smoking tobacco is a major cause of lung cancer while having multiple sexual partners is known to cause cervical cancer.

How to relieve stress in a cancer patient

To relieve stress we need something that may distract the patient from his streams of hopeless thoughts. There are a number of activities that may help a patient be relieved of stress but still the person’s attitude towards the activity will matter so it is important to incorporate the patient’s likes and feelings in every strategy towards stress relief.

Reflexology

Reflexology involves the practice of massaging or applying pressure to various acupressure points on the body with the goal of reducing stress and supporting overall health. This however needs to be done by a qualified integrative cancer doctor in order to reap the desired benefits.

Sound therapy CD

Sound therapy is effective in stress relief in cancer patients. It involves the patient listening to the vibrations from the harmonics overtones of the 5th interval and the 7h cord which is made up of two 5th intervals. The vibrations are said to promote healing in the parts of brains that are responsible for endorphin release by causing a pathetic resonance to these parts. Endorphins are brain chemicals that transmit signals from one neuron to the other and help in reducing stress and enhancing the immune system.

Ballroom dance

Exercise is a great way that helps in stress reduction not only to cancer patient but also to people who dot have cancer cells in them. However for a cancer patient, he may not be having strength enough for a gym workout needless to mention the exercise they need to do is one that is fun like ballroom dancing which increases the blood circulation and reduces muscle tension. It also activates hormonal activities which is key in cancer treatment.

Valid company

StressStress can be worse if the patient is kept in isolation where he does not meet his family and share his moments with them. This explains why patients undergoing home treatment may recover within a short time. Keeping the cancer patients accompanied at all times reduces their stress as they know they have people they can count on.

You need to learn on ways to prevent the disease. You need reliable information to help you do this. Contact Dr. Dalal Akoury (MD) for more information on health matters and be empowered to take good care of your life. Check her website for more information. As always she is readily available for consultations.

Stress Relief Is Essential in Cancer Care

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Personalized Cancer Treatment

July 29, 2014

 

An Integrative Personalized Cancer Treatment

Cancer is a multi-faceted disease that needs to be treated in a multi-dimensional approach. The times are gone when all cancer patients went for conventional cancer treatment methods like chemotherapy just to be treated with one drug. This is not a good approach and will not help any cancer patient. This is because cancer is fuelled by different agents. We all have different gene composition and our bodies react to drugs differently. The new era of cancer treatments involves personalized treatment; where an individual’s condition, genetic composition, the patient’s preference as well as the doctors experience count in the type of treatment the patient receives. Personalized treatments are working much better than the orthodox cancer treatment methods. This is because before a drug is administered to a patient, it is tested and its ability to treat the disease is analyzed in the labs before introducing it into the body of the patient. Tests such as chemosensitivity test, Biofocus tests and the greet test have been used to test and verify drugs and treatment options that can work best with the patient.

Integrative cancer treatment approach is a better approach than tying a cancer patient to one way treatment methods that may not yield any fruit. In fact that would be an insult to the researchers who have worked all the years just to bring us different alternative cancer treatments in a bid to make cancer treatment less stressful and to reduce the severity of the side effects that conventional cancer treatment methods like chemotherapy and radiation therapy are associated with. Integrated cancer treatment approach also heals the patient wholly and does not just aim at killing the cancerous cells.

Integrative cancer treatment can also be personalized for better effects on the patient. The integrative oncologist has got experience in handling cancer patients needless to repeat he combines the conventional cancer treatment with other alternative cancer treatments to get the best cure for a cancer patient. He understands that patients react to treatments differently and will do the necessary tests that will aid him in giving the right treatment to the patient. Being at liberty to combine best treatments both conventional and naturopathic, the doctor will craft a treatment that best suits the situation. He has numerous options to choose from here are some of the options.

The dietary approach

There are very many diet plans that are considered to work well in certain situations and with given type of cancers. After the doctor has done some tastes and has known what deficiencies needs to be addressed, he will decide on the best diet to recommend to the patient so as to help in treating the patient. Here is an example of diet treatment approach.

The Gerson’s therapy- This is a natural approach to treatment of cancer. The therapy is based on organic diet that is mainly composed of vegetables and vegetable juices. The diet helps the body to recover by activating the body’s natural healing abilities. Gerson’s program also features coffee enemas plus other natural supplements that are geared towards helping the body to heal itself. It also helps in boosting immune system and is helpful in fighting cancer. The Gerson’s therapy does not only treat the symptoms of the disease but removes all the toxic substances entirely from the body. It cures directly from the cell level and that means that it uproots the disease causing agents from their roots destroying them completely.

The doctor will assess the viability of the Gerson’s therapy in treating the patient before implementing it. In some cases the dietary approach may be used alongside chemotherapy to enhance drug uptake by the cancer cells and to reduce the side effects.

Advanced diagnostic approach

Advanced diagnostic involves a thorough and reliable diagnosis. Through these tests the doctor will be able to personalize the treatment. The advanced diagnostic will use the following tests to verify which treatment option best suits the condition. A review of health history, Physical examination, Laboratory tests, Genetic tests and bone scans. The tests will help the doctor to locate the tumors and also to know the stage of the disease therefore will help him in deciding on the best treatment combinations to treat the patient. This method also allows the doctor to monitor how the drugs are working on the tumor as well as the response of the cells to the treatment, at this point the doctor will decide whether to continue with the routine or try some treatment option. The possibility of any severe side effect is also considered.

