Breast Cancer and Alcohol; Role of Alcohol

March 17, 2014

Breast cancer and Alcohol-Role of alcohol

Breast cancer and Alcohol-Definition

Alcohol has great effect on the causes of cancer, keep health by a voiding alcohol

Breast cancer is that which forms in tissues of the breast. The most common type of breast cancer is ductal carcinoma, which begins in the lining of the milk ducts (thin tubes that carry milk from the lobules of the breast to the nipple).

Another type of breast cancer is lobular carcinoma, which begins in the lobules (milk glands) of the breast. Invasive breast cancer is breast cancer that has spread from where it began in the breast ducts or lobules to surrounding normal tissue. Breast cancer occurs in both men and women, although male breast cancer is rare.

Breast cancer and Alcohol-Potential link between alcohol consumption and the cancer

Scientists looking at particular enzyme found a biological molecule that accelerates chemical reactions known as CYP2E1. Their findings offer a possible target to improve outcomes for patients in the later stages of the disease.

This enzyme, known as CYP2E1, has been implicated in various liver diseases linked to alcohol consumption, Alcoholic Liver Disease (ALD), as well as diabetes, obesity and cancer. That is Breast Cancer and Alcohol are closely linked.

They wanted to understand why an enzyme known to function mainly in the liver was found to be heavily present in some types of breast cancer tissues. They also wanted to explore what other activities this enzyme might have that control the development of breast cancer. Their findings revealed that the enzyme breaks down various molecules within cells, including alcohol. The by-products of this metabolism include reactive oxygen species (ROS), resulting in something called oxidative stress, in normal physiological conditions this aids cellular functions, whereas when concentrations of ROS are high or oxidative stress becomes chronic, cells can be seriously damaged. Breast Cancer and Alcohol are closely related.

Previous studies have shown that the enzyme is most strongly expressed in early stages of breast tumors rather than more developed tumors and scientists believe that it contributes to the progression of breast cancer.

The study, published in Breast Cancer Research, found that depending on the stage of the breast cancer, high levels of the enzyme can help cells survive during stress. It was also found that inhibiting the activity of the enzyme in cells with high migratory potential promoted cell migration a process linked to cancer spreading known as metastasis.

Breast cancer and Alcohol-Causes and risk factors

We have not fully understood the causes of breast cancer, as a result of this may be difficult to say with certainty why one woman may develop breast cancer and another may not. However the risk factors are known, some of these can change the likelihood that someone may develop breast cancer. There are some factors you cannot do anything about, but there are some you can change.

Alcohol

Your risk of developing breast cancer can increase with the amount of alcohol you drink. Research shows that, for every 200 women who regularly have two alcoholic drinks a day, there are three more women with breast cancer compared with women who do not drink at all. That study confirms that Breast Cancer and Alcohol has a cause and effect relationship.

Age

The risk of developing breast cancer increases as you get older. Breast cancer is most common among women over 50 who have been through the menopause. 8 out of 10 breast cancer cases occur in women over 50.

All women between 50 and 70 years of age should be screened for breast cancer every three years as part of the NHS Breast Screening programme. Women over the age of 70 are still eligible to be screened and can arrange this through their GP or local screening unit. Currently, there are ongoing pilot studies looking at widening the screening age range to 47-73.

Family history

If you have close relatives who have had breast cancer or ovarian cancer, you may have a higher risk of developing breast cancer. However, as breast cancer is the most common cancer in women, it is possible for it to occur more than once in the same family by chance.

Most breast cancer cases are not hereditary. However, particular genes, known as BRCA1 and BRCA2, can increase your risk of developing both breast and ovarian cancer. It is possible for these genes to be passed on from a parent to their child. If you have, for example, two or more close relatives from the same side of your family who have had breast cancer under the age of 50, you may be eligible for surveillance for breast cancer or for genetic screening to look for the genes that make developing breast cancer more likely.

Previous diagnosis of breast cancer

If you have previously had breast cancer or early non-invasive cancer cell changes contained within breast ducts, you have a higher risk of developing it again, either in your other breast or in the same breast again.

Previous benign breast lump

A benign breast lump does not mean you have breast cancer, but certain types of lump may slightly increase your risk of developing it. Certain benign changes in your breast tissue, such as atypical ductal hyperplasia (cells growing abnormally in ducts) or lobular carcinoma in situ (abnormal cells inside your breast lobes), can make getting breast cancer more likely. If you drink alcohol specially more than 2 glasses per day it will increase your risk to develop breast cancer. Breast cancer and alcohol go hand in hand.

Breast density

Your breasts are made up of thousands of tiny glands (lobules), which produce milk. This glandular tissue contains a higher concentration of breast cells than other breast tissue, making it denser. Women with denser breast tissue may have a higher risk of developing breast cancer because there are more cells that can become cancerous. This is specially true if you drink alcohol regularly. Breast cancer and alcohol have been closely associated.

Dense breast tissue can also make a breast scan (mammogram) harder to read because it makes any lumps or areas of abnormal tissue harder to spot. Younger women tend to have denser breasts. As you get older, the amount of glandular tissue in your breasts decreases and is replaced by fat, so your breasts become less dense.

Being overweight or obese

Breast Cancer and Alcohol; The role of Alcohol is more pronounced if you have been through the menopause and are overweight or obese, you may be more at risk of developing breast cancer. This is thought to be linked to the amount of estrogen in your body, as being overweight or obese after the menopause causes more estrogen to be produced.

Being tall

If you are taller than average, you are more likely to develop breast cancer than someone who is shorter than average. This may be due to interactions between genes, nutrition and hormones, but the reason is not fully understood.

Hormone replacement therapy (HRT)

Hormone replacement therapy (HRT) is associated with a slightly increased risk of developing breast cancer. Both combined HRT and estrogen-only HRT can increase your risk of developing breast cancer, although the risk is slightly higher if you take combined HRT. When you are considering HRT pay attention to the fact that Breast Cancer and Alcohol may play a role in Breast cancer development with HRT.

It is estimated there will be an extra 19 cases of breast cancer for every 1,000 women taking combined HRT for 10 years. The risk continues to increase slightly the longer you take HRT, but returns to normal once you stop taking it.

Breast cancer and Alcohol-Role of alcohol

The source of death in Cocaine and Heroin

March 17, 2014

The source of death in Cocaine and Heroin-Drug Scourge

There is evidence of heroin and cocaine deaths in male than female according to studies conducted

The society and the world over are weeping in great anguish of endless death thanks to the renewed vigor in drug usage. You take a walk in the streets and parks of our beautiful nations and you are saddened with what you see, young and old together drinking and smoking publicly and secretly. Our governments have legalized the use of some of these drugs and are making millions and millions of money inform of taxes all in the name of revenue for development, security and wellbeing of its citizens.

When you take a keen observation on majority of illness keeping patients in hospitals for weeks, months and even years are 90 percent related to the drug consumption. It does not matter the intensity of the consumption, whether one is an addict or not the common denominator is that both are using drugs. Legal or illegal, cheap or expensive whatever the adjective you choose to describe the noun drug we have patients in hospitals, at homes and learning institutions suffering from different illnesses associated with drug use.

Researches are working round the clock trying to find remedies for drug related problems and the authorities/governments are spending a big percentage of the revenue they collect from firms associated with drugs in treatment research and creating awareness of what they themselves are promoting in some way. Anyway there are numerous types of drugs being abused today and it is all important that we talk about them openly and without any shame. I beseech all of us to face the society with the real truth about the abuse of drugs but for the purpose of this article I want to zero in to two killer drugs in our society (especially in Europe) today that is Cocaine and Heroin.

The source of death in Cocaine and Heroin-Drug induced deaths

Much as there are many unreported cases, the number of reported drug-induced deaths today can be influenced by the prevalence and patterns of drug use (injection, polydrug use), the age and the co-morbidities of drug users, and the availability of treatment and emergency services, as well as by the quality of data collection and reporting. Improvements in the reliability of European data have allowed better descriptions of trends, and most countries have now adopted a case definition endorsed by the EMCDDA. Nevertheless, caution must be exercised when comparing countries because there are still differences in reporting methodology and data sources. But the common denominator is that drug induced deaths are skyrocketing.

The source of death in Cocaine and Heroin-Opioids

Opioids, mainly heroin or its metabolites, are present in the majority of drug-induced deaths reported in Europe. In the 22 countries providing data for 2008 or 2009, opioids accounted for the large majority of all cases: over 90 % in five countries, and between 80 % and 90 % in a further 12. Substances often found in addition to heroin include alcohol, benzodiazepines, other opioids and, in some countries, cocaine.

This suggests that a substantial proportion of all drug-induced fatalities occur in a context of polydrug use, as illustrated by a review of toxicology of drug-related deaths in Scotland in 2000-07. It showed that the presence of heroin and alcohol were positively associated, particularly among older males. Among men whose deaths were related to heroin, alcohol was present in 53 % of those aged 35 and more, compared to 36 % in cases under 35.

Men account for most overdose deaths reported in Europe at 81 %. Overall, there are around four males for each female case (with the ratio ranging from 1.4:1 in Poland to 31:1 in Romania). In the Member States that joined the EU more recently, reported drug-induced deaths are more likely in males and in younger people compared to the pre-2004 Member States and Norway. Patterns differ across Europe, with higher proportions of males reported in southern countries. Denmark, the Netherlands, Sweden and Norway report higher proportions of older cases. In the majority of countries, the average age of those dying of heroin overdoses is in the mid-thirties, and in many countries it is increasing.

A number of factors are associated with fatal and non-fatal heroin overdoses. These include injection and simultaneous use of other substances, in particular alcohol, benzodiazepines and some antidepressants. Other factors linked with overdoses are binge drug use, co-morbidity, homelessness, poor mental health (e.g. depression and intentional poisoning), not being in drug treatment, previous experience of overdose, and being alone at the time of overdose. The time immediately after release from prison or discharge from drug treatment is a particularly risky period for overdoses, as illustrated by a number of longitudinal studies.

The source of death in Cocaine and Heroin-Trends in drug-induced deaths

Drug-induced deaths increased sharply in Europe during the 1980s and early 1990s, paralleling the increase in heroin use and drug injection, and thereafter remained at high levels. Between 2000 and 2003, most EU Member States reported a decrease, followed by a subsequent increase from 2003 until 2008. Preliminary data available for 2009 suggest an overall figure equal to or slightly below that for 2008. Where a comparison is possible, the numbers of deaths reported have decreased in some of the largest countries, including Germany, Italy and the United Kingdom.

The reasons for the sustained or increasing numbers of reported drug-induced deaths in some countries are difficult to explain, especially given the indications of decreases in injecting drug use and increases in the numbers of opioid users in contact with treatment and harm-reduction services. Possible explanations include: increased levels of polydrug use or high-risk behavior; increases in the numbers of relapsing opioid users leaving prison or treatment; and an ageing cohort of more vulnerable drug users.

The source of death in Cocaine and Heroin-Overall mortality related to drug use

Overall mortality related to drug use comprises drug-induced deaths and those caused indirectly through the use of drugs, such as through the transmission of infectious diseases, cardiovascular problems and accidents. Deaths indirectly related to drug use are difficult to quantify, but their impact on public health can be considerable. Such deaths are mainly concentrated among problem drug users, although some (e.g. traffic accidents) occur among occasional users.

Estimates of overall drug-related mortality can be derived in various ways, for example by combining information from mortality cohort studies with estimates of drug use prevalence. Another approach is to use existing general mortality statistics and estimate the proportion related to drug use.

The source of death in Cocaine and Heroin-Drug Scourge

Buprenorphine for the treatment of addiction

March 15, 2014

Buprenorphine for the treatment of addiction-Is it the best

If you are suffering from addiction seek treatment but remember Buprenorphine may not be a better option.

Buprenorphine is used to help you keep off street drugs such as heroin. It can prevent or reduce the unpleasant withdrawal symptoms when you stop using such drugs. It is a medicine that is similar to heroin and works as a replacement treatment. Many people choose to stay on buprenorphine long-term, although some people gradually reduce their dose and come off it.

The effects of buprenorphine last longer than heroin so it is usually prescribed as a once-daily dose. To begin with, you will usually be asked to take it under the supervision of the pharmacist who dispenses the buprenorphine to you. This means there can be no doubt about how much buprenorphine you take at each dose. This supervision may be relaxed after a few months of your taking a regular maintenance dose.

Buprenorphine is also available combined with another medicine called naloxone (the tablet brand name is Suboxone). Naloxone blocks the action of buprenorphine and the effect of the combination is that, if you are tempted to crush the tablet and try to inject it, you will start to get withdrawal effects.

Buprenorphine for the treatment of addiction-Can buprenorphine cause problems?

As with all medications, Buprenorphine (Suboxone) drug treatment also has some disadvantages. It is still a medication and if you prefer to break free from any kind of addiction immediately, then Buprenorphine may not be the way to go. Also, you may not be completely Buprenorphine-free by the time you leave drug treatment, even if you opt for an inpatient drug rehab program.

Some may consider these disadvantages while others consider them well worth the advantage of avoiding opiate withdrawal symptoms. Also, some initial studies on long-term use of Buprenorphine suggest that there are anti-depressant effects of the drug as well. The dosing schedule is also relatively easy to maintain as most don’t even have to take it every day. Additionally, you can’t abuse Suboxone, get high off of it or overdose on it like you can with some other opiate addiction maintenance or detox drugs, like methadone. Much as this may offer treatment for addiction, it is in itself addiction and should not be encouraged. Its demerits far much out ways the merits just have a look at the conditions lined below before and during its usage.

Buprenorphine for the treatment of addiction-Before taking buprenorphine

Some medicines are not suitable for people with certain conditions, and sometimes a medicine may only be used if extra care is taken. For these reasons, before you start taking buprenorphine it is important that your doctor knows:

If you have liver or kidney problems.
If you have prostate problems or any difficulties passing urine.
If you have any breathing problems, such as asthma or chronic obstructive pulmonary disease (COPD).
If you have been told you have low blood pressure.
If you have any problems with your thyroid or adrenal glands.
If you have epilepsy.
If you have a problem with your bile duct.
If you are pregnant or breast-feeding.
If you have been constipated for more than a week or have an inflammatory bowel problem.
If you have a condition causing muscle weakness, called myasthenia gravis.
If you have recently had a severe head injury.
If you have ever had an allergic reaction to a medicine.
If you are taking any other street drugs or medicines. This includes any medicines you are taking which are available to buy without a prescription, such as herbal and complementary medicines.

Buprenorphine for the treatment of addiction-Getting the most from your treatment

Some people feel uncomfortable during the first 2 to 3 days of taking buprenorphine. Do not be tempted to take heroin on top, and do not take more than the dose your doctor has prescribed for you.
It is important that you keep your regular appointments with your doctor or clinic so your progress can be reviewed. You will be asked to give a urine sample from time to time.
Buprenorphine cannot be supplied to you without a prescription. You will not be able to ask for any changes to be made to your supply, as your pharmacist can only dispense the prescription exactly as your doctor has directed.
There are several different brands and strengths of buprenorphine tablets, so each time you collect a supply, check to make sure it contains what you are expecting.
You are more likely to succeed in staying off heroin if you have support and counseling in addition to taking buprenorphine. Local drug community teams, self-help groups and other agencies may be of help. It is much harder to ‘do it alone’, so go for counseling and help if it is available in your area.
You should not take any street drugs or drink too much alcohol while you are on buprenorphine. This is because other street drugs such as benzodiazepines (benzos) and alcohol can affect buprenorphine and increase the chance of unwanted effects.
You should tell the DVLA that you are taking buprenorphine if you are a driver. You are likely to be banned from driving at first, although you may be allowed to drive again later, subject to an annual medical review. Your doctor will tell you when you can resume driving.
Do not stop taking buprenorphine without discussing this with your doctor or drug-team worker first. It is important that buprenorphine should be taken regularly to reduce the risk of withdrawal symptoms occurring. When you are ready to consider becoming drug-free, your doctor or drug-team worker will be able to help you decide on the best way to do this in order to keep withdrawal effects to a minimum.
If you are planning any trip abroad, you should carry a letter with you from your doctor to explain that you have been prescribed buprenorphine. This is because buprenorphine is classed as a ‘controlled drug’ and is subject to certain restrictions.
If you buy any medicines, check with a pharmacist that they are suitable for you to take with buprenorphine. Many other medicines have similar side-effects to buprenorphine and taking them together will increase the risk of unwanted effects.
If you are having an operation or dental treatment, tell the person carrying out the treatment that you are taking buprenorphine.

So many side effects and so many conditions attached making buprenorphine not to be right for addiction treatment not now and certainly not ever.

Buprenorphine for the treatment of addiction-Is it the best

Why You Cannot Lose Weight Fast, Act Now, Call the expert!

February 18, 2014

12 Reasons why you Cannot Lose Weight Fast

Why You Cannot Lose Weight Fast, Act Now, Call the expert!

why you may not lose weight is due to poor eating habits and sleep deprivation.

Many at times we tend to follow the right ways in an attempt to losing weight by eating well and exercising, but despite all these efforts weight just won’t go away or worse still it’s going up! Surely, making desperate attempts to lose weight can be so frustrating may create a real stress in our lives. I can say with certainty that weight is the number one stress for women the world over.

We go round and round trying to control what we eat and yet we feeling like failures because the scale doesn’t move, we punishing ourselves for not being more in control, and then manifesting a huge amount of bodily stress that causes further problems in our bodies. Weight loss is achievable by following the right practices and being discipline to then. However there are several reasons that may make us not to lose weight, some of them include:

Why you cannot Lose Weight Fast -Lack of adequate sleep

Sleep deprivation may be hindering your weight loss targets. This brings down your metabolism and affects the hunger hormones leptin and gherkin. You cannot Lose weight Fast if you do not have time to restore.

Leptin hormones has a major function of communicating with the brain to stop eating, whereas Ghrelin is produced in the stomach and has a function of stimulates hunger. Research suggests that inadequate sleep is associated with low levels of leptin, high levels of ghrelin and weight gain.

the solution to sleep deprivation is to off your phone laptop and any other thing that may bring disruption and focus on good sleep hygiene, get to bed early, make sure your room is dark and cool and avoid all drugs including cigarettes, alcohol and sleeping pills. You cannot lose weight fast if you drink alcohol.

Why You Cannot Lose Weight Fast -Consumption of hidden sugars

Sugars are everywhere. The biggest culprits include muesli bars, breakfast cereals, sports drinks, sauces and spreads – even certain peanut butter brands contain sugar. So what’s the big deal? Added sugars are now considered to be more damaging than dietary fat to your weight and overall health, contributing to conditions including dental decay, diabetes, heart disease and obesity.

The solution to this is to avoid products with high amounts of added sugar. It may be listed as corn syrup, sucrose, malt, glucose, molasses, fructose, maltose or fruit juice concentrate. You cannot Lose weight Fast if you eat Simple sugars.

You count calories, not nutrients

There is no question that portions need to be smaller in order to lose weight. However, we have become so obsessed with calorie control that we often overlook the most important aspect of food the nutrients.

The solution will be think quality. Don’t just focus on the calories. Instead, choose nutrient oriented food and nourish your body with the vitamins, minerals and antioxidants found in fruit, vegetables and wholefoods.

Why you cannot lose weight Fast -You’re absorbing environmental estrogens

Also known as xenoestrogen, these are synthetic chemicals found in plastics, fertilizers, detergents and cosmetics. While the effects of xenoestrogens on the body are still being studied, it is believed they can mimic the biological hormone estrogen. Excess estrogen can result in weight gain in both men and women.

You sit down too much

Watching the Karda Are you eating well and exercising, but your weight just won’t budge? Or it’s going up? Desperate attempts to lose weight can be so frustrating and create a real stress in our lives. In fact, I’ll go as far as saying that weight is the NUMBER ONE stress for women I know. You cannot Lose weight Fast if you are stressed out.

It’s a vicious cycle of trying to control what we eat, feeling like a failure because the scale doesn’t move, punishing ourselves for not being “more in control,” and then manifesting a huge amount of bodily stress that causes further havoc in our bodies. Then we binge or take our diet to an extreme (never healthy) and the cycle continues…

Shians, doing sedentary jobs and stalking old flames on Facebook is a far cry from our hunter-gatherer ancestors. You may think you’re too busy to exercise, but the reality is we are meant to move.

Solution: You may laugh, but this is known as NEAT non-exercise activity thermogenesis). Research suggests those who fidget burn hundreds of extra calories throughout the day. Fidgeting includes crossing or uncrossing the legs, stretching, standing up often or maintaining a good posture. Aim to move every 30 minutes to bump your body out of hibernation mode. You cannot Lose weight Fast if you do not move.

You don’t have time to cook

The combination of busy lifestyles and fast food at our fingertips has resulted in less food preparation in the home. Grabbing breakfast on the go or takeaway for dinner is not good for your waistline.

Solution: Set a goal to attempt a new, healthy 20-minute meal each week. Whenever you make a meal, make extra and freeze portions for those days you don’t have time to cook.

You’re dealing with a hormonal condition

Hormone conditions such as hypothyroidism, polycystic ovarian syndrome and insulin resistance can cause weight gain and make it hard to lose weight.

Solution: Talk to your GP and get tested. If you have one of these conditions, diet may help. Exclude refined carbohydrates and increase good-quality protein, vegetables, seaweed and essential fatty acids. You cannot Lose weight Fast if your hormones are off balance.

You’re not eating enough good fats

For decades dietary fat was considered the enemy when it came to weight loss. But interestingly, since the introduction of low-fat products we have seen an increase in obesity around the world.

Solution: Scrap your negative view on fat and include a small amount of “good” fats in each meal. The essential fatty acids in flaxseed oil, oily fish, nuts and seeds not only help you feel full but also facilitate fat breakdown. You cannot Lose weight Fast if you do not eat enough good fats.

You believe the food hype

Marketing of processed foods can be confusing. A package may read “source of calcium” or “no artificial colors” but still be packed with sugar. Why You Cannot Lose Weight Fast if you do not read labels.

Solution: Read the ingredient list. If sugar is in the first three ingredients or it has chemicals you haven’t heard of, don’t buy it.

Your body has a set point

The set point theory says our body is programmed to be a certain weight and fights to stay there. This may explain why calorie restriction alone doesn’t produce long-term weight loss.

Solution: Steady weight loss through a balanced diet and exercise is the only proven way to lower your set point. Aim for a loss of a kilo a week and give your body time to adjust.

You’re not getting enough Vitamin D.

A huge number of the populations have low Vitamin D, which is associated with weight gain and several metabolic processes. If you spend much of your life indoors, get your Vitamin D checked with your doctor.

Your liver is sluggish and you need a good cleanse!

You cannot lose weight fast if your liver is sluggish. If you’re feeling low, tired, and moody and your diet contains alcohol, coffee and sugar, you need to give your body a break. When your liver is sluggish, it struggles to process substances/toxins/hormones efficiently and this leads to toxic build up and this will inevitably cause weight gain. You might benefit from a seasonal cleanse.

12 Reasons why you cannot lose weight fast

Female hormones and weight loss

February 10, 2014

Female hormones and weight loss-what you need to know

Female hormones and their sites

A quick observation at a male versus a female body tells you right away something is different. While we can certainly recognize the obvious, we ignore these differences when we talk about diet and exercise for fat loss. The standard health and fitness advice of eat less and exercise more often does not work once people get out of their twenties and into their thirties, forties and beyond, and women are especially impacted.

So what are the difference between men and women, what determines where women store fat, and what can women do to address the fitness and fat loss issues that are unique to them?

The differences between men and women:

Women usually have smaller waists and more fat storage on the hips, thighs, and breasts. Estrogen and progesterone have much to do with this.

Estrogen is largely responsible for greater fat storage around the hips and thighs while both estrogen and progesterone impact larger breasts.

Because wom en experience monthly hormone fluctuations through the menstrual cycle, they know from experience that hormones impact how they feel, function, and look. They seem to intuitively get the fact that hormones play a role in determining whether they store fat or burn fat and where on the body it is lost or gained. To understand why women are so different, you have to understand their hormones.

Brief review of the menstrual cycle.

No discussion of female fat loss can take place without understanding the normal female menstrual cycle. The first day of bleeding for a woman represents day one of the menstrual cycle.

The menstrual cycle can then be divided into two phases, the follicular phase (named for the maturing of the ovarian follicle) and the luteal phase (named for the corpeus luteum which ovarian follicles become after ovulation). Ovulation, the release of an egg from the ovaries separates these two parts of the cycle.

The follicular phase is associated with higher estrogen levels compared to progesterone, while the luteal phase is the reverse. The relative ratios of these two hormones can have an impact on female related fat loss and health.

Estrogen and progesterone balance

A key fat loss measure in women is the estrogen and progesterone balance and how those hormones interact with other hormones like cortisol or insulin. Bigger hips and thighs on a women suggest greater estrogen levels relative to progesterone. The reverse of that, larger breasts and smaller hips and thighs, MAY indicate the opposite balance of these hormones.

The menstrual cycle is another key indicator of hormone balance. Since the time just before menses is usually a progesterone dominant time, PMS is a strong indication there is a progesterone deficiency relative to estrogen.

A woman can have higher than normal progesterone levels but still have a relative deficiency if estrogen levels are much higher in comparison. Many women with low progesterone relative to estrogen will report feeling like a completely different person before ovulation (the first two weeks of cycle) vs. after ovulation (last two weeks of cycle), where they feel much worse. This ill feeling usually manifests as depression, breast tenderness, moodiness, fatigue, lack of motivation, bloating, and other complaints.

Female fat distributions

Progesterone & estrogen both play a role in keeping the waist of women smaller. This is because estrogen works against the action of insulin (and testosterone a belly fat storing hormone in women) while both estrogen and progesterone oppose the action of cortisol. Insulin and cortisol, together with testosterone and low estrogen, are implicated in belly fat deposition in women.

Estrogen is the biggest factor in increasing fat storage at the hips and thighs providing the hour-glass shape. Progesterone with estrogen halts the storage of fat around the waist, but stress can have more of a negative impact on progesterone’s action. High stress has been shown to negatively impact progesterone, so women who see fat accumulating around the waist may want to work to reduce stress and raise progesterone.

Estrogen is a little different. Estrogen works to increase fat storage by up-regulating what is known as alpha-adrenergic receptors in female fat depots around the hips and thighs. Adrenergic receptors are like the gas and brake peddles on your car and work to accelerate or decrease fat usage. Beta-adrenergic receptors increase fat burning while alpha adrenergic receptors block it. The hips and thighs of a woman have higher amounts of alpha adrenergic receptors compared to men. This is also the major reason it is so difficult for some women to lose fat from the hips and thighs.

It is interesting to note here that one of the best ways to decrease the action of these alpha receptors is by using a low carb diet. This is why many women find fantastic results when they switch from the standard high carb diets and adopt more low carb eating patterns.

Many women have plenty of fat to spare in the hips and thighs but instead of burning it, they will become smaller in the torso and breast first and remain bigger on the bottom. This is a very frustrating scenario for many. Estrogen increases alpha-adrenergic receptor numbers while progesterone decreases it. Progesterone, like testosterone in men, MAY increase beta-adrenergic receptors. In this way, estrogen and progesterone work to influence the ability to burn fat and determine from which areas it will be taken from. This is an issue of hormone balance not calories.

Female hormone changes: age, lifestyle, and the environment

Female hormones have a great contribution to loosing weight

Women are often duped into believing the low calorie diet and aerobic exercise myth. This approach to weight loss rarely works and often creates damage to their body as a consequence. As a woman ages, as a consequence of stress, or because of environmental estrogen mimicking compounds several things begin to occur. The ovaries decrease their production of estrogen and progesterone. This exacerbates estrogen and progesterone balance, further pushing the body more towards estrogen dominance.

There are also many estrogen mimickers in our food and environment. At the same time, fat cells continue to produce estrogen through an enzyme called aromatase present in fat cells. This also leads the estrogen/progesterone balance to shift more towards estrogen. At the same time slimming and muscle building hormones, like human growth hormone (HGH) and DHEA, decline. Together this creates the perfect storm for female related fat gain and most of it occurs in the mid-section.

DHEA, HGH and progesterone are all hormones that act to keep a woman lean and block the storage of fat in the middle of her body. The tricky part is that a low calorie diet and a focus on aerobic exercise makes this worse because they do nothing to restore these powerful hormones and may actually worsen the estrogen progesterone imbalance in the long run.

Solutions to the problem:

Women should be focused on eating more of the right things and exercising smarter. This means eating higher amounts of vegetables and “estrogen free protein as well as engaging in weight training over cardio. There are only three ways to reliably restore HGH in the body: sleep, adequate protein, and intense exercise using weights.

Weight training is perhaps the most important aspect of this and is critical for female health especially to stop the belly fat that accumulates during aging. HGH is to women what testosterone is to men. It keeps them looking young, lean, and firm. Once progesterone levels fall due to stress, menopause, or other factors, HGH is all that is left to keep belly fat in check

Women falsely believe less intense exercise like walking and yoga will give them the desired “look” of their younger years. While these activities are exceedingly healthy, they will not be adequate to generate the hormonal effect needed to raise HGH. However, they will work synergistically with more intense exercise to lower the negative impact of cortisol.

Female hormones and weight loss-what you need to know

Category Archives: Estrogen