NAC, the Cystine-Glutamate Antiporter and Addiction

February 5, 2015

NAC, the Cystine-Glutamate Antiporter and Addiction

Addiction is one complex problem faced by many. There is no limit to how many things people can get addicted to. If you cannot go a day without watching a movie, and then it gets to a point when you must slot in a couple of hours in your daily schedule to watch movies then that is your addiction.

If you keep getting those cravings for soda or sugary meals, you try to stay without them but the urge is so much that you only calm down after satisfying that thirst then that is an addiction.

Addiction can be good or bad. You can be addicted to work, you love your work that you can’t spend time away from your job. That is addiction. Such positive addictions too may be unhealthy. If you are addicted to work for instance, you will hardly spare time for other essential activities, such as being with your family.

Other forms of addiction often associated with the term, such as drug and substance abuse are detrimental to your health. A person who is addicted to alcohol for instance cannot live without it. Their lives often revolve around the liquor. The same applies to coke, cigarettes, marijuana and all other recreational drugs. The substance of addiction gets to dictate how you live your life.

the Cystine-Glutamate Antiporter

Facts about addiction

The habit is a problem. You have to first admit it in order to be able to get over it. An addict who finds it difficult to get over the problem may often be tempted to blame it on someone, or something else. But that is not a solution, acceptance is key.

Giving in to one’s yearnings is a matter of choice. At the beginning of any addiction you often see yourself in control of the situation. You are not forced to do anything, you just do it because you enjoy the act. With time though, this control diminishes and you become increasingly more vulnerable to the substance of your addiction.

You are in a position to drop your addictions by saying ‘no’ to the substance. This is the premise under which psychosocial support for addiction recovery is usually built. Through guidance one is offered a way out of their drug or substance habit. At such point, it is upon you to decide whether or not you are going to adopt a clean lifestyle.

NAC and Addiction

N-Acetyl L-Cysteine is a chemically changed version of the non-essential amino acids in the body. NAC works by purifying your body by removing harmful toxins. It is highly essential in recovery from drug addiction. alcohol and other drugs commonly abused cause a lot of damage to the liver, lungs, kidneys and other organs and this is likely to result in chronic ailments that are life threatening. This amino acid is essential as it protects cells from getting damaged in addition to its role in preserving functions of the liver.

It is a known precursor to Glutathione which is the most effective in destroying free radicals. The amino acid works to protect the brain and the liver from damages caused by toxins like alcohol, acidic mater, particles found in the air and cigarettes smoke. It also has other significant functions that are key to the wellbeing of an individual.

Among them, it helps the body to promote its burning of fat and aids the muscle building process. Studies also indicate that it can rid the body of copper by a chelating effect, and is used in the treatment of particular diseases including bronchitis, emphysema and certain respiratory problems among adults.

NAC plays a key role in the production of white blood cells necessary for body immunity. The white cells fight diseases that attack the body and help boost the natural immune response of the body. As such, the amino acid is essential for the defense of the body against disease attack. It further helps in insulin metabolism and functions, which is key to the body’s blood sugar regulation.

the Cystine-Glutamate Antiporter

Sources of NAC

N-Acetyl L-Cysteine can always be naturally manufactured by the body on its own. The high-protein foods such as eggs and meat are however potent dietary sources of this amino acid. Other good sources include foods such as broccoli, garlic, wheat, onions and red peppers.

Other sources that can be recommended for this important amino acid for those who are recovering from the damage caused by drug addiction include nutritional supplements found in a number of nutrition outlets in different continents. It is however important to seek recommendations form a physician since this product is largely unregulated and health consumers are likely to purchase a product that contains incorrect amount of ingredients recommended for the particular patient.

NAC, the Cystine-Glutamate Antiporter and Addiction

Alcohol Abuse Linked to Esophageal Cancer

January 21, 2015

Alcohol Abuse and Esophageal Cancer

Alcohol abuse has become prison walls to many people, needless to mention economies are crippled because of this societal vice that has made many people incapable of even fending for themselves. Apart from the whole known fight with alcohol addiction and its related consequences, alcohol abuse has also been identified by researchers as a cause of different cancers. Unfortunately alcoholism is not very easy to quit especially without professional help. Many people who try to stop alcoholism have to give in to the cravings for alcohol. Some may also be pulled back into alcoholism due to the withdrawal symptoms that may be hard to deal with. However hard dealing with alcohol addiction can be, there are numerous ways that medics can use to help an addict break the chain of addiction and help him reduce his chances of falling victim to certain cancers. One of the most important factors that will determine whether the addict will succeed in the fight against addiction is the willingness and commitment of the addict to put up with every advice of the doctors. If you are abusing alcohol and you haven’t seen the need to quit it, I guess you should since it has been linked to many different cancers. One of the cancers that alcohol abuse has been linked to is the esophageal cancer. You may not know much about it but it’s good to note that just like any other type of cancer, esophageal cancer is not lenient at all and so you should carve your path and walk away from this disease.

In this article we will look at how alcohol causes these two main types of esophageal cancers; esophageal squamous cell carcinoma (ESCC) and esophageal adenocarcinoma (EA). In the past it has been known that tobacco smoking is a leading cause of different types of cancers including esophageal cancer but recently research study reports have also indicated that excessive alcohol consumption increase the risk of esophageal squamous cell carcinoma.

Today, esophageal cancer (EC) is the 8th most common incident cancer in the world and, because of its high fatality rate, ranks 6th among all cancers in mortality. It is not surprising, therefore, that the etiology of EC has been investigated for over a century. Based on clinical observations, Craver in his Clinical study of etiology of gastric and esophageal carcinoma in 1932 and Watson in 1939 list excessive use of alcohol and tobacco, low socioeconomic status, poor oral health, and consumption of hot drinks as risk factors for EC. These two scientists even cited past research papers on EC etiology published to back up their findings. In particular Craver cites a 1920 article from Argentina that suggests maté drinking as a risk factor for EC.

Alcohol consumption has long been known to be a major cause of esophageal cancer in most areas of the world just like tobacco smoking which is known by many people as a huge cancer risk. Classic ecologic and case-control studies by Tuyns and others in the 1970s and 1980s in his study Cancer of the esophagus: further evidence of the relation to drinking habits in France, established alcohol as a strong cause of esophageal cancer in many countries, and showed that alcohol drinking and tobacco smoking interact to increase esophageal cancer risk in a multiplicative manner. IARC has classified alcohol drinking as a known cause of esophageal cancer.

Generally, it has been found that excessive alcohol consumption is a cause of esophageal cancer however alcohol abuse increases the risk of esophageal squamous cell carcinoma than it does with esophageal adenocarcinoma (EA), but these are just different sides of the same coin-esophageal cancer. When used in excessive amounts (3 or more drinks per day), alcohol has almost universally been associated with an elevated risk of esophageal squamous cell carcinoma; it typically increases risk by 3–5 fold. In contrast, there is little evidence for an association between alcohol drinking and esophageal adenocarcinoma. However, the majority of the case-control and cohort studies that have investigated this association have found no overall relationship between alcohol consumption and esophageal adenocarcinoma, or have found relatively weak associations between alcohol and esophageal adenocarcinoma.

Nevertheless there has been some sort of controversy on this issue as some researchers have opined that some studies have suggested that only certain types of alcohol may be have effects on esophageal adenocarcinoma. for instance in this study; Obesity, alcohol, and tobacco as risk factors for cancers of the esophagus and gastric cardia: adenocarcinoma versus squamous cell carcinoma, done by Vaughan TL, Davis S, Kristal A, Thomas DB in 1995, the reports suggests that drinking wine may reduce risk. However no other study has come up to support these findings.

Esophageal Cancer In the past the link between alcohol and cancer was not easy to establish since alcohol itself does not bind DNA, is not mutagenic, and does not cause cancer in animals but there are mechanisms that have been known that has since helped to establish the link between alcohol abuse and increased risk of certain cancers. One of these mechanisms is that it is converted to acetaldehyde which is harmful as it causes DNA alteration leading to gene mutation which escalates risks to cancer. Alcohol is also a solvent to other mutagens and also causes nutritional deficiency.

Drug addiction is a vice that should be fought by all means that is why we at AWAREmed Health and Wellness Resource Center are committed to availing help to addicts and offering them a place to call home. We offer NER Treatment and Amino acid therapy that are the most effective approaches to addiction treatment and recovery. You call on Dr. Dalal Akoury (MD) today and begin your journey to victory against addiction.

Alcohol Abuse and Esophageal Cancer

Alcohol Abuse Linked To Head and Neck Cancer

January 21, 2015

Alcohol Abuse Increases The Risk of Head and Neck Cancer

There are several types of cancers that are not known to many but are just as serious as the other common cancers like the breast cancer, prostate cancer and even the cervical cancer. Head and neck cancers may be new to you but they have been in existence for just as long as the other common types of cancer it’s only that most people refer to this group by the identity of the individual cancers in the group. Today, head and neck cancers account for approximately 3 percent of all cancers in the United States alone. These cancers are nearly twice as common among men as they are among women. Head and neck cancers are also diagnosed more often among people over age 50 than they are among younger people but indulgence in behaviors that might increase your risk of getting head and neck cancers begin earlier.

Causes of the head and neck cancers

There are many causes of head and neck cancer but alcohol and smoking are the biggest culprits. This doesn’t come as a surprise as alcohol and smoking have been known to be carcinogenic. Researchers of the past have long been able to make it known that about 75 percent of head and neck cancers are caused by a combination of alcohol and tobacco use. Not long ago, two large studies have reviewed patterns of alcohol and tobacco use in people with cancer of the mouth, throat, and larynx, the head and neck cancers most likely to be caused by smoking and drinking.

Of these studies, one study was published in the American Journal of Epidemiology, and another was published in the Journal of the National Cancer Institute. Both studies assembled data from previous case-controlled studies and included myriads of cases of laryngeal, pharyngeal, and oral cancers matched against normal controls. The reported findings from these studies shed some light on just how alcohol and tobacco alone or in combination can influence the development of the head and neck cancers. Cancer and smoking to most seem synonymous but lately researchers have been able to establish links between cancers and alcohol drinking too. Here are some of the findings from these two studies findings.

Smoking lightly for many years increases the risk of head and neck cancer more than smoking heavily for only a few years.
Drinking heavily for a few years increases the risk of head and neck cancer more than drinking moderately for many years.
Smoking is most strongly associated with laryngeal cancer.
Just smoking increases the risk of head and neck cancer substantially and the risk goes up with the frequency and duration of smoking.
Just drinking only increases the risk of head and neck cancer if you have three or more drinks a day.

“These studies are interesting but the most important thing for people to know is that smoking and drinking each increase your risk of head and neck cancer and smoking and drinking together multiply your risk. That means that the cumulative effect is worse than just adding the two risk factors together,” warns Tamer Ghanem, MD, PhD, an ear, nose, and throat specialist at Henry Ford Hospital in Detroit.

How alcohol Drinking and tobacco smoking causes cancer

As stated earlier, both alcohol and tobacco are known to be carcinogenic. The most known cause of cancer is DNA alteration which leads to gene mutation. Alcohol is full of these carcinogens that once inside the body triggers changes in the DNA make up. Equally tobacco is made up of a cocktail of many toxins that when consumed causes a series of DNA alterations.

Alcohol alone has been shown to cause changes in the cells of the oral mucosa and may damage head and neck cell DNA. This finding now points out to the reality that alcohol abuse alone even without the combination with cigarette smoking is enough to cause the head and neck cancers.

These reports also showed that in a tobacco smoke there are more than 60 are carcinogenic chemicals that does more harm than good when inhaled.

Alcohol may act as a solvent, making it easier for carcinogens in tobacco to enter head and neck cells. This may explain that in combination the effects of smoking and drinking of alcohol can be adverse and escalate the risk of head and neck cancers catching up with the smoker.

Head and Neck Cancer From these study findings we can say that people who use both tobacco and alcohol are at greater risk of developing these cancers than people who use either tobacco or alcohol alone. However it is safe to quit using alcohol even if you are not a smoker as these two studies plus other earlier ones have been able to establish and cement the fact that alcohol drinking alone is enough to cause DNA alterations which eventually leads to cancers of the Head and neck.

Some common symptoms of Head and neck cancers

Some of these symptoms may include swollen Pharynx, breathing problems, a lump or a sore that does not heal, a sore throat that does not go away, difficulty in swallowing, and a change or hoarseness in the voice. When you find yourself suffering from these symptoms that may also be same as those people suffer when sick of colds and fever it is good to check with a doctor before it’s too late.

Finally, Drug abuse, addiction and independence are problems that people grapple with every day. These problems need to be treated effectively through integrative medicine. Dr. Dalal Akoury (MD) is an expert at this. Call her on (843) 213-1480 for help.

Alcohol Abuse and Head and Neck Cancer

Alcohol Abuse and Colorectal Cancer

January 21, 2015

Research Shows Alcohol Abuse Can Cause Colorectal Cancer

colorectal cancer In the past few articles we looked into the effects of alcohol abuse in relation to initiating some cancers. Alcohol abuse has been linked to different cancers and this may be because of alcohol’s general effects on the body which includes the following;

Alcohol generates reactive oxygen species. These are chemically reactive molecules that contain oxygen which can damage DNA, proteins, and lipids through the process known as oxidation.

Alcohol also breaks down ethanol present in alcoholic drinks to acetaldehyde, which is a toxic chemical and a probable human carcinogen. This substance is toxic enough to damage both DNA and the genetic materials that make up the genes and this may cause mutation which causes cancer.

Alcohol also impairs the body’s own ability to metabolize and absorb a variety of nutrients that may be associated with a reduction in cancer risk, including vitamin A; nutrients in the vitamin B complex, such as folate; vitamin C; vitamin D; vitamin E; and carotenoids. Absence of these nutrients escalates the risk of cancer. It is also believed to increase the levels of estrogen hormone which is also associated with increased cancer risks.

Alcoholic drinks are also made up of very harmful contents which are mostly introduced during production. These may include nitrosamines, asbestos fibers, phenols, and hydrocarbons which may increase cancer risks.

Colorectal cancer

As the name suggests, colorectal cancer refers to cancers that affect the colon and the rectum. Colon cancer is cancer of the colon, which is at the lower part of the digestive system. On the other hand, rectal cancer is cancer of the rectum which is part of the last inches of the colon. Together these two cancers can be referred to as colorectal cancers. In the colon cancer may begin as small lumps that are non-cancerous clumps of cells known as adenomatous polyps, however these polyps will grow into cancerous cells. At the beginning these polyps will not show any symptom associated with cancer and this may even pose a greater health challenge, therefore it is important to have yourself screened regularly for colorectal cancer. There are several cancers of the colon and rectum but adenocarcinomas are the dominant cancer type constituting up to 95 percent of colorectal cancer but there are other rare types of tumors that are also equally dangerous.

Signs and symptoms of colon cancer

Just like any other disease there are indicators that you may be suffering from colorectal cancers. These signs and symptoms may include;

Persistent abdominal discomfort, such as cramps, gas or pain
A feeling that your bowel doesn’t empty completely
Weakness or fatigue
Unexplained weight loss
Constipation
Diarrhea
A change in consistency of passing stool
Rectal bleeding or blood in your stool

These symptoms though unpleasant may help you to know your status in relation to colorectal cancers and help you seek treatment in good time. However these symptoms may not show at early stages making it hard for colorectal cancer to be detected early. It is therefore advisable to go for screening to help with early treatment. If you notice any symptoms of colon cancer, such as blood in your stool or a persistent change in bowel habits the best you can do is to seek medical help.

Alcohol linked to colorectal cancer

Excessive alcohol consumption has been regarded as a risk factor for developing colorectal adenomas. In a study aimed to investigate the influence of excessive alcohol consumption on the occurrence of colorectal cancer among patients with at least one colonic adenoma done by M Bardou, S Montembault, V Giraud, A Balian, E Borotto, C Houdayer, F Capron, J-C Chaput and S Naveau it was found that In patients with at least one colorectal adenoma, excessive alcohol consumption increases the likelihood of developing high risk adenomas or colorectal cancer. In this study the participants were divided into three groups. All had at least one colorectal adenoma. The first group consisted of 401 heavy drinkers; the second group consisted of 152 patients suffering from irritable bowel syndrome (IBS) while the third group consisted of 108 patients with a family history (FH) of colorectal adenoma or cancer. For this study exclusive criteria were anemia, haematochezia, personal history of colorectal adenoma or cancer, and for groups heavy drinking and IBS a family history of colorectal adenoma and/or cancer.

This is not the first study to show this relation between alcohol abuse and colorectal cancer. This relation between alcohol consumption and risk of developing colorectal adenomas has been demonstrated previously by several authors. In a research it was found that the risk of polyps was increased three times for drinkers who did not smoke and 12 times for both drinkers and smokers compared with the risk of total abstainers. Naveau et al found that alcoholism and cirrhosis were two independent risk factors for colorectal adenomatous polyps after successive adjustments for sex, age, smoking, and serum cholesterol levels.

Alcohol addiction is a vice that should be fought by all means that is why we at AWAREmed Health and Wellness Resource Center are committed to availing help to addicts and offering them a place to call home. We offer NER Treatment and Amino acid therapy that are the most effective approaches to addiction treatment and recovery. You call on Dr. Dalal Akoury (MD) today and begin your journey to victory against addiction.

Alcohol Abuse and Colorectal Cancer

Alcohol Abuse Increases Risk of Cancer

January 20, 2015

How Does Alcohol Increase The Risk Of Cancer?

Risk of cancer Alcohol drinking is a common practice. To some people they do it when seeking pleasure but to others it has become an addiction that they can’t live without. The pleasure seekers ay only take alcohol once in a week, possibly on weekends but to those already addicted to the rum they can’t go a day without it. Most people however engage in alcohol drinking as a way to bond with friends and give them that sense of belonging. Whatever the reason you take alcohol for it is important that you be aware of the risks associated with drinking alcohol. Apart from alcohol addiction that every person never wants to be chained to, there are other serious risks associated with alcohol drinking. One of these risks that are associated with alcohol drinking is that it increases the risk of cancer.

Cancer is currently one of the most dreaded diseases worldwide. It is a disease that is not only expensive to treat but is synonymous to pain. The chronic pain that is associated with cancer in itself a risk to addiction to opiates that are normally used to quell the pain. even today doctors are still working to avail other better options of treating cancer so as to avoid its debilitating effects on its victims but still it pays a great deal to stay out of all the factors that may increase your risks of cancer debilitating you. having learnt of the current unbreakable link between alcohol to increased risk of cancer the best thing to do for any alcohol addicted fellow is to seek medical heap especially through an integrative doctor to help him quit alcohol and wholly heal him from the effects of alcohol before it pave way for cancer to creep in. with this said I think it is better we get the specifics of this link so that you may judge for yourself if quitting alcohol is worth it. Here are some possible explanations for how alcohol can increase risk of cancer.

Acetaldehyde is a carcinogen

When taken, alcohol is converted into a toxic chemical called acetaldehyde in our bodies. Acetaldehyde can cause cancer by damaging DNA and stopping our cells from repairing this damage. The International Agency for Research on Cancer have classified acetaldehyde formed as a result of drinking alcohol as being a cause of cancer, along with alcohol itself. It also causes liver cells to grow faster than normal. These regenerating cells are more likely to pick up changes in their genes that could lead to cancer.

Typically, ethanol is broken down mainly by the liver, but lots of other cell types can do this as well. Some of the bacteria that live in our mouths and the linings of our guts are also able to convert ethanol into acetaldehyde. The reactive nature of acetaldehyde is such that it can form DNA adducts of which, the most well-known and extensively studied, is N2-ethyl-2′-deoxyguanosine (N2-ethyl-dG). Studies done on rats that were put on a drinking water with 10% (v/v) alcohol proves that indeed acetaldehyde is harmful and causes cancer.

Alcohol increases estrogen levels

Estrogen dominance causes cancer. It is because of estrogen dominance in obese women that exposes them to breast cancer. Several past studies have proved this. Alcohol increases risk of cancer by increasing the levels of estrogen in a person. Despite its very essential purposes as a hormone estrogen has a dark side too this can be made worse by alcohol consumption-risk of cancer.

Alcohol damages liver cells

Alcohol consumption damages the liver cells leading to a disease known as liver cirrhosis. This even increases your risk of developing liver cancer. Apart from this, it also makes it easier for the tissues of the mouth and throat to absorb the cancer-causing chemicals in tobacco. This explains why people who drink and smoke multiply the damage they receive and have especially high risks of cancer. Alcohol also impairs the body’s ability to break down and absorb a variety of nutrients that may be associated with cancer risk, leading to lack of these essential Vitamins: vitamin A; nutrients in the vitamin B family such as Thiamine and folate; vitamin C; vitamin D; vitamin E; and carotenoids. Lack of these essential nutrients escalates the risk of cancer.

Alcohol depletes Folate

Excessive or long term consumption of alcohol leads to depletion of folate. Folate is an important vitamin that helps our cells produce new DNA correctly. People who drink alcohol tend to have lower levels of folate in their blood. Some studies have linked low levels of folate to cancer.

Alcohol generates ROS

Alcohol generate damaging reactive oxygen species (chemically reactive molecules that contain oxygen), which can damage DNA, proteins, and lipids (fats) through a process called oxidation. Any damage on DNA increases risk of cancer. Besides alcoholic beverages may also contain a variety of carcinogenic contaminants that are introduced during fermentation and production, these may include; nitrosamines, asbestos fibers, phenols, and hydrocarbons.

Alcohol addiction is a vice that should be fought by all means that is why we at AWAREmed Health and Wellness Resource Center are committed to availing help to addicts and offering them a place to call home. We offer NER Treatment and Amino acid therapy that are the most effective approaches to addiction treatment and recovery. You call on Dr. Dalal Akoury (MD) today and begin your journey to victory against addiction.

How Does Alcohol Increase The Risk Of Cancer?

Category Archives: Addiction Courses