        Target cancer therapies

The integrative doctor may decide to use drugs that are designed to interfere with specific molecules necessary for tumor growth and metastasis. The aim of target therapies is to fight cancer more strategically with few side effects. Again before the doctor decides to use the target therapies he must do a lab test to verify that it can work well for the patient.

The target therapy is aimed at killing the cancer cells without harming the healthy body cells. It can also be used alongside chemotherapy. Your doctor will decide which the best for your condition is.

With personalized cancer treatment the patients and doctors are relieved on repeat treatment especially haphazard chemotherapy that may not yield any benefits. Through personalized treatment the cure for the cancer is known before the chemotherapy drugs are injected into the patient making this treatment more preferable. Dr. Dalal Akoury runs a website that equips people with relevant information about cancer. Check on her website regularly to benefit from her wealth of health knowledge.

An Integrative Personalized Cancer Treatment

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DMSO and Cancer Treatment

July 22, 2014

DMSO As an Alternative Cancer Treatment

DMSOCancer is a disease that is synonymous to pain. The pain that the cancer patients suffer while going through treatment can never be underestimated. Conventional chemotherapy may be effective in treating the disease but it has far more severe side effects that make patients to seek for other alternative cancer treatments. Doctors on the other hand have been trying to get better ways through which cancer can be treated more effectively without hurting the healthy cells as common with the conventional chemotherapy. Very many developments have been Made even in the chemotherapy treatment to make it more effective and less painful. Other alternative have also been discovered yet others are still coming up. One of the alternatives to cancer treatment is the use of DMSO which has become popular over a time.

What is DMSO?

DMSO (Dimethyl Sulfoxide) is  purely a natural product from the timber industry. It had been in the timber industry for a long time before its medicinal abilities were discovered. The product has been used in the past in its crude form by doctors and athletes to address muscle problems and some injuries. It is said to be a good healing agent as it increases the blood supply to the areas that are injured. This product has been approved by FDA as a treatment for interstitial cystitis (bladder inflammation). It is very gentle but has very powerful healing properties. Several research have been done to reveal the ability of the Dimethyl Sulfoxide in treating cancer, however this is one of the effective cancer treatments that is not easily understood. The patients that have used it got healed but it’s hard to tell which properties it contains that is so powerful in killing cancer cell. Even after the many patients that have been healed by Dimethyl Sulfoxide treatment, FDA has only approved of it as an organ preservative and a cure for interstitial cystitis.

The history of DMSO as a pharmaceutical product can be traced back to the 1961. It is said that its medical abilities were discovered by Dr. Jacob who was the head of an organ transplant program at Oregon Health University. He tested the colorless liquid as an organ preservative and found that it could penetrate deep into the skin without causing any harm on the skin. His discovery led to his journey; researching on the medical properties of DMSO. After Dr. Jacob’s discovery DMSO became so known through the various media that spread its medicinal potential. This generated lots of interest in cancer doctors and researchers who began doing lots of research  on the ability of this product in treating cancer.

With many researches that were conducted and tests on cancer patients, DMSO was found to be effective in cancer treatment. With reference to the state of cancer patients that were put on the DMSO treatment, it was verified that DMSO is an effective cancer treatment as it done away with the most aggressive tumors that had even metastasized to the lymph nodes and other areas of the body. The use of DMSO in cancer treatment has been successful mostly in the fight against the lymphomas, glioblastoma, melanoma, prostate, and colon cancer. The use of DMSO is also common with other types of cancers where it has also been successful.

How does it help in cancer treatment?

DMSO was referred to us a medical wonder product or better yet as the aspirin of the 21st century by the  Encyclopedia of Medical Breakthroughs and Forbidden Treatments (published by Medical Research Associates LLC). This medicinal wonder product has a molecular bond with water that is 1.3 times stronger than water molecular bond with itself. It is faster in penetrating through the cell membranes, taking with it substances that would not have penetrated the cell membrane. It is effective in restoring damaged cells as it penetrates into the cells thereby hydrating them. DMSO penetrates into the cell changing its water structure and improves cell permeability which is good in flushing out toxins in a cell. Leaving the cells more nourished and free from the toxins that may cause cancer.

This wonderful product is rich in medicinal abilities that have been seen to cure cancer, however it is not understood how it achieves all this just like aspirin medicinal abilities were not understood until recently. DMSO is known as a carrier solvent. So when it penetrates the tumor cells it carries away the dextrose that the cancer cell relies on for energy leaving them to starve. It is also believed to kill the most metabolically active cells; cancer cells. This leads to the effective killing of cancer cells without harm to the body cells.

Those who have used the DMSO treatment opine that it can penetrate the proteins that surrounds the cancer cells forming a shell and so may help other medications such as the chemotherapy drugs in reaching the cells killing them. As it penetrates the cancer cells it carries away the nutrients that the cancer cells rely on reducing the energy levels in the cancer cells leaving them weak and benign.

DMSOIt is also known to stimulate the immune system  .It is also known to scavenge for hydroxyl radicals which are the most potent free radicals. This is one of the ways it helps in cancer treatment since the free radicals are known to fuel cancer cell growth and metastasis. Their ability to scavenge for free radicals has seen this treatment becoming popular for cancer patients while undergoing chemotherapy. Chemotherapy must generate free radicals to kill the cancer cell and it’s these free radicals that are responsible for those side effects as hair loss and nausea. Patients who use DMSO while on chemotherapy evade these side effects.

Dr. Dalal Akoury (MD) has profound knowledge on this topic and can offer you a good advice on how to easily adopt the program. Frequently check this website for most current updates on cancer treatment. Generally, this approach to cancer treatment is worth a try.

DMSO As an Alternative Cancer Treatment

